Pharmacokinetics of the selective prostacyclin receptor agonist selexipag in rats, dogs and monkeys

Tomohiko IchikawaPharmacokinetics and Safety Assessment Department, Nippon Shinyaku Co., Ltd, Kyoto, Japan and Correspondence[email protected]

Tetsuhiro YamadaPharmacokinetics and Safety Assessment Department, Nippon Shinyaku Co., Ltd, Kyoto, Japan and

Alexander TreiberPreclinical Pharmacokinetics and Metabolism, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

Carmela GnerrePreclinical Pharmacokinetics and Metabolism, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

Kiyoko NonakaPharmacokinetics and Safety Assessment Department, Nippon Shinyaku Co., Ltd, Kyoto, Japan and

References

Asaki T, Kuwano K, Morrison K, et al. (2015). Selexipag: an oral and selective IP prostacyclin receptor agonist for the treatment of pulmonary arterial hypertension. J Med Chem 58:7128–37.
PubMed Web of Science ®Google Scholar
Kuwano K, Hashino A, Asaki T, et al. (2007). 2-[4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug. J Pharmacol Ther 322:1181–8.
PubMed Web of Science ®Google Scholar
Li B, Sedlacek M, Manoharan I, et al. (2005). Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma. Biochem Pharmacol 70:1673–84.
PubMed Web of Science ®Google Scholar
Nakamura A, Yamada T, Asaki T. (2007). Synthesis and evaluation of N-acylsulfonamide and N-acylsulfonylurea prodrugs of a prostacyclin receptor agonist. Bioorg Med Chem 15:7720–5.
PubMed Web of Science ®Google Scholar
Scott LJ. (2016). Selexipag: first global approval. Drugs 76:413–8.
PubMed Web of Science ®Google Scholar
Treiber A, Miraval T, Bolli MH, et al. (2016). The metabolism of the dual endothelin receptor antagonist macitentan in rat and dog. Xenobiotica 46:253–67.
PubMed Web of Science ®Google Scholar

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Pharmacokinetics of the selective prostacyclin receptor agonist selexipag in rats, dogs and monkeys

References

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Pharmacokinetics of the selective prostacyclin receptor agonist selexipag in rats, dogs and monkeys

References

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date