Pharmacokinetic interaction of aconitine, liquiritin and 6-gingerol in a traditional Chinese herbal formula, Sini Decoction

References

• Beyer J, Peters FT, Kraemer T, Maurer HH. (2007). Detection and validated quantification of toxic alkaloids in human blood plasma-comparison of LC-APCI-MS with LC-ESI-MS/MS. J Mass Spectrom 42:621–33
   PubMed Web of Science ®Google Scholar
• Chen L, Yang J, Davey AK, et al. (2009). Effects of diammonium glycyrrhizinate on the pharmacokinetics of aconitine in rats and the potential mechanism. Xenobiotica 39:955–63
   PubMed Web of Science ®Google Scholar
• Chen S, Wu S, Li W, et al. (2014). Investigation of the therapeutic effectiveness of active components in Sini Decoction by a comprehensive GC/LC–MS based metabolomics and network pharmacology approaches. Mol Biosyst 10:3310–21
   PubMed Web of Science ®Google Scholar
• Fan YF, Xie Y, Liu L, et al. (2012). Paeoniflorin reduced acute toxicity of aconitine in rats is associated with the pharmacokinetic alteration of aconitine. J Ethnopharmacol 141:701–8
   PubMed Web of Science ®Google Scholar
• Gao QT, Chen XH, Bi KS. (2004). Comparative pharmacokinetic behavior of glycyrrhetic acid after oral administration of glycyrrhizic acid and Gancao-Fuzi-Tang. Biol Pharm Bull 27:226–8
   PubMed Web of Science ®Google Scholar
• Guo JY, Huo HR, Li LF, et al. (2009). Sini tang prevents depression-like behavior in rats exposed to chronic unpredictable stress. Am J Chin Med 37:261–72
   PubMed Web of Science ®Google Scholar
• Li N, Tsao R, Sui Z, et al. (2012). Intestinal transport of pure diester-type alkaloids from an aconite extract across the Caco-2 cell monolayer model. Planta Med 78:692–7
   PubMed Web of Science ®Google Scholar
• Liang Y, Zhou Y, Zhang J, et al. (2013). In vitro to in vivo evidence of the inhibitor characteristics of Schisandra lignans toward P-glycoprotein. Phytomedicine 20:1030–8
   PubMed Web of Science ®Google Scholar
• Liu HX, Lin WH, Wang XL, Yang JS. (2005). Flavonoids from preparation of traditional Chinese medicines named Sini-Tang. J Asian Nat Prod Res 7:139–43
   PubMed Web of Science ®Google Scholar
• Liu J, Peter K, Shi D, et al. (2014a). Anti-inflammatory effects of the Chinese herbal formula Sini Tang in myocardial infarction rats. Evid Based Complement Alternat Med 2014:309378
   PubMedGoogle Scholar
• Liu J, Peter K, Shi D, et al. (2014b). Traditional formula, modern application: Chinese medicine formula Sini Tang improves early ventricular remodeling and cardiac function after myocardial infarction in rats. Evid Based Complement Alternat Med 2014:141938
   PubMedGoogle Scholar
• Peter K, Schinnerl J, Felsinger S, et al. (2013). A novel concept for detoxification: complexation between aconitine and liquiritin in a Chinese herbal formula ('Sini Tang'). J Ethnopharmacol 149:562–9
   PubMed Web of Science ®Google Scholar
• Sun B, Zhang M, Zhang Q, et al. (2014a). Metabonomics study of the effects of pretreatment with glycyrrhetinic acid on mesaconitine-induced toxicity in rats. J Ethnopharmacol 154:839–46
   PubMed Web of Science ®Google Scholar
• Sun S, Zhang H, Sun F, et al. (2014b). Intestinal transport of sophocarpine across the Caco-2 cell monolayer model and quantification by LC/MS. Biomed Chromatogr 28:885–90
   PubMed Web of Science ®Google Scholar
• Tang L, Gong Y, Lv C, et al. (2012). Pharmacokinetics of aconitine as the targeted marker of Fuzi (Aconitum carmichaeli) following single and multiple oral administrations of Fuzi extracts in rat by UPLC/MS/MS. J Ethnopharmacol 141:736–41
   PubMed Web of Science ®Google Scholar
• Wang L, Zhand D, Qu X, et al. (2009). Experimental research on cardiotonic effect of active compound from raw and processing aconite roots. Zhongguo Zhong Yao Za Zhi 34:596–9
   PubMedGoogle Scholar
• Wang S, Hu Y, Tan W, et al. (2012). Compatibility art of traditional Chinese medicine: from the perspective of herb pairs. J Ethnopharmacol 143:412–23
   PubMed Web of Science ®Google Scholar
• Xin Y, Liu S. (2015). Quantitative assessment of the influence of Rhizoma Zingiberis on the level of aconitine in rat gut sacs and qualitative analysis of the major influencing components of Rhizoma Zingiberis on aconitine using UPLC/MS. PLoS One 10:e0124110
   PubMed Web of Science ®Google Scholar
• Xu SJ, Chen CX, Gao JP. (2003). Attenuated effect of active components of Radix glycyrrhizae on Radix aconiti laterlis and the related mechanisms. Chin Trad Pat Med 28:526–30
   Google Scholar
• Yang M, Liu XB, Huang QD. (2003). The increasing effect and reducing ill effect principle of compatibility of Radix aconiti. Lishizhen Med Mater Med Res 14:197–8
   Google Scholar
• Ye L, Yang X, Yang Z, et al. (2013). The role of efflux transporters on the transport of highly toxic aconitine, mesaconitine, hypaconitine, and their hydrolysates, as determined in cultured Caco-2 and transfected MDCKII cells. Toxicol Lett 216:86–99
   PubMed Web of Science ®Google Scholar
• Yuan Y, Zhang H, Ma W, et al. (2013). Influence of compound Danshen tablet on the pharmacokinetics of losartan and its metabolite EXP3174 by liquid chromatography coupled with mass spectrometry. Biomed Chromatogr 27:1219–24
   PubMed Web of Science ®Google Scholar
• Zhang JM, Liao W, He YX, et al. (2013). Study on intestinal absorption and pharmacokinetic characterization of diester diterpenoid alkaloids in precipitation derived from Fuzi-Gancao herb-pair decoction for its potential interaction mechanism investigation. J Ethnopharmacol 147:128–35
   PubMed Web of Science ®Google Scholar
• Zhang P, Kong D, Du Q, et al. (2016). A conscious rat model involving bradycardia and hypotension after oral administration: a toxicokinetical study of aconitine. Xenobiotica . [Epub ahead of print]. doi: http://dx.doi.org/10.1080/00498254.2016.1204484
   Google Scholar
• Zhang W, Zhang H, Sun S, et al. (2015). Comparative pharmacokinetics of hypaconitine after oral administration of pure hypaconitine, Aconitum carmichaelii extract and Sini Decoction to rats. Molecules 20:1560–70
   PubMed Web of Science ®Google Scholar