References
- Bakhiya N, Arlt VM, Bahn A, et al. (2009a). Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy. Toxicology 264:74–9.
- Bakhiya N, Monien B, Frank H, et al. (2009b). Renal organic anion transporters OAT1 and OAT3 mediate the cellular accumulation of 5-sulfooxymethylfurfural, a reactive, nephrotoxic metabolite of the Maillard product 5-hydroxymethylfurfural. Biochem Pharmacol 78:414–19.
- Braun A, Hammerle S, Suda K, et al. (2000). Cell cultures as tools in biopharmacy. Eur J PharmSci 11:S51–60.
- Cihlar T, Ho ES. (2000). Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1. Anal Biochem 283:49–55.
- Crespi CL, Langenbach R, Penman BW. (1993). Human cell-lines, derived from Ahh-1 Tk+/- human lymphoblasts, genetically-engineered for expression of cytochromes-P450. Toxicology 82:89–104.
- Debelle FD, Vanherweghem JL, Nortier JL. (2008). Aristolochic acid nephropathy: a worldwide problem. Kidney Int 74:158–69.
- Dracinska H, Barta F, Levova K, et al. (2016). Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivo. Toxicology 344–346:7–18.
- Gustafsson F, Foster AJ, Sarda S, et al. (2014). A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans. Toxicol Sci 137:189–211.
- Hong SS, Seo K, Lim SC, Han HK. (2007). Interaction characteristics of flavonoids with human organic anion transporter 1 (hOAT1) and 3 (hOAT3). Pharmacol Res 56:468–73.
- Hosoyamada M, Sekine T, Kanai Y, Endou H. (1999). Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am J Physiol 276:F122–8.
- Knights KM, Rowland A, Miners JO. (2013). Renal drug metabolism in humans: the potential for drug-endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT). Br J Clin Pharmacol 76:587–602.
- Ma L, Qin Y, Shen Z, et al. (2015). Aristolochic acid I is a substrate of BCRP but not P-glycoprotein or MRP2. J Ethnopharmacol 172:430–5.
- Mace K, Gonzalez FJ, McConnell IR, et al. (1994). Activation of promutagens in a human bronchial epithelial cell line stably expressing human cytochrome P450 1A2. Mol Carcinog 11:65–73.
- Schmeiser HH, Bieler CA, Wiessler M, et al. (1996). Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy. Cancer Res 56:2025–8.
- Sidorenko VS, Attaluri S, Zaitseva I, et al. (2014). Bioactivation of the human carcinogen aristolochic acid. Carcinogenesis 35:1814–22.
- Stiborova M, Frei E, Arlt VM, Schmeiser HH. (2009). The role of biotransformation enzymes in the development of renal injury and urothelial cancer caused by aristolochic acid: urgent questions and difficult answers. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 153:5–11.
- Stiborova M, Frei E, Wiessler M, Schmeiser HH. (2001). Human enzymes involved in the metabolic activation of carcinogenic aristolochic acids: evidence for reductive activation by cytochromes P450 1A1 and 1A2. Chem Res Toxicol 14:1128–37.
- Stiborova M, Levova K, Barta F, et al. (2012). Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2. Toxicol Sci 125:345–58.
- Stiborova M, Martinek V, Frei E, et al. (2013). Enzymes metabolizing aristolochic acid and their contribution to the development of aristolochic acid nephropathy and urothelial cancer. Curr Drug Metab 14:695–705.
- Sweet DH. (2005). Organic anion transporter (Slc22a) family members as mediators of toxicity. Toxicol Appl Pharmacol 204:198–215.
- Ting Chan XL. (2014). The interactions of herbal compounds with human organic anion/cation transporters. J Pharmacogen Pharmacoprot 5:142.
- Tu M, Li L, Lei H, et al. (2014). Involvement of organic cation transporter 1 and CYP3A4 in retrorsine-induced toxicity. Toxicology 322:34–42.
- Tu M, Sun S, Wang K, et al. (2013). Organic cation transporter 1 mediates the uptake of monocrotaline and plays an important role in its hepatotoxicity. Toxicology 311:225–30.
- Wang L, Sweet DH. (2012). Potential for food-drug interactions by dietary phenolic acids on human organic anion transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11). Biochem Pharmacol 84:1088–95.
- Wang L, Sweet DH. (2013a). Competitive inhibition of human organic anion transporters 1 (SLC22A6), 3 (SLC22A8) and 4 (SLC22A11) by major components of the medicinal herb Salvia miltiorrhiza (Danshen). Drug Metab Pharmacokinet 28:220–8.
- Wang L, Sweet DH. (2013b). Interaction of natural dietary and herbal anionic compounds and flavonoids with human organic anion transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11). Evid Based Complement Alternat Med 2013:612527.
- Wong CC, Barron D, Orfila C, et al. (2011). Interaction of hydroxycinnamic acids and their conjugates with organic anion transporters and ATP-binding cassette transporters. Mol Nutr Food Res 55:979–88.
- Xue X, Gong LK, Maeda K, et al. (2011). Critical role of organic anion transporters 1 and 3 in kidney accumulation and toxicity of aristolochic acid I. Mol Pharm 8:2183–92.
- Yu FY, Wu TS, Chen TW, Liu BH. (2011). Aristolochic acid I induced oxidative DNA damage associated with glutathione depletion and ERK1/2 activation in human cells. Toxicol In Vitro 25:810–16.
- Zhou L, Fu P, Huang XR, et al. (2010). Activation of p53 promotes renal injury in acute aristolochic acid nephropathy. J Am Soc Nephrol 21:31–41.
- Zhu SH, Wang Y, Jin J, et al. (2012). Endoplasmic reticulum stress mediates aristolochic acid I-induced apoptosis in human renal proximal tubular epithelial cells. Toxicol In Vitro 26:663–71.