The current understanding of the interactions between nanoparticles and cytochrome P450 enzymes – a literature-based review

References

• Evelyn A, Mannick S, Sermon PA. 2002. Unusual carbon-based nanofibers and chains among diesel-emitted particles. Nano Lett 3:63–64.
   Web of Science ®Google Scholar
• Adeyemi OS, Sulaiman FA. (2015). Evaluation of metal nanoparticles for drug delivery systems. J Biomed Res 29:145–9.
   PubMed Web of Science ®Google Scholar
• Afshari A, Matson U, Ekberg LE. (2005). Characterization of indoor sources of fine and ultrafine particles: a study conducted in a full-scale chamber. Indoor Air 15:141–50.
   PubMed Web of Science ®Google Scholar
• Al-Hadi AM, Periasamy VS, Athinarayanan J, Alshatwi AA. (2016). The presence of carbon nanostructures in bakery products induces metabolic stress in human mesenchymal stem cells through CYP1A and p53 gene expression. Environ Toxicol Pharmacol 41:103–12.
   PubMed Web of Science ®Google Scholar
• Albano E. (2008). Oxidative mechanisms in the pathogenesis of alcoholic liver disease. Mol Aspects Med 29:9–16.
   PubMed Web of Science ®Google Scholar
• Alshatwi AA, Periasamy VS, Subash-Babu P, et al. (2013). CYP1A and POR gene mediated mitochondrial membrane damage induced by carbon nanoparticle in human mesenchymal stem cells. Environ Toxicol Pharmacol 36:215–22.
   PubMed Web of Science ®Google Scholar
• Balasubramanian SK, Jittiwat J, Manikandan J, et al. (2010). Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in rats. Biomaterials 31:2034–42.
   PubMed Web of Science ®Google Scholar
• Bebianno MJ, Gonzalez-Rey M, Gomes T, et al. (2015). Is gene transcription in mussel gills altered after exposure to Ag nanoparticles? Environ Sci Pollut Res 22:17425–33.
   PubMed Web of Science ®Google Scholar
• Van Berlo D, Albrecht C, Knaapen AM, et al. (2010). Comparative evaluation of the effects of short-term inhalation exposure to diesel engine exhaust on rat lung and brain. Arch Toxicol 84:553–62.
   PubMed Web of Science ®Google Scholar
• Bhogale A, Patel N, Sarpotdar P, et al. (2013). Systematic investigation on the interaction of bovine serum albumin with ZnO nanoparticles using fluorescence spectroscopy. Colloid Surf B: Biointerface 102:257–64.
   PubMed Web of Science ®Google Scholar
• Brewer CT, Chen T. (2016). PXR variants: the impact on drug metabolism and therapeutic responses. Acta Pharm Sin B 6:441–9.
   PubMed Web of Science ®Google Scholar
• Brown PK, Qureshi AT, Moll AN, et al. (2013). Silver nanoscale antisense drug delivery system for photoactivated gene silencing. ACS Nano 7:2948–59.
   PubMed Web of Science ®Google Scholar
• Capdevila JH, Falck JR, Harris RC. (2000). Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. J Lipid Res 41:163–81.
   PubMed Web of Science ®Google Scholar
• Chae YJ, Pham CH, Lee J, et al. (2009). Evaluation of the toxic impact of silver nanoparticles on Japanese medaka (Oryzias latipes). Aquat Toxicol 94:320–7.
   PubMed Web of Science ®Google Scholar
• Chen J, Glaus C, Laforest R, et al. (2010). Gold nanocages as photothermal transducers for cancer treatment. Small 6:811–7.
   PubMed Web of Science ®Google Scholar
• Chen YL, Peng HC, Tan SW, et al. (2013). Amelioration of ethanol-induced liver injury in rats by nanogold flakes. Alcohol 47:467–72.
   PubMed Web of Science ®Google Scholar
• Choi K, Riviere JE, Monteiro-Riviere NA. (2017). Protein corona modulation of hepatocyte uptake and molecular mechanisms of gold nanoparticle toxicity. Nanotoxicology 11:64–75.
   PubMed Web of Science ®Google Scholar
• Christen V, Fent K. (2012). Silica nanoparticles and silver-doped silica nanoparticles induce endoplasmatic reticulum stress response and alter cytochrome P4501A activity. Chemosphere 87:423–34.
   PubMed Web of Science ®Google Scholar
• Connolly M, Fernández M, Conde E, et al. (2016). Tissue distribution of zinc and subtle oxidative stress effects after dietary administration of ZnO nanoparticles to rainbow trout. Sci Total Environ 51–552:334–43.
   Web of Science ®Google Scholar
• Cornu R, Rougier N, Pellequer Y, et al. (2018). Interspecies differences in the Cytochrome P450: activity of hepatocytes exposed to PLGA and silica nanoparticles: an in vitro and in vivo investigation. Nanoscale 10:5171–5181.
   PubMed Web of Science ®Google Scholar
• Cr W, P C, Ej P, Vs S. (2017). Combined silver nanoparticles and temperature effects in the cape river crab Potamanautes perlatus - interactions between chemical and climatic stressors. J Nanomater Mol Nanotechnol 6:2.
   Google Scholar
• Cui Y, Gong X, Duan Y, et al. (2010). Hepatocyte apoptosis and its molecular mechanisms in mice caused by titanium dioxide nanoparticles. J Hazard Mater 183:874–80.
   PubMed Web of Science ®Google Scholar
• Degger N, Tse ACK, Wu RSS. (2015). Silver nanoparticles disrupt regulation of steroidogenesis in fish ovarian cells. Aquat Toxicol 169:143–51.
   PubMed Web of Science ®Google Scholar
• Delfino RJ, Sioutas C, Malik S. (2005). Potential role of ultrafine particles in associations between airborne particle mass and cardiovascular health. Environ Health Perspect 113:934–46.
   PubMed Web of Science ®Google Scholar
• Dobias J, Bernier-Latmani R. (2013). Silver release from silver nanoparticles in natural waters. Environ Sci Technol 47:4140–6.
   PubMed Web of Science ®Google Scholar
• Dragoni S, Franco G, Regoli M, et al. (2012). Gold nanoparticles uptake and cytotoxicity assessed on rat liver precision-cut slices. Toxicol Sci 128:186–97.
   PubMed Web of Science ®Google Scholar
• El-Sayed R, Bhattacharya K, Gu Z, et al. (2016). Single-walled carbon nanotubes inhibit the cytochrome P450 enzyme, CYP3A4. Sci Rep 6:12.
   PubMed Web of Science ®Google Scholar
• Falfushynska H, Gnatyshyna L, Fedoruk O, et al. (2016). Endocrine activities and cellular stress responses in the marsh frog Pelophylax ridibundus exposed to cobalt, zinc and their organic nanocomplexes. Aquat Toxicol 170:62–71.
   PubMed Web of Science ®Google Scholar
• Falfushynska H, Gnatyshyna L, Horyn O, et al. (2017). Endocrine and cellular stress effects of zinc oxide nanoparticles and nifedipine in marsh frogs Pelophylax ridibundus. Aquat Toxicol 185:171–82.
   PubMed Web of Science ®Google Scholar
• Fröhlich E. (2013). Cellular targets and mechanisms in the cytotoxic action of non-biodegradable engineered nanoparticles. Curr Drug Metab 14:976–88.
   PubMed Web of Science ®Google Scholar
• Fröhlich E, Kueznik T, Samberger C, et al. (2010). Size-dependent effects of nanoparticles on the activity of cytochrome P450 isoenzymes. Toxicol Appl Pharmacol 242:326–32.
   PubMed Web of Science ®Google Scholar
• Galkin O, Vekilov PG. (2004). Mechanisms of homogeneous nucleation of polymers of sickle cell anemia hemoglobin in deoxy state. J Mol Biol 336:43–59.
   PubMed Web of Science ®Google Scholar
• Garshick E, Laden F, Hart JE, et al. (2004). Lung cancer in railroad workers exposed to diesel exhaust. Environ Health Perspect 112:1539–43.
   PubMed Web of Science ®Google Scholar
• Gharbi N, Pressac M, Hadchouel M, et al. (2005). [60]Fullerene is a powerful antioxidant in vivo with no acute or subacute toxicity. Nano Lett 5:2578–85.
   PubMed Web of Science ®Google Scholar
• Gilbert LI, Warren JT. 2005. A molecular genetic approach to the biosynthesis of the insect steroid molting hormone. Vitam Horm 73:31–57.
   PubMed Web of Science ®Google Scholar
• Guittard E, Blais C, Maria A, et al. (2011). CYP18A1, a key enzyme of Drosophila steroid hormone inactivation, is essential for metamorphosis. Dev Biol 349:35–45.
   PubMed Web of Science ®Google Scholar
• Hassan HHAM, El-Banna SG, Elhusseiny AF, Mansour ESME. (2012). Antioxidant activity of new aramide nanoparticles containing redox-active N-phthaloyl valine moieties in the hepatic cytochrome P450system in male rats. Molecules 17:8255–75.
   PubMed Web of Science ®Google Scholar
• Ho CC, Lee HL, Chen CY, et al. (2017). Involvement of the cytokine–IDO1–AhR loop in zinc oxide nanoparticle-induced acute pulmonary inflammation. Nanotoxicology 11:360–70.
   PubMed Web of Science ®Google Scholar
• Hodges RE, Minich DM. (2015). Modulation of metabolic detoxification pathways using foods and food-derived components: a scientific review with clinical application. J Nutr Metab 2015:1.
   Google Scholar
• Hu JS, Li FC, Xu KZ, et al. (2016). Mechanisms of TiO2 NPs-induced phoxim metabolism in silkworm (Bombyx mori) fat body. Pestic Biochem Physiol 129:89–94.
   PubMed Web of Science ®Google Scholar
• Imai S, Yoshioka Y, Morishita Y, et al. (2014). Size and surface modification of amorphous silica particles determine their effects on the activity of human CYP3A4 in vitro. Nanoscale Res Lett 9:651–7.
   PubMed Web of Science ®Google Scholar
• Ioannides C, Lewis DFV. (2004). Cytochromes P450 in the bioactivation of chemicals. Curr Top Med Chem 4:1767–88.
   PubMed Web of Science ®Google Scholar
• Isobe H, Tomita N, Jinno S, et al. (2001). Synthesis and transfection capability of multi-functionalized fullerene polyamine. Chem Lett 30:1214–5.
   Google Scholar
• Izak-Nau E, Voetz M, Eiden S, et al. (2013). Altered characteristics of silica nanoparticles in bovine and human serum: the importance of nanomaterial characterization prior to its toxicological evaluation. Part Fibre Toxicol 10:56.
   PubMed Web of Science ®Google Scholar
• Jeevanandam J, Barhoum A, Chan YS, et al. (2018). Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations. Beilstein J Nanotechnol 9:1050–74.
   PubMed Web of Science ®Google Scholar
• Jia F, Sun Z, Yan X, et al. (2014). Effect of pubertal nano-TiO2 exposure on testosterone synthesis and spermatogenesis in mice. Arch Toxicol 88:781–8.
   PubMed Web of Science ®Google Scholar
• Jurašin DD, Ćurlin M, Capjak I, et al. (2016). Surface coating affects behavior of metallic nanoparticles in a biological environment. Beilstein J Nanotechnol 7:246–62.
   PubMed Web of Science ®Google Scholar
• Kenyon C. (1988). The nematode Caenorhabditis elegans. Science 240:1448–53.
   PubMed Web of Science ®Google Scholar
• Kim B, Kim H, Yu IJ. (2014). Assessment of nanoparticle exposure in nanosilica handling process: including characteristics of nanoparticles leaking from a vacuum cleaner. Ind Health 52:152–62.
   PubMed Web of Science ®Google Scholar
• Kim S, Choi JE, Choi J, et al. (2009). Oxidative stress-dependent toxicity of silver nanoparticles in human hepatoma cells. Toxicol Vitro 23:1076–84.
   PubMed Web of Science ®Google Scholar
• Koo EH, Lansbury PT, Kelly JW. (1999). Amyloid diseases: abnormal protein aggregation in neurodegeneration. Proc Natl Acad Sci USA 96:9989–90.
   PubMed Web of Science ®Google Scholar
• Krippendorff BF, Lienau P, Reichel A, Huisinga W. (2007). Optimizing classification of drug-drug interaction potential for CYP450 isoenzyme inhibition assays in early drug discovery. J Biomol Screen 12:92–9.
   PubMedGoogle Scholar
• Kulthong K, Maniratanachote R, Kobayashi Y, et al. (2012). Effects of silver nanoparticles on rat hepatic cytochrome P450 enzyme activity. Xenobiotica 42:854–62.
   PubMed Web of Science ®Google Scholar
• Kuznetsova GP, Larina OV, Petushkova NA, et al. (2014). Effects of fullerene C60 on proteomic profile of Danio rerio fish embryos. Bull Exp Biol Med 156:694–8.
   PubMed Web of Science ®Google Scholar
• Lai JCK, Lai MB, Jandhyam S, et al. (2008). Exposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblasts. Int J Nanomed 3:533–45.
   PubMed Web of Science ®Google Scholar
• Lamb JG, Hathaway LB, Munger MA, et al. (2010). Nanosilver particle effects on drug metabolism in vitro. Drug Metab Dispos 38:2246–51.
   PubMed Web of Science ®Google Scholar
• Lanone S, Boczkowski J. (2006). Biomedical applications and potential health risks of nanomaterials: molecular mechanisms. Curr Mol Med 6:651–63.
   PubMed Web of Science ®Google Scholar
• Lewis NA, Williams TD, Chipman JK. (2006). Functional analysis of a metal response element in the regulatory region of flounder cytochrome P450 1A and implications for environmental monitoring of pollutants. Toxicol Sci 92:387–93.
   PubMed Web of Science ®Google Scholar
• Li C, Li X, Jigami J, et al. (2012). Effect of nanoparticle-rich diesel exhaust on testosterone biosynthesis in adult male mice. Inhal Toxicol 24:599–608.
   PubMed Web of Science ®Google Scholar
• Li C, Li X, Suzuki AK, et al. (2013). Effects of exposure to nanoparticle-rich diesel exhaust on pregnancy in rats. J Reprod Dev 59:145–50.
   PubMed Web of Science ®Google Scholar
• Li F, Gu Z, Wang B, et al. (2014). Effects of the biosynthesis and signaling pathway of ecdysterone on silkworm (Bombyx mori) following exposure to titanium dioxide nanoparticles. J Chem Ecol 40:913–22.
   PubMed Web of Science ®Google Scholar
• Li JJ, Zou L, Hartono D, et al. (2008). Gold nanoparticles induce oxidative damage in lung fibroblasts in vitro. Adv Mater 20:138–42.
   Web of Science ®Google Scholar
• Link V, Shevchenko A, Heisenberg CP. (2006). Proteomics of early zebrafish embryos. BMC Dev Biol 6:1.
   PubMed Web of Science ®Google Scholar
• Lu H, Gui Y, Zheng L, Liu X. (2013). Morphological, crystalline, thermal and physicochemical properties of cellulose nanocrystals obtained from sweet potato residue. Food Res Int 50:121–8.
   Web of Science ®Google Scholar
• Lu HJ, Gui Y, Guo T, et al. (2015). Effect of the particle size of cellulose from sweet potato residues on lipid metabolism and cecal conditions in ovariectomized rats. Food Funct 6:1185–93.
   PubMed Web of Science ®Google Scholar
• ManuGarcia T, Costa G, Franca L, Hofmann MC. (2013). Sub-acute intravenous administration of silver nanoparticles in male mice alters Leydig cell function and testosterone levels. Reprod Toxicol 31:1713–23.
   Google Scholar
• Marambio-Jones C, Hoek EMV. (2010). A review of the antibacterial effects of silver nanomaterials and potential implications for human health and the environment. J Nanopart Res 12:1531–51.
   Web of Science ®Google Scholar
• Marchesan S, Da Ros T, Spalluto G, et al. (2005). Anti-HIV properties of cationic fullerene derivatives. Bioorg Med Chem Lett 15:3615–8.
   PubMed Web of Science ®Google Scholar
• Maselli V, Siciliano A, Giorgio A, et al. (2017). Multigenerational effects and DNA alterations of QDs-indolicidin on Daphnia magna. Environ Pollut 224:597–605.
   PubMed Web of Science ®Google Scholar
• Mehta BB, Tiwari A, Sharma S, et al. (2018). Amelioration of collagen antibody induced arthritis in mice by an antibody directed against the fibronectin type III repeats of tenascin-C. Int Immunopharmacol 58:15–23.
   PubMed Web of Science ®Google Scholar
• Mirzaei M, Razi M, Sadrkhanlou R. (2017). Nanosilver particles increase follicular atresia: correlation with oxidative stress and aromatization. Environ Toxicol 32:2244–55.
   PubMed Web of Science ®Google Scholar
• Moustafa EM, Mohamed MA, Thabet NM. (2017). Gallium nanoparticle-mediated reduction of brain specific serine protease-4 in an experimental metastatic cancer model. Asian Pac J Cancer Prev 18:895–903.
   PubMedGoogle Scholar
• Murphy G, Rouse RL, Polk WW, et al. (2008). Combustion-derived hydrocarbons localize to lipid droplets in respiratory cells. Am J Respir Cell Mol Biol 38:532–40.
   PubMed Web of Science ®Google Scholar
• Nemmar A, Vanbilloen H, Hoylaerts MF, et al. (2001). Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster. Am J Respir Crit Care Med 164:1665–8.
   PubMed Web of Science ®Google Scholar
• Ning Z, Cheung CS, Fu J, et al. (2006). Experimental study of environmental tobacco smoke particles under actual indoor environment. Sci Total Environ 367:822–30.
   PubMed Web of Science ®Google Scholar
• Ollikainen E, Liu D, Kallio A, et al. (2017). The impact of porous silicon nanoparticles on human cytochrome P450 metabolism in human liver microsomes in vitro. Eur J Pharm Sci 104:124–32.
   PubMed Web of Science ®Google Scholar
• Payne AH, Hales DB. (2004). Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev 25:947–70.
   PubMed Web of Science ®Google Scholar
• Pelkonen O, Turpeinen M, Hakkola J, et al. (2008). Inhibition and induction of human cytochrome P450 enzymes: current status. Arch Toxicol 82:667–715.
   PubMed Web of Science ®Google Scholar
• Periasamy VS, Athinarayanan J, Al-Hadi AM, et al. (2015a). Effects of titanium dioxide nanoparticles isolated from confectionery products on the metabolic stress pathway in human lung fibroblast cells. Arch Environ Contam Toxicol 68:521–33.
   PubMed Web of Science ®Google Scholar
• Periasamy VS, Athinarayanan J, Al-Hadi AM, et al. (2015b). Identification of titanium dioxide nanoparticles in food products: induce intracellular oxidative stress mediated by TNF and CYP1A genes in human lung fibroblast cells. Environ Toxicol Pharmacol 39:176–86.
   PubMed Web of Science ®Google Scholar
• Poynton HC, Lazorchak JM, Impellitteri CA, et al. (2011). Differential gene expression in Daphnia magna suggests distinct modes of action and bioavailability for ZnO nanoparticles and Zn ions. Environ Sci Technol 45:762–8.
   PubMed Web of Science ®Google Scholar
• Ramdhan DH, Ito Y, Yanagiba Y, et al. (2009). Nanoparticle-rich diesel exhaust may disrupt testosterone biosynthesis and metabolism via growth hormone. Toxicol Lett 191:103–8.
   PubMed Web of Science ®Google Scholar
• Rathore R, Schramm KW. (2014). Ethoxyresorufin-O-deethylase (EROD) activity modulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3,3’,4,4’,5-pentachlorobiphenyl (PCB 126) in the presence of aqueous suspensions of nano-C60. ATLA Altern Lab Anim 42:71–80.
   PubMed Web of Science ®Google Scholar
• Reed RB, Ladner DA, Higgins CP, et al. (2012). Solubility of nano-zinc oxide in environmentally and biologically important matrices. Environ Toxicol Chem 31:93–9.
   PubMed Web of Science ®Google Scholar
• Reichert K, Menzel R. (2005). Expression profiling of five different xenobiotics using a Caenorhabditis elegans whole genome microarray. Chemosphere 61:229–37.
   PubMed Web of Science ®Google Scholar
• Rocheleau S, Arbour M, Elias M, et al. (2015). Toxicogenomic effects of nano- and bulk-TiO2 particles in the soil nematode Caenorhabditis elegans. Nanotoxicology 9:502–12.
   PubMed Web of Science ®Google Scholar
• Rouse RL, Murphy G, Boudreaux MJ, et al. (2008). Soot nanoparticles promote biotransformation, oxidative stress, and inflammation in murine lungs. Am J Respir Cell Mol Biol 39:198–207.
   PubMed Web of Science ®Google Scholar
• Schuler MA. (1996). The role of cytochrome P450 monooxygenases in plant-insect interactions. Plant Physiol 112:1411–9.
   PubMed Web of Science ®Google Scholar
• Sereemaspun A, Hongpiticharoen P, Rojanathanes R, et al. (2008). Inhibition of human CYP by metallic nanoparticles: a preliminary to nanogenomics.pdf. Int J Pharmacol 4:492–5.
   Google Scholar
• Shi H, Magaye R, Castranova V, Zhao J. (2013). Titanium dioxide nanoparticles: a review of current toxicological data. Part Fibre Toxicol 10:15.
   PubMed Web of Science ®Google Scholar
• Sierra MI, Valdés A, Fernández AF, et al. (2016). The effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome. Int J Nanomed 11:6297–306.
   PubMed Web of Science ®Google Scholar
• Silkworth JB, Koganti A, Illouz K, et al. (2005). Comparison of TCDD and PCB CYP1A induction sensitivities in fresh hepatocytes from human donors, Sprague-Dawley rats, and rhesus monkeys and HepG2 cells. Toxicol Sci 87:508–19.
   PubMed Web of Science ®Google Scholar
• Simon V, Avet C, Grange-Messent V, et al. (2017). Carbon black nanoparticles inhibit aromatase expression and estradiol secretion in human granulosa cells through the ERK1/2 pathway. Endocrinology 158:3200–11.
   PubMed Web of Science ®Google Scholar
• Smith DA, Dickins M, Fahmi OA, et al. (2007). The time to move cytochrome P450 induction into mainstream pharmacology is long overdue. Drug Metab Dispos 35:697–8.
   PubMed Web of Science ®Google Scholar
• Stoeger T, Reinhard C, Takenaka S, et al. (2005). Instillation of six different ultrafine carbon particles indicates a surface area threshold dose for acute lung inflammation in mice. Environ Health Perspect 114:328–33.
   Web of Science ®Google Scholar
• Stoeger T, Takenaka S, Frankenberger B, et al. (2009). Deducing in vivo toxicity of combustion-derived nanoparticles from a cell-free oxidative potency assay and metabolic activation of organic compounds. Environ Health Perspect 117:54–60.
   PubMed Web of Science ®Google Scholar
• Sung JH, Ji JH, Yoon JU, et al. (2008). Lung function changes in Sprague-Dawley rats after prolonged inhalation exposure to silver nanoparticles. Inhal Toxicol 20:567–74.
   PubMed Web of Science ®Google Scholar
• Tan BH, Pan Y, Dong AN, Ong CE. (2017). In vitro and in silico approaches to study cytochrome P450-mediated interactions. J Pharm Pharm Sci 20:319–28.
   PubMed Web of Science ®Google Scholar
• Tang HQ, Xu M, Rong Q, et al. (2016). The effect of ZnO nanoparticles on liver function in rats. Int J Nanomed 11:4275–85.
   PubMed Web of Science ®Google Scholar
• Tian JH, Xue B, Hu JH, et al. (2017). Exogenous substances regulate silkworm fat body protein synthesis through MAPK and PI3K/Akt signaling pathways. Chemosphere 171:202–7.
   PubMed Web of Science ®Google Scholar
• Tse ACK, Lau KYT, Ge W, Wu RSS. (2013). A rapid screening test for endocrine disrupting chemicals using primary cell culture of the marine medaka. Aquat Toxicol 144–145:50–8.
   PubMed Web of Science ®Google Scholar
• Vannuccini ML, Grassi G, Leaver MJ, Corsi I. (2015). Combination effects of nano-TiO and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on biotransformation gene expression in the liver of European sea bass Dicentrarchus labrax. Comp Biochem Physiol C: Toxicol Pharmacol 176–177:71–8.
   PubMed Web of Science ®Google Scholar
• Wan OW, Chung KKK. (2012). The role of alpha-synuclein oligomerization and aggregation in cellular and animal models of Parkinson’s disease. PLoS One 7:e38545.
   PubMed Web of Science ®Google Scholar
• Wang L, Su M, Zhao X, et al. (2015). Nanoparticulate TiO protection of midgut damage in the silkworm (Bombyx mori) following phoxim exposure. Arch Environ Contam Toxicol 68:534–42.
   PubMed Web of Science ®Google Scholar
• Warisnoich W, Hongpitich P, Lawanprase S. (2011). Alteration in enzymatic function of human cytochrome P450 by silver nanoparticles. Res J Environ Toxicol 5:58.
   Google Scholar
• Xie J, Dong W, Liu R, et al. (2018). Research on the hepatotoxicity mechanism of citrate-modified silver nanoparticles based on metabolomics and proteomics. Nanotoxicology 12:18–31.
   PubMed Web of Science ®Google Scholar
• Yang J, Luo M, Tan Z, et al. (2017). Oral administration of nano-titanium dioxide particle disrupts hepatic metabolic functions in a mouse model. Environ Toxicol Pharmacol 49:112–8.
   PubMed Web of Science ®Google Scholar
• Ye M, Tang L, Luo M, et al. (2014). Size- and time-dependent alteration in metabolic activities of human hepatic cytochrome P450 isozymes by gold nanoparticles via microsomal coincubations. Nanoscale Res Lett 9:642–16.
   PubMed Web of Science ®Google Scholar
• Zakharian TY, Seryshev A, Sitharaman B, et al. (2005). A fullerene − paclitaxel chemotherapeutic: synthesis, characterization, and study of biological activity in tissue culture. J Am Chem Soc 127:12508–9.
   PubMed Web of Science ®Google Scholar
• Zeng Y, Kurokawa Y, Win-Shwe TT, et al. (2016). Effects of PAMAM dendrimers with various surface functional groups and multiple generations on cytotoxicity and neuronal differentiation using human neural progenitor cells. J Toxicol Sci 41:351–70.
   PubMed Web of Science ®Google Scholar