Efflux transporter breast cancer resistance protein dominantly expresses on the membrane of red blood cells, hinders partitioning of its substrates into the cells, and alters drug–drug interaction profiles

References

• Bayne WF, Tao FT, Rogers G, et al. (1981). Time course and disposition of methazolamide in human plasma and red blood cells. J Pharm Sci 70:75–81
   PubMed Web of Science ®Google Scholar
• Biollaz J, Munafo A, Buclin T, et al. (1995). Whole-blood pharmacokinetics and metabolic effects of the topical carbonic anhydrase inhibitor dorzolamide. Eur J Clin Pharmacol 47:455–60
   PubMed Web of Science ®Google Scholar
• Capecchi MR. (1980). High efficiency transformation by direct microinjection of DNA into cultured mammalian cells. Cell 22:479–88
   PubMed Web of Science ®Google Scholar
• Cascorbi I. (2006). Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs. Pharmacol Ther 112:457–73
   PubMed Web of Science ®Google Scholar
• Chisaka O, Capecchi MR. (1991). Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5. Nature 350:473–9
   PubMed Web of Science ®Google Scholar
• Collste P, Garle M, Rawlins MD, Sjoqvist F. (1976). Interindividual differences in chlorthalidone concentration in plasma and red cells of man after single and multiple doses. Eur J Clin Pharmacol 9:319–25
   PubMed Web of Science ®Google Scholar
• Cossum PA. (1988). Role of the red blood cell in drug metabolism. Biopharm Drug Dispos 9:321–36
   PubMed Web of Science ®Google Scholar
• Davidson AL, Dassa E, Orelle C, Chen J. (2008). Structure, function, and evolution of bacterial ATP-binding cassette systems. Microbiol Mol Biol Rev 72:317–64
   PubMed Web of Science ®Google Scholar
• Deuticke B. (1977). Properties and structural basis of simple diffusion pathways in the erythrocyte membrane. Rev Physiol Biochem Pharmacol 78:1–97
   PubMed Web of Science ®Google Scholar
• Doyle LA, Yang W, Abruzzo LV, et al. (1998). A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci USA. 95:15665–70
   PubMed Web of Science ®Google Scholar
• Fallon JK, Neubert H, Hyland R, et al. (2013). Targeted quantitative proteomics for the analysis of 14 UGT1As and -2Bs in human liver using nanoUPLC-MS/MS with selected reaction monitoring. J Proteome Res 12:4402–13
   PubMed Web of Science ®Google Scholar
• Fallon JK, Smith PC, Xia CQ, Kim MS. (2016). Quantification of four efflux drug transporters in liver and kidney across species using targeted quantitative proteomics by isotope dilution nanoLC-MS/MS. Pharma Res 33:2280–8
   Google Scholar
• Higgins JW, Bao JQ, Ke AB, et al. (2014). Utility of Oatp1a/1b-knockout and OATP1B1/3-humanized mice in the study of OATP-mediated pharmacokinetics and tissue distribution: case studies with pravastatin, atorvastatin, simvastatin, and carboxydichlorofluorescein. Drug Metab Dispos 42:182–92
   PubMed Web of Science ®Google Scholar
• Hinderling PH. (1984). Kinetics of partitioning and binding of digoxin and its analogues in the subcompartments of blood. J Pharm Sci 73:1042–53
   PubMed Web of Science ®Google Scholar
• Hinderling PH. (1997). Red blood cells: a neglected compartment in pharmacokinetics and pharmacodynamics. Pharmacol Rev 49:279–95
   PubMed Web of Science ®Google Scholar
• Hogben CA. (1963). Active transport and passive diffusion. Marquette Med Rev 29:82–5
   PubMedGoogle Scholar
• International Transporter Consortium, Giacomini KM, Huang SM, Tweedie DJ, et al. (2010). Membrane transporters in drug development. Nat Rev Drug Discov 9:215–36
   PubMed Web of Science ®Google Scholar
• Jones PM, George AM. (2004). The ABC transporter structure and mechanism: perspectives on recent research. Cell Mol Life Sci 61:682–99
   PubMed Web of Science ®Google Scholar
• Jonker JW, Wagenaar E, Van Eijl S, Schinkel AH. (2003). Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations. Mol Cell Biol 23:7902–8
   PubMed Web of Science ®Google Scholar
• Kawai R, Lemaire M, Steimer JL, et al. (1994). Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125. J Pharmacokinet Biopharm 22:327–65
   PubMedGoogle Scholar
• Koller BH, Smithies O. (1989). Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination. Proc Natl Acad USA 86:8932–5
   PubMed Web of Science ®Google Scholar
• Lee MG, Chen ML, Huang SM, Chiou WL. (1981). Pharmacokinetics of drugs in blood. I. Unusual distribution of gentamicin. Biopharm Drug Dispos 2:89–97
   PubMed Web of Science ®Google Scholar
• Liao M, Chuang BC, Zhu Q, et al. (2017). Preclinical absorption, distribution, metabolism, excretion and pharmacokinetics of a novel selective inhibitor of breast cancer resistance protein (BCRP). Xenobiotica. [Epub ahead of print]. doi: 10.1080/00498254.2017.1328147
   Web of Science ®Google Scholar
• Lin JH, Lin TH, Cheng H. (1992). Uptake and stereoselective binding of the enantiomers of MK-927, a potent carbonic anhydrase inhibitor, by human erythrocytes in vitro. Pharm Res 9:339–44
   PubMed Web of Science ®Google Scholar
• Ling V. (1997). Multidrug resistance: molecular mechanisms and clinical relevance. Cancer Chemother Pharmacol 40:Suppl:S3–8
   PubMed Web of Science ®Google Scholar
• Ma Y, Lin Z, Fallon JK, et al. (2015). New mouse xenograft model modulated by tumor-associated fibroblasts for human multi-drug resistance in cancer. Oncol Rep 34:2699–705
   PubMed Web of Science ®Google Scholar
• Maeda K, Sugiyama Y. (2008). Impact of genetic polymorphisms of transporters on the pharmacokinetic, pharmacodynamic and toxicological properties of anionic drugs. Drug Metab Pharmacokinet 23:223–35
   PubMed Web of Science ®Google Scholar
• Mansour SL, Thomas KR, Capecchi MR. (1988). Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 336:348–52
   PubMed Web of Science ®Google Scholar
• Mohammed SS, Christopher MM, Mehta P, et al. (1993). Increased erythrocyte and protein binding of codeine in patients with sickle cell disease. J Pharm Sci 82:1112–17
   PubMed Web of Science ®Google Scholar
• Pang KS, Maeng HJ, Fan J. (2009). Interplay of transporters and enzymes in drug and metabolite processing. Mol Pharm 6:1734–55
   PubMed Web of Science ®Google Scholar
• San George RC, Nagel RL, Fabry ME. (1984). On the mechanism for the red-cell accumulation of mefloquine, an antimalarial drug. Biochim Biophys Acta 803:174–81
   PubMed Web of Science ®Google Scholar
• Schanker LS, Johnson JM, Jeffrey JJ. (1964). Rapid passage of organic anions into human red cells. Am J Physiol 207:503–8
   PubMedGoogle Scholar
• Schanker LS, Nafpliotis PA, Johnson JM. (1961). Passage of organic bases into human red cells. J Pharmacol Exp Ther 133:325–31
   PubMed Web of Science ®Google Scholar
• Schinkel AH, Mol CA, Wagenaar E, et al. (1995). Multidrug resistance and the role of P-glycoprotein knockout mice. Eur J Cancer 31A:1295–8
   PubMed Web of Science ®Google Scholar
• Sha'afi RI, Gary-Bobo CM, Solomon AK. (1971). Permeability of red cell membranes to small hydrophilic and lipophilic solutes. J Gen Physiol 58:238–58
   PubMed Web of Science ®Google Scholar
• Sissung TM, Gardner ER, Gao R, Figg WD. (2008). Pharmacogenetics of membrane transporters: a review of current approaches. Methods Mol Biol 448:41–62
   PubMedGoogle Scholar
• Steck TL, Kant JA. (1974). Preparation of impermeable ghosts and inside-out vesicles from human erythrocyte membranes. Methods Enzymol 31:172–80
   PubMedGoogle Scholar
• Thomas KR, Capecchi MR. (1987). Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51:503–12
   PubMed Web of Science ®Google Scholar
• Thomas KR, Folger KR, Capecchi MR. (1986). High frequency targeting of genes to specific sites in the mammalian genome. Cell 44:419–28
   PubMed Web of Science ®Google Scholar
• Vlaming ML, Lagas JS, Schinkel AH. (2009). Physiological and pharmacological roles of ABCG2 (BCRP): recent findings in Abcg2 knockout mice. Adv Drug Deliv Rev 61:14–25
   PubMed Web of Science ®Google Scholar
• Wallace SM, Reigelman S. (1977). Uptake of acetazolamide by human erythrocytes in vitro. J Pharm Sci 66:729–31
   PubMed Web of Science ®Google Scholar
• Yu S, Li S, Yang H, et al. (2005). A novel liquid chromatography/tandem mass spectrometry based depletion method for measuring red blood cell partitioning of pharmaceutical compounds in drug discovery. Rapid Commun Mass Spectrom 19:250–4
   PubMed Web of Science ®Google Scholar