Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 48, 2018 - Issue 12
198
Views
4
CrossRef citations to date
0
Altmetric
Molecular Toxicology

Toxicity of new synthetic amphetamine drug mephedrone On Rat Heart mitochondria: a warning for its abuse

, , , &
Pages 1278-1284 | Received 12 Sep 2017, Accepted 02 Nov 2017, Published online: 28 Nov 2017

References

  • Bernardi P. (1999). Mitochondrial transport of cations: channels, exchangers, and permeability transition. Physiol Rev 79:1127–55
  • Bonora M, Pinton P. (2014). The mitochondrial permeability transition pore and cancer: molecular mechanisms involved in cell death. Front Oncol 4:302
  • Bradford MM. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–54
  • Brenneisen R, Fisch HU, Koelbing U, et al. (1990). Amphetamine-like effects in humans of the Khat alkaloid cathinone. Br J Clin Pharmacol 30:825–8
  • Brown DA, O'rourke B. (2010). Cardiac mitochondria and arrhythmias. Cardiovasc Res 88:241–9
  • Cadet JL, Bisagno V, Milroy CM. (2014). Neuropathology of substance use disorders. Acta Neuropathol 127:91–107
  • Carroll F, Lewin AH, Mascarella SW, et al. (2012). Designer drugs: a medicinal chemistry perspective. Ann N Y Acad Sci 1248:18–38
  • Chen Q, Vazquez EJ, Moghaddas S, et al. (2003). Production of reactive oxygen species by mitochondria: central role of complex III. J Biol Chem 278:36027–31
  • Dai DF, Hsieh EJ, Liu Y, et al. (2011). Mitochondrial proteome remodelling in pressure overload-induced heart failure: the role of mitochondrial oxidative stress. Cardiovasc Res 93:79–88
  • Drose S, Brandt U. (2012). Molecular mechanisms of superoxide production by the mitochondrial respiratory chain. Adv Exp Med Biol 748:145–69
  • Elmore S. (2007). Apoptosis: a review of programmed cell death. Toxicol Pathol 35:495–516
  • Eskandari MR, Moghaddam F, Shahraki J, Pourahmad J. (2015). A comparison of cardiomyocyte cytotoxic mechanisms for 5-fluorouracil and its pro-drug capecitabine. Xenobiotica 45:79–87
  • Feniouk BA, Junge W. (2005). Regulation of the F0F1-ATP synthase: the conformation of subunit epsilon might be determined by directionality of subunit gamma rotation. FEBS Lett 579:5114–18
  • Fernie AR, Carrari F, Sweetlove LJ. (2004). Respiratory metabolism: glycolysis, the TCA cycle and mitochondrial electron transport. Curr Opin Plant Biol 7:254–61
  • Ghazi‐Khansari M, Mohammadi‐Bardbori A, Hosseini MJ. (2006). Using Janus green B to study paraquat toxicity in rat liver mitochondria: role of ACE inhibitors (thiol and nonthiol ACEi). Ann N Y Acad Sci 1090:98–107
  • Gille L, Staniek K, Nohl H. (2001). Effects of tocopheryl quinone on the heart: model experiments with xanthine oxidase, heart mitochondria, and isolated perfused rat hearts. Free Radic Biol Med 30:865–76
  • Kalix P, Braenden O. (1985). Pharmacological aspects of the chewing of Khat leaves. Pharmacol Rev 37:149–64
  • Karila L, Billieux J, Benyamina A, et al. (2016). The effects and risks associated to mephedrone and methylone in humans: a review of the preliminary evidences. Brain Res Bull 126:61–7
  • Kohli JD, Goldberg LI. (1982). Cardiovascular effects of (−)-cathinone in the anaesthetized dog: comparison with (+)-amphetamine. J Pharm Pharmacol 34:338–40
  • Lanza IR, Nair KS. (2009). Functional assessment of isolated mitochondria in vitro. Meth Enzymol 457:349–72
  • Manke A, Wang L, Rojanasakul Y. (2013). Mechanisms of nanoparticle-induced oxidative stress and toxicity. BioMed Res Int 2013:942916
  • Meng H, Cao J, Kang J, et al. (2012). Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat. Toxicol Lett 208:62–8
  • Pourahmad J, Hosseini MJ. (2012). Application of isolated mitochondria in toxicological and clinical studies. Iran J Pharm Res 11:703
  • Rathod AL, Sahota SS, Garg RK. (2017). Mephedrone–an emerging drug of abuse in India. Curr Sci 112:2212–18
  • Razzaghi-Asl N, Seydi E, Alikhani R, et al. (2017). Synthesis and toxicity assessment of 3-oxobutanamides against human lymphocytes and isolated mitochondria. Environl Toxicol Pharmacol 51:71–84
  • Salimi A, Eybagi S, Seydi E, et al. (2016). Toxicity of macrolide antibiotics on isolated heart mitochondria: a justification for their cardiotoxic adverse effect. Xenobiotica 46:82–93
  • Selwyn AP, Raby K, Vita JA, et al (1991). Diurnal rhythms and clinical events in coronary artery disease. Postgrad Med J 67(Suppl 5):S44–7
  • Seydi E, Motallebi A, Dastbaz M, et al. (2015). Selective toxicity of Persian gulf sea cucumber (Holothuria parva) and sponge (Haliclona oculata) methanolic extracts on liver mitochondria isolated from an animal model of hepatocellular carcinoma. Hepat Mon 15:e33073
  • Seydi E, Rasekh HR, Salimi A, et al. (2016a). Myricetin selectively induces apoptosis on cancerous hepatocytes by directly targeting their mitochondria. Basic Clin Pharmacol Toxicol 119:249–58
  • Seydi E, Rasekh HR, Salimi A, et al. (2016b). Selective toxicity of apigenin on cancerous hepatocytes by directly targeting their mitochondria. Anticancer Agents Med Chem 16:1576–86
  • Shaki F, Hosseini MJ, Ghazi-Khansari M, Pourahmad J. (2013). Depleted uranium induces disruption of energy homeostasis and oxidative stress in isolated rat brain mitochondria. Metallomics 5:736–44
  • Tafreshi NK, Hosseinkhani S, Sadeghizadeh M, et al. (2007). The influence of insertion of a critical residue (Arg356) in structure and bioluminescence spectra of firefly luciferase. J Biol Chem 282:8641–7
  • Tesfaye F, Byass P, Wall S, Berhane Y, Bonita R. (2008). Association of smoking and Khat (Catha edulis Forsk) use with high blood pressure among adults in Addis Ababa, Ethiopia, 2006. Prev Chronic Dis 5:A89
  • Vardakou I, Pistos C, Spiliopoulou C. (2011). Drugs for youth via Internet and the example of mephedrone. Toxicol Lett 201:191–5
  • Varner KJ, Daigle K, Weed PF, et al. (2013). Comparison of the behavioral and cardiovascular effects of mephedrone with other drugs of abuse in rats. Psychopharmacology 225:675–85
  • Widler P, Mathys K, Brenneisen R, et al. (1994). Pharmacodynamics and pharmacokinetics of Khat: a controlled study. Clin Pharmacol Ther 55:556–62
  • Winstock AR, Mitcheson LR, Deluca P, et al. (2011). Mephedrone, new kid for the chop? Addiction 106:154–61
  • Wood DM, Davies S, Greene SL, et al. (2010). Case series of individuals with analytically confirmed acute mephedrone toxicity. Clin Toxicol 48:924–7
  • Yang KC, Bonini MG, Dudley SC. Jr. (2014). Mitochondria and arrhythmias. Free Radic Biol Med 71:351–61
  • Zenebe WJ, Nazarewicz RR, Parihar MS, Ghafourifar P. (2007). Hypoxia/reoxygenation of isolated rat heart mitochondria causes cytochrome c release and oxidative stress; evidence for involvement of mitochondrial nitric oxide synthase. J Mol Cell Cardiol 43:411–19
  • Zhang XH, Chen SY, Tang L, et al. (2013). Myricetin induces apoptosis in HepG2 cells through Akt/p70S6K/bad signaling and mitochondrial apoptotic pathway. Anticancer Agents Med 13:1575–81
  • Zhao Y, Ye L, Liu H, et al. (2010). Vanadium compounds induced mitochondria permeability transition pore (PTP) opening related to oxidative stress. J Inorg Biochem 104:371–8

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.