2,101
Views
329
CrossRef citations to date
0
Altmetric
Research Article

Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family

&
Pages 778-801 | Received 03 Dec 2007, Accepted 13 Feb 2008, Published online: 22 Sep 2008

References

  • Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D, Nomura H, Unno M, Suzuki M, Naitoh T, et al. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. Journal of Biology and Chemistry 1999; 274: 17159–17163
  • Abe T, Unno M, Onogawa T, Tokui T, Kondo TN, Nakagomi R, Adachi H, Fujiwara K, Okabe M, Suzuki T, et al. LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology 2001; 120: 1689–1699
  • Abramson J, Smirnova I, Kasho V, Verner G, Kaback HR, Iwata S. Structure and mechanism of the lactose permease of Escherichia coli. Science 2003; 301(5633)610–615
  • Adachi H, Suzuki T, Abe M, Asano N, Mizutamari H, Tanemoto M, Nishio T, Onogawa T, Toyohara T, Kasai S, et al. Molecular characterization of human and rat organic anion transporter OATP-D. American Journal of Physiology and Renal Physiology 2003; 285(6)1197
  • Ambudkar SV, Kimchi-Sarfaty C, Sauna ZE, Gottesman MM. P-glycoprotein: From genomics to mechanism. Oncogene 2003; 22(47)7468–7485
  • Ancona N, Maglietta R, Piepoli A, D’Addabbo A, Cotugno R, Savino M, Liuni S, Carella M, Pesole G, Perri F. On the statistical assessment of classifiers using DNA microarray data. BMC Bioinformatics 2006; 7: 387
  • Badagnani I, Castro RA, Taylor TR, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, et al. Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants. Journal of Pharmacology and Experimental Therapy 2006; 318(2)521–529
  • Bailey DG, Dresser GK, Leake BF, Kim RB. Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice. Clinical Pharmacology and Therapy 2007; 81(4)495–502
  • Bakos E, Homolya L. Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1). Pflugers Archives 2007; 453(5)621–641
  • Baldes C, Koenig P, Neumann D, Lenhof HP, Kohlbacher O, Lehr CM. Development of a fluorescence-based assay for screening of modulators of human organic anion transporter 1B3 (OATP1B3). European Journal of Pharmacology and Biopharmacology 2006; 62(1)39–43
  • Bossuyt X, Muller M, Meier PJ. Multispecific amphipathic substrate transport by an organic anion transporter of human liver. Journal of Hepatology 1996; 25(5)733–738
  • Briz O, Romero MR, Martinez-Becerra P, Macias RI, Perez MJ, Jimenez F, San Martin FG, Marin JJ. OATP8/1B3-mediated cotransport of bile acids and glutathione: An export pathway for organic anions from hepatocytes?. Journal of Biology and Chemistry 2006; 281(41)30326–30335
  • Briz O, Serrano MA, MacIas RI, Gonzalez-Gallego J, Marin JJ. Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta–maternal liver tandem excretory pathway for foetal bilirubin. Biochemistry Journal 2003; 371(Pt 3)897–905
  • Briz O, Serrano MA, Rebollo N, Hagenbuch B, Meier PJ, Koepsell H, Marin JJG. Carriers involved in targeting the cytostatic bile acid-cisplatin derivatives cis-diammine-chloro-cholylglycinate-platinum(II) and cis-diammine-bisursodeoxycholate-platinum(II) toward liver cells. Molecular Pharmacology 2002; 61: 853–860
  • Bronger H, Konig J, Kopplow K, Steiner HH, Ahmadi R, Herold-Mende C, Keppler D, Nies AT. ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood–tumor barrier. Cancer Research 2005; 65(24)11419–11428
  • Brown KA, Bouchard N, Lussier JG, Sirois J. Down-regulation of messenger ribonucleic acid encoding an importer of sulfoconjugated steroids during human chorionic gonadotropin-induced follicular luteinization in vivo. Journal of Steroid Biochemistry and Molecular Biology 2007; 103(1)10–19
  • Chu XY, Bleasby K, Yabut J, Cai X, Chan GH, Hafey MJ, Xu S, Bergman AJ, Braun MP, Dean DC, et al. Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein. Journal of Pharmacology and Experimental Therapy 2007; 321(2)673–683
  • Cui Y, König J, Leier I, Buchholz U, Keppler D. Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. Journal of Biology and Chemistry 2001; 276: 9626–9630
  • Cui Y, Konig J, Nies AT, Pfannschmidt M, Hergt M, Franke WW, Alt W, Moll R, Keppler D. Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma. Laboratory Investigation 2003; 83(4)527–538
  • Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB. Oatp and p-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metabolism and Disposition 1999; 27: 866–871
  • Dresser GK, Bailey DG, Leake BF, Schwarz UI, Dawson PA, Freeman DJ, Kim RB. Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine. Clinical Pharmacology and Therapy 2002; 71: 11–20
  • Fehrenbach T, Cui Y, Faulstich H, Keppler D. Characterization of the transport of the bicyclic peptide phalloidin by human hepatic transport proteins. Naunyn Schmiedebergs Archives of Pharmacology 2003; 368(5)415–420
  • Fischer WJ, Altheimer S, Cattori V, Meier PJ, Dietrich DR, Hagenbuch B. Organic anion transporting polypeptides expressed in liver and brain mediate uptake of microcystin. Toxicology and Applied Pharmacology 2005; 203(3)257–263
  • Fuchikami H, Satoh H, Tsujimoto M, Ohdo S, Ohtani H, Sawada Y. Effects of herbal extracts on the function of human organic anion-transporting polypeptide OATP-B. Drug Metabolism and Disposition 2006; 34(4)577–582
  • Fujino H, Saito T, Ogawa S, Kojima J. Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase. Journal of Pharmacy and Pharmacology 2005; 57(10)1305–1311
  • Fujiwara K, Adachi H, Nishio T, Unno M, Tokui T, Okabe M, Onogawa T, Suzuki T, Asano N, Tanemoto M, et al. Identification of thyroid hormone transporters in humans: Different molecules are involved in a tissue-specific manner. Endocrinology 2001; 142: 2005–2012
  • Gao B, Hagenbuch B, Kullak-Ublick GA, Benke D, Aguzzi A, Meier PJ. Organic anion-transporting polypeptides mediate transport of opioid peptides across blood–brain barrier. Journal of Pharmacology and Experimental Therapy 2000; 294: 73–79
  • Gao B, Huber RD, Wenzel A, Vavricka SR, Ismair MG, Reme C, Meier PJ. Localization of organic anion transporting polypeptides in the rat and human ciliary body epithelium. Experimental Eye Research 2005; 80(1)61–72
  • Gao B, Wenzel A, Grimm C, Vavricka SR, Benke D, Meier PJ, Remè CE. Localization of organic anion transport protein 2 in the apical region of rat retinal pigment epithelium. Investigation of Ophthalmology and Visual Science 2002; 43: 510–514
  • Geyer J, Doring B, Failing K, Petzinger E. Molecular cloning and functional characterization of the bovine (Bos taurus) organic anion transporting polypeptide Oatp1a2 (Slco1a2). Comparison of Biochemistry and Physiology B Biochemistry and Molecular Biology 2004; 137(3)317–329
  • Glaeser H, Bailey DG, Dresser GK, Gregor JC, Schwarz UI, McGrath JS, Jolicoeur E, Lee W, Leake BF, Tirona RG, et al. Intestinal drug transporter expression and the impact of grapefruit juice in humans. Clinical Pharmacology and Therapy 2007; 81(3)362–370
  • Grube M, Kock K, Karner S, Reuther S, Ritter CA, Jedlitschky G, Kroemer HK. Modification of OATP2B1-mediated transport by steroid hormones. Molecular Pharmacology 2006a; 70(5)1735–1741
  • Grube M, Kock K, Oswald S, Draber K, Meissner K, Eckel L, Bohm M, Felix SB, Vogelgesang S, Jedlitschky G, et al. Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart. Clinical Pharmacology and Therapy 2006b; 80(6)607–620
  • Gui C, Miao Y, Thompson L, Wahlgren B, Mock M, Stieger B, Hagenbuch B. Effect of PXR ligands on transport mediated by human OATP1B1 and OATP1B3. European Journal of Pharmacology 2008; 584(1)57–65
  • Hagenbuch B. Cellular entry of thyroid hormones by organic anion transporting polypeptides. Best Practice and Research Clinical Endocrinology and Metabolism 2007; 21(2)209–221
  • Hagenbuch B, Meier PJ. The superfamily of organic anion transporting polypeptides. Biochimica et Biophysica Acta 2003; 1609(1)1–18
  • Hagenbuch B, Meier PJ. Organic anion transporting polypeptides of the OATP/SLC21 family: Phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Archives 2004; 447(5)653–665
  • Hänggi E, Grundschober AF, Leuthold S, Meier PJ, St-Pierre MV. Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1. Molecular Pharmacology 2006; 70(3)806–817
  • Hardwick LJ, Velamakanni S, Van Veen HW. The emerging pharmacotherapeutic significance of the breast cancer resistance protein (ABCG2). British Journal of Pharmacology 2007; 151(2)163–174
  • Hirano M, Maeda K, Shitara Y, Sugiyama Y. Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. Journal of Pharmacology and Experimental Therapy 2004; 311(1)139–146
  • Hirano M, Maeda K, Shitara Y, Sugiyama Y. Drug–drug interaction between pitavastatin and various drugs via OATP1B1. Drug Metabolism and Disposition 2006; 34(7)1229–1236
  • Ho RH, Tirona RG, Leake BF, Glaeser H, Lee W, Lemke CJ, Wang Y, Kim RB. Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Gastroenterology 2006; 130(6)1793–1806
  • Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang W-P, Kirchgessner TG. A novel human hepatic organic anion transporting polypeptide (OATP2). Journal of Biology and Chemistry 1999; 274: 37161–37168
  • Huang Y, Lemieux MJ, Song J, Auer M, Wang DN. Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli. Science 2003; 301(5633)616–620
  • Huber RD, Gao B, Sidler Pfandler MA, Zhang-Fu W, Leuthold S, Hagenbuch B, Folkers G, Meier PJ, Stieger B. Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain. American Journal of Physiology 2007; 292(2)C795–C806
  • Ishiguro N, Maeda K, Kishimoto W, Saito A, Harada A, Ebner T, Roth W, Igarashi T, Sugiyama Y. Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans. Drug Metabolism and Disposition 2006; 34(7)1109–1115
  • Ismair MG, Stanca C, Ha HR, Renner EL, Meier PJ, Kullak-Ublick GA. Interactions of glycyrrhizin with organic anion transporting polypeptides of rat and human liver. Hepatology Research 2003; 26(4)343–347
  • Ismair MG, Stieger B, Cattori V, Hagenbuch B, Fried M, Meier PJ, Kullak-Ublick GA. Hepatic uptake of cholecystikinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver. Gastroenterology 2001; 121: 1185–1190
  • Jacquemin E, Hagenbuch B, Stieger B, Wolkoff AW, Meier PJ. Expression cloning of a rat liver Na+-independent organic anion transporter. Proceedings of the National Academy of Sciences, USA 1994; 91(1)133–137
  • Kalgutkar AS, Feng B, Nguyen HT, Frederick KS, Campbell SD, Hatch HL, Bi YA, Kazolias DC, Davidson RE, Mireles RJ, et al. Role of transporters in the disposition of the selective phosphodiesterase-4 inhibitor (+)-2-[4-({[2-(benzo[1,3]dioxol-5-yloxy)-pyridine-3-carbonyl]-amino}-methy l)-3-fluoro-phenoxy]-propionic acid in rat and human. Drug Metabolism and Disposition 2007; 35(11)2111–2118
  • Karwatsky JM, Georges E. Drug binding domains of MRP1 (ABCC1) as revealed by photoaffinity labeling. Current Medicinal Chemistry. Anti-Cancer Agents 2004; 4(1)19–30
  • Katz DA, Carr R, Grimm DR, Xiong H, Holley-Shanks R, Mueller T, Leake B, Wang Q, Han L, Wang PG, et al. Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics. Clinical Pharmacology and Therapy 2006; 79(3)186–196
  • Kobayashi D, Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I. Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. Journal of Pharmacology and Experimental Therapy 2003; 306(2)703–708
  • Komatsu M, Furukawa T, Ikeda R, Takumi S, Nong Q, Aoyama K, Akiyama S, Keppler D, Takeuchi T. Involvement of mitogen-activated protein kinase signaling pathways in microcystin-LR-induced apoptosis after its selective uptake mediated by OATP1B1 and OATP1B3. Toxicology Science 2007; 97(2)407–416
  • König J, Cui Y, Nies AT, Keppler D. Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. Journal of Biology and Chemistry 2000a; 275: 23161–23168
  • König J, Cui Y, Nies AT, Keppler D. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. American Journal of Physiology 2000b; 278: G156–G164
  • König J, Seithel A, Gradhand U, Fromm MF. Pharmacogenomics of human OATP transporters. Naunyn Schmiedebergs Archives of Pharmacology 2006; 372(6)432–443
  • Kopplow K, Letschert K, Konig J, Walter B, Keppler D. Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells. Molecular Pharmacology 2005; 68(4)1031–1038
  • Kullak-Ublick GA, Fisch T, Oswald M, Hagenbuch B, Meier PJ, Beuers U, Paumgartner G. Dehydroepiandrosterone sulfate (DHEAS): Identification of a carrier protein in human liver and brain. FEBS Letters 1998; 424: 173–176
  • Kullak-Ublick GA, Glasa J, Boker C, Oswald M, Grutzner U, Hagenbuch B, Stieger B, Meier PJ, Beuers U, Kramer W, et al. Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas. Gastroenterology 1997; 113(4)1295–1305
  • Kullak-Ublick GA, Hagenbuch B, Stieger B, Schteingart CD, Hofmann AF, Wolkoff AW, Meier PJ. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology 1995; 109(4)1274–1282
  • Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B. Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology 2001; 120: 525–533
  • Lau YY, Huang Y, Frassetto L, Benet LZ. Effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers. Clinical Pharmacology and Therapy 2007; 81(2)194–204
  • Lee SY, Williamson B, Caballero OL, Chen YT, Scanlan MJ, Ritter G, Jongeneel CV, Simpson AJ, Old LJ. Identification of the gonad-specific anion transporter SLCO6A1 as a cancer/testis (CT) antigen expressed in human lung cancer. Cancer and Immunology 2004; 4: 13
  • Lee TK, Koh AS, Cui Z, Pierce RH, Ballatori N. N-glycosylation controls functional activity of Oatp1, an organic anion transporter. American Journal of Physiology Gastrointest Liver Physiology 2003; 285(2)G371–G381
  • Lee W, Glaeser H, Smith LH, Roberts RL, Moeckel GW, Gervasini G, Leake BF, Kim RB. Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): Implications for altered drug disposition and central nervous system drug entry. Journal of Biology and Chemistry 2005; 280(10)9610–9617
  • Letschert K, Faulstich H, Keller D, Keppler D. Molecular characterization and inhibition of amanitin uptake into human hepatocytes. Toxicology Science 2006; 91(1)140–149
  • Letschert K, Keppler D, Konig J. Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8). Pharmacogenetics 2004; 14(7)441–452
  • Liu L, Cui Y, Chung AY, Shitara Y, Sugiyama Y, Keppler D, Pang KS. Vectorial transport of enalapril by Oatp1a1/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers. Journal of Pharmacology and Experimental Therapy 2006; 318(1)395–402
  • Lu R, Kanai N, Bao Y, Schuster VL. Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA (HPGT). Journal of Clinical Investigation 1996; 98(5)1142–1149
  • Lu WJ, Huang JD, Lai ML. The effects of ergoloid mesylates and ginkgo biloba on the pharmacokinetics of ticlopidine. Journal of Clinical Pharmacology 2006a; 46(6)628–634
  • Lu WJ, Tamai I, Nezu J, Lai ML, Huang JD. Organic anion transporting polypeptide-C mediates arsenic uptake in HEK-293 cells. Journal of Biomedical Science 2006b; 13(4)525–533
  • Maeda K, Kambara M, Tian Y, Hofmann AF, Sugiyama Y. Uptake of ursodeoxycholate and its conjugates by human hepatocytes: Role of Na(+)-taurocholate cotransporting polypeptide (NTCP), organic anion transporting polypeptide (OATP) 1B1 (OATP-C), and oatp1B3 (OATP8). Molecular Pharmacology 2006; 3(1)70–77
  • Maeda T, Takahashi K, Ohtsu N, Oguma T, Ohnishi T, Atsumi R, Tamai I. Identification of influx transporter for the quinolone antibacterial agent levofloxacin. Molecular Pharmacology 2007; 4(1)85–94
  • Meier PJ, Eckhardt U, Schroeder A, Hagenbuch B, Stieger B. Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. Hepatology 1997; 26: 1667–1677
  • Meier-Abt F, Faulstich H, Hagenbuch B. Identification of phalloidin uptake systems of rat and human liver. Biochimica et Biophysica Acta 2004; 1664(1)64–69
  • Meier-Abt F, Mokrab Y, Mizuguchi K. Organic anion transporting polypeptides of the OATP/SLCO superfamily: Identification of new members in nonmammalian species, comparative modeling and a potential transport mode. Journal of Membrane Biology 2005; 208(3)213–227
  • Miao Y, Hagenbuch B. Conserved positively charged amino acid residues in the putative binding pocket are important for OATP1B1 function. FASEB Journal 2007; 21: A196
  • Miki Y, Suzuki T, Kitada K, Yabuki N, Shibuya R, Moriya T, Ishida T, Ohuchi N, Blumberg B, Sasano H. Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma. Cancer Research 2006; 66(1)535–542
  • Mikkaichi T, Suzuki T, Onogawa T, Tanemoto M, Mizutamari H, Okada M, Chaki T, Masuda S, Tokui T, Eto N, et al. Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proceedings of the National Academy of Sciences, USA, 2004. 101: 3569–3574, (10)
  • Monks NR, Liu S, Xu Y, Yu H, Bendelow AS, Moscow JA. Potent cytotoxicity of the phosphatase inhibitor microcystin LR and microcystin analogues in OATP1B1- and OATP1B3-expressing HeLa cells. Molecular Cancer Therapy 2007; 6(2)587–598
  • Muto M, Onogawa T, Suzuki T, Ishida T, Rikiyama T, Katayose Y, Ohuchi N, Sasano H, Abe T, Unno M. Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma. Cancer Science 2007; 98(10)1570–1576
  • Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Research 1998; 5: 355–364
  • Nakagomi-Hagihara R, Nakai D, Kawai K, Yoshigae Y, Tokui T, Abe T, Ikeda T. OATP1B1, OATP1B3, and mrp2 are involved in hepatobiliary transport of olmesartan, a novel angiotensin II blocker. Drug Metabolism and Disposition 2006; 34: 862–869
  • Nakai D, Nakagomi R, Furuta Y, Tokui T, Abe T, Ikeda T, Nishimura K. Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes. Journal of Pharmacology and Experimental Therapy 2001; 297: 861–867
  • Nakao N, Takagi T, Iigo M, Tsukamoto T, Yasuo S, Masuda T, Yanagisawa T, Ebihara S, Yoshimura T. Possible involvement of organic anion transporting polypeptide 1c1 in the photoperiodic response of gonads in birds. Endocrinology 2006; 147(3)1067–1073
  • Nishimura T, Kubo Y, Kato Y, Sai Y, Ogihara T, Tsuji A. Characterization of the uptake mechanism for a novel loop diuretic, M17055, in Caco-2 cells: Involvement of organic anion transporting polypeptide (OATP)-B. Pharmacology Research 2007; 24(1)90–98
  • Noe J, Portmann R, Brun ME, Funk C. Substrate-dependent drug–drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3. Drug Metabolism and Disposition 2007; 35(8)1308–1314
  • Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I. Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. Journal of Pharmacology and Experimental Therapy 2004a; 308(2)438–445
  • Nozawa T, Minami H, Sugiura S, Tsuji A, Tamai I. Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: In vitro evidence and effect of single nucleotide polymorphisms. Drug Metabolism and Disposition 2005a; 33(3)434–439
  • Nozawa T, Sugiura S, Nakajima M, Goto A, Yokoi T, Nezu J, Tsuji A, Tamai I. Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: Implications for understanding troglitazone hepatotoxicity. Drug Metabolism and Disposition 2004b; 32(3)291–294
  • Nozawa T, Suzuki M, Takahashi K, Yabuuchi H, Maeda T, Tsuji A, Tamai I. Involvement of estrone-3-sulfate transporters in proliferation of hormone-dependent breast cancer cells. Journal of Pharmacology and Experimental Therapy 2004c; 311: 1032–1037
  • Nozawa T, Suzuki M, Yabuuchi H, Irokawa M, Tsuji A, Tamai I. Suppression of cell proliferation by inhibition of estrone-3-sulfate transporter in estrogen-dependent breast cancer cells. Pharmacology Research 2005b; 22(10)1634–1641
  • Nozawa T, Tamai I, Sai Y, Nezu J, Tsuji A. Contribution of organic anion transporting polypeptide OATP-C to hepatic elimination of the opioid pentapeptide analogue [D-Ala, D-Leu]-enkephalin. Journal of Pharmacy and Pharmacology 2003; 55: 1013–1020
  • Pascolo L, Cupelli F, Anelli PL, Lorusso V, Visigalli M, Uggeri F, Tiribelli C. Molecular mechanisms for the hepatic uptake of magnetic resonance imaging contrast agents. Biochemistry and Biophysics Research Communications 1999; 257(3)746–752
  • Perry JL, Dembla-Rajpal N, Hall LA, Pritchard JB. A three-dimensional model of human organic anion transporter 1: Aromatic amino acids required for substrate transport. Journal of Biology and Chemistry 2006; 281(49)38071–38079
  • Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ. Identification of a novel human organic anion transporting polypeptide (OATP-F) as a high affinity thyroxine transporter. Molecular Endocrinology 2002; 16: 2283–2296
  • Pizzagalli F, Varga Z, Huber RD, Folkers G, Meier PJ, St-Pierre MV. Identification of steroid sulfate transport processes in the human mammary gland. Journal of Clinical Endocrinology and Metabolism 2003; 88(8)3902–3912
  • Poirier A, Funk C, Lave T, Noe J. New strategies to address drug–drug interactions involving OATPs. Current Opinions in Drug Discovery and Development 2007; 10(1)74–83
  • Popp C, Gorboulev V, Muller TD, Gorbunov D, Shatskaya N, Koepsell H. Amino acids critical for substrate affinity of rat organic cation transporter 1 line the substrate binding region in a model derived from the tertiary structure of lactose permease. Molecular Pharmacology 2005; 67(5)1600–1611
  • Sai Y, Kaneko Y, Ito S, Mitsuoka K, Kato Y, Tamai I, Artursson P, Tsuji A. Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells. Drug Metabolism and Disposition 2006; 34(8)1423–1431
  • Saier MH, Jr, Beatty JT, Goffeau A, Harley KT, Heijne WH, Huang SC, Jack DL, Jahn PS, Lew K, Liu J, et al. The major facilitator superfamily. Journal of Molecular Microbiology and Biotechnology 1999; 1(2)257–279
  • Sandhu P, Lee W, Xu X, Leake BF, Yamazaki M, Stone JA, Lin JH, Pearson PG, Kim RB. Hepatic uptake of the novel antifungal agent caspofungin. Drug Metabolism and Disposition 2005; 33(5)676–682
  • Sasaki M, Suzuki H, Ito K, Abe T, Sugiyama Y. Transcellular transport of organic anions across a double-transfected Madin–Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and Multidrug resistance-associated protein 2 (MRP2/ABCC2). Journal of Biology and Chemistry 2002; 277(8)6497–6503
  • Sato K, Sugawara J, Sato T, Mizutamari H, Suzuki T, Ito A, Mikkaichi T, Onogawa T, Tanemoto M, Unno M, et al. Expression of organic anion transporting polypeptide E (OATP-E) in human placenta. Placenta 2003; 24: 144–148
  • Satoh H, Yamashita F, Tsujimoto M, Murakami H, Koyabu N, Ohtani H, Sawada Y. Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B. Drug Metabolism and Disposition 2005; 33(4)518–523
  • Schneck DW, Birmingham BK, Zalikowski JA, Mitchell PD, Wang Y, Martin PD, Lasseter KC, Brown CD, Windass AS, Raza A. The effect of gemfibrozil on the pharmacokinetics of rosuvastatin. Clinical Pharmacology and Therapy 2004; 75(5)455–463
  • Schuster VL. Molecular mechanisms of prostaglandin transport. Annual Reviews in Physiology 1998; 60: 221–242
  • Schuster VL. Prostaglandin transport. Prostaglandins and Other Lipid Mediation 2002; 68–69: 633–647
  • Shimizu M, Fuse K, Okudaira K, Nishigaki R, Maeda K, Kusuhara H, Sugiyama Y. Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans. Drug Metabolism and Disposition 2005; 33(10)1477–1481
  • Shitara Y, Itoh T, Sato H, Li AP, Sugiyama Y. Inhibition of transporter-mediated hepatic uptake as a mechanism for drug–drug interaction between cerivastatin and cyclosporin A. Journal of Pharmacology and Experimental Therapy 2003; 304(2)610–616
  • Shitara Y, Sato H, Sugiyama Y. Evaluation of drug–drug interaction in the hepatobiliary and renal transport of drugs. Annual Reviews in Pharmacology and Toxicology 2005; 45: 689–723
  • Smith NF, Acharya MR, Desai N, Figg WD, Sparreboom A. Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel. Cancer Biology and Therapy 2005a; 4(8)815–818
  • Smith NF, Figg WD, Sparreboom A. Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination. Expert Opinions in Drug Metabolism and Toxicology 2005b; 1(3)429–445
  • St-Pierre MV, Ugele B, Hagenbuch B, Meier PJ, Stallmach T. Characterization of an organic anion transporting polypeptide (OATP-B) in human placenta. Journal of Clinical Endocrinology and Metabolism 2002; 87: 1856–1863
  • Su Y, Zhang X, Sinko PJ. Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells. Molecular Pharmacology 2004; 1(1)49–56
  • Sugiyama D, Kusuhara H, Shitara Y, Abe T, Sugiyama Y. Effect of 17β-estradiol-D-17β-glucuronide on the rat organic anion transporting polypeptide 2-mediated transport differs depending on substrates. Drug Metabolism and Disposition 2002; 30: 220–223
  • Suzuki T, Onogawa T, Asano N, Mizutamari H, Mikkaichi T, Tanemoto M, Abe M, Satoh F, Unno M, Nunoki K, et al. Identification and characterization of novel rat and human gonad specific organic anion transporters. Molecular Endocrinology 2003; 17(7)1203–1215
  • Takada T, Weiss HM, Kretz O, Gross G, Sugiyama Y. Hepatic transport of PKI166, an epidermal growth factor receptor kinase inhibitor of the pyrrolo-pyrimidine class, and its main metabolite, ACU154. Drug Metabolism and Disposition 2004; 32(11)1272–1278
  • Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochemistry and Biophysics Research Communications 2000; 273: 251–260
  • Tamai I, Nozawa T, Koshida M, Nezu J, Sai Y, Tsuji A. Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C. Pharmacology Research 2001; 18(9)1262–1269
  • Tirona RG, Leake BF, Wolkoff AW, Kim RB. Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. Journal of Pharmacology and Experimental Therapy 2003; 304(1)223–228
  • Treiber A, Schneiter R, Hausler S, Stieger B. Bosentan is a substrate of human OATP1B1 and OATP1B3: Inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil. Drug Metabolism and Disposition 2007; 35(8)1400–1407
  • Tsuda-Tsukimoto M, Maeda T, Iwanaga T, Kume T, Tamai I. Characterization of hepatobiliary transport systems of a novel alpha4beta1/alpha4beta7 dual antagonist, TR-14035. Pharmacology Research 2006; 23(11)2646–2656
  • Van Montfoort JE, Hagenbuch B, Fattinger K, Müller M, Groothuis GMM, Meijer DKF, Meier PJ. Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. Journal of Pharmacology and Experimental Therapy 1999; 291: 147–152
  • Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K. Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology 2002; 36: 164–172
  • Wang P, Wang JJ, Xiao Y, Murray JW, Novikoff PM, Angeletti RH, Orr GA, Lan D, Silver DL, Wolkoff AW. Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface. Journal of Biology and Chemistry 2005a; 280(34)30143–30149
  • Wang X, Wolkoff AW, Morris ME. Flavonoids as a novel class of human organic anion-transporting polypeptide OATP1B1 (OATP-C) modulators. Drug Metabolism and Disposition 2005b; 33(11)1666–1672
  • Yamada A, Maeda K, Kamiyama E, Sugiyama D, Kondo T, Shiroyanagi Y, Nakazawa H, Okano T, Adachi M, Schuetz JD, et al. Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor. Drug Metabolism and Disposition 2007; 35(12)2166–2176
  • Yamaguchi H, Okada M, Akitaya S, Ohara H, Mikkaichi T, Ishikawa H, Sato M, Matsuura M, Saga T, Unno M, et al. Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3. Journal of Lipid Research 2006; 47(6)1196–1202
  • Yamashiro W, Maeda K, Hirouchi M, Adachi Y, Hu Z, Sugiyama Y. Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans. Drug Metabolism and Disposition 2006; 34(7)1247–1254
  • Yin Y, He X, Szewczyk P, Nguyen T, Chang G. Structure of the multidrug transporter EmrD from Escherichia coli. Science 2006; 312(5774)741–744
  • Zhang X, Shirahatti NV, Mahadevan D, Wright SH. A conserved glutamate residue in transmembrane helix 10 influences substrate specificity of rabbit OCT2 (SLC22A2). Journal of Biology and Chemistry 2005; 280(41)34813–34822

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.