Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 47, 2017 - Issue 7
353
Views
1
CrossRef citations to date
0
Altmetric
Xenobiotic Transporters

Effect of OATP-binding on the prediction of biliary excretion

&
Pages 614-631 | Received 25 May 2016, Accepted 02 Jul 2016, Published online: 02 Aug 2016

References

  • Breiman L. (2001). Random forests. Mach Learn 45:5–32
  • Breiman L, Friedman JH, Olshen RA, Stone CJ. (1984). Classification and regression trees. Monterey, CA: Wadsworth & Brooks/Cole Advanced Books & Software, CRC Press
  • Carlson TJ, Fisher MB. (2008). Recent advances in high throughput screening for ADME properties. Comb Chem High Throughput Screen 11:258–64
  • Chang C, Pang KS, Swaan PW, Ekins S. (2005). Comparative pharmacophore modeling of organic anion transporting polypeptides: a meta-analysis of rat Oatp1a1 and human OATP1B1. J Pharmacol Exp Ther 314:533–41
  • Chen Y, Cameron K, Guzman-Perez A, et al. (2010). Structure-pharmacokinetic relationship of in vivo rat biliary excretion. Biopharm Drug Dispos 31:82–90
  • Cvetkovic M, Leake B, Fromm MF, et al. (1999). OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos 27:866–71
  • De Bruyn T, van Westen GJ, Ijzerman AP, et al. (2013). Structure-based identification of OATP1B1/3 inhibitors. Mol Pharmacol 83:1257–67
  • El-Kattan A, Varma M. 2012. Oral absorption, intestinal metabolism and human oral bioavailability. In: Paxton J, ed. Topics on drug metabolism. Rijeka, Croatia: InTech. doi: 10.5772/31087
  • Fenner KS, Jones HM, Ullah M, et al. (2012). The evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance. Xenobiotica 44:28–45
  • Friedman JH. (1991). Multivariate adaptive regression splines. Ann Stat 19:1–67
  • Gandhi YA, Morris ME. (2012). Re-evaluation of a quantitative structure pharmacokinetic model for biliary excretion in rats. Drug Metab Dispos 40:1259–62
  • Ghafourian T, Barzegar-Jalali M, Dastmalchi S, et al. (2006). QSPR models for the prediction of apparent volume of distribution. Int J Pharm 319:82–97
  • Ghafourian T, Cronin MTD. (2005). The impact of variable selection on the modelling of oestrogenicity. SAR QSAR Environ Res 16:171–90
  • Giacomini KM, Huang SM, International Transporter Consortium, et al. (2010). Membrane transporters in drug development. Nat Rev Drug Discov 9:215–36
  • Hagenbuch B, Meier PJ. (2003). The superfamily of organic anion transporting polypeptides. Biochim Biophys Acta 1609:1–18
  • Hagenbuch B, Meier PJ. (2004). Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch 447:653–65
  • Hall LH, Kier LB. (2007). The molecular connectivity chi indexes and kappa shape indexes in structure-property modeling. Rev Comp Chem 2:367–422
  • Hill T, Lewicki P. (2006). Statistics, methods and applications, a comprehensive reference for science, industry and data mining. 1st ed. Tulsa, OK: StatSoft Inc
  • Hosey CM, Broccatelli F, Benet LZ. (2014). Predicting when biliary excretion of parent drug is a major route of elimination in humans. AAPS J 16:1085–96
  • Hsiang B, Zhu Y, Wang Z, et al. (1999). A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem 274:37161–8
  • Ismair MG, Stieger B, Cattori V, et al. (2001). Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver. Gastroenterology 121:1185–90
  • Kalliokoski A, Niemi M. (2009). Impact of OATP transporters on pharmacokinetics. Br J Pharmacol 158:693–705
  • Karlgren M, Ahlin G, Bergström CA, et al. (2012b). In vitro and in silico strategies to identify OATP1B1 inhibitors and predict clinical drug-drug interactions. Pharm Res 29:411–26
  • Karlgren M, Vildhede A, Norinder U, et al. (2012a). Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. J Med Chem 55:4740–63
  • Kim RB. (2003). Organic anion-transporting polypeptide (OATP) transporter family and drug disposition. Eur J Clin Invest 33:21–5
  • Kullak-Ublick GA, Ismair MG, Stieger B, et al. (2001). Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology 120:525–33
  • Kullak-Ublick GA, Stieger B, Hagenbuch B, Meier PJ. (2000). Hepatic transport of bile salts. Semin Liver Dis 20:273–92
  • Lau YY, Okochi H, Huang Y, Benet LZ. (2006). Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: application of in vitro and ex situ systems. J Pharmacol Exp Ther 316:762–71
  • Luo G, Johnson S, Hsueh M, et al. (2010). In silico prediction of biliary excretion of drugs in rats based on physicochemical properties. Drug Metab Dispos 38:422–30
  • Meier-Abt F, Mokrab Y, Mizuguchi K. (2005). Organic anion transporting polypeptides of the OATP/SLCO superfamily: identification of new members in nonmammalian species, comparative modeling and a potential transport mode. J Membr Biol 208:213–27
  • Mikkaichi T, Suzuki T, Tanemoto M, et al. (2004). The organic anion transporter (OATP) family. Drug Metab Pharmacokinet 19:171–9
  • Muller M, Jansen PL. (1997). Molecular aspects of hepatobiliary transport. Am J Physiol 272:1285–303
  • Newby D, Freitas AA, Ghafourian T. (2013). Pre-processing feature selection for improved C&RT models for oral absorption. J Chem Inf Model 53:2730–42
  • Niemi M, Pasanen MK, Neuvonen PJ. (2011). Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev 63:157–81
  • Rollins DE, Klaassen CD. (1979). Biliary excretion of drugs in man. J Clin Pharmacokinet 4:368–79
  • Sharifi M, Ghafourian T. (2014). Estimation of biliary excretion of foreign compounds using properties of molecular structure. AAPS J 16:65–78
  • Shitara Y, Maeda K, Ikejiri K, et al. (2013). Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption. Biopharm Drug Dispos 34:45–78
  • Shitara Y, Sugiyama D, Kusuhara H, et al. (2002). Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res 19:147–53
  • Shugarts S, Benet LZ. (2009). The role of transporters in the pharmacokinetics of orally administered drugs. Pharm Res 26:2039–54
  • Smith NF, Figg WD, Sparreboom A. (2005). Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination. Expert Opin Drug Metab Toxicol 1:429–45
  • Soars MG, Barton P, Elkin LL, et al. (2014). Application of an in vitro OAT assay in drug design and optimization of renal clearance. Xenobiotica 44:657–65
  • Soars MG, Barton P, Ismair M, et al. (2012). The development, characterization, and application of an OATP1B1 inhibition assay in drug discovery. Drug Metab Dispos 40:1641–8
  • Sun H, Huang Y, Frassetto L, Benet LZ. (2004). Effects of uremic toxins on hepatic uptake and metabolism of erythromycin. Drug Metab Dispos 32:1239–46
  • Tu M, Mathiowetz AM, Pfefferkorn JA, et al. (2013). Medicinal chemistry design principles for liver targeting through OATP transporters. Curr Top Med Chem 13:857–66
  • Varma MV, Chang G, Lai Y, et al. (2012). Physicochemical property space of hepatobiliary transport and computational models for predicting rat biliary excretion. Drug Metab Dispos 40:1527–37
  • Yang X, Gandhi YA, Duignan DB, Morris ME. (2009). Prediction of biliary excretion in rats and humans using molecular weight and quantitative structure-pharmacokinetic relationships. AAPS J 11:511–25

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.