Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 49, 2019 - Issue 5
212
Views
6
CrossRef citations to date
0
Altmetric
Animal Pharmacokinetics and Metabolism

Characterization of in vitro and in vivo metabolism of leelamine using liquid chromatography-tandem mass spectrometry

, , , & ORCID Icon
Pages 577-583 | Received 27 Mar 2018, Accepted 22 May 2018, Published online: 12 Jun 2018

References

  • Asha S, Vidyavathi M. (2010). Role of human liver microsomes in in vitro metabolism of drugs–a review. Appl Biochem Biotechnol 160:1699–722.
  • Bernard S, Neville KA, Nguyen AT, Flockhart DA. (2006). Interethnic differences in genetic polymorphisms of CYP2D6 in the U.S. population: clinical implications. Oncologist 11:126–35.
  • Beverage JN, Sissung TM, Sion AM, et al. (2007). CYP2D6 polymorphisms and the impact on tamoxifen therapy. J Pharm Sci 96:2224–31.
  • Cadoudal T, Distel E, Durant S, et al. (2008). Pyruvate dehydrogenase kinase 4: regulation by thiazolidinediones and implication in glyceroneogenesis in adipose tissue. Diabetes 57:2272–9.
  • Gowda R, Inamdar GS, Kuzu O, et al. (2017). Identifying the structure-activity relationship of leelamine necessary for inhibiting intracellular cholesterol transport. Oncotarget 8:28260–77.
  • Gowda R, Madhunapantula SV, Kuzu OF, et al. (2014a). Targeting multiple key signaling pathways in melanoma using leelamine. Mol Cancer Ther 13:1679–89.
  • Gowda R, Madhunapantula SV, Sharma A, et al. (2014b). Nanolipolee-007, a novel nanoparticle-based drug containing leelamine for the treatment of melanoma. Mol Cancer Ther 13:2328–40.
  • Ingelman-Sundberg M. (2005). Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity. Pharmacogenomics J 5:6–13.
  • Jeoung NH, Harris RA. (2010). Role of pyruvate dehydrogenase kinase 4 in regulation of blood glucose levels. Korean Diabetes J 34:274–83.
  • Kovaleva KS, Yarovaya OI, Shernyukov AV, et al. (2017). Synthesis of new heterocyclic dehydroabietylamine derivatives and their biological activity. Chem Heterocycl Compd (NY) 53:364–70.
  • Kuzu OF, Gowda R, Sharma A, Robertson GP. (2014). Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport. Mol Cancer Ther 13:1690–703.
  • Lee J, Liu X. (2007). The conduct of drug metabolism studies considered good practice (II): in vitro experiments. Curr Drug Metab 8:822–9.
  • Lee SK, Kim DH, Yoo HH. (2011). Comparative metabolism of sildenafil in liver microsomes of different species by using LC/MS-based multivariate analysis. J Chromatogr B Analyt Technol Biomed Life Sci 879:3005–11.
  • Lin JH, Lu AYH. (1997). Role of pharmacokinetics and metabolism in drug discovery and development. Pharmacol Rev 49:403–49:
  • Prasad B, Garg A, Takwani H, Singh S. (2011). Metabolite identification by liquid chromatography-mass spectrometry. Trends Analyt Chem 30:360–87.
  • Sehrawat A, Kim SH, Hahm ER, et al. (2017). Cancer-selective death of human breast cancer cells by leelamine is mediated by bax and bak activation. Mol Carcinog 56:337–48.
  • Sim J, Nam W, Lee D, et al. (2015). Selective induction of hepatic cytochrome P450 2B activity by leelamine in vivo, as a potent novel inducer. Arch Pharm Res 38:725–33.
  • Song M, Lee D, Lee T, Lee S. (2013). Determination of leelamine in mouse plasma by LC-MS/MS and its pharmacokinetics. J Chromatogr B Analyt Technol Biomed Life Sci 931:170–3.
  • Tiller PR, Romanyshyn LA. (2002). Liquid chromatographic/tandem mass spectrometric quantification with metabolite screening as a strategy to enhance the early drug discovery process. Rapid Commun Mass Spectrom 16:1225–31.
  • Zanger UM, Schwab M. (2013). Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther 138:103–41.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.