Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 49, 2019 - Issue 3
153
Views
5
CrossRef citations to date
0
Altmetric
Animal Pharmacokinetics and Metabolism

Distribution and metabolism of 14C-sulfoquinovosylacylpropanediol (14C-SQAP) after a single intravenous administration in tumor-bearing mice

, , , , , , , , , , , , , & show all
Pages 346-362 | Received 15 Jan 2018, Accepted 02 Mar 2018, Published online: 24 Apr 2018

References

  • Aoki S, Matsumoto K, Ohta K, et al. (2006). An emulsion of sulfoquinovosylacylglycerol and long-chain alkane increases its permeability in tumor cells. J Membrane Biol 213:11–8.
  • Aoki S, Ohta K, Yamazaki T, et al. (2005). Mammalian mitotic centromere-associated kinesin (MCAK), a new molecular target of sulfoquinovosylacylglycerols (SQAGs), novel anti-tumor and immunosuppressive agents. FEBS J 272:2132–40.
  • Hanashima S, Mizushina Y, Ohta K, et al. (2000a). Structure-activity relationship of a novel inhibitor group of mammalian DNA polymerases, synthetic sulfoquinovosylacylglycerols. Jpn J Cancer Res 91:73–83.
  • Hanashima S, Mizushina Y, Yamazaki T, et al. (2000b). Structural determination of sulfoquinovosyldiacylglycerol by chiral synthesis. Tetrahedron Lett 41:4403–7.
  • Hanashima S, Mizushina Y, Yamazaki T, et al. (2001). Synthesis of sulfoquinovosylacylglycerols, inhibitors of eukaryotic DNA polymerase α and β. Bioorg Med Chem 9:367–76.
  • Herman TS, Teicher BA, Dewhirst MW, Zimmerman D. (1990). Rate of infusion: an important factor in circulatory effects of perfluorochemical emulsions (PFCES). Int J Radiat Oncol Biol Phys 19:136.
  • Iwamoto H, Nakamura T, Koga H, et al. (2015). Inhibition of hypoxia-inducible factor via upregulation of von Hippel-Lindau protein induces “angiogenic switch off” in a hepatoma mouse model. Mol Ther Oncolytics 2:15020.
  • Izaguirre-Carbonell J, Kawakubo H, Murata H, et al. (2015). Novel anticancer agent, SQAP, binds to focal adhesion kinase and modulate its activity. Nat Commun 5:15136.
  • Izaguirre-Carbonell J, Murata H, Ohta K, et al. (2014). Identification and study of SQAP-binding proteins from a T7 phage display screen. Planta Med 80:PH4.
  • Miura M, Sakimoto I, Ohta K, et al. (2007). Sulfoglycolipids as candidate antiangiogenetic radiosensitizers: a review. Anticancer Drugs 18:1–5.
  • Ohta K, Mizushina Y, Yamazaki T, et al. (2001). Specific interaction between oligosaccharide on tumor cell surface and novel antitumor agents, sulfoquinovosylmonoacylglycerols. Biochem Biophys Res Commun 288:893–900.
  • Ohta K, Murata H, Mori Y, et al. (2010). Remodeling of the tumor microenvironment by combined treatment with a novel radiosensitizer, α-sulfoquinovosylmonoacylglycerol (α-SQMG) and X-irradiation. Anticancer Res 30:4397–404.
  • Sakaguchi K. (2015). A prospect of a new potent radiosensitizer SQAG/SQAP (a review in Japanese). Radiat Biol Res Commun 50:1–17.
  • Sakaguchi K, Sugawara F. (2008). New cancer chemotherapy agents: Inhibitors of DNA polymerase: a review. Curr Drug Ther 3:44–53.
  • Sakimoto I, Ohta K, Yamazaki T, et al. (2006). α-sulfoquinovosylmonoacylglycerol is a novel potent radiosensitizer targeting tumor angiogenesis. Cancer Res 66:2287–95.
  • Sawada Y, Omoto K, Kohei H, et al. (2015). Sulfoquinovosylacylpropanediol is a novel potent radiosensitizer in prostate cancer. Int J Urol 22:590–5.
  • Takakusagi Y, Matsumoto S, Saito K, et al. (2015). Increase in tumor oxygenation and radiosensitivity caused by SQAP (CG-0321): the mechanism of actions revealed by in vivo imaging studies. ICRR (15th International Congress of Radiation Research) 3-PS2E-27.
  • Takakusagi Y, Takakusagi K, Ida N, et al. (2011). Binding region and interaction properties of sulfoquinovosylacylglycerol (SQAG) with human vascular endothelial growth factor 165 revealed by biosensor-based assays. Med Chem Commun 2:1188–93.
  • Takakusagi Y, Takakusagi K, Sugawara F, Sakaguchi K. (2010). Use of phage display technology for the determination of the targets for small-molecule therapeutics (a review). Expert Opin Drug Discov 5:361–89.
  • Yuan H, Schroeder T, Bowsher JE, et al. (2006). Intertumoral differences in hypoxia selectivity of the PET imaging agent 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone). J Nucl Med 47:989–98.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.