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Xenobiotica
the fate of foreign compounds in biological systems
Volume 38, 2008 - Issue 1
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Research Article

Quantitative analysis of aryl hydrocarbon receptor activation using fluorescence-based cell imaging—A high-throughput mechanism-based assay for drug discovery

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Pages 1-20 | Received 13 Aug 2007, Accepted 06 Sep 2007, Published online: 22 Sep 2008

References

  • Backlund M, Ingelman-Sundberg M. Regulation of aryl hydrocarbon receptor signal transduction by protein tyrosine kinases. Cellular Signalling 2005; 17: 39–48
  • Backlund M, Weidolf L, Ingelman-Sundberg M. Structural and mechanistic aspects of transcriptional induction of cytochrome P450 1A1 by benzimidazole derivatives in rat hepatoma H4IIE cells. European Journal of Biochemistry 1999; 261: 66–71
  • Beischlag TV, Wang S, Rose DW, Torchia J, Reisz-Porszasz S, Muhammad K, Nelson WE, Probst MR, Rosenfeld MG, Hankinson O. Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex. Molecular Cellular Biology 2002; 22: 4319–4333
  • Bridgland-Taylor MH, Hargreaves AC, Easter A, Orme A, Henthom DC, Ding M, Davis AM, Small BG, Heapy CG, Abi-Gerges N, et al. Optimisation and validation of a medium-throughput electrophysiology-based hERG assay using lon Works HT. Journal of Pharmacology and Toxicology Methods 2006; 54: 189–199
  • Carr BA, Franklin MR. Induction of drug metabolizing enzymes by 1,7-phenanthroline and oltipraz in mice is unrelated to Ah-responsiveness. Journal of Biochemistry and Molecular Toxicology 1999; 13: 77–82
  • Carver LA, Bradfield CA. Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo. Journal of Biological Chemistry 1997; 272: 11452–11456
  • Daujat M, Peryt B, Lesca P, Fourtanier G, Domergue J, Maurel P. Omeprazole, an inducer of human CYP1A1 and 1A2, is not a ligand for the Ah receptor. Biochemical and Biophysical Research Communications 1992; 188: 820–825
  • Denison MS, Nagy SR. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annual Review of Pharmacology and Toxicology 2003; 43: 309–334
  • Denison MS, Whitlock JP, Jr. Xenobiotic-inducible transcription of cytochrome P450 genes. Journal of Biological Chemistry 1995; 270: 18175–18178
  • Dzeletovic N, McGuire J, Daujat M, Tholander J, Ema M, Fujii-Kuriyama Y, Bergman J, Maurel P, Poellinger L. Regulation of dioxin receptor function by omeprazole. Journal of Biological Chemistry 1997; 272: 12705–12713
  • Fenech M. In vitro micronucleus technique to predict chemo sensitivity. Methods in molecular medicine 2005; 111: 3–32
  • Fernandez-Salguero PM, Hilbert DM, Rudikoff S, Ward JM, Gonzalez FJ. Aryl-hydrocarbon receptor-deficient micq are resistant to 2,3,7,8 tetrachlorodibenzo-p-dioxin-induced toxicity. Toxicology and Applied Pharmacology 1996; 140: 173–179
  • Garside H, Stevens A, Farrow S, Normand C, Houle B, Berry A, Maschera B, Ray D. Glucocorticoid ligands specify different interactions with NF-kappaB by allosteric effects on the glucocorticoid receptor DNA binding domain. Journal of Biological Chemistry 2004; 279: 50050–50059
  • Hankinson O. The aryl hydrocarbon receptor complex. Annual Review of Pharmacology and Toxicology 1995; 35: 307–340
  • Jensen BA, Hahn ME. cDNA cloning and characterization of a high affinity aryl hydrocarbon receptor in a cetacean, the beluga, Delphinapterus leucas. Toxicological Sciences 2001; 64: 41–56
  • Kazlauskas A, Poellinger L, Pongratz I. Evidence that the co-chaperone p23 regulates ligand responsiveness of the dioxin (Aryl hydrocarbon) receptor. Journal of Biological Chemistry 1999; 274: 13519–13524
  • Kikuchi H, Fukushige S, Shibazaki M, Shiratori Y. Presence on human chromosome 10 of omeprazole-sensitivity gene whose product mediates CYP1A1 induction. Cytogenetic Genome Research 2002; 97: 51–57
  • Kikuchi H, Hossain A. Signal transduction-mediated CYP1A1 induction by omeprazole in human HepG2 cells. Experimental and Toxicologic Pathology 1999; 51: 342–346
  • Kikuchi H, Hossain A, Yoshida H, Kobayashi S. Induction of cytochrome P-450 1A1 by omeprazole in human HepG2 cells is protein tyrosine kinase-dependent and is not inhibited by alpha-naphthoflavone. Archives of Biochemistry and Biophysics 1998; 358: 351–358
  • Kikuchi H, Kato H, Mizuno M, Hossain A, Ikawa S, Miyazaki J, Watanabe, M. Differences in inducibility of CYP1A1-mRNA by benzimidazole compounds between human and mouse cells: Evidences of a human-specific signal transduction pathway for CYP1A1 induction. Archives of Biochemistry and Biophysics 1996; 334: 235–240
  • Kumar MB, Ramadoss P, Reen RK, Vanden Heuvel JP, Perdew GH. The Q-rich subdomain of the human Ah receptor transactivation domain is required for dioxin-mediated transcriptional activity. Journal of Biological Chemistry 2001; 276: 42302–42310
  • Lahvis GP, Lindell SL, Thomas RS, McCuskey RS, Murphy C, Glover E, Bentz M, Southard J, Bradfield CA. Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice. Proceedings of the National Academy of Sciences of the United States of America 2000; 97: 10442–10447
  • Lu C, Li AP. Species comparison in P450 induction: Effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague-Dawley rat, minipig, and beagle dog. Chemico-biological Interactions 2001; 134: 271–281
  • Ma Q, Whitlock JP, Jr. A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Journal of Biological Chemistry 1997; 272: 8878–8884
  • Mackenzie AR, Brroks S. New Chloraenegens. Chemical and Engineering News 1998; 76: 8
  • Nair SC, Toran EJ, Rimerman RA, Hjermstad S, Smithgall TE, Smith DF. A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor. Cell Stress and Chaperones 1996; 1: 237–250
  • Nebert DW. Drug-metabolizing enzymes in ligand-modulated transcription. Biochemical Pharmacology 1994; 47: 25–37
  • Nguyen TA, Hoivik D, Lee JE, Safe S. Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex. Archives of Biochemistry and Biophysics 1999; 367: 250–257
  • Oesch-Bartlomowicz B, Huelster A, Wiss O, Antoniou-Lipfert P, Dietrich C, Arand M, Weiss C, Bockamp E, Oesch F. Aryl hydrocarbon receptor activation by cAMP vs. dioxin: Divergent signaling pathways. Proceedings of the National Academy of Sciences of the United States of America 2005; 102: 9218–9223
  • Pepperkok R, Ellenberg J. High-throughput fluorescence microscopy for systems biology. Nature Reviews Molecular Cell Biology 2006; 7: 690–696
  • Perdew GH. Association of the Ah receptor with the 90-kDa heat shock protein. Journal of Biological Chemistry 1988; 263: 13802–13805
  • Pohjanvirta R, Viluksela M, Tuomisto JT, Unkila M, Karasinska J, Franc MA, Holowenko M, Giannone JV, Harper PA, Tuomisto J, Okey AB. Physicochemical differences in the AH receptors of the most TCDD-susceptible and the most TCDD-resistant rat strains. Toxicology and Applied Pharmacology 1999; 155: 82–95
  • Pollenz RS, Dougherty EJ. Redefining the role of the endogenous XAP2 and C-terminal hsp70-interacting protein on the endogenous Ah receptors expressed in mouse and rat cell lines. Journal of Biological Chemistry 2005; 280: 33346–33356
  • Poland A, Knutson EJ. 2,3,7,8-tetrachorodibenzo-f-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annual Review of Pharmacology and Toxicology 1982; 22: 517–554
  • Pollenz RS, Sattler CA, Poland A. The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa 1c1c7 cells by immunofluorescence microscopy. Molecular Pharmacology 1994; 45: 428–438
  • Roberts EA, Johnson KC, Dippold WG. Ah receptor mediating induction of cytochrome P450IA1 in a novel continuous human liver cell line (Mz-Hep-1). Detection by binding with [3H]2,3,7,8-tetrachlorodibenzo-p-dioxin and relationship to the activity of aryl hydrocarbon hydroxylase. Biochemical Pharmacology 1991; 42: 521–528
  • Saeki K, Matsuda T, Kato TA, Yamada K, Mizutani T, Matsui S, Fukuhara K, Miyata N. Activation of the human Ah receptor by aza-polycyclic aromatic hydrocarbons and their halogenated derivatives. Biological and Pharmaceutical Bulletin 2003; 26: 448–452
  • Safe S. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: Environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). Critical Reviews in Toxicology 1990; 21: 51–88
  • Scarri L, Zaki I, Millard LG. Severe halogen cone due to a trifluoro methyl pyrazole derivative and its resistance to isotretinion. British Journal of Permotology 1993; 132: 144–148
  • Santostefano M, Merchant M, Arellano L, Morrison V, Denison MS, Safe S. alpha-Naphthoflavone-induced CYP1A1 gene expression and cytosolic aryl hydrocarbon receptor transformation. Molecular Pharmacology 1993; 43: 200–206
  • Schmidt JV, Su GH, Reddy JK, Simon MC, Bradfield CA. Characterization of a murine Ahr null allele: Involvement of the Ah receptor in hepatic growth and development. Proceedings of the National Academy of Sciences of the United States of America 1996a; 93: 6731–6736
  • Seglen PO. Preparation of isolated rat liver cells. Methods in Cell Biology 1976; 13: 29–83
  • Stevens A, Garside H, Berry A, Waters C, White A, Ray D. Dissociation of steroid receptor coactivator 1 and nuclear receptor corepressor recruitment to the human glucocorticoid receptor by modification of the ligand-receptor interface: The role of tyrosine 735. Molecular Endocrinology 2003; 17: 845–859
  • Sugihara K, Kitamura S, Yamada T, Okayama T, Ohta S, Yamashita K, Yasuda M, Fujii-Kuriyama Y, Saeki K, Matsui S, Matsuda T. Aryl hydrocarbon receptor-mediated induction of microsomal drug-metabolizing enzyme activity by indirubin and indigo. Biochemical and Biophysical Research Communications 2004; 318: 571–578
  • Surry DD, Meneses-Lorente G, Heavens R, Jack A, Evans DC. Rapid determination of rat hepatocyte mRNA induction potential using oligonucleotide probes for CYP1A1, 1A2, 3A and 4A1. Xenobiotica 2000; 30: 441–456
  • Tan Z, Huang M, Puga A, Xia Y. A critical role for MAP kinases in the control of Ah receptor complex activity. Toxicological Sciences 2004; 82: 80–87
  • Vargas M, Lamb JG, Franklin MR. Phase II-selective induction of hepatic drug-metabolizing enzymes by oltipraz -5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione-, 1,7-phenanthroline, and 2,2-dipyridyl in rats is not accompanied by induction of intestinal enzymes. Drug Metabolism and Disposition 1998; 26: 91–97
  • Wilhelmsson A, Cuthill S, Denis M, Wikstrom AC, Gustafsson JA, Poellinger L. The specific DNA binding activity of the dioxin receptor is modulated by the 90 kd heat shock protein. The EMBO Journal 1990; 9: 69–76
  • Yarrow JC, Totsawoka G, Charros GT, Mitchison TJ. Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor. Chemical Biology 2005; 12: 385–395
  • Zaher H, Fernandez-Salguero PM, Letterio J, Sheikh MS, Fornace AJ, Jr, Roberts AB, Gonzalez FJ. The involvement of aryl hydrocarbon receptor in the activation of transforming growth factor-beta and apoptosis. Molecular Pharmacology 1998; 54: 313–321

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