Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 47, 2017 - Issue 7
132
Views
0
CrossRef citations to date
0
Altmetric
Animal Pharmacokinetics and Metabolism

Leveraging model-based study designs and serial micro-sampling techniques to understand the oral pharmacokinetics of the potent LTB4 inhibitor, CP-105696, for mouse pharmacology studies

, , , , , & show all
Pages 600-606 | Received 05 Feb 2016, Accepted 25 Jun 2016, Published online: 20 Jul 2016

References

  • Aiello RJ, Bourassa PA, Lindsey S, et al. (2002). Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice. Arterioscler Thromb Vasc Biol 22:443–9
  • Birke FW, Meade CJ, Anderskewitz R, et al. (2001). In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist. J Pharmacol Exp Ther 297:458–66
  • Di Gennaro A, Haeggstrom JZ. (2013). Targeting leukotriene B in inflammation. Expert Opin Ther Targets 8:79–93
  • Goodnow RA Jr, Hicks A, Sidduri A, et al. (2010). Discovery of novel and potent leukotriene B4 receptor antagonists. Part 1. J Med Chem 53:3502–16
  • Griffiths RJ, Pettipher ER, Koch K, et al. (1995). Leukotriene B4 plays a critical role in the progression of collagen-induced arthritis. Proc Natl Acad Sci USA 92:517–21
  • Guerrero AT, Verri WA Jr, Cunha TM, et al. (2008). Involvement of LTB4 in zymosan-induced joint nociception in mice: participation of neutrophils and PGE2. J Leukoc Biol 83:122–30
  • Huang Q, Riviere JE. (2014). The application of allometric scaling principles to predict pharmacokinetic parameters across species. Expert Opin Drug Metab Toxicol 10:1241–53
  • Liston TE, Conklyn MJ, Houser J, et al. (1998). Pharmacokinetics and pharmacodynamics of the leukotriene B4 receptor antagonist CP-105,696 in man following single oral administration. Br J Clin Pharmacol 45:115–21
  • Mahmood I, Balian JD. (1996). Interspecies scaling: predicting clearance of drugs in humans. Three different approaches. Xenobiotica 26:887–95
  • Rahavendran SV, Vekich S, Skor H, et al. (2012). Discovery pharmacokinetic studies in mice using serial microsampling, dried blood spots and microbore LC-MS/MS. Bioanalysis 4:1077–95
  • Showell HJ, Pettipher ER, Cheng JB, et al. (1995). The in vitro and in vivo pharmacologic activity of the potent and selective leukotriene B4 receptor antagonist CP-105696. J Pharmacol Exp Ther 273:176–84
  • Singh RK, Tandon R, Dastidar SG, Ray A. (2013). A review on leukotrienes and their receptors with reference to asthma. J Asthma: Off J Assoc Care Asthma 50:922–31
  • Souza DG, Pinho V, Cassali GD, et al. (2002). Effect of a BLT receptor antagonist in a model of severe ischemia and reperfusion injury in the rat. Eur J Pharmacol 440:61–9
  • Yokomizo T. (2011). Leukotriene B4 receptors: novel roles in immunological regulations. Adv Enzyme Regul 51:59–64

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.