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Xenobiotica
the fate of foreign compounds in biological systems
Volume 39, 2009 - Issue 9
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Research Article

Utility of unbound plasma drug levels and P-glycoprotein transport data in prediction of central nervous system exposure

H. HeDepartment of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, Rahway, NJ, USA
,
K.A. LyonsDepartment of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, Rahway, NJ, USA
,
X. ShenLaboratory Animal Resources, Merck Research Laboratories, Rahway, NJ, USA
,
Z. YaoLaboratory Animal Resources, Merck Research Laboratories, Rahway, NJ, USA
,
K. BleasbyDepartment of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, Rahway, NJ, USA
,
G. ChanDepartment of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, Rahway, NJ, USA
,
M. HafeyDepartment of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, Rahway, NJ, USA
,
X. LiDepartment of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, Rahway, NJ, USA
,
S. XuDepartment of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, Rahway, NJ, USA
,
G. M. SalituroDepartment of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, Rahway, NJ, USA
,
L. H. CohenDepartment of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, Rahway, NJ, USACorrespondence[email protected]
&
W. TangDepartment of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, Rahway, NJ, USACorrespondence[email protected]
 show all
Pages 687-693 | Received 06 Apr 2009, Accepted 04 May 2009, Published online: 01 Jul 2009

References

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