Inhibitor selectivity of CNTs and ENTs

References

• Arimany-Nardi C, Claudio-Montero A, Viel-Oliva A, et al. (2017). Identification and characterization of a secondary sodium-binding site and the main selectivity determinants in the human concentrative nucleoside transporter 3. Mol Pharm 14:1980–7.
   PubMedGoogle Scholar
• Bonan CD. (2012). Ectonucleotidases and nucleotide/nucleoside transporters as pharmacological targets for neurological disorders. CNS Neurol Disord Drug Targets 11:739–50.
   PubMed Web of Science ®Google Scholar
• Cano-Soldado P, Pastor-Anglada M. (2012). Transporters that translocate nucleosides and structural similar drugs: structural requirements for substrate recognition. Med Res Rev 32:428–57.
   PubMed Web of Science ®Google Scholar
• Chandrasena G, Giltay R, Patil SD, et al. (1997). Functional expression of human intestinal Na+-dependent and Na+-independent nucleoside transporters in Xenopus laevis oocytes. Biochem Pharmacol 53:1909–18.
   PubMed Web of Science ®Google Scholar
• Chang C, Swaan PW, Ngo LY, et al. (2004). Molecular requirements of the human nucleoside transporters hCNT1, hCNT2, and hENT1. Mol Pharmacol 65:558–70.
   PubMed Web of Science ®Google Scholar
• Choi JS, Berdis AJ. (2012). Nucleoside transporters: biological insights and therapeutic applications. Future Med Chem 4:1461–78.
   PubMed Web of Science ®Google Scholar
• Clarke ML, Damaraju VL, Zhang J, et al. (2006). The role of human nucleoside transporters in cellular uptake of 4′-thio-beta-D-arabinofuranosylcytosine and beta-D-arabinosylcytosine. Mol Pharmacol 70:303–10.
   PubMed Web of Science ®Google Scholar
• Damaraju VL, Kuzma M, Mowles D, et al. (2015). Interactions of multitargeted kinase inhibitors and nucleoside drugs: achilles heel of combination therapy? Mol Cancer Ther 14:236–45.
   PubMed Web of Science ®Google Scholar
• Damaraju VL, Mowles D, Yao S, et al. (2012). Role of human nucleoside transporters in the uptake and cytotoxicity of azacitidine and decitabine. Nucleos Nucleot Nucl Acids 31:236–55.
   PubMed Web of Science ®Google Scholar
• Endo Y, Obata T, Murata D, et al. (2007). Cellular localization and functional characterization of the equilibrative nucleoside transporters of antitumor nucleosides. Cancer Sci 98:1633–7.
   PubMed Web of Science ®Google Scholar
• Errasti-Murugarren E, Cano-Soldado P, Pastor-Anglada M, Casado FJ. (2008). Functional characterization of a nucleoside-derived drug transporter variant (hCNT3C602R) showing altered sodium-binding capacity. Mol Pharmacol 73:379–86.
   PubMed Web of Science ®Google Scholar
• Fernandez-Calotti PX, Colomer D, Pastor-Anglada M. (2011). Translocation of nucleoside analogs across the plasma membrane in hematologic malignancies. Nucleos Nucleot Nucl Acids 30:1324–40.
   PubMed Web of Science ®Google Scholar
• Friesner RA, Banks JL, Murphy RB, et al. (2004). Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. J Med Chem 47:1739–49.
   PubMed Web of Science ®Google Scholar
• Govindarajan R, Bakken AH, Hudkins KL, et al. (2007). In situ hybridization and immunolocalization of concentrative and equilibrative nucleoside transporters in the human intestine, liver, kidneys, and placenta. Am J Physiol Regul Integr Comp Physiol 293:R1809–22.
   PubMed Web of Science ®Google Scholar
• Govindarajan R, Endres CJ, Whittington D, et al. (2008). Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes. Am J Physiol Gastrointest Liver Physiol 295:G570–80.
   PubMed Web of Science ®Google Scholar
• Graham KA, Leithoff J, Coe IR, et al. (2000). Differential transport of cytosine-containing nucleosides by recombinant human concentrative nucleoside transporter protein hCNT1. Nucleosides Nucleotides Nucleic Acids 19:415–34.
   PubMed Web of Science ®Google Scholar
• Halgren TA, Murphy RB, Friesner RA, et al. (2004). Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening. J Med Chem 47:1750–9.
   PubMed Web of Science ®Google Scholar
• Hillgren KM, Keppler D, Zur AA, et al. (2013). Emerging transporters of clinical importance: an update from the International Transporter Consortium. Clin Pharmacol Ther 94:52–63.
   PubMed Web of Science ®Google Scholar
• King KM, Damaraju VL, Vickers MF, et al. (2006). A comparison of the transportability, and its role in cytotoxicity, of clofarabine, cladribine, and fludarabine by recombinant human nucleoside transporters produced in three model expression systems. Mol Pharmacol 69:346–53.
   PubMed Web of Science ®Google Scholar
• Koczor CA, Torres RA, Lewis W. (2012). The role of transporters in the toxicity of nucleoside and nucleotide analogs. Expert Opin Drug Metab Toxicol 8:665–76.
   PubMed Web of Science ®Google Scholar
• Lang TT, Selner M, Young JD, Cass CE. (2001). Acquisition of human concentrative nucleoside transporter 2 (hcnt2) activity by gene transfer confers sensitivity to fluoropyrimidine nucleosides in drug-resistant leukemia cells. Mol Pharmacol 60:1143–52.
   PubMed Web of Science ®Google Scholar
• Lang TT, Young JD, Cass CE. (2004). Interactions of nucleoside analogs, caffeine, and nicotine with human concentrative nucleoside transporters 1 and 2 stably produced in a transport-defective human cell line. Mol Pharmacol 65:925–33.
   PubMed Web of Science ®Google Scholar
• Lee EW, Lai Y, Zhang H, Unadkat JD. (2006). Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in mitochondrial toxicity of fialuridine. J Biol Chem 281:16700–6.
   PubMed Web of Science ®Google Scholar
• Loewen SK, Ng AM, Yao SY, et al. (1999). Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2. J Biol Chem. 274:24475–84.
   PubMed Web of Science ®Google Scholar
• Lostao MP, Mata JF, Larrayoz IM, et al. (2000). Electrogenic uptake of nucleosides and nucleoside-derived drugs by the human nucleoside transporter 1 (hCNT1) expressed in Xenopus laevis oocytes. FEBS Lett 481:137–40.
   PubMed Web of Science ®Google Scholar
• Munoz G, San Martin R, Farias M, et al. (2006). Insulin restores glucose inhibition of adenosine transport by increasing the expression and activity of the equilibrative nucleoside transporter 2 in human umbilical vein endothelium. J Cell Physiol 209:826–35.
   PubMed Web of Science ®Google Scholar
• Nagai K, Nagasawa K, Kihara Y, et al. (2007). Anticancer nucleobase analogues 6-mercaptopurine and 6-thioguanine are novel substrates for equilibrative nucleoside transporter 2. Int J Pharm 333:56–61.
   PubMed Web of Science ®Google Scholar
• Nagai K, Nagasawa K, Koma M, et al. (2006). Cytidine is a novel substrate for wild-type concentrative nucleoside transporter 2. Biochem Biophys Res Commun 347:439–43.
   PubMed Web of Science ®Google Scholar
• Ngo LY, Patil SD, Unadkat JD. (2001). Ontogenic and longitudinal activity of Na(+)-nucleoside transporters in the human intestine. Am J Physiol Gastrointest Liver Physiol 280:G475–81.
   PubMed Web of Science ®Google Scholar
• Nordh S, Ansari D, Andersson R. (2014). hENT1 expression is predictive of gemcitabine outcome in pancreatic cancer: a systematic review. World J Gastroenterol 20:8482–90.
   PubMed Web of Science ®Google Scholar
• Pastor-Anglada M, Molina-Arcas M, Casado FJ, et al. (2004). Nucleoside transporters in chronic lymphocytic leukaemia. Leukemia 18:385–93.
   PubMed Web of Science ®Google Scholar
• Pastor-Anglada M, Perez-Torras S. (2015). Nucleoside transporter proteins as biomarkers of drug responsiveness and drug targets. Front Pharmacol 6:13.
   PubMed Web of Science ®Google Scholar
• Pennycooke M, Chaudary N, Shuralyova I, et al. (2001). Differential expression of human nucleoside transporters in normal and tumor tissue. Biochem Biophys Res Commun 280:951–9.
   PubMed Web of Science ®Google Scholar
• Ritzel MW, Ng AM, Yao SY, et al. (2001). Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). J Biol Chem 276:2914–27.
   PubMed Web of Science ®Google Scholar
• Ritzel MW, Yao SY, Huang MY, et al. (1997). Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1). Am J Physiol 272:C707–14.
   PubMed Web of Science ®Google Scholar
• Schaner ME, Wang J, Zhang L, et al. (1999). Functional characterization of a human purine-selective, Na+-dependent nucleoside transporter (hSPNT1) in a mammalian expression system. J Pharmacol Exp Ther 289:1487–91.
   PubMed Web of Science ®Google Scholar
• Smith KM, Slugoski MD, Cass CE, et al. (2007). Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3. Mol Membr Biol 24:53–64.
   PubMed Web of Science ®Google Scholar
• Takahashi K, Yoshisue K, Chiba M, et al. (2015). Involvement of concentrative nucleoside transporter 1 in intestinal absorption of trifluridine using human small intestinal epithelial cells. J Pharm Sci 104:3146–53.
   PubMed Web of Science ®Google Scholar
• Tang PCT, Yang C, Li RW, et al. (2016). Inhibition of human equilibrative nucleoside transporters by 4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-6-imino-N-(naphthalen-2-yl)-1,3,5-tr iazin-2-amine. Eur J Pharmacol 791:544–51.
   PubMed Web of Science ®Google Scholar
• Toan SV, To KK, Leung GP, et al. (2003). Genomic organization and functional characterization of the human concentrative nucleoside transporter-3 isoform (hCNT3) expressed in mammalian cells. Pflugers Arch 447:195–204.
   PubMed Web of Science ®Google Scholar
• Ueda K, Hosokawa M, Iwakawa S. (2015). Cellular uptake of decitabine by equilibrative nucleoside transporters in HCT116 cells. Biol Pharm Bull 38:1113–9.
   PubMed Web of Science ®Google Scholar
• Volonté C, D’Ambrosi N. (2009). Membrane compartments and purinergic signalling: the purinome, a complex interplay among ligands, degrading enzymes, receptors and transporters. FEBS J 276:318–29.
   PubMed Web of Science ®Google Scholar
• Wang J, Giacomini KM. (1999). Serine 318 is essential for the pyrimidine selectivity of the N2 Na+-nucleoside transporter. J Biol Chem 274:2298–302.
   PubMed Web of Science ®Google Scholar
• Wang J, Su SF, Dresser MJ, et al. (1997). Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization. Am J Physiol 273:F1058–65.
   PubMed Web of Science ®Google Scholar
• Ward JL, Sherali A, Mo ZP, Tse CM. (2000). Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters, ENT1 and ENT2, stably expressed in nucleoside transporter-deficient PK15 cells. Ent2 exhibits a low affinity for guanosine and cytidine but a high affinity for inosine. J Biol Chem 275:8375–81.
   PubMed Web of Science ®Google Scholar
• Yao SY, Ng AM, Cass CE, et al. (2011). Nucleobase transport by human equilibrative nucleoside transporter 1 (hENT1). J Biol Chem 286:32552–62.
   PubMed Web of Science ®Google Scholar
• Young JD, Yao SY, Baldwin JM, et al. (2013). The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29. Mol Aspects Med 34:529–47.
   PubMed Web of Science ®Google Scholar
• Zhang J, Smith KM, Tackaberry T, et al. (2005). Uridine binding and transportability determinants of human concentrative nucleoside transporters. Mol Pharmacol 68:830–9.
   PubMed Web of Science ®Google Scholar