Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 38, 2008 - Issue 1
137
Views
13
CrossRef citations to date
0
Altmetric
Research Article

In vivo effects of Urtica urens (dwarf nettle) on the expression of CYP1A in control and 3-methylcholanthrene-exposed rats

, &
Pages 48-61 | Received 24 Aug 2007, Accepted 29 Sep 2007, Published online: 22 Sep 2008

References

  • Abbas AB, Clifford MN, Walker R, Ioannides C. Marked antimutagenic potential of aqueous green tea extracts: Mechanism of action. Mutagenesis 1994; 9: 325–931
  • Arinc E, Philpot RM. Preparation and properties of partially purified pulmonary cytochrome P450 from rabbits. Journal of Biological Chemistry 1976; 251: 3213–3220
  • Arinc E, Sen A. Effects of in vivo benzo(a)pyrene treatment on liver microsomal mixed-function oxidase activities of gilthead seabream (Sparus aurata). Comparative Biochemistry and Physiology 1994; 107C: 405–414
  • Aydın M, Aslaner A, Zengin A. Using Urtica dioica in esophageal cancer: A report of a case. Internet Journal of Surgery 2006; 7(2), (available at: http://www.ispub.com/ostia/index.php?xmlFilePath=journals/ijs/vol7n2/esophageal.xml) (accessed on 11 August 2007)
  • Berthou F, Guillois B, Riche C, Dreano Y, Jacqz-Aigrain E, Beaune PH. Interspecies variations in caffeine metabolism related to cytochrome P4501A enzymes. Xenobiotica 1992; 22: 671–680
  • Bondy SC, Naderi S. Contribution of hepatic cytochrome P450 systems to the generation of reactive oxygen species. Biochemical Pharmacology 1994; 48: 155–159
  • Bonner MR, Han D, Nie J, Rogerson P, Vena JE, Muti P, Trevisan M, Edge SB, Freudenheim JL. Breast cancer risk and exposure in early life to polycyclic aromatic hydrocarbons using total suspended particulates as a proxy measure. Cancer Epidemiology Biomarkers and Prevention 2005; 14: 53–60
  • Brauze D, Widerak M, Cwykiel J, Szyfter K, Baer-Dubowska W. The effect of aryl hydrocarbon receptor ligands on the expression of AhR, AhRR, ARNT, Hif1 alpha, CYP1A1 and NQO1 genes in rat liver. Toxicology Letters 2006; 167: 212–220
  • Burke MD, Mayer RT. Ethoxyresorufin: direct fluorometric assay of microsomal O-dealkylation which is preferentially induced by 3-methylcholanthrene. Drug Metabolism and Disposition 1974; 2: 583–588
  • Cochin J, Axelrod J. Biochemical and pharmacological changes in the rat following chronic administration of morphine, nalorphine, and normorphine. Journal of Pharmacology and Experimental Therapeutics 1959; 125: 105–110
  • Conney AH. Pharmacological implications of microsomal induction. Pharmacological Reviews 1967; 19: 317–366
  • Cooper DY, Levin S, Narasim Hulu S, Rosenthal O, Estabrook RW. Photochemical action spectrum of the terminal oxidase of mixed function oxidase systems. Science 1965; 147: 400–402
  • Danielson PB. The cytochrome P450 superfamily: Biochemistry, evolution and drug metabolism in humans. Current Drug Metabolism 2002; 3: 561–597
  • Elbekai RH, Korashy HM, Wills K, Gharavi N, El-Kadi AOS. Benzo[a]pyrene, 3-methylcholanthrene and beta-naphthoflavone induce oxidative stress in hepatoma hepa 1c1c7 cells by an AHR-dependent pathway. Free Radical Research 2004; 38: 1191–1200
  • Gonzalez FJ. Molecular genetics of the P450 superfamily. Pharmacology and Therapeutics 1990; 45: 1–38
  • Gonzalez FJ, Gelboin HV. Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins. Drug Metabolism Reviews 1994; 26: 165–183
  • Gonzalez FJ, Kimura S, Nebert DW. Comparison of the flanking regions and introns of the 2,3,7,8-tetrachlorodibenzo-p-dioxin inducible cytochrome P1450 and P3450 genes. Journal of Biological Chemistry 1985; 260: 5040–5049
  • Guengerich FP. Roles of cytochrome P450 enzymes in chemical carcinogenesis and cancer chemotherapy. Cancer Research 1988; 48: 2946–2954
  • Hammons GJ, Fletcher JV, Stepps KR, Smith EA, Balentine DA, Harbowy ME, Kadlubar FF. Effects of chemoprotective agents on the metabolic activation of the carcinogenic arylamines PhIP and 4-aminobiphenyl in human and rat liver microsomes. Nutrition and Cancer 1999; 33: 46–52
  • Hayashi S-I, Watanabe J, Nakachi K, Eguchi H, Gotoh O, Kawajiri K. Interindividual difference in expression of human Ah receptor and related P450 genes. Carcinogenesis 1994; 15: 801–806
  • Hennig B, Meerarani P, Slim R, Toborek M, Daugherty A, Silverstone AE, Robertson LW. Proinflammatory properties of coplanar PCBs: In vitro and in vivo evidence. Toxicology and Applied Pharmacology 2002; 181: 174–183
  • Kavalali G, Tuncel H, Goksel S, Hatemi HH. Hypoglycemic activity of Urtica pilulifera in streptozotocin-diabetic rats. Journal of Ethnopharmacology 2003; 84: 241–245
  • Keiloff GJ, Boone CW, Crowell JA, Steele VE, Lubet RA, Doody LA, Malone WF, Hawk ET, Sigman CC. New agents for cancer chemoprevention. Journal of Cellular Biochemistry 2005; 63: 1–28
  • Kimura S, Gonzalez FJ, Nebert DW. Tissue-specific expression of the mouse dioxin-inducible P(1)450 and P(3)450 genes: Differential transcriptional activation and mRNA stability in liver and extrahepatic tissues. Molecular and Cellular Biology 1986; 6: 1471–1477
  • Konrad L, Muller HH, Lenz C, Laubinger H, Aumuller G, Lichius JJ. Antiproliferative effect on human prostate cancer cells by a stinging nettle root (Urtica dioica) extract. Planta Medica 2000; 66: 44–47
  • Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680–684
  • Lee H-C, Hwang S-G, Lee Y-G, Sohn H-O, Lee D-W, Hwang S-Y, Kwak Y-S, Jae-Wee J, Joo W-H, Cho Y-K, et al. In vivo effects of Panax ginseng extracts on the cytochrome P450-dependent monooxygenase system in the liver of 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed guinea pig. Life Sciences 2002; 71: 759–769
  • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Lu AYH, Levin W. The resolution and reconstitution of the liver microsomal hydroxylation system. Biochimica et Biophysica Acta 1974; 344: 205–240
  • McLemore TL, Adelberg S, Liu MC, McMahon NA, Yu SJ, Hubbard WC, Czerwinski M, Wood TG, Storeng R, Lubet RA, et al. Expression of CYP1A1 gene in patients with lung cancer: Evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas. Journal of the National Cancer Institute 1990; 82: 1333–1339
  • Minn A-L, Pelczar H, Denizot C, Martinet M, Heydel J-M, Walther B, Minn A, Goudonnet H, Artur Y. Characterızatıon of microsomal cytochrome P450-dependent monooxygenases in the rat olfactory mucosa. Drug Metabolism and Disposition 2005; 33: 1229–1237
  • Miranda CL, Yang Y-H, Henderson MC, Stevens JF, Santana-Rios G, Deinzer ML, Buhler DR. Prenylflavonoids from hops inhibit the metabolic activation of the carcinogenic heterocyclic amine 2-amino-3-methylimidazo[4,5-f]quinoline, mediated by cDNA-expressed human CYP1A2. Drug Metabolism and Disposition 2000; 28: 1297–1302
  • Moon YJ, Wang X, Morris ME. Dietary flavonoids: Effects on xenobiotic and carcinogen metabolism. Toxicology In Vitro 2006; 20: 187–210
  • Nash T. The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. Biochemical 1953; 55: 416–421
  • Nebert DW. The Ah locus: Genetic differences in toxicity, cancer, mutation, and birth defects. Critical Reviews in Toxicology 1989; 20: 153–174
  • Nebert DW, McKinnon RA. Cytochrome P450: Evolution and functional diversity. Progressive Liver Diseases 1994; 12: 63–97
  • Nebert DW, Nelson DR, Coon MJ, Estabrook RW, Feyereisen R, Fujii-Kuriyama Y, Gonzalez F, Guengerich FP, Gunsalus IC, Johnson EF, et al. The P450 superfamily: Update on new sequence, gene mapping, and recommended nomenclature. DNA and Cell Biology 1991; 10: 1–14
  • Nelson DR, Koymans L, Kamataki T, Stegeman JJ, Feyereisen R, Waxman DJ, Waterman MR, Gotoh O, Coon MJ, Estabrook RW, et al. P450 superfamily: Update on new sequences, gene mapping, accession numbers, and nomenclature. Pharmacogenetics 1996; 6: 1–43
  • Ozen T, Korkmaz H. Modulatory effect of Urtica dioica L. (Urticaceae) leaf extract on biotransformation enzyme systems, antioxidant enzymes, lactate dehydrogenase and lipid peroxidation in mice. Phytomedicine 2003; 10: 405–415
  • Pieroni A, Janiak V, Durr CM, Ludeke S, Trachsel E, Heinrich M. In vitro antioxidant activity of non-cultivated vegetables of ethnic Albanians in Southern Italy. Phytotherapy Research 2002; 16: 467–473
  • Prakash J, Gupta SK. Chemopreventive activity of Ocimum sanctum seed oil. Journal of Ethnopharmacology 2000; 72: 29–34
  • Ryan DE, Thomas PE, Levin W. Hepatic microsomal cytochrome P450 from rats treated with isosafrole; purification and characterization of four forms. Journal of Biological Chemistry 1980; 255: 7941–7955
  • Samur M, Bozcuk HS, Kara A, Savas B. Factors associated with utilization of nonproven cancer therapies in Turkey. A study of 135 patients from a single center Supportive Care in Cancer 2001; 9: 452–458
  • Schenkman JB, Cinti DL. Preparation of microsome with calcium. Methods in Enzymology 1978; 52: 83–89
  • Schulze-Tanzil G, DeSouza P, Behnke B, Klingelhoefer S, Scheid A, Shakibaei M. Effects of the antirheumatic remedy hox alpha — a new stinging nettle leaf extract — on matrix metalloproteinases in human chondrocytes in vitro. Histology and Histopathology 2002; 17: 477–485
  • Sen A, Arinc E. Preparation of highly purified cytochrome P4501A1 from leaping mullet (Liza saliens) liver microsomes and its biocatalytic, molecular and immunochemical properties. Comparative Biochemistry and Physiology 1998; 121C: 249–265
  • Sen A, Arinc E. Further immunochemical and biocatalytic characterization of CYP1A1 from feral leaping mullet liver (Liza saliens) microsomes. Comparative Biochemistry and Physiology 2000; 126C: 235–244
  • Sen A, Sahin B, Agus HH, Bayav M, Sevim H, Semiz A. Prevention of carbon tetrachloride-induced hepatotoxicity by Urtica urens in rats. Journal of Applied Biological Sciences 2007; 1: 29–32
  • Sivaraman L, Leatham MP, Yee J, Wilkens LR, Lau AF, Marchand LL. CYP1A1 genetic polymorphisms and in situ colorectal cancer. Cancer Research 1994; 54: 3692–3695
  • Sogawa K, Gotoh O, Kawajiri K, Fujii-Kuriyama Y. Complete nucleotide sequence of a methylcholanthrene inducible cytochrome P450 (P450d) gene in rat. Journal of Biological Chemistry 1985; 260: 5026–5032
  • Sokeland J. Combined sabal and Urtica extract compared with finasteride in men with benign prostatic hyperplasia: Analysis of prostate volume and therapeutic outcome. British Journal of Urology International 2000; 86: 439–442
  • Spatzenegger M, Horsmans Y, Verbeeck RK. Differential activities of CYP1A isozymes in hepatic and intestinal microsomes of control and 3-methylcholanthrene-induced rats. Pharmacology and Toxicology 2000; 86: 71–77
  • Strittmatter P, Velick SF. The purification and properties of microsomal cytochrome reductase. Journal of Biological Chemistry 1957; 228: 785–799
  • Tukey RH, Nebert DW. Regulation of mouse cytochrome P3–450 by the Ah receptor. Studies with a P3-450 cDNA clone. Biochemistry 1984; 23: 6003–6008
  • Wargovich MJ, Woods C, Hollis DM, Zander ME. Herbals, cancer prevention and health. Journal of Nutrition 2001; 131: 3034S–3036S
  • Waterman MR, John ME, Simpson ER. Regulation of synthesis and activity of cytochrome P-450 enzymes in physiological pathways. Cytochrome P-450. Structure, mechanism, and biochemistry, PR Ortiz de Montellano. Plenum, New York, NY 1986; 345–386
  • Watt JM, Breyer-Brandwijk MG. The medicinal and poisonous plants of southern and eastern Africa2nd. Livingstone, London 1962
  • Whitlock JP. The regulation of cytochrome P450 gene expression. Annual Review of Pharmacology and Toxicology 1986; 26: 333–369
  • Yamazoe Y, Kato R. Activation of chemical carcinogens. Cytochrome P-450, T Omura, Y Ishimura, Y Furii-Kuriyama. Kodansha, Tokyo 1993; 159–170
  • Yoshida R, Ogawa Y. Oxidative stress induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin: An application of oxidative stress markers to cancer risk assessment of dioxins. Industrial Health 2000; 38: 5–14
  • Young RC, Wilson CM. Cancer prevention: Past, present, and future. Clinical Cancer Research 2002; 8: 11–16
  • Zacharova LY, Gulyaeva LF, Lyakhovich VV, Mikhailova ON, Timofeeva OA, Filipenko MF, Kaledin VI. Cytochrome P4501A1 and 1A2 Gene Expression in the liver of 3-methylcholanthrene- and o-aminoazotoluene-treated mice: A comparison between PAH-responsive and PAH-nonresponsive strains. Toxicological Sciences 2003; 73: 108–113

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.