Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 39, 2009 - Issue 4
754
Views
79
CrossRef citations to date
0
Altmetric
Research Article

Intestinal flora induces the expression of Cyp3a in the mouse liver

, , , , , , & show all
Pages 323-334 | Received 28 Oct 2008, Accepted 27 Nov 2008, Published online: 01 Apr 2009

References

  • Bailey MT, Coe CL. 1999. Maternal separation disrupts the integrity of the intestinal microflora in infant rhesus monkeys. Dev Psychobiol 35:146–155.
  • Chin NX, Neu HC. 1984. Ciprofloxacin, a quinolone carboxylic acid compound active against aerobic and anaerobic bacteria. Antimicrob Agents Chemother 25:319–326.
  • Choudhary D, Jansson I, Schenkman JB, Sarfarazi M, Stoilov I. 2003. Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues. Arch Biochem Biophys 414:91–100.
  • Emoto C, Yamazaki H, Yamasaki S, Shimada N, Nakajima M, Yokoi T. 2000. Characterization of cytochrome P450 enzymes involved in drug oxidations in mouse intestinal microsomes. Xenobiotica 30:943–953.
  • Fukumori S, Murata T, Taguchi M, Hashimoto Y. 2007. Rapid and drastic induction of CYP3A4 mRNA expression via vitamin D receptor in human intestinal LS180 cells. Drug Metab Pharmacokinet 22:377–381.
  • Hayashi H, Sakamoto M, Benno Y. 2002. Fecal microbial diversity in a strict vegetarian as determined by molecular analysis and cultivation. Microbiol Immunol 46:819–831.
  • Hernandez JP, Chapman LM, Kretschmer XC, Baldwin WS. 2006. Gender-specific induction of cytochrome P450s in nonylphenol-treated FVB/NJ mice. Toxicol Appl Pharmacol 216:186–196.
  • Ikeda M, Ohira H, Toyama Y, Katagiri T, Sakakibara B. 2007. Effect of intestinal microflora on the production of interleukin 10 and prostaglandin e(2) in serum and Kupffer cells from germfree and conventional mice. J Clin Biochem Nutr 41:169–174.
  • Ishizaki T, Horai Y. 1999. Review article: cytochrome P450 and the metabolism of proton pump inhibitors—emphasis on rabeprazole. Aliment Pharmacol Ther 13:27–36.
  • Itoh S, Satoh M, Abe Y, Hashimoto H, Yanagimoto T, Kamataki T. 1994. A novel form of mouse cytochrome P450 3A (Cyp3a-16). Its cDNA cloning and expression in fetal liver. Eur J Biochem 226:877–882.
  • Jackson JP, Ferguson SS, Negishi M, Goldstein JA. 2006. Phenytoin induction of the cyp2c37 gene is mediated by the constitutive androstane receptor. Drug Metab Dispos 34:2003–2010.
  • Jung D, Mangelsdorf DJ, Meyer UA. 2006. Pregnane − receptor is a target of farnesoid − receptor. J Biol Chem 281:19081–19091.
  • Kitada H, Miyata M, Nakamura T, Tozawa A, Honma W, Shimada M, Nagata K, Sinal CJ, Guo GL, Gonzalez FJ, Yamazoe Y. 2003. Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity. J Biol Chem 278:17838–17844.
  • Klaassen CD, Slitt AL. 2005. Regulation of hepatic transporters by xenobiotic receptors. Curr Drug Metab 6:309–328.
  • Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 277:680–685.
  • Lee IJ, Jeong KS, Roberts BJ, Kallarakal AT, Fernandez-Salguero P, Gonzalez FJ, Song BJ. 1996. Transcriptional induction of the cytochrome P4501A1 gene by a thiazolium compound, YH439. Mol Pharmacol 49:980–988.
  • Levert KL, Waldrop GL, Stephens JM. 2002. A biotin analog inhibits acetyl-CoA carboxylase activity and adipogenesis. J Biol Chem 277:16347–16350.
  • Lim YP, Huang JD. 2008. Interplay of pregnane − receptor with other nuclear receptors on gene regulation. Drug Metab Pharmacokinet 23:14–21.
  • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–275.
  • Madsen D, Beaver M, Chang L, Bruckner-Kardoss E, Wostmann B. 1976. Analysis of bile acids in conventional and germfree rats. J Lipid Res 17:107–111.
  • Maejima K, Nomura T. 1975. An experience of application of sterility test of germfree mice and rats recommended by JEARA. Jikken Dobutsu 24:177–181. [in Japanese]
  • Maglich JM, Stoltz CM, Goodwin B, Hawkins-Brown D, Moore JT, Kliewer SA. 2002. Nuclear pregnane − receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. Mol Pharmacol 62:638–646.
  • Masubuchi Y, Horie T. 2004. Endotoxin-mediated disturbance of hepatic cytochrome P450 function and development of endotoxin tolerance in the rat model of dextran sulfate sodium- induced experimental colitis. Drug Metab Dispos 32:437–441.
  • Mitsuoka T, Ono K. 1977. Fecal flora of man. V. Communication: the fluctuation of the fecal flora of the healthy adult. Zentralbl Bakteriol [Orig A] 238:228–236.
  • Morishita Y, Ogata M. 1970. Studies on the alimentary flora of pig. V. Influence of starvation on the microbial flora. Nippon Juigaku Zasshi 32:19–24.
  • Müller M, Jansen PL. 1997. Molecular aspects of hepatobiliary transport. Am J Physiol 272:G1285–G1303.
  • Neut C, Bulois P, Desreumaux P, Membré JM, Lederman E, Gambiez L, Cortot A, Quandalle P, Van Kruiningen H, Colombel JF. 2002. Changes in the bacterial flora of the neoterminal ileum after ileocolonic resection for Crohn’s disease. Am J Gastroenterol 97:939–946.
  • Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, Nakaya R. 1990. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 98:694–702.
  • Perloff MD, Von Moltke LL, Court MH, Kotegawa T, Shader RI, Greenblatt DJ. 2000. Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms. J Pharmacol Exp Ther 292:618–628.
  • Pichard L, Fabre I, Fabre G, Domergue J, Saint Aubert B, Mourad G, Maurel P. 1990. Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes. Drug Metab Dispos 18:595–606.
  • Radominska A, Treat S, Little J. 1993. Bile acid metabolism and the pathophysiology of cholestasis. Semin Liver Dis 13:219–234.
  • Ridlon JM, Kang DJ, Hylemon PB. 2006. Bile salt biotransformations by human intestinal bacteria. J Lipid Res 47:241–259.
  • Sakuma T, Takai M, Endo Y, Kuroiwa M, Ohara A, Jarukamjorn K, Honma R, Nemoto N. 2000. A novel female-specific member of the CYP3A gene subfamily in the mouse liver. Arch Biochem Biophys 377:153–162.
  • Savage DC, Dubos R, Schaedler RW. 1968. The gastrointestinal epithelium and its autochthonous bacterial flora. J Exp Med 127:67–76.
  • Sonoda J, Xie W, Rosenfeld JM, Barwick JL, Guzelian PS, Evans RM. 2002. Regulation of a xenobiotic sulfonation cascade by nuclear pregnane − receptor (PXR). Proc Natl Acad Sci USA 99:13801–13806.
  • Staudinger JL, Goodwin B, Jones SA, Hawkins-Brown D, MacKenzie KI, LaTour A, Liu Y, Klaassen CD, Brown KK, Reinhard J, Willson TM, Koller BH, Kliewer SA. 2001. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci USA 98:3369–3374.
  • Stevens JC, Hines RN, Gu C, Koukouritaki SB, Manro JR, Tandler PJ, Zaya MJ. 2003. Developmental expression of the major human hepatic CYP3A enzymes. J Pharmacol Exp Ther 307:573–582.
  • Suzuki K, Harasawa R, Yoshitake Y, Mitsuoka T. 1983. Effects of crowding and heat stress on intestinal flora, body weight gain, feed efficiency of growing rats and chicks. Nippon Juigaku Zasshi 45:331–338.
  • Teng S, Piquette-Miller M. 2007. Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis. Br J Pharmacol 151:367–376.
  • Xie HJ, Broberg U, Griskevicius L, Lundgren S, Carlens S, Meurling L, Paul C, Rane A, Hassan M. 2003. Alteration of pharmacokinetics of cyclophosphamide and suppression of the cytochrome p450 genes by ciprofloxacin. Bone Marr Transpl 31:197–203.
  • Xie W, Radominska-Pandya A, Shi Y, Simon CM, Nelson MC, Ong ES, Waxman DJ, Evans RM. 2001. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc Natl Acad Sci USA 98:3375–3380.
  • Yamaoka K, Tanigawara Y, Nakagawa T, Uno T. 1981. A pharmacokinetic analysis program (multi) for microcomputer. J Pharmacobiodyn 4:879–885.
  • Yoshinari K, Takagi S, Sugatani J, Miwa M. 2006. Changes in the expression of cytochromes P450 and nuclear receptors in the liver of genetically diabetic db/db mice. Biol Pharm Bull 29:1634–1638.
  • Zhang J, Huang W, Qatanani M, Evans RM, Moore DD. 2004. The constitutive androstane receptor and pregnane − receptor function coordinately to prevent bile acid-induced hepatotoxicity. J Biol Chem 279:49517–49522.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.