Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 49, 2019 - Issue 3
497
Views
24
CrossRef citations to date
0
Altmetric
Xenobiotic Transporters

Interactions of organophosphorus pesticides with solute carrier (SLC) drug transporters

, &
Pages 363-374 | Received 28 Dec 2017, Accepted 14 Feb 2018, Published online: 06 Mar 2018

References

  • Ahlin G, Karlsson J, Pedersen JM, et al. (2008). Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. J Med Chem 51:5932–42.
  • Alavanja MC, Dosemeci M, Samanic C, et al. (2004). Pesticides and lung cancer risk in the agricultural health study cohort. Am J Epidemiol 160:876–85.
  • Androutsopoulos VP, Hernandez AF, Liesivuori J, Tsatsakis AM. (2013). A mechanistic overview of health associated effects of low levels of organochlorine and organophosphorous pesticides. Toxicology 307:89–94.
  • Bain LJ, LeBlanc GA. (1996). Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein. Toxicol Appl Pharmacol 141:288–98.
  • Bain LJ, McLachlan JB, LeBlanc GA. (1997). Structure-activity relationships for xenobiotic transport substrates and inhibitory ligands of P-glycoprotein. Environ Health Perspect 105:812–18.
  • Barr DB, Barr JR, Maggio VL, et al. (2002). A multi-analyte method for the quantification of contemporary pesticides in human serum and plasma using high-resolution mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 778:99–111.
  • Bijnsdorp IV, Giovannetti E, Peters GJ. (2011). Analysis of drug interactions. Methods Mol Biol 731:421–34.
  • Bradford MM. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–54.
  • Bucher S, Le Vee M, Jouan E, Fardel O. (2014). Regulation of hepatic drug transporter activity and expression by organochlorine pesticides. J Biochem Mol Toxicol 28:119–28.
  • Cavret S, Videmann B, Mazallon M, Lecoeur S. (2005). Diazinon cytotoxicity and transfer in Caco-2 cells: effect of long-term exposure to the pesticide. Environ Toxicol Pharmacol 20:375–80.
  • Chedik L, Bruyere A, Le Vee M, et al. (2017). Inhibition of human drug transporter activities by the pyrethroid pesticides allethrin and tetramethrin. PLoS One 12:e0169480.
  • Chou TC. (2010). Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res 70:440–6.
  • Chowdhary S, Bhattacharyya R, Banerjee D. (2014). Acute organophosphorus poisoning. Clin Chim Acta 431:66–76.
  • Colas C, Ung PM, Schlessinger A. (2016). SLC transporters: structure, function, and drug discovery. Medchemcomm 7:1069–81.
  • De Bruyn T, van Westen GJ, Ijzerman AP, et al. (2013). Structure-based identification of OATP1B1/3 inhibitors. Mol Pharmacol 83:1257–67.
  • DeGorter MK, Xia CQ, Yang JJ, Kim RB. (2012). Drug transporters in drug efficacy and toxicity. Annu Rev Pharmacol Toxicol 52:249–73.
  • Doring B, Petzinger E. (2014). Phase 0 and phase III transport in various organs: combined concept of phases in xenobiotic transport and metabolism. Drug Metab Rev 46:261–82.
  • Elersek T, Filipic O. (2011). Organophosphorous pesticides – mechanisms of their toxicity, pesticides – the impacts of pesticides exposure, Prof. Margarita Stoytcheva, ed. InTech, DOI: 10.5772/14020. Available at: https://www.intechopen.com/books/pesticides-the-impacts-of-pesticides-exposure/organophosphorous-pesticides-mechanisms-of-their-toxicity.
  • Fardel O, Kolasa E, Le Vee M. (2012). Environmental chemicals as substrates, inhibitors or inducers of drug transporters: implication for toxicokinetics, toxicity and pharmacokinetics. Expert Opin Drug Metab Toxicol 8:29–46.
  • Fiedler N, Kipen H, Kelly-McNeil K, Fenske R. (1997). Long-term use of organophosphates and neuropsychological performance. Am J Ind Med 32:487–96.
  • Giacomini KM, Huang SM, Tweedie DJ, et al. (2010). Membrane transporters in drug development. Nat Rev Drug Discov 9:215–36.
  • Gonzalez-Alzaga B, Hernandez AF, Rodriguez-Barranco M, et al. (2015). Pre- and postnatal exposures to pesticides and neurodevelopmental effects in children living in agricultural communities from South-Eastern Spain. Environ Int 85:229–37.
  • Grundemann D, Hahne C, Berkels R, Schomig E. (2003). Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2). J Pharmacol Exp Ther 304:810–17.
  • Guyton KZ, Loomis D, Grosse Y, et al. (2015). Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate. Lancet Oncol 16:490–1.
  • Hernandez AF, Parron T, Tsatsakis AM, et al. (2013). Toxic effects of pesticide mixtures at a molecular level: their relevance to human health. Toxicology 307:136–45.
  • Hodgson E, Rose RL. (2006). Organophosphorus chemicals: potent inhibitors of the human metabolism of steroid hormones and xenobiotics. Drug Metab Rev 38:149–62.
  • Jigorel E, Le Vee M, Boursier-Neyret C, et al. (2005). Functional expression of sinusoidal drug transporters in primary human and rat hepatocytes. Drug Metab Dispos 33:1418–22.
  • Jonker JW, Schinkel AH. (2004). Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3). J Pharmacol Exp Ther 308:2–9.
  • Jouan E, Le Vee M, Denizot C, et al. (2014). The mitochondrial fluorescent dye rhodamine 123 is a high-affinity substrate for organic cation transporters (OCTs) 1 and 2. Fundam Clin Pharmacol 28:65–77.
  • Kang HG, Jeong SH, Cho JH, et al. (2004). Chlropyrifos-methyl shows anti-androgenic activity without estrogenic activity in rats. Toxicology 199:219–30.
  • Kido Y, Matsson P, Giacomini KM. (2011). Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. J Med Chem 54:4548–58.
  • Konig J, Muller F, Fromm MF. (2013). Transporters and drug-drug interactions: important determinants of drug disposition and effects. Pharmacol Rev 65:944–66.
  • Koureas M, Tsakalof A, Tsatsakis A, Hadjichristodoulou C. (2012). Systematic review of biomonitoring studies to determine the association between exposure to organophosphorus and pyrethroid insecticides and human health outcomes. Toxicol Lett 210:155–68.
  • Lacher SE, Skagen K, Veit J, et al. (2015). P-glycoprotein transport of neurotoxic pesticides. J Pharmacol Exp Ther 355:99–107.
  • Le Vee M, Jouan E, Noel G, et al. (2015). Polarized location of SLC and ABC drug transporters in monolayer-cultured human hepatocytes. Toxicol In Vitro 29:938–46.
  • Le Vee M, Noel G, Jouan E, et al. (2013). Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells. Toxicol In Vitro 27:1979–86.
  • Li Q, Nagahara N, Takahashi H, et al. (2002). Organophosphorus pesticides markedly inhibit the activities of natural killer, cytotoxic T lymphocyte and lymphokine-activated killer: a proposed inhibiting mechanism via granzyme inhibition. Toxicology 172:181–90.
  • Maroni M, Fait A. (1993). Health effects in man from long-term exposure to pesticides. A review of the 1975–1991 literature. Toxicology 78:1–180.
  • Mostafalou S, Abdollahi M. (2017). Pesticides: an update of human exposure and toxicity. Arch Toxicol 91:549–99.
  • Munoz-Quezada MT, Lucero BA, Barr DB, et al. (2013). Neurodevelopmental effects in children associated with exposure to organophosphate pesticides: a systematic review. Neurotoxicology 39:158–68.
  • Naksen W, Prapamontol T, Mangklabruks A, et al. (2016). A single method for detecting 11 organophosphate pesticides in human plasma and breastmilk using GC-FPD. J Chromatogr B Analyt Technol Biomed Life Sci 1025:92–104.
  • Narayan S, Sinsheimer JS, Paul KC, et al. (2015). Genetic variability in ABCB1, occupational pesticide exposure, and Parkinson's disease. Environ Res 143:98–106.
  • Natoff IL. (1971). Organophosphorus pesticides: pharmacology. Prog Med Chem 8:1–37.
  • Nicklisch SC, Rees SD, McGrath AP, et al. (2016). Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure. Sci Adv 2:e1600001.
  • Nornberg BF, Batista CR, Almeida DV, et al. (2015). ABCB1 and ABCC4 efflux transporters are involved in methyl parathion detoxification in ZFL cells. Toxicol In Vitro 29:204–10.
  • Oosterhuis B, Vukman K, Vagi E, et al. (2008). Specific interactions of chloroacetanilide herbicides with human ABC transporter proteins. Toxicology 248:45–51.
  • Paul KC, Sinsheimer JS, Rhodes SL, et al. (2016). Organophosphate pesticide exposures, nitric oxide synthase gene variants, and gene-pesticide interactions in a case-control study of Parkinson's disease, California (USA). Environ Health Perspect 124:570–7.
  • Pivcevic B, Zaja R. (2006). Pesticides and their binary combinations as P-glycoprotein inhibitors in NIH 3T3/MDR1 cells. Environ Toxicol Pharmacol 22:268–76.
  • Prueksaritanont T, Chu X, Gibson C, et al. (2013). Drug-drug interaction studies: regulatory guidance and an industry perspective. AAPS J 15:629–45.
  • Salm P, Taylor PJ, Roberts D, de Silva J. (2009). Liquid chromatography-tandem mass spectrometry method for the simultaneous quantitative determination of the organophosphorus pesticides dimethoate, fenthion, diazinon and chlorpyrifos in human blood. J Chromatogr B Analyt Technol Biomed Life Sci 877:568–74.
  • Schinkel AH, Jonker JW. (2003). Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv Drug Deliv Rev 55:3–29.
  • Shitara Y, Horie T, Sugiyama Y. (2006). Transporters as a determinant of drug clearance and tissue distribution. Eur J Pharm Sci 27:425–46.
  • Sreeramulu K, Liu R, Sharom FJ. (2007). Interaction of insecticides with mammalian P-glycoprotein and their effect on its transport function. Biochim Biophys Acta 1768:1750–7.
  • Stephens R, Spurgeon A, Calvert IA, et al. (1995). Neuropsychological effects of long-term exposure to organophosphates in sheep dip. Lancet 345:1135–9.
  • Szakacs G, Varadi A, Ozvegy-Laczka C, Sarkadi B. (2008). The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox). Drug Discov Today 13:379–93.
  • Tamura H, Yoshikawa H, Gaido KW, et al. (2003). Interaction of organophosphate pesticides and related compounds with the androgen receptor. Environ Health Perspect 111:545–52.
  • Tribull TE, Bruner RH, Bain LJ. (2003). The multidrug resistance-associated protein 1 transports methoxychlor and protects the seminiferous epithelium from injury. Toxicol Lett 142:61–70.
  • Vale A. (2015). Organophosphorus insecticide poisoning. BMJ Clin Evid (2015).
  • Whyatt RM, Barr DB, Camann DE, et al. (2003). Contemporary-use pesticides in personal air samples during pregnancy and blood samples at delivery among urban minority mothers and newborns. Environ Health Perspect 111:749–56.
  • Zhang L, Gorset W, Dresser MJ, Giacomini KM. (1999). The interaction of n-tetraalkylammonium compounds with a human organic cation transporter, hOCT1. J Pharmacol Exp Ther 288:1192–8.
  • Zhao L, Wientjes MG, Au JL. (2004). Evaluation of combination chemotherapy: integration of nonlinear regression, curve shift, isobologram, and combination index analyses. Clin Cancer Res 10:7994–8004.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.