Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 37, 2007 - Issue 12
190
Views
5
CrossRef citations to date
0
Altmetric
Research Article

Nonlinear intestinal pharmacokinetics of mitemcinal, the first acid-resistant non-peptide motilin receptor agonist, in rats

, , , , , , , , & show all
Pages 1421-1432 | Received 04 Jul 2007, Accepted 06 Sep 2007, Published online: 22 Sep 2008

References

  • Amidon GL, Lennernas H, Shah VP, Crison JR. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharmaceutical Research 1995; 12: 413–420
  • Benet LZ, Cummins CL, Wu CY. Unmasking the dynamic interplay between efflux transporters and metabolic enzymes. International Journal of Pharmaceutics 2004; 11: 3–9
  • Dowty ME, Dietsch CR. Improved prediction of in vivo peroral absorption from in vitro intestinal permeability using an internal standard to control for intra- and inter-rat variability. Pharmaceutical Research 1997; 14: 1792–1797
  • Fang J, McCallum R, DiBaise J, Schmitt C, Kipnes M. Effects of mitemcinal fumarate (GM-611) on gastric emptying inpatients with idiopathic or diabetic gastroparesis. Gastroenterology 2004; 126: A483
  • Harrison A, Betts A, Fenner K, Beaumont K, Edgington A, Roffey S, Davis J, Comby P, Morgan P. Nonlinear oral pharmacokinetics of the alpha-antagonist 4-amino-5-(4-fluorophenyl)-6,7-dimethoxy-2-[4-(morpholinocarbonyl)-perhydro-1,4-diazepin-1-yl]quinoline in humans: use of preclinical data to rationalize clinical observations. Drug Metabolism and Disposition 2004; 32: 197–204
  • Hellriegel ET, Bjornsson TD, Hauck WW. Interpatient variability in bioavailability is related to the extent of absorption: implications for bioavailability and bioequivalence studies. Clinical Pharmacology and Therapeutics 1996; 60: 601–607
  • Hoffman DJ, Seifert T, Borre A, Nellans HN. Method to estimate the rate and extent of intestinal absorption in conscious rats using an absorption probe and portal blood sampling. Pharmaceutical Research 1995; 12: 889–894
  • Kato M, Chiba K, Hisaka A, Ishigami M, Kayama M, Mizuno N, Nagata Y, Takakuwa S, Tsukamoto Y, Ueda K, Kusuhara H, Ito K, Sugiyama Y. The intestinal first-pass metabolism of substrates of CYP3A4 and P-glycoprotein-quantitative analysis based on information from the literature. Drug Metabolism and Pharmacokinetics 2003; 18: 365–372
  • Koga H, Sato T, Tsuzuki K, Onoda H, Kuboniwa H, Takanashi H. Potent, acid-stable and orally active macrolide-type motilin receptor agonist, GM-611 and the derivatives. Bioorganic & Medicinal Chemistry Letters 1994; 4: 1347–1352
  • Latini R, Bonati M, Marzi E, Tacconi MT, Sadurska B, Bizzi A. Caffeine disposition and effects in young and one-year old rats. Journal of Pharmacy and Pharmacology 1980; 32: 596–599
  • McCallum RW, Cynshi O and US Investigative Team. Efficacy of mitemcinal, a motilin agonist, on gastrointestinal symptoms in patients with symptoms suggesting diabetic gastropathy: A randomized, multi-center, placebo-controlled trial. Alimentary Pharmacology and Therapeutics 2007; 26: 107–116
  • Ozaki K, Sudo H, Onoma M, Kamei K, Akima M, Koga H, Itoh Z, Õmura S, Takanashi H. Effects of mitemcinal (GM-611), an acid-resistant nonpeptide motilin receptor agonist, on the gastrointestinal contractile activity in conscious dogs. Pharmacology 2007; 79: 223–235
  • Sabath LD, Lorian V, Gerstein D, Loder PB, Finland M. Enhancing effect on alkalinization of the medium on the activity of erythromycin against gram-negative bacteria. Applied Microbiology 1968; 16: 1288–1292
  • Takanashi H, Yogo K, Ozaki K, Koga H, Itoh Z, Õmura S. In vitro pharmacological characterization of mitemcinal (GM-611), the first acid-resistant nonpeptide motilin receptor agonist, in smooth muscle of rabbit small intestine. Pharmacology 2007; 79: 137–148
  • Takano M, Hasegawa R, Fukuda T, Yumoto R, Nagai J, Murakami T. Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells. European Journal of Pharmacology 1998; 358: 289–294
  • Takeuchi T, Yoshitomi S, Higuchi T, Ikemoto K, Niwa S, Ebihara T, Katoh M, Yokoi T, Asahi S. Establishment and characterization of the transformants stably-expressing MDR1 derived from various animal species in LLC-PK1. Pharmaceutical Research 2006; 23: 1460–1472
  • Tamai I, Saheki A, Saitoh R, Sai Y, Yamada I, Tsuji A. Nonlinear intestinal absorption of 5-hydroxytryptamine receptor antagonist caused by absorptive and secretory transporters. Journal of Pharmacology and Experimental Therapeutics 1997; 283: 108–115
  • Tanigawara Y, Okamura N, Hirai M, Yasuhara M, Ueda K, Kioka N, Komano T, Hori R. Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1). Journal of Pharmacology and Experimental Therapeutics 1992; 263: 840–845
  • Wacher VJ, Wu CY, Benet LZ. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy. Molecular Carcinogenesis 1995; 13: 129–134
  • Wakasugi H, Yano I, Ito T, Hashida T, Futami T, Nohara R, Sasayama S, Inui K. Effect of clarithromycin on renal excretion of digoxin: interaction with P-glycoprotein. Clinical Pharmacology and Therapeutics 1998; 64: 123–128
  • Yogo K, Ozaki K, Takanashi H, Koto M, Itoh Z, Õmura S. Effects of motilin and mitemcinal (GM-611) on the gastrointestinal contractile activity in Rhesus monkeys in vivo and in vitro. Digestive Diseases and Sciences. doi: 10.1007/s10620-006-9672-5. 2007
  • Yunker MH, Borodkin S. Determination of rate constants for in vitro three-compartment transfer using a two-phase system. Journal of Pharmaceutical Sciences 1971; 60: 52–56

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.