References
- Avila DV, Barker DF, Zhang J, et al. (2016). Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis. J Pathol 240:96–107
- Beyoglu D, Idle JR. (2013). The metabolomic window into hepatobiliary disease. J Hepatol 59:842–58
- Born SL, Api AM, Ford RA, et al. (2003). Comparative metabolism and kinetics of coumarin in mice and rats. Food Chem Toxicol 41:247–58
- Chen C, Krausz KW, Idle JR, et al. (2008a). Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice. J Biol Chem 283:4543–59
- Chen C, Shah YM, Morimura K, et al. (2008b). Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis. Cell Metab 7:135–47
- de Leon J. (2003). Glucuronidation enzymes, genes and psychiatry. Int J Neuropsychopharmacol 6:57–72
- Duffy CF, O'kennedy R. (1998). Determination of 7-hydroxycoumarin and its glucuronide and sulphate conjugates in liver slice incubates by capillary zone electrophoresis. J Pharm Biomed Anal 17:1279–84
- Fang ZZ, Krausz KW, Li F, et al. (2012). Metabolic map and bioactivation of the anti-tumour drug noscapine. Br J Pharmacol 167:1271–86
- Garcia-Fontana B, Morales-Santana S, Navarro CD, et al. (2016). Metabolomic profile related to cardiovascular disease in patients with type 2 diabetes mellitus: a pilot study. Talanta 148:135–43
- Giri S, Krausz KW, Idle JR, et al. (2007). The metabolomics of (+/−)-arecoline 1-oxide in the mouse and its formation by human flavin-containing monooxygenases. Biochem Pharmacol 73:561–73
- Hu X, Huang W, Yang Y. (2015). Cytochrome P450 isoenzymes in rat and human liver microsomes associate with the metabolism of total coumarins in Fructus Cnidii. Eur J Drug Metab Pharmacokinet 40:373–7
- Jarzab A, Grabarska A, Kielbus M, et al. (2014). Osthole induces apoptosis, suppresses cell-cycle progression and proliferation of cancer cells. Anticancer Res 34:6473–80
- Katsori AM, Hadjipavlou-Litina D. (2014). Coumarin derivatives: an undated patent review (2012--2014). Expert Opin Ther Patents 24:1323–1347
- Kind T, Fiehn O. (2007). Seven golden rules for heuristic filtering of molecular formulas obtained by accurate mass spectrometry. BMC Bioinformatics 8:105. doi: 10.1186/1471-2105-8-105
- Lewis DF, Ito Y, Lake BG. (2006). Metabolism of coumarin by human P450s: a molecular modelling study. Toxicol Vitro 20:256–64
- Li C, Li G, Tan DX, et al. (2013a). A novel enzyme-dependent melatonin metabolite in humans. J Pineal Res 54:100–6
- Li F, Jiang C, Larsen MC, et al. (2014). Lipidomics reveals a link between CYP1B1 and SCD1 in promoting obesity. J Proteome Res 13:2679–87
- Li F, Pang X, Krausz KW, et al. (2013b). Stable isotope- and mass spectrometry-based metabolomics as tools in drug metabolism: a study expanding tempol pharmacology. J Proteome Res 12:1369–76
- Li F, Patterson AD, Krausz KW, et al. (2012). Metabolomics reveals the metabolic map of procainamide in humans and mice. Biochem Pharmacol 83:1435–44
- Li F, Yang XW, Krausz KW, et al. (2015). Modulation of colon cancer by nutmeg. J Proteome Res 14:1937–46
- Liang HJ, Suk FM, Wang CK, et al. (2009). Osthole, a potential antidiabetic agent, alleviates hyperglycemia in db/db mice. Chem Biol Interact 181:309–15
- Liu X, Lu Y, Guan X, et al. (2015). Metabolomics reveals the formation of aldehydes and minimum in gefitinib metabolism. Biochem Pharmacol 97:111–21
- Lv X, Wang CY, Hou J, et al. (2012a). Isolation and identification of metabolites of osthole in rats. Xenobiotica 42:1120–7
- Lv X, Xin XL, Deng S, et al. (2012b). Biotransformation of osthole by Mucor spinosus. Process Biochem 47:2542–6
- Mandard S, Muller M, Kersten S. (2004). Peroxisome proliferator-activated receptor alpha target genes. Cell Mol Life Sci 61:393–416
- Ogawa H, Sasai N, Kamisako T, et al. (2007). Effects of osthol on blood pressure and lipid metabolism in stroke-prone spontaneously hypertensive rats. J Ethnopharmacol 112:26–31
- Ojewole JAO, Adesina SK. (1983). Cardiovascular and neuromuscular actions of scopoletin from fruit of tetrapleura tetraptera. Planta Med 49:99–102
- Okamoto T, Kobayashi T, Yoshida S. (2005). Chemical aspects of coumarin compounds for the prevention of hepatocellular carcinomas. Curr Med Chem Anticancer Agents 5:47–51
- Okamoto T, Kobayashi T, Yoshida S. (2007). Synthetic derivatives of osthole for the prevention of hepatitis. Med Chem 3:35–44
- Okudaira M, Inoue A, Shuto A, et al. (2014). Separation and quantification of 2-acyl-1-lysophospholipids and 1-acyl-2-lysophospholipids in biological samples by LC-MS/MS. J Lipid Res 55:2178–92
- Olsen L, Oostenbrink C, Jorgensen FS. (2015). Prediction of cytochrome P450 mediated metabolism. Adv Drug Deliv Rev 86:61–71
- Patterson AD, Li H, Eichler GS, et al. (2008). UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation. Anal Chem 80:665–74
- Patterson AD, Slanar O, Krausz KW, et al. (2009). Human urinary metabolomic profile of PPARα induced fatty acid beta-oxidation. J Proteome Res 8:4293–300
- Qi Z, Xue J, Zhang Y, et al. (2011). Osthole ameliorates insulin resistance by increment of adiponectin release in high-fat and high-sucrose-induced fatty liver rats. Planta Med 77:231–5
- Qi ZG, Zhao X, Zhong W, et al. (2016). Osthole improves glucose and lipid metabolism via modulation of PPARα/γ-mediated target gene expression in liver, adipose tissue, and skeletal muscle in fatty liver rats. Pharm Biol 54:882–8
- Qiu Z, Yu J, Dai Y, et al. (2017). A simple LC-MS/MS method for the simultaneous quantification of resveratrol and its major phase II metabolites: assessment of their urinary and biliary excretions in rats. J Chromatogr B 1048:85–93
- Song F, Xie ML, Zhu LJ, et al. (2006). Experimental study of osthole on treatment of hyperlipidemic and alcoholic fatty liver in animals. World J Gastroenterol 12:4359–63
- Sun F, Xie ML, Xue J, et al. (2010). Osthol regulates hepatic PPAR α-mediated lipogenic gene expression in alcoholic fatty liver murine. Phytomedicine 17:669–73
- Teng C, Lin C, Ko F, et al. (1994). The relaxant action of osthole isolated from Angelica pubescens in guinea-pig trachea. Naunyn Schmiedebergs Arch Pharmacol 349:202–8
- Tontonoz P, Spiegelman BM. (2008). Fat and beyond: the diverse biology of PPARγ. Annu Rev Biochem 77:289–312
- Tsukamoto H, Hisada S, Nishibe S. (1985). Coumarins from bark of Fxaxinus japonica and F. mandshurica var. japonica. Chem Pharm Bull 33:4069–73
- Venugopala KN, Rashmi V, Odhav B. (2013). Review on natural coumarin lead compounds for their pharmacological activity. Biomed Res Int 2013:963248. doi: 10.1155/2013/963248
- Wang X, Zhu W, Qiu J, et al. (2017). Enantioselective metabolism and enantiomerization of benalaxyl in mice. Chemosphere 169:308–15
- Wang Y, Zhao M, Ou Y, et al. (2016). Metabolic profile of esculin in rats by ultra high performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry. J Chromatogr B 1020:120–8
- Wen YC, Lee WJ, Tan P, et al. (2015). By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer. Oncotarget 6:21120–36
- Yuan Z, Xu H, Wang K, et al. (2009). Determination of osthol and its metabolites in a phase I reaction system and the Caco-2 cell model by HPLC-UV and LC-MS/MS. J Pharm Biomed Anal 49:1226–32
- Yun F, Kang A, Shan J, et al. (2013). A rapid and sensitive LC-MS/MS method for the determination of osthole in rat plasma: application to pharmacokinetic study. Biomed Chromatogr 27:676–80
- Zhang ZR, Leung WN, Cheung HY, et al. (2015). Osthole: a review on its bioactivities, pharmacological properties, and potential as alternative medicine. Evid Based Complement Alternat Med 2015:919616. doi: 10.1155/2015/919616
- Zhao X, Xue J, Wang XL, et al. (2014). Involvement of hepatic peroxisome proliferator-activated receptor α/γ in the therapeutic effect of osthole on high-fat and high-sucrose-induced steatohepatitis in rats. Int Immunopharmacol 22:176–81