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Xenobiotica
the fate of foreign compounds in biological systems
Volume 48, 2018 - Issue 10
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General Xenobiochemistry

The potent mechanism-based inactivation of CYP2D6 and CYP3A4 with fusidic acid in in vivo bioaccumulation

Xiu-Xian LinDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China, ;Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China,
,
Guang-Hui LianDepartment of gastroenterology, Xiangya Hospital, Central South University, Changsha, Hunan, China,
,
Ying XuDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China, ;Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China,
,
Qing ZhaoDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China, ;Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China,
,
Jian XiaoDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, China,
,
Shi-Fang PengDepartment of Hepatology and Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China, and ;Health Management Center, Xiangya Hospital, Central South University, Changsha, Hunan, China
,
Mei-Fang XiaoDepartment of Hepatology and Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China, and ;Health Management Center, Xiangya Hospital, Central South University, Changsha, Hunan, China
,
Dong-Sheng OuyangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China, ;Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China,
,
Zhi-Rong TanDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China, ;Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China,
,
Yi-Cheng WangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China, ;Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China,
,
Jing-Bo PengDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China, ;Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China,
,
Wei ZhangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China, ;Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China,
&
Yao ChenDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China, ;Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China, Correspondence[email protected]
 show all
Pages 999-1005 | Received 05 Sep 2017, Accepted 06 Oct 2017, Published online: 10 Nov 2017

References

  • Bulitta JB, Okusanya OO, Forrest A, et al. (2013). Population pharmacokinetics of fusidic acid: rationale for front-loaded dosing regimens due to autoinhibition of clearance. Antimicrob Agents Chemother 57:498–507
  • Burtenshaw AJ, Sellors G, Downing R. (2008). Presumed interaction of fusidic acid with simvastatin. Anaesthesia 63:656–8
  • Chen D, Lin XX, Zhao Q, et al. (2017). Screening of drug metabolizing enzymes for fusidic acid and its interactions with isoform-selective substrates in vitro. Xenobiotica 47:778–84
  • Chen J, Zhao KN, Chen C. (2014). The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis. Ann Transl Med 2:7
  • Godtfredsen W, Roholt K, Tybring L. (1962). Fucidin: a new orally active antibiotic. Lancet 1:928–31
  • Goey AK, Mooiman KD, Beijnen JH, et al. (2013). Relevance of in vitro and clinical data for predicting CYP3A4-mediated herb-drug interactions in cancer patients. Cancer Treat Rev 39:773–83
  • Kent UM, Juschyshyn MI, Hollenberg PF. (2001). Mechanism-based inactivators as probes of cytochrome P450 structure and function. Curr Drug Metab 2:215–43
  • Kitz R, Wilson IB. (1962). Esters of methanesulfonic acid as irreversible inhibitors of acetylcholinesterase. J Biol Chem 237:3245–9
  • Lautenbach EE, Robinson RG, Koornhof HJ. (1975). Serum and tissue concentrations of sodium fusidate in patients with chronic osteomyelitis and in normal volunteers. S Afr J Surg 13:21–32
  • MacGowan AP, Greig MA, Andrews JM, et al. (1989). Pharmacokinetics and tolerance of a new film-coated tablet of sodium fusidate administered as a single oral dose to healthy volunteers. J Antimicrob Chemother 23:409–15
  • Magee CN, Medani SA, Leavey SF, et al. (2010). Severe rhabdomyolysis as a consequence of the interaction of fusidic acid and atorvastatin. Am J Kidney Dis 56:e11–15
  • Munkholm P, Hey H, Rasmussen SN, Johansen PB. (1994). Antibiotic activity in serum following single and repeated oral administration of sodium fusidate in volunteers. Eur J Drug Metab Pharmacokinet 19:337–41
  • Nandy A, Gaini S. (2016). Severe Rhabdomyolysis as complication of interaction between atorvastatin and fusidic acid in a patient in lifelong antibiotic prophylaxis: a dangerous combination. Case Rep Med 2016:4705492
  • Ostergaard C, Yieng-Kow RV, Knudsen JD, et al. (2003). Evaluation of fusidic acid in therapy of experimental Staphylococcus aureus meningitis. J Antimicrob Chemother 51:1301–5
  • Peter JD, Jehl F, Pottecher T, et al. (1993). Pharmacokinetics of intravenous fusidic acid in patients with cholestasis. Antimicrob Agents Chemother 37:501–6
  • Saeed NT, Azam M. (2009). Rhabdomyolysis secondary to interaction between atorvastatin and fusidic acid. BMJ Case Rep doi: 10.1136/bcr.06.2009.2040
  • Saggers BA, Harwood HF, Day BH. (1968). Serum levels with sodium fusidate. Br J Clin Pract 22:429–30
  • Sevrioukova IF, Poulos TL. (2013). Understanding the mechanism of cytochrome P450 3A4: recent advances and remaining problems. Dalton Trans 42:3116–26
  • Still JG, Clark K, Degenhardt TP, et al. (2011). Pharmacokinetics and safety of single, multiple, and loading doses of fusidic acid in healthy subjects. Clin Infect Dis 52:S504–12
  • Teckchandani S, Robertson S, Almond A, et al. (2010). Rhabdomyolysis following co-prescription of fusidic acid and atorvastatin. J Roy Coll Phys Edinb 40:33–6
  • Tsuji BT, Okusanya OO, Bulitta JB, et al. (2011). Application of pharmacokinetic-pharmacodynamic modeling and the justification of a novel fusidic acid dosing regimen: raising Lazarus from the dead. Clin Infect Dis 52:S513–19
  • Turnidge J. (1999). Fusidic acid pharmacology, pharmacokinetics and pharmacodynamics. Int J Antimicrob Agents 12:S23–34
  • Vaillant L, Machet L, Taburet AM, et al. (1992). Levels of fusidic acid in skin blister fluid and serum after repeated administration of two dosages (250 and 500 mg). Br J Dermatol 126:591–5
  • Yang J, Jamei M, Yeo KR, et al. (2005). Kinetic values for mechanism-based enzyme inhibition: assessing the bias introduced by the conventional experimental protocol. Eur J Pharm Sci 26:334–40
  • Zanger UM, Schwab M. (2013). Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther 138:103–41
  • Zheng L, Cao J, Lu D, et al. (2015). Imperatorin is a mechanism-based inactivator of CYP2B6. Drug Metab Dispos 43:82–8

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