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Xenobiotica
the fate of foreign compounds in biological systems
Volume 48, 2018 - Issue 6
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General Xenobiochemistry

Utility of in vitro and in vivo systems for studying the permeability of capsaicin and nonivamide through different intestinal regions

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Pages 541-545 | Received 10 Apr 2017, Accepted 16 Jun 2017, Published online: 06 Jul 2017

References

  • Akiba Y, Kato S, Katsube K, et al. (2004). Transient receptor potential vanilloid subfamily 1 expressed in pancreatic islet beta cells modulates insulin secretion in rats. Biochem Biophys Res Commun 321:219–25
  • Bhatt DL, Topol EJ. (2003). Scientific and therapeutic advances in antiplatelet therapy. Nat Rev Drug Discov 2:15–28
  • Deplancke B, Gaskins HR. (2001). Microbial modulation of innate defense: goblet cells and the intestinal mucus layer. Am J Clin Nutr 73:1131S
  • Duan L, Yan Y, Liu Y, et al. (2013a). [Analysis of capsaicin in rat plasma using liquid chromatography-tandem mass spectrometry]. Nan Fang Yi Ke Da Xue Xue Bao 33:1165–8
  • Duan L, Yan Y, Sun Y, et al. (2013b). Contribution of TRPV1 and multidrug resistance proteins in the permeation of capsaicin across different intestinal regions. Int J Pharm 445:134–40
  • Fang JY, Wu PC, Huang YB, Tsai YH. (1996). In vivo percutaneous absorption of capsaicin, nonivamide and sodium nonivamide acetate from ointment bases: skin erythema test and non-invasive surface recovery technique in humans. Int J Pharm 131:143–51
  • Janssens PL, Hursel R, Westerterp-Plantenga MS. (2014). Capsaicin increases sensation of fullness in energy balance, and decreases desire to eat after dinner in negative energy balance. Appetite 77:46–51
  • Kawada T, Watanabe T, Katsura K, et al. (1985). Formation and metabolism of pungent principle of Capsicum fruits. XV. Microdetermination of capsaicin by high-performance liquid chromatography with electrochemical detection. J Chromatogr 329:99
  • Lennernäs H, Nylander S, Ungell AL. (1997). Jejunal permeability: a comparison between the ussing chamber technique and the single-pass perfusion in humans. Pharm Res 14:667–71
  • Ludy MJ, Moore GE, Mattes RD. (2012). The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans. Chem Senses 37:103
  • Mittelstadt SW, Nelson RA, Daanen JF, et al. (2012). Capsaicin-induced inhibition of platelet aggregation is not mediated by transient receptor potential vanilloid type 1. Blood Coagul Fibrinolysis 23:94
  • Nimmerfall F, Rosenthaler J. (1980). Significance of the goblet-cell mucin layer, the outermost luminal barrier to passage through the gut wall. Biochem Biophys Res Commun 94:960–6
  • Papoiu AD, Yosipovitch G. (2010). Topical capsaicin. The fire of a ‘hot’ medicine is reignited. Expert Opin Pharmacother 11:1359–71
  • Reyes-Escogido ML, Gonzalez-Mondragon EG, Vazquez-Tzompantzi E. (2011). Chemical and pharmacological aspects of capsaicin. Molecules 16:1253–70
  • Skofitsch G, Donnerer J, Lembeck F. (1984). Comparison of nonivamide and capsaicin with regard to their pharmacokinetics and effects on sensory neurons. Arzneimittel-Forschung 34:154–6
  • Tsai YH, Huang YB, Fang JY, Wu PC. (1994). Percutaneous absorption of capsaicin and its derivatives. Drug Dev Ind Pharm 20:719–30
  • Ursu D, Knopp K, Beattie RE, et al. (2010). Pungency of TRPV1 agonists is directly correlated with kinetics of receptor activation and lipophilicity. Eur J Pharmacol 641:114–22
  • van de Kerkhof EG, Ungell AL, Sjöberg AK, et al. (2006). Innovative methods to study human intestinal drug metabolism in vitro: precision-cut slices compared with Ussing chamber preparations. Drug Metab Dispos 34:1893–902
  • Wen X, Walle T. (2006). Methylated flavonoids have greatly improved intestinal absorption and metabolic stability. Drug Metab Dispos 34:1786
  • Zhang R, Humphreys I, Sahu RP, et al. (2008). In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway. Apoptosis 13:1465–78

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