Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 48, 2018 - Issue 10
793
Views
18
CrossRef citations to date
0
Altmetric
Xenobiotic Transporters

In vitro studies with two human organic anion transporters: OAT2 and OAT7

, , , , , , , , , , , & show all
Pages 1037-1049 | Received 15 Aug 2017, Accepted 21 Sep 2017, Published online: 13 Oct 2017

References

  • Annaert P, Ye ZW, Stieger B, et al. (2010). Interaction of HIV protease inhibitors with OATP1B1, 1B3, and 2B1. Xenobiotica 40:163–76
  • Balogh LM, Kimoto E, Chupka J, et al. (2013). Membrane protein quantification by peptide-based mass spectrometry approaches: studies on the organic anion-transporting polypeptide family. J Proteomics Bioinform 6:229–36
  • Bi YA, Kazolias D, Duignan DB. (2006). Use of cryopreserved human hepatocytes in sandwich culture to measure hepatobiliary transport. Drug Metab Dispos 34:1658–65
  • Bi YA, Scialis RJ, Lazzaro S, et al. (2017). Reliable rate measurements for active and passive hepatic uptake using plated human hepatocytes. AAPS J 19:787–96
  • Burckhardt G. (2012). Drug transport by organic anion transporters (OATs). Pharmacol Ther 136:106–30
  • Cheng Y, Vapurcuyan A, Shahidullah M, et al. (2012). Expression of organic anion transporter 2 in the human kidney and its potential role in the tubular secretion of guanine-containing antiviral drugs. Drug Metab Dispos 40:617–24
  • Cropp CD, Komori T, Shima JE, et al. (2008). Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP. Mol Pharmacol 73:1151–8
  • Ebihara T, Takeuchi T, Moriya Y, et al. (2016). Characterization of transporters in the hepatic uptake of TAK-475 M-I, a squalene synthase inhibitor, in rats and humans. Drug Res (Stuttg) 66:316–23
  • Ebner T, Ishiguro N, Taub ME. (2015). The use of transporter probe drug cocktails for the assessment of transporter-based drug–drug interactions in a clinical setting-proposal of a four component transporter cocktail. J Pharm Sci 104:3220–8
  • Emami Riedmaier A, Burk O, van Eijck BA, et al. (2016). Variability in hepatic expression of organic anion transporter 7/SLC22A9, a novel pravastatin uptake transporter: impact of genetic and regulatory factors. Pharmacogenom J 16:341–51
  • Enomoto A, Takeda M, Shimoda M, et al. (2002). Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. J Pharmacol Exp Ther 301:797–802
  • Furihata T, Morio H, Zhu M, et al. (2017). Human organic anion transporter 2 is an entecavir, but not tenofovir, transporter. Drug Metab Pharmacokinet 32:116–19
  • Han YH, Busler D, Hong Y, et al. (2010). Transporter studies with the 3-O-sulfate conjugate of 17alpha-ethinylestradiol: assessment of human liver drug transporters. Drug Metab Dispos 38:1072–82
  • Hasannejad H, Takeda M, Taki K, et al. (2004). Interactions of human organic anion transporters with diuretics. J Pharmacol Exp Ther 308:1021–9
  • Henjakovic M, Hagos Y, Krick W, et al. (2015). Human organic anion transporter 2 is distinct from organic anion transporters 1 and 3 with respect to transport function. Am J Physiol Renal Physiol 309:F843–51
  • Hirano M, Maeda K, Shitara Y, et al. (2004). Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. J Pharmacol Exp Ther 311:139–46
  • Hotchkiss AG, Berrigan L, Pelis RM. (2015). Organic anion transporter 2 transcript variant 1 shows broad ligand selectivity when expressed in multiple cell lines. Front Pharmacol 6:1–9
  • Huang J, Li N, Hong W, et al. (2013). Conserved tryptophan residues within putative transmembrane domain 6 affect transport function of organic anion transporting polypeptide 1B1. Mol Pharmacol 84:521–7
  • Imamura Y, Murayama N, Okudaira N, et al. (2011). Prediction of fluoroquinolone-induced elevation in serum creatinine levels: a case of drug–endogenous substance interaction involving the inhibition of renal secretion. Clin Pharmacol Ther 89:81–8
  • Izumi S, Nozaki Y, Komori T, et al. (2013). Substrate-dependent inhibition of organic anion transporting polypeptide 1B1: comparative analysis with prototypical probe substrates estradiol-17β-glucuronide, estrone-3-sulfate, and sulfobromophthalein. Drug Metab Dispos 41:1859–66
  • Jigorel E, Le Vee M, Boursier-Neyret C, et al. (2005). Functional expression of sinusoidal drug transporters in primary human and rat hepatocytes. Drug Metab Dispos 33:1418–22
  • Jouan E, Le Vée M, Denizot C, et al. (2016). Drug transporter expression and activity in human hepatoma HuH-7 cells. Pharmaceutics 9:E3
  • Jung KY, Takeda M, Kim DK, et al. (2001). Characterization of ochratoxin A transport by human organic anion transporters. Life Sci 69:2123–35
  • Karlgren M, Vildhede A, Norinder U, et al. (2012). Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug–drug interactions. J Med Chem 55:4740–63
  • Khamdang S, Takeda M, Noshiro R, et al. (2002). Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther 303:534–9
  • Kim RB, Leake B, Cvetkovic M, et al. (1999). Modulation by drugs of human hepatic sodium-dependent bile acid transporter (sodium taurocholate cotransporting polypeptide) activity. J Pharmacol Exp Ther 291:1204–9
  • Kimoto E, Yoshida K, Balogh LM, et al. (2012). Characterization of organic anion transporting polypeptide (OATP) expression and its functional contribution to the uptake of substrates in human hepatocytes. Mol Pharm 9:3535–42
  • Kindla J, Müller F, Mieth M, et al. (2011). Influence of non-steroidal anti-inflammatory drugs on organic anion transporting polypeptide (OATP) 1B1- and OATP1B3-mediated drug transport. Drug Metab Dispos 39:1047–53
  • Klein K, Jüngst C, Mwinyi J, et al. (2010). The human organic anion transporter genes OAT5 and OAT7 are transactivated by hepatocyte nuclear factor-1α (HNF-1α). Mol Pharmacol 78:1079–87
  • Kobayashi Y, Ohshiro N, Sakai R, et al. (2005). Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]). J Pharm Pharmacol 57:573–8
  • Kunze A, Huwyler J, Camenisch G, et al. (2014). Prediction of organic anion-transporting polypeptide 1B1- and 1B3-mediated hepatic uptake of statins based on transporter protein expression and activity data. Drug Metab Dispos 42:1514–21
  • Le Vée M, Jouan E, Denizot C, et al. (2015). Analysis of sinusoidal drug uptake transporter activities in primary human hepatocytes. Methods Mol Biol 1250:287–302
  • Lepist EI, Zhang X, Hao J, et al. (2014). Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat. Kidney Int 86:350–7
  • Li XL, Guo ZT, Wang YD, et al. (2015). Potential role of organic anion transporting polypeptide 1B1 (OATP1B1) in the selective hepatic uptake of hematoporphyrin monomethyl ether isomers. Acta Pharmacol Sin 36:268–80
  • Mathialagan S, Rodrigues AD, Feng B. (2017). Evaluation of renal transporter inhibition employing creatinine as a substrate in vitro to assess the clinical risk of elevated serum creatinine. J Pharm Sci 106:2535–41
  • Nigam SK, Bush KT, Martovetsky G, et al. (2015). The organic anion transporter (OAT) family: a systems biology perspective. Physiol Rev 95:83–123
  • Nishimura M, Naito S. (2005). Tissue-specific mRNA expression profiles of human ATP-binding cassette and solute carrier transporter superfamilies. Drug Metab Pharmacokinet 20:452–7
  • Ohtsuki S, Schaefer O, Kawakami H, et al. (2012). Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities. Drug Metab Dispos 40:83–92
  • Prasad B, Johnson K, Billington S, et al. (2016). Abundance of drug transporters in the human kidney cortex as quantified by quantitative targeted proteomics. Drug Metab Dispos 44:1920–4
  • Schaefer O, Ohtsuki S, Kawakami H, et al. (2012). Absolute quantification and differential expression of drug transporters, cytochrome P450 enzymes, and UDP-glucuronosyltransferases in cultured primary human hepatocytes. Drug Metab Dispos 40:93–103
  • Sekine T, Cha SH, Tsuda M, et al. (1998). Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett 429:179–82
  • Shen H, Lai Y, Rodrigues AD. (2016). Organic anion transporter 2: an enigmatic human solute carrier. Drug Metab Dispos 45:228–36
  • Shen H, Liu T, Morse BL, et al. (2015). Characterization of organic anion transporter 2 (SLC22A7): a highly efficient transporter for creatinine and species-dependent renal tubular expression. Drug Metab Dispos 43:984–93
  • Shin HJ, Anzai N, Enomoto A, et al. (2007). Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate. Hepatology 45:1046–55
  • Sun W, Wu RR, van Poelje PD, et al. (2001). Isolation of a family of organic anion transporters from human liver and kidney. Biochem Biophys Res Commun 283:417–22
  • Vildhede A, Wiśniewski JR, Norén A, et al. (2015). Comparative proteomic analysis of human liver tissue and isolated hepatocytes with a focus on proteins determining drug exposure. J Proteome Res 14:3305–14
  • Watanabe M, Watanabe T, Yabuki M, et al. (2015). Dehydroepiandrosterone sulfate, a useful endogenous probe for evaluation of drug–drug interaction on hepatic organic anion transporting polypeptide (OATP) in cynomolgus monkeys. Drug Metab Pharmacokinet 30:198–204
  • Williamson B, Soars AC, Owen A, et al. (2013). Dissecting the relative contribution of OATP1B1-mediated uptake of xenobiotics into human hepatocytes using siRNA. Xenobiotica 43:920–31
  • Yang YH, Dudoit S, Luu P, et al. (2002). Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res 30:e15

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.