Lipidomics reveal aryl hydrocarbon receptor (Ahr)-regulated lipid metabolic pathway in alpha-naphthyl isothiocyanate (ANIT)-induced intrahepatic cholestasis

References

• Bansal A, Harris RA, DeGrado TR. (2012). Choline phosphorylation and regulation of transcription of choline kinase α in hypoxia. J Lipid Res 53:149–57.
   PubMed Web of Science ®Google Scholar
• Barouki R, Coumoul X, Fernandez-Salguero PM. (2007). The aryl hydrocarbon receptor, more than a xenobiotic-interacting protein. FEBS Lett 581:3608–15.
   PubMed Web of Science ®Google Scholar
• Chen C, Krausz KW, Shah YM, et al. (2009). Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity. Chem Res Toxicol 22:699–707.
   PubMed Web of Science ®Google Scholar
• Chen C, Shah YM, Morimura K, et al. (2008). Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis. Cell Metab 7:135–47.
   PubMed Web of Science ®Google Scholar
• Chisholm JW, Dolphin PJ. (1996). Abnormal lipoproteins in the ANIT-treated rat: a transient and reversible animal model of intrahepatic cholestasis. J Lipid Res 37:1086–98.
   PubMed Web of Science ®Google Scholar
• Chisholm JW, Paterniti JR, Dolphin PJ. (2000). Accumulation of cholestatic lipoproteins in ANIT-treated human apolipoprotein A-I transgenic rats is diminished through dose-dependent apolipoprotein A-I activation of LCAT. Biochim Biophys Acta 1487:145–54.
   PubMed Web of Science ®Google Scholar
• Dietrich CG, Ottenhoff R, de Waart DR, Oude ER. (2001). Role of MRP2 and GSH in intrahepatic cycling of toxins. Toxicology 167:73–81.
   PubMed Web of Science ®Google Scholar
• Faiola B, Peterson RA, Kimbrough CL, et al. (2010). Acute ANIT toxicity in male IL-10 knockout and wild-type mice. Toxicol Pathol 38:745–55.
   PubMed Web of Science ®Google Scholar
• Fang ZZ, Krausz KW, Tanaka N, et al. (2013). Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum. Arch Toxicol 87:1975–87.
   PubMed Web of Science ®Google Scholar
• Fang ZZ, Tanaka N, Lu D, et al. (2017). Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury. Arch Toxicol 91:2235–44.
   PubMed Web of Science ®Google Scholar
• Fernando H, Bhopale KK, Kondraganti S, et al. (2011). Lipidomic changes in rat liver after long-term exposure to ethanol. Toxicol Appl Pharmacol 255:127–37.
   PubMed Web of Science ®Google Scholar
• Garrido JA, Luque NR, D'Angelo E, Ros E. (2013). Distributed cerebellar plasticity implements adaptable gain control in a manipulation task: a closed-loop robotic simulation. Front Neural Circuits 7:159.
   PubMed Web of Science ®Google Scholar
• Hannun YA. (1994). The sphingomyelin cycle and the second messenger function of ceramide. J Biol Chem 269:3125–8.
   PubMed Web of Science ®Google Scholar
• Kodali P, Wu P, Lahiji PA, et al. (2006). ANIT toxicity toward mouse hepatocytes in vivo is mediated primarily by neutrophils via CD18. Am J Physiol Gastrointest Liver Physiol 291:G355–63.
   PubMed Web of Science ®Google Scholar
• Kossor DC, Meunier PC, Handler JA, et al. (1993). Temporal relationship of changes in hepatobiliary function and morphology in rats following alpha-naphthylisothiocyanate (ANIT) administration. Toxicol Appl Pharmacol 119:108–14.
   PubMed Web of Science ®Google Scholar
• Lam SM, Shui G. (2013). Lipidomics as a principal tool for advancing biomedical research. J Genet Genomics 40:375–90.
   PubMed Web of Science ®Google Scholar
• Leucht K, Fischbeck A, Caj M, et al. (2014). Sphingomyelin and phosphatidylcholine contrarily affect the induction of apoptosis in intestinal epithelial cells. Mol Nutr Food Res 58:782–98.
   PubMed Web of Science ®Google Scholar
• Li F, Jiang C, Krausz KW, et al. (2013). Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity. Nat Commun 4:2384.
   PubMed Web of Science ®Google Scholar
• Liu-Wu Y, Hurt-Camejo E, Wiklund O. (1998). Lysophosphatidylcholine induces the production of IL-1beta by human monocytes. Atherosclerosis 137:351–7.
   PubMed Web of Science ®Google Scholar
• Matsubara T, Tanaka N, Krausz KW, et al. (2012). Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis. Cell Metab 16:634–44.
   PubMed Web of Science ®Google Scholar
• Matsubara T, Tanaka N, Patterson AD, et al. (2011). Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice. Hepatology 53:1282–93.
   PubMed Web of Science ®Google Scholar
• Meikle PJ, Christopher MJ. (2011). Lipidomics is providing new insight into the metabolic syndrome and its sequelae. Curr Opin Lipidol 22:210–5.
   PubMed Web of Science ®Google Scholar
• Moffat ID, Boutros PC, Chen H, et al. (2010). Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities. BMC Genomics 11:263.
   PubMed Web of Science ®Google Scholar
• Murphy SA, Nicolaou A. (2013). Lipidomics applications in health, disease and nutrition research. Mol Nutr Food Res 57:1336–46.
   PubMed Web of Science ®Google Scholar
• Nishioka H, Horiuchi H, Arai H, Kita T. (1998). Lysophosphatidylcholine generates superoxide anions through activation of phosphatidylinositol 3-kinase in human neutrophils. FEBS Lett 441:63–6.
   PubMed Web of Science ®Google Scholar
• Ozeki J, Uno S, Ogura M, et al. (2011). Aryl hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin enhances liver damage in bile duct-ligated mice. Toxicology 280:10–7.
   PubMed Web of Science ®Google Scholar
• Patterson AD, Shah YM, Matsubara T, et al. (2012). Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity. Hepatology 56:281–90.
   PubMed Web of Science ®Google Scholar
• Tanaka N, Matsubara T, Krausz KW, et al. (2012). Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis. Hepatology 56:118–29.
   PubMed Web of Science ®Google Scholar
• Volz DC, Kullman SW, Howarth DL, et al. (2008). Protective response of the Ah receptor to ANIT-induced biliary epithelial cell toxicity in see-through medaka. Toxicol Sci 102:262–77.
   PubMed Web of Science ®Google Scholar
• Wang H, Fang ZZ, Meng R, et al. (2017). Glycyrrhizin and glycyrrhetinic acid inhibits alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption. Toxicology 386:133–42.
   PubMed Web of Science ®Google Scholar
• Wu G, Aoyama C, Young SG, Vance DE. (2008). Early embryonic lethality caused by disruption of the gene for choline kinase alpha, the first enzyme in phosphatidylcholine biosynthesis. J Biol Chem 283:1456–62.
   PubMed Web of Science ®Google Scholar