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Xenobiotica
the fate of foreign compounds in biological systems
Volume 47, 2017 - Issue 12
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Pharmacogenetics

Association of PEAR1 rs12041331 polymorphism and pharmacodynamics of ticagrelor in healthy Chinese volunteers

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Pages 1130-1138 | Received 30 Oct 2016, Accepted 09 Dec 2016, Published online: 12 Jan 2017

References

  • Eicher JD, Xue L, Ben-Shlomo Y, et al. (2016). Replication and hematological characterization of human platelet reactivity genetic associations in men from the Caerphilly Prospective Study (CaPS). J Thromb Thrombolysis 41:343–50
  • Faraday N, Yanek LR, Yang XP, et al. (2011). Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression. Blood 118:3367–75
  • Fisch AS, Yerges-Armstrong LM, Backman JD, et al. (2015). Genetic variation in the platelet endothelial aggregation receptor 1 gene results in endothelial dysfunction. PLoS One 10:e0138795
  • Guo X, Chen XP, Cheng ZN, et al. (2009). No effect of MDR1 C3435T polymorphism on oral pharmacokinetics of telmisartan in 19 healthy Chinese male subjects. Clin Chem Lab Med 47:38–43
  • Haufroid V, Mourad M, Van Kerckhove V, et al. (2004). The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients. Pharmacogenetics 14:147–54
  • Herrera-Galeano JE, Becker DM, Wilson AF, et al. (2008). A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregability. Arterioscler Thromb Vasc Biol 28:1484–90
  • Johnson AD, Yanek LR, Chen MH, et al. (2010). Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. Nat Genet 42:608–13
  • Jones CI, Bray S, Garner SF, et al. (2009). A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways. Blood 114:1405–16
  • Kauskot A, Di Michele M, Loyen S, et al. (2012). A novel mechanism of sustained platelet alphaIIbbeta3 activation via PEAR1. Blood 119:4056–65
  • Kauskot A, Vandenbriele C, Louwette S, et al. (2013). PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway. Blood 121:5208–17
  • Kim KA, Park PW, Hong SJ, Park JY. (2008). The effect of CYP2C19 polymorphism on the pharmacokinetics and pharmacodynamics of clopidogrel: a possible mechanism for clopidogrel resistance. Clin Pharmacol Ther 84:236–42
  • Kim Y, Suktitipat B, Yanek LR, et al. (2013). Targeted deep resequencing identifies coding variants in the PEAR1 gene that play a role in platelet aggregation. PLoS One 8:e64179
  • Lewis JP, Ryan K, O'connell JR, et al. (2013). Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes. Circ Cardiovasc Genet 6:184–92
  • Li MP, Tang J, Wen ZP, et al. (2015). Influence of P2Y12 polymorphisms on platelet activity but not ex-vivo antiplatelet effect of ticagrelor in healthy Chinese male subjects. Blood Coagul Fibrinolysis 26:874–81
  • Li MP, Xiong Y, Xu A, et al. (2014). Association of platelet ITGA2B and ITGB3 polymorphisms with ex vivo antiplatelet effect of ticagrelor in healthy Chinese male subjects. Int J Hematol 99:263–71
  • Nanda N, Phillips DR. (2006). Novel targets for antithrombotic drug discovery. Blood Cells Mol Dis 36:228–31
  • Olivi L, Vandenbriele C, Gu YM, et al. (2015). PEAR1 is not a human hypertension-susceptibility gene. Blood Press 24:61–4
  • Postula M, Kaplon-Cieslicka A, Rosiak M, et al. (2011). Genetic determinants of platelet reactivity during acetylsalicylic acid therapy in diabetic patients: evaluation of 27 polymorphisms within candidate genes. J Thromb Haemost 9:2291–301
  • Price MJ, Murray SS, Angiolillo DJ, et al. (2012). Influence of genetic polymorphisms on the effect of high- and standard-dose clopidogrel after percutaneous coronary intervention: the GIFT (Genotype Information and Functional Testing) study. J Am Coll Cardiol 59:1928–37
  • Qayyum R, Becker LC, Becker DM, et al. (2015). Genome-wide association study of platelet aggregation in African Americans. BMC Genet 16:58
  • Santos-Gallego CG. (2015). Legacy of blood: does prasugrel inhibit megakaryocytes and do juvenile platelets inherit this inhibition? Haematologica 100:1103–5
  • Sokol J, Biringer K, Skerenova M, et al. (2015). Different models of inheritance in selected genes in patients with sticky platelet syndrome and fetal loss. Semin Thromb Hemost 41:330–5
  • Storey RF, Angiolillo DJ, Patil SB, et al. (2010). Inhibitory effects of ticagrelor compared with clopidogrel on platelet function in patients with acute coronary syndromes: the PLATO (PLATelet inhibition and patient Outcomes) PLATELET substudy. J Am Coll Cardiol 56:1456–62
  • Storey RF, Melissa Thornton S, Lawrance R, et al. (2009). Ticagrelor yields consistent dose-dependent inhibition of ADP-induced platelet aggregation in patients with atherosclerotic disease regardless of genotypic variations in P2RY12, P2RY1, and ITGB3. Platelets 20:341–8
  • Tantry US, Bliden KP, Wei C, et al. (2010). First analysis of the relation between CYP2C19 genotype and pharmacodynamics in patients treated with ticagrelor versus clopidogrel: the ONSET/OFFSET and RESPOND genotype studies. Circ Cardiovasc Genet 3:556–66
  • Tregouet DA, Garelle V. (2007). A new JAVA interface implementation of THESIAS: testing haplotype effects in association studies. Bioinformatics 23:1038–9
  • Varenhorst C, Eriksson N, Johansson A, et al. (2015). Effect of genetic variations on ticagrelor plasma levels and clinical outcomes. Eur Heart J 36:1901–12
  • Wallentin L, Becker RC, Budaj A, et al. (2009). Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 361:1045–57
  • Wallentin L, James S, Storey RF; Plato Investigators, et al. (2010). Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial. Lancet 376:1320–8
  • Wurtz M, Nissen PH, Grove EL, et al. (2014). Genetic determinants of on-aspirin platelet reactivity: focus on the influence of PEAR1. PLoS One 9:e111816
  • Xiang Q, Cui Y, Zhao X, Zhao N. (2013). Identification of PEAR1 SNPs and their influences on the variation in prasugrel pharmacodynamics. Pharmacogenomics 14:1179–89
  • Yao Y, Tang XF, Zhang JH, et al. (2016). Association of PEAR1 genetic variants with platelet reactivity in response to dual antiplatelet therapy with aspirin and clopidogrel in the Chinese patient population after percutaneous coronary intervention. Thromb Res 141:28–34
  • Zang M, Zhao L, Zhu F, et al. (2015). Effect of CAR polymorphism on the pharmacokinetics of artemisinin in healthy Chinese subjects. Drug Metab Pharmacokinet 30:123–6

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