SLC28 genes and concentrative nucleoside transporter (CNT) proteins

References

• Aymerich I, Foufelle F, Ferre P, Casado FJ, Pastor-Anglada M. Extracellular adenosine activates AMP-dependent protein kinase (AMPK). Journal of Cell Science 2006; 119(Pt 8)1612–1621
   PubMed Web of Science ®Google Scholar
• Aymerich I, Pastor-Anglada M, Casado FJ. Long term endocrine regulation of nucleoside transporters in rat intestinal epithelial cells. Journal of General Physiology 2004; 124(5)505–512
   PubMed Web of Science ®Google Scholar
• Badagnani I, Chan W, Castro RA, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, et al. Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3). Pharmacogenomics Journal 2005; 5(3)157–165
   PubMed Web of Science ®Google Scholar
• Baldwin SA, Mackey JR, Cass CE, Young JD. Nucleoside transporters: Molecular biology and implications for therapeutic development. Molecular Medicine Today 1999; 5(5)216–224
   PubMedGoogle Scholar
• Balzarini J. Effect of antimetabolite drugs of nucleotide metabolism on the anti-human immunodeficiency virus activity of nucleoside reverse transcriptase inhibitors. Pharmacology and Therapy 2000; 87(2–3)175–187
   PubMed Web of Science ®Google Scholar
• Cano-Soldado P, Lorrayoz IM, Molina-Arcas M, Casado FJ, Martinez-Picado J, Lostao MP, Pastor-Anglada M. Interaction of nucleoside inhibitors of HIV-1 reverse transcriptase with the concentrative nucleoside transporter-1 (SLC28A1). Antiviral Therapy 2004; 9(6)993–1002
   PubMed Web of Science ®Google Scholar
• Cano-Soldado P, Molina-Arcas M, Alguero B, Larrayoz I, Lostao MP, Grandas A, Casado FJ, Pastor-Anglada M. Compensatory effects of the human nucleoside transporters on the response to nucleoside-derived drugs in breast cancer MCF7 cells. Biochemistry and Pharmacology 2008; 75(3)639–648
   PubMed Web of Science ®Google Scholar
• Chang C, Swaan PW, Ngo LY, Lum PY, Patil SD, Unadkat JD. Molecular requirements of the human nucleoside transporters hCNT1, hCNT2, and hENT1. Molecular Pharmacology 2004; 65(3)558–570
   PubMed Web of Science ®Google Scholar
• Che M, Ortiz DF, Arias IM. Primary structure and functional expression of a cDNA encoding the bile canalicular, purine-specific Na(+)-nucleoside cotransporter. Journal of Biology and Chemistry 1995; 270(23)13596–13599
   PubMed Web of Science ®Google Scholar
• Clarke ML, Damaraju VL, Zhang J, Mowles D, Tackaberry T, Lang T, Smith KM, Young JD, Tomkinson B, Cass CE. The role of human nucleoside transporters in cellular uptake of 4á-thio-beta-D-arabinofuranosylcytosine and beta-D-arabinosylcytosine. Molecular Pharmacology 2006; 70(1)303–310
   PubMed Web of Science ®Google Scholar
• Craig JE, Zhang Y, Gallagher MP. Cloning of the nupC gene of Escherichia coli encoding a nucleoside transport system, and identification of an adjacent insertion element, IS 186. Molecular Microbiology 1994; 11(6)1159–1168
   PubMed Web of Science ®Google Scholar
• Damaraju S, Zhang J, Visser F, Tackaberry T, Dufour J, Smith KM, Slugoski M, Ritzel MW, Baldwin SA, Young JD, et al. Identification and functional characterization of variants in human concentrative nucleoside transporter 3, hCNT3 (SLC28A3), arising from single nucleotide polymorphisms in coding regions of the hCNT3 gene. Pharmacogenetics and Genomics 2005a; 15(3)173–182
   PubMed Web of Science ®Google Scholar
• Damaraju VL, Visser F, Zhang J, Mowles D, Ng AM, Young JD, Jayaram HN, Cass CE. Role of human nucleoside transporters in the cellular uptake of two inhibitors of IMP dehydrogenase, tiazofurin and benzamide riboside. Molecular Pharmacology 2005b; 67(1)273–279
   PubMed Web of Science ®Google Scholar
• Daniel H. Molecular and integrative physiology of intestinal peptide transport. Annual Reviews in Physiology 2004; 66: 361–384
   PubMed Web of Science ®Google Scholar
• Del Santo B, Tarafa G, Felipe A, Casado FJ, Pastor-Anglada M. Developmental regulation of the concentrative nucleoside transporters CNT1 and CNT2 in rat liver. Journal of Hepatology 2001; 34(6)873–880
   PubMed Web of Science ®Google Scholar
• Donofrio J, Coleman MS, Hutton JJ, Daoud A, Lampkin B, Dyminski J. Overproduction of adenine deoxynucleosides and deoxynucletides in adenosine deaminase deficiency with severe combined immuno-deficiency disease. Journal of Clinical Investigation 1978; 62(4)884–887
   PubMed Web of Science ®Google Scholar
• Dragan Y, Valdes R, Gomez-Angelats M, Felipe A, Javier Casado F, Pitot H, Pastor-Anglada M. Selective loss of nucleoside carrier expression in rat hepatocarcinomas. Hepatology 2000; 32(2)239–246
   PubMed Web of Science ®Google Scholar
• Dresser MJ, Leabman MK, Giacomini KM. Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters. Journal of Pharmaceutical Science 2001; 90(4)397–421
   PubMed Web of Science ®Google Scholar
• Duflot S, Calvo M, Casado FJ, Enrich C, Pastor-Anglada M. Concentrative nucleoside transporter (rCNT1) is targeted to the apical membrane through the hepatic transcytotic pathway. Experimental Cell Research 2002; 281(1)77–85
   PubMed Web of Science ®Google Scholar
• Duflot S, Riera B, Fernandez-Veledo S, Casado V, Norman RI, Casado FJ, Lluis C, Franco R, Pastor-Anglada M. ATP-sensitive K(+) channels regulate the concentrative adenosine transporter CNT2 following activation by A(1) adenosine receptors. Molecular Cell Biology 2004; 24(7)2710–2719
   PubMed Web of Science ®Google Scholar
• Emami S, Kumar P, Yang J, Kresolic Z, Paproski R, Cass C, McEwan AJ, Wiebe LI. Synthesis, transportability and hypoxiaselective binding of 1-beta-D-(5-deoxy-5-fluororibofuranosyl)-2-nitroimidazole (beta-5-FAZR), a configurational isomer of the clinical hypoxia marker, FAZA. Journal of Pharmacy and Pharmaceutical Science 2007; 10(2)237–245
   PubMed Web of Science ®Google Scholar
• Errasti-Murugarren E, Cano-Soldado P, Pastor-Anglada M, Casado FJ. Functional characterization of a nucleoside-derived drug transporter variant (hCNT3C602R) showing altered sodium-binding capacity. Molecular Pharmacology 2008; 73(2)379–386
   PubMed Web of Science ®Google Scholar
• Errasti-Murugarren E, Pastor-Anglada M, Casado FJ. Role of CNT3 in the transepithelial flux of nucleosides and nucleoside-derived drugs. Journal of Physiology 2007; 582(Pt 3)1249–1260
   PubMed Web of Science ®Google Scholar
• Farre X, Guillen-Gomez E, Sanchez L, Hardisson D, Plaza Y, Lloberas J, Casado FJ, Palacios J, Pastor-Anglada M. Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors. International Journal of Cancer 2004; 112(6)959–966
   PubMed Web of Science ®Google Scholar
• Felipe A, Valdes R, Santo B, Lloberas J, Casado J, Pastor-Anglada M. Na+-dependent nucleoside transport in liver: two different isoforms from the same gene family are expressed in liver cells. Biochemistry Journal 1998; 330(Pt 2)997–1001
   PubMed Web of Science ®Google Scholar
• Fernandez-Veledo S, Jover R, Casado FJ, Gomez-Lechon MJ, Pastor-Anglada M. Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells. Biochemical and Biophysical Research Communications 2007; 353(2)381–388
   PubMed Web of Science ®Google Scholar
• Fernandez-Veledo S, Valdes R, Wallenius V, Casado FJ, Pastor-Anglada M. Up-regulation of the high-affinity pyrimidine-preferring nucleoside transporter concentrative nucleoside transporter 1 by tumor necrosis factor-alpha and interleukin-6 in liver parenchymal cells. Journal of Hepatology 2004; 41(4)538–544
   PubMed Web of Science ®Google Scholar
• Ferraris RP. Dietary and developmental regulation of intestinal sugar transport. Biochemistry Journal 2001; 360(Pt 2)265–276
   PubMed Web of Science ®Google Scholar
• Flanagan SA, Meckling-Gill KA. Characterization of a novel Na+-dependent, guanosine-specific, nitrobenzylthioinosine-sensitive transporter in acute promyelocytic leukemia cells. Journal of Biology and Chemistry 1997; 272(29)18026–18032
   PubMed Web of Science ®Google Scholar
• Fotoohi AK, Lindqvist M, Peterson C, Albertioni F. Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines. Biochemical and Biophysical Research Communications 2006; 343(1)208–215
   PubMed Web of Science ®Google Scholar
• Galmarini CM. Nucleoside analogues in cancer treatment. Electronic Journal of Oncology 2002; 1: 22–32
   Google Scholar
• Galmarini CM, Mackey JR, Dumontet C. Nucleoside analogues: mechanisms of drug resistance and reversal strategies. Leukemia 2001; 15(6)875–890
   PubMed Web of Science ®Google Scholar
• Garcia-Manteiga J, Molina-Arcas M, Casado FJ, Mazo A, Pastor-Anglada M. Nucleoside transporter profiles in human pancreatic cancer cells: Role of hCNT1 in 2′,2′-difluorodeoxycytidine-induced cytotoxicity. Clinical Cancer Research 2003; 9(13)5000–5008
   PubMed Web of Science ®Google Scholar
• Gloeckner-Hofmann K, Guillen-Gomez E, Schmidtgen C, Porstmann R, Ziegler R, Stoss O, Casado FJ, Ruschoff J, Pastor-Anglada M. Expression of the high-affinity fluoropyrimidine-preferring nucleoside transporter hCNT1 correlates with decreased disease-free survival in breast cancer. Oncology 2006; 70(3)238–244
   PubMed Web of Science ®Google Scholar
• Gourdeau H, Clarke ML, Ouellet F, Mowles D, Selner M, Richard A, Lee N, Mackey JR, Young JD, Jolivet J, et al. Mechanisms of uptake and resistance to troxacitabine, a novel deoxycytidine nucleoside analogue, in human leukemic and solid tumor cell lines. Cancer Research 2001; 61(19)7217–7224
   PubMed Web of Science ®Google Scholar
• Govindarajan R, Bakken AH, Hudkins KL, Lai Y, Casado FJ, Pastor-Anglada M, Tse CM, Hayashi J, Unadkat JD. In situ hybridization and immunolocalization of concentrative and equilibrative nucleoside transporters in the human intestine, liver, kidneys, and placenta. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 2007; 293(5)R1809–R1822
   PubMed Web of Science ®Google Scholar
• Graham KA, Leithoff J, Coe IR, Mowles D, Mackey JR, Young JD, Cass CE. Differential transport of cytosine-containing nucleosides by recombinant human concentrative nucleoside transporter protein hCNT1. Nucleosides, Nucleotides and Nucleic Acids 2000; 19(1–2)415–434
   PubMed Web of Science ®Google Scholar
• Gray JH, Mangravite LM, Owen RP, Urban TJ, Chan W, Carlson EJ, Huang CC, Kawamoto M, Johns SJ, Stryke D, et al. Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations. Molecular Pharmacology 2004a; 65(3)512–519
   PubMed Web of Science ®Google Scholar
• Gray JH, Owen RP, Giacomini KM. The concentrative nucleoside transporter family, SLC28. Pflugers Archives 2004b; 447(5)728–734
   PubMed Web of Science ®Google Scholar
• Griffith DA, Jarvis SM. Nucleoside and nucleobase transport systems of mammalian cells. Biochimica et Biophysica Acta 1996; 1286(3)153–181
   PubMed Web of Science ®Google Scholar
• Guallar JP, Cano-Soldado P, Aymerich I, Domingo JC, Alegre M, Domingo P, Villarroya F, Javier Casado F, Giralt M, Pastor-Anglada M. Altered expression of nucleoside transporter genes (SLC28 and SLC29) in adipose tissue from HIV-1-infected patients. Antiviral Therapy 2007; 12(6)853–863
   PubMed Web of Science ®Google Scholar
• Gutierrez MM, Brett CM, Ott RJ, Hui AC, Giacomini KM. Nucleoside transport in brush border membrane vesicles from human kidney. Biochimica et Biophysica Acta 1992; 1105(1)1–9
   PubMed Web of Science ®Google Scholar
• Gutierrez MM, Giacomini KM. Substrate selectivity, potential sensitivity and stoichiometry of Na(+)-nucleoside transport in brush border membrane vesicles from human kidney. Biochimica et Biophysica Acta 1993; 1149(2)202–208
   PubMed Web of Science ®Google Scholar
• Hamilton SR, Yao SY, Ingram JC, Hadden DA, Ritzel MW, Gallagher MP, Henderson PJ, Cass CE, Young JD, Baldwin SA. Subcellular distribution and membrane topology of the mammalian concentrative Na+-nucleoside cotransporter rCNT1. Journal of Biology and Chemistry 2001; 276(30)27981–27988
   PubMed Web of Science ®Google Scholar
• Hansen PB, Schnermann J. Vasoconstrictor and vasodilator effects of adenosine in the kidney. American Journal of Physiology and Renal Physiology 2003; 285(4)F590–F599
   PubMed Web of Science ®Google Scholar
• Hu H, Endres CJ, Chang C, Umapathy NS, Lee EW, Fei YJ, Itagaki S, Swaan PW, Ganapathy V, Unadkat JD. Electrophysiological characterization and modeling of the structure activity relationship of the human concentrative nucleoside transporter 3 (hCNT3). Molecular Pharmacology 2006; 69(5)1542–1553
   PubMed Web of Science ®Google Scholar
• Huang QQ, Yao SY, Ritzel MW, Paterson AR, Cass CE, Young JD. Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein. Journal of Biology and Chemistry 1994; 269(27)17757–17760
   PubMed Web of Science ®Google Scholar
• Jordheim LP, Dumontet C. Review of recent studies on resistance to cytotoxic deoxynucleoside analogues. Biochimica et Biophysica Acta 2007; 1776(2)138–159
   PubMed Web of Science ®Google Scholar
• Kato R, Maeda T, Akaike T, Tamai I. Nucleoside transport at the blood–testis barrier studied with primary-cultured Sertoli cells. Journal of Pharmacology and Experimental Therapy 2005; 312(2)601–608
   PubMed Web of Science ®Google Scholar
• King AE, Ackley MA, Cass CE, Young JD, Baldwin SA. Nucleoside transporters: From scavengers to novel therapeutic targets. Trends in Pharmacology Science 2006; 27(8)416–425
   PubMed Web of Science ®Google Scholar
• King K, Damaraju V, Vickers M, Yao S, Lang T, Tackaberry T, Mowles D, Ng A, Young J, Cass C. A comparison of the transportability, and its role in cytotoxicity, of clofarabine, cladribine and fludarabine by recombinant human nucleoside transporters produced in three model expression systems. Molecular Pharmacology, 2005; 69(1)346–353
   PubMed Web of Science ®Google Scholar
• Kong W, Engel K, Wang J. Mammalian nucleoside transporters. Current Drug Metabolism 2004.; 5(1)63–84
   PubMed Web of Science ®Google Scholar
• Lai Y, Bakken AH, Unadkat JD. Simultaneous expression of hCNT1-CFP and hENT1-YFP in Madin–Darby canine kidney cells. Localization and vectorial transport studies. Journal of Biology and Chemistry 2002; 277(40)37711–37717
   PubMed Web of Science ®Google Scholar
• Lai Y, Lee EW, Ton CC, Vijay S, Zhang H, Unadkat JD. Conserved residues F316 and G476 in the concentrative nucleoside transporter 1 (hCNT1) affect guanosine sensitivity and membrane expression, respectively. American Journal of Physiology and Cell Physiology 2005; 288(1)C39–C45
   PubMed Web of Science ®Google Scholar
• Lang TT, Selner M, Young JD, Cass CE. Acquisition of human concentrative nucleoside transporter 2 (hcnt2) activity by gene transfer confers sensitivity to fluoropyrimidine nucleosides in drug-resistant leukemia cells. Molecular Pharmacology 2001; 60(5)1143–1152
   PubMed Web of Science ®Google Scholar
• Lang TT, Young JD, Cass CE. Interactions of nucleoside analogs, caffeine, and nicotine with human concentrative nucleoside transporters 1 and 2 stably produced in a transport-defective human cell line. Molecular Pharmacology 2004; 65(4)925–933
   PubMed Web of Science ®Google Scholar
• Larrayoz IM, Casado FJ, Pastor-Anglada M, Lostao MP. Electrophysiological characterization of the human Na(+)/nucleoside cotransporter 1 (hCNT1) and role of adenosine on hCNT1 function. Journal of Biology and Chemistry 2004; 279(10)8999–9007
   PubMed Web of Science ®Google Scholar
• Loewen SK, Ng AM, Mohabir NN, Baldwin SA, Cass CE, Young JD. Functional characterization of a H+/nucleoside co-transporter (CaCNT) from Candida albicans, a fungal member of the concentrative nucleoside transporter (CNT) family of membrane proteins. Yeast 2003; 20(8)661–675
   PubMed Web of Science ®Google Scholar
• Loewen SK, Ng AM, Yao SY, Cass CE, Baldwin SA, Young JD. Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2. Journal of Biology and Chemistry 1999; 274(35)24475–24484
   PubMed Web of Science ®Google Scholar
• Loewen SK, Yao SY, Slugoski MD, Mohabir NN, Turner RJ, Mackey JR, Weiner JH, Gallagher MP, Henderson PJ, Baldwin SA, et al. Transport of physiological nucleosides and anti-viral and anti-neoplastic nucleoside drugs by recombinant Escherichia coli nucleoside-H(+) cotransporter (NupC) produced in Xenopus laevis oocytes. Molecular Membrane Biology 2004; 21(1)1–10
   PubMed Web of Science ®Google Scholar
• Lu H, Chen C, Klaassen C. Tissue distribution of concentrative and equilibrative nucleoside transporters in male and female rats and mice. Drug Metabolism and Disposition 2004; 32(12)1455–1461
   PubMed Web of Science ®Google Scholar
• Mackey JR, Galmarini CM, Graham KA, Joy AA, Delmer A, Dabbagh L, Glubrecht D, Jewell LD, Lai R, Lang T, et al. Quantitative analysis of nucleoside transporter and metabolism gene expression in chronic lymphocytic leukemia (CLL): Identification of fludarabine-sensitive and -insensitive populations. Blood 2005; 105(2)767–774
   PubMed Web of Science ®Google Scholar
• Mackey JR, Yao SY, Smith KM, Karpinski E, Baldwin SA, Cass CE, Young JD. Gemcitabine transport in Xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters. Journal of the National Cancer Institute 1999; 91(21)1876–1881
   PubMedGoogle Scholar
• Mangravite LM, Badagnani I, Giacomini KM. Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney. European Journal of Pharmacology 2003; 479(1–3)269–281
   PubMed Web of Science ®Google Scholar
• Mangravite LM, Giacomini KM. Sorting of rat SPNT in renal epithelium is independent of N-glycosylation. Pharmacology Research 2003; 20(2)319–323
   PubMed Web of Science ®Google Scholar
• Mangravite LM, Lipschutz JH, Mostov KE, Giacomini KM. Localization of GFP-tagged concentrative nucleoside transporters in a renal polarized epithelial cell line. American Journal of Physiology and Renal Physiology 2001; 280(5)F879–F885
   PubMed Web of Science ®Google Scholar
• Mata JF, Garcia-Manteiga JM, Lostao MP, Fernandez-Veledo S, Guillen-Gomez E, Larrayoz IM, Lloberas J, Casado FJ, Pastor-Anglada M. Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5[Prime]-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug. Molecular Pharmacology 2001; 59(6)1542–1548
   PubMed Web of Science ®Google Scholar
• Nagase K, Tomi M, Tachikawa M, Hosoya K. Functional and molecular characterization of adenosine transport at the rat inner blood–retinal barrier. Biochimica et Biophysica Acta 2006; 1758(1)13–19
   PubMed Web of Science ®Google Scholar
• Ngo LY, Patil SD, Unadkat JD. Ontogenic and longitudinal activity of Na(+)-nucleoside transporters in the human intestine. American Journal of Physiology and Gastrointestinal Liver Physiology 2001; 280(3)G475–G481
   PubMed Web of Science ®Google Scholar
• Nishizato Y, Ieiri I, Suzuki H, Kimura M, Kawabata K, Hirota T, Takane H, Irie S, Kusuhara H, Urasaki Y, et al. Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics. Clinical Pharmacology and Therapy 2003; 73(6)554–565
   PubMed Web of Science ®Google Scholar
• Nozawa T, Nakajima M, Tamai I, Noda K, Nezu J, Sai Y, Tsuji A, Yokoi T. Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): Allele frequencies in the Japanese population and functional analysis. Journal of Pharmacology and Experimental Therapy 2002; 302(2)804–813
   PubMed Web of Science ®Google Scholar
• Owen RP, Badagnani I, Giacomini KM. Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, CNT2. Journal of Biology and Chemistry 2006; 281(36)26675–26682
   PubMed Web of Science ®Google Scholar
• Owen RP, Gray JH, Taylor TR, Carlson EJ, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, Giacomini KM. Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2. Pharmacogenetics and Genomics 2005; 15(2)83–90
   PubMed Web of Science ®Google Scholar
• Pastor-Anglada M, Cano-Soldado P, Molina-Arcas M, Lostao MP, Larrayoz I, Martinez-Picado J, Casado FJ. Cell entry and export of nucleoside analogues. Virus Research 2005; 107(2)151–164
   PubMed Web of Science ®Google Scholar
• Pastor-Anglada M, Casado FJ. Role of nucleoside transporters SLC28 and SLC29 in cancer chemotherapy. Deoxynucleoside analogs in cancer therapy, JP Godefridus. Human, Totowa, NJ 2006; 1–28
   Google Scholar
• Pastor-Anglada M, Felipe A, Casado FJ. Transport and mode of action of nucleoside derivatives used in chemical and antiviral therapies. Trends in Pharmacology Science 1998; 19(10)424–430
   PubMed Web of Science ®Google Scholar
• Patching SG, Baldwin SA, Baldwin AD, Young JD, Gallagher MP, Henderson PJ, Herbert RB. The nucleoside transport proteins, NupC and NupG, from Escherichia coli: specific structural motifs necessary for the binding of ligands. Organic and Biomolecular Chemistry 2005; 3(3)462–470
   PubMed Web of Science ®Google Scholar
• Patil SD, Ngo LY, Unadkat JD. Structure–inhibitory profiles of nucleosides for the human intestinal N1 and N2 Na+-nucleoside transporters. Cancer Chemotherapy and Pharmacology 2000; 46(5)394–402
   PubMed Web of Science ®Google Scholar
• Redzic ZB, Biringer J, Barnes K, Baldwin SA, Al-Sarraf H, Nicola PA, Young JD, Cass CE, Barrand MA, Hladky SB. Polarized distribution of nucleoside transporters in rat brain endothelial and choroid plexus epithelial cells. Journal of Neurochemistry 2005; 94(5)1420–1426
   PubMed Web of Science ®Google Scholar
• Ribelayga C, Mangel SC. A circadian clock and light/dark adaptation differentially regulate adenosine in the mammalian retina. Journal of Neuroscience 2005; 25(1)215–222
   PubMed Web of Science ®Google Scholar
• Ritzel MW, Ng AM, Yao SY, Graham K, Loewen SK, Smith KM, Hyde RJ, Karpinski E, Cass CE, Baldwin SA, et al. Recent molecular advances in studies of the concentrative Na+-dependent nucleoside transporter (CNT) family: Identification and characterization of novel human and mouse proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). Molecular Membrane Biology 2001a; 18(1)65–72
   PubMed Web of Science ®Google Scholar
• Ritzel MW, Ng AM, Yao SY, Graham K, Loewen SK, Smith KM, Ritzel RG, Mowles DA, Carpenter P, Chen XZ, et al. Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). Journal of Biology and Chemistry 2001b; 276(4)2914–2927
   PubMed Web of Science ®Google Scholar
• Ritzel MW, Yao SY, Huang MY, Elliott JF, Cass CE, Young JD. Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1). American Journal of Physiology 1997; 272(2 Pt 1)C707–C714
   PubMed Web of Science ®Google Scholar
• Ritzel MW, Yao SY, Ng AM, Mackey JR, Cass CE, Young JD. Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. Molecular Membrane Biology 1998; 15(4)203–211
   PubMed Web of Science ®Google Scholar
• Rodriguez-Mulero S, Errasti-Murugarren E, Ballarin J, Felipe A, Doucet A, Casado FJ, Pastor-Anglada M. Expression of concentrative nucleoside transporters SLC28 (CNT1, CNT2, and CNT3) along the rat nephron: Effect of diabetes. Kidney International 2005; 68(2)665–672
   PubMed Web of Science ®Google Scholar
• Saito H, Nishimura M, Shinano H, Makita H, Tsujino I, Shibuya E, Sato F, Miyamoto K, Kawakami Y. Plasma concentration of adenosine during normoxia and moderate hypoxia in humans. American Journal of Respiratory and Critical Care Medicine 1999; 159(3)1014–1018
   PubMed Web of Science ®Google Scholar
• Savci V, Wurtman RJ. Effect of cytidine on membrane phospholipid synthesis in rat striatal slices. Journal of Neurochemistry 1995; 64(1)378–384
   PubMed Web of Science ®Google Scholar
• Schachter JB, Yasuda RP, Wolfe BB. Adenosine receptor activation potentiates phosphoinositide hydrolysis and arachidonic acid release in DDT1-MF2 cells: putative interrelations. Cell Signal 1995; 7(7)659–668
   PubMed Web of Science ®Google Scholar
• Schaner ME, Wang J, Zhang L, Su SF, Gerstin KM, Giacomini KM. Functional characterization of a human purine-selective, Na+-dependent nucleoside transporter (hSPNT1) in a mammalian expression system. Journal of Pharmacology and Experimental Therapy 1999; 289(3)1487–1491
   PubMed Web of Science ®Google Scholar
• Shin HC, Landowski CP, Sun D, Vig BS, Kim I, Mittal S, Lane M, Rosania G, Drach JC, Amidon GL. Functional expression and characterization of a sodium-dependent nucleoside transporter hCNT2 cloned from human duodenum. Biochemical and Biophysical Research Communications 2003; 307(3)696–703
   PubMed Web of Science ®Google Scholar
• Shryock JC, Belardinelli L. Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology, and pharmacology. American Journal of Cardiology 1997; 79(12A)2–10
   PubMed Web of Science ®Google Scholar
• Shu Y, Leabman MK, Feng B, Mangravite LM, Huang CC, Stryke D, Kawamoto M, Johns SJ, DeYoung J, Carlson E, et al. Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1. Proceedings of the National Academy of Sciences, USA, 2003. 100: 5902–5907, (10)
   Google Scholar
• Slugoski MD, Loewen SK, Ng AM, Smith KM, Yao SY, Karpinski E, Cass CE, Baldwin SA, Young JD. Specific mutations in transmembrane helix 8 of human concentrative Na+/nucleoside cotransporter hCNT1 affect permeant selectivity and cation coupling. Biochemistry 2007; 46(6)1684–1693
   PubMed Web of Science ®Google Scholar
• Smith KM, Ng AM, Yao SY, Labedz KA, Knaus EE, Wiebe LI, Cass CE, Baldwin SA, Chen XZ, Karpinski E, et al. Electrophysiological characterization of a recombinant human Na+-coupled nucleoside transporter (hCNT1) produced in Xenopus oocytes. Journal of Physiology 2004; 558(Pt 3)807–823
   PubMed Web of Science ®Google Scholar
• Smith KM, Slugoski MD, Loewen SK, Ng AM, Yao SY, Chen XZ, Karpinski E, Cass CE, Baldwin SA, Young JD. The broadly selective human Na+/nucleoside cotransporter (hCNT3) exhibits novel cation-coupled nucleoside transport characteristics. Journal of Biology and Chemistry 2005; 280(27)25436–25449
   PubMed Web of Science ®Google Scholar
• Soler C, Felipe A, Garcia-Manteiga J, Serra M, Guillen-Gomez E, Casado FJ, MacLeod C, Modolell M, Pastor-Anglada M, Celada A. Interferon-gamma regulates nucleoside transport systems in macrophages through signal transduction and activator of transduction factor 1 (STAT1)-dependent and -independent signalling pathways. Biochemistry Journal 2003; 375(Pt 3)777–783
   PubMed Web of Science ®Google Scholar
• Soler C, Garcia-Manteiga J, Valdes R, Xaus J, Comalada M, Casado FJ, Pastor-Anglada M, Celada A, Felipe A. Macrophages require different nucleoside transport systems for proliferation and activation. FASEB Journal 2001a; 15(11)1979–1988
   PubMed Web of Science ®Google Scholar
• Soler C, Valdes R, Garcia-Manteiga J, Xaus J, Comalada M, Casado FJ, Modolell M, Nicholson B, MacLeod C, Felipe A, et al. Lipopolysaccharide-induced apoptosis of macrophages determines the up-regulation of concentrative nucleoside transporters Cnt1 and Cnt2 through tumor necrosis factor-alpha-dependent and independent mechanisms. Journal of Biology and Chemistry 2001b; 276(32)30043–30049
   PubMed Web of Science ®Google Scholar
• Thomson S, Bao D, Deng A, Vallon V. Adenosine formed by 5á-nucleotidase mediates tubuloglomerular feedback. Journal of Clinical Investigation 2000; 106(2)289–298
   PubMed Web of Science ®Google Scholar
• Tirona RG, Leake BF, Merino G, Kim RB. Polymorphisms in OATP-C: Identification of multiple allelic variants associated with altered transport activity among European- and African-Americans. Journal of Biology and Chemistry 2001; 276(38)35669–35675
   PubMed Web of Science ®Google Scholar
• Toan SV, To KK, Leung GP, De Souza MO, Ward JL, Tse CM. Genomic organization and functional characterization of the human concentrative nucleoside transporter-3 isoform (hCNT3) expressed in mammalian cells. Pflugers Archives 2003; 447(2)195–204
   PubMed Web of Science ®Google Scholar
• Valdes R, Casado FJ, Pastor-Anglada M. Cell-cycle-dependent regulation of CNT1, a concentrative nucleoside transporter involved in the uptake of cell-cycle-dependent nucleoside-derived anticancer drugs. Biochemical and Biophysical Research Communications 2002; 296(3)575–579
   PubMed Web of Science ®Google Scholar
• Valdes R, Fernandez-Veledo S, Aymerich I, Casado FJ, Pastor-Anglada M. TGF-beta transcriptionally activates the gene encoding the high-affinity adenosine transporter CNT2 in rat liver parenchymal cells. Cell and Molecular Life Science 2006; 63(21)2527–2537
   PubMed Web of Science ®Google Scholar
• Valdes R, Ortega MA, Casado FJ, Felipe A, Gil A, Sanchez-Pozo A, Pastor-Anglada M. Nutritional regulation of nucleoside transporter expression in rat small intestine. Gastroenterology 2000; 119(6)1623–1630
   PubMed Web of Science ®Google Scholar
• Walker UA, Auclair M, Lebrecht D, Kornprobst M, Capeau J, Caron M. Uridine abrogates the adverse effects of antiretroviral pyrimidine analogues on adipose cell functions. Antiviral Therapy 2006; 11(1)25–34
   PubMed Web of Science ®Google Scholar
• Wang J, Giacomini KM. Molecular determinants of substrate selectivity in Na+-dependent nucleoside transporters. Journal of Biology and Chemistry 1997; 272(46)28845–28848
   PubMed Web of Science ®Google Scholar
• Wang J, Giacomini KM. Characterization of a bioengineered chimeric Na+-nucleoside transporter. Molecular Pharmacology 1999a; 55(2)234–240
   PubMed Web of Science ®Google Scholar
• Wang J, Giacomini KM. Serine 318 is essential for the pyrimidine selectivity of the N2 Na+-nucleoside transporter. Journal of Biology and Chemistry 1999b; 274(4)2298–2302
   PubMed Web of Science ®Google Scholar
• Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB, Giacomini KM. Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization. American Journal of Physiology 1997; 273(6 Pt 2)F1058–F1065
   PubMedGoogle Scholar
• Xiao G, Wang J, Tangen T, Giacomini KM. A novel proton-dependent nucleoside transporter, CeCNT3, from Caenorhabditis elegans. Molecular Pharmacology 2001; 59(2)339–348
   PubMed Web of Science ®Google Scholar
• Yagil C, Katni G, Yagil Y. The effects of adenosine on transepithelial resistance and sodium uptake in the inner medullary collecting duct. Pflugers Archives 1994; 427(3–4)225–232
   PubMed Web of Science ®Google Scholar
• Yamamoto T, Kuniki K, Takekuma Y, Hirano T, Iseki K, Sugawara M. Ribavirin uptake by cultured human choriocarcinoma (BeWo) cells and Xenopus laevis oocytes expressing recombinant plasma membrane human nucleoside transporters. European Journal of Pharmacology 2007; 557(1)1–8
   PubMed Web of Science ®Google Scholar
• Yao SY, Ng AM, Loewen SK, Cass CE, Baldwin SA, Young JD. An ancient prevertebrate Na+-nucleoside cotransporter (hfCNT) from the Pacific hagfish (Eptatretus stouti). American Journal of Physiology and Cell Physiology 2002; 283(1)C155–C168
   PubMed Web of Science ®Google Scholar
• Yao SY, Ng AM, Slugoski MD, Smith KM, Mulinta R, Karpinski E, Cass CE, Baldwin SA, Young JD. Conserved glutamate residues are critically involved in Na+/nucleoside cotransport by human concentrative nucleoside transporter 1 (hCNT1). Journal of Biology and Chemistry 2007; 282(42)30607–30617
   PubMed Web of Science ®Google Scholar
• Young JD, Paterson AR, Henderson JF. Nucleoside transport and metabolism in erythrocytes from the Yucatan miniature pig. Evidence that inosine functions as an in vivo energy substrate. Biochimica et Biophysica Acta 1985; 842(2–3)214–224
   PubMed Web of Science ®Google Scholar
• Zhang J, Smith KM, Tackaberry T, Visser F, Robins MJ, Nielsen LP, Nowak I, Karpinski E, Baldwin SA, Young JD, et al. Uridine binding and transportability determinants of human concentrative nucleoside transporters. Molecular Pharmacology 2005; 68(3)830–839
   PubMed Web of Science ®Google Scholar
• Zhang J, Tackaberry T, Ritzel MW, Raborn T, Barron G, Baldwin SA, Young JD, Cass CE. Cysteine-accessibility analysis of transmembrane domains 11–13 of human concentrative nucleoside transporter 3. Biochemistry Journal 2006; 394(Pt 2)389–398
   PubMed Web of Science ®Google Scholar
• Zhang J, Visser F, King KM, Baldwin SA, Young JD, Cass CE. The role of nucleoside transporters in cancer chemotherapy with nucleoside drugs. Cancer Metastasis Reviews 2007; 26(1)85–110
   PubMed Web of Science ®Google Scholar
• Zhang J, Visser F, Vickers MF, Lang T, Robins MJ, Nielsen LP, Nowak I, Baldwin SA, Young JD, Cass CE. Uridine binding motifs of human concentrative nucleoside transporters 1 and 3 produced in Saccharomyces cerevisiae. Molecular Pharmacology 2003; 64(6)1512–1520
   PubMed Web of Science ®Google Scholar
• Zou AP, Nithipatikom K, Li PL, Cowley AW, Jr. Role of renal medullary adenosine in the control of blood flow and sodium excretion. American Journal of Physiology 1999; 276(3 Pt 2)R790–R798
   PubMedGoogle Scholar