Kinetics of dextromethorphan-O-demethylase activity and distribution of CYP2D in four commonly-used subcellular fractions of rat brain

References

• Agarwal V, Kommaddi RP, Valli K, et al. (2008). Drug metabolism in human brain: high levels of cytochrome P4503A43 in brain and metabolism of anti-anxiety drug alprazolam to its active metabolite. PLoS One 3:e2337.
   PubMed Web of Science ®Google Scholar
• Anandatheerthavarada HK, Addya S, Dwivedi RS, et al. (1997). Localization of multiple forms of inducible cytochromes P450 in rat liver mitochondria: immunological characteristics and patterns of xenobiotic substrate metabolism. Arch Biochem Biophys 339:136–50.
   PubMed Web of Science ®Google Scholar
• Anandatheerthavarada HK, Biswas G, Mullick J, et al. (1999). Dual targeting of cytochrome P4502B1 to endoplasmic reticulum and mitochondria involves a novel signal activation by cyclic AMP-dependent phosphorylation at ser128. EMBO J 18:5494–504.
   PubMed Web of Science ®Google Scholar
• Asai Y, Tanaka H, Nadai M, Katoh M. (2018). Status epilepticus decreases brain cytochrome P450 2D4 expression in rats. J Pharm Sci 107:975–8.
   PubMed Web of Science ®Google Scholar
• Bhagwat SV, Boyd MR, Ravindranath V. (1995). Rat brain cytochrome P450. Reassessment of monooxygenase activities and cytochrome P450 levels. Drug Metab Dispos 23:651–4.
   PubMed Web of Science ®Google Scholar
• Bhagwat SV, Boyd MR, Ravindranath V. (2000). Multiple forms of cytochrome P450 and associated monooxygenase activities in human brain mitochondria. Biochem Pharmacol 59:573–82.
   PubMed Web of Science ®Google Scholar
• Boopathi E, Anandatheerthavarada HK, Bhagwat SV, et al. (2000). Accumulation of mitochondrial P450MT2, NH(2)-terminal truncated cytochrome P4501A1 in rat brain during chronic treatment with beta-naphthoflavone. A role in the metabolism of neuroactive drugs. J Biol Chem 275:34415–23.
   PubMed Web of Science ®Google Scholar
• Coleman T, Spellman EF, Rostami-Hodjegan A, et al. (2000). The 1'-hydroxylation of Rac-bufuralol by rat brain microsomes. Drug Metab Dispos 28:1094–9.
   PubMed Web of Science ®Google Scholar
• Dasari VR, Anandatheerthavarada HK, Robin MA, et al. (2006). Role of protein kinase C-mediated protein phosphorylation in mitochondrial translocation of mouse CYP1A1, which contains a non-canonical targeting signal. J Biol Chem 281:30834–47.
   PubMed Web of Science ®Google Scholar
• DuBois BN, Mehvar R. (2018). UPLC-MS/MS analysis of dextromethorphan-O-demethylation kinetics in rat brain microsomes. J Chromatogr B Analyt Technol Biomed Life Sci 1096:66–72.
   PubMed Web of Science ®Google Scholar
• Funae Y, Kishimoto W, Cho T, et al. (2003). CYP2D in the brain. Drug Metab Pharmacokinet 18:337–49.
   PubMedGoogle Scholar
• Ghersi-Egea JF, Perrin R, Leininger-Muller B, et al. (1993). Subcellular localization of cytochrome P450, and activities of several enzymes responsible for drug metabolism in the human brain. Biochem Pharmacol 45:647–58.
   PubMed Web of Science ®Google Scholar
• Ghersi-Egea JF, Walther B, Minn A, Siest G. (1987). Quantitative measurement of cerebral cytochrome P-450 by second derivative spectrophotometry. J Neurosci Methods 20:261–9.
   PubMed Web of Science ®Google Scholar
• Hiroi T, Chow T, Imaoka S, Funae Y. (2002). Catalytic specificity of CYP2D isoforms in rat and human. Drug Metab Dispos 30:970–6.
   PubMed Web of Science ®Google Scholar
• Hiroi T, Imaoka S, Chow T, Funae Y. (1998). Tissue distributions of CYP2D1, 2D2, 2D3 and 2D4 mRNA in rats detected by RT-PCR. Biochim Biophys Acta 1380:305–12.
   PubMed Web of Science ®Google Scholar
• Jolivalt C, Minn A, Vincent-Viry M, et al. (1995). Dextromethorphan O-demethylase activity in rat brain microsomes. Neurosci Lett 187:65–8.
   PubMed Web of Science ®Google Scholar
• Kristian T. (2010). Isolation of mitochondria from the CNS. Curr Protoc Neurosci, Chapter 7: Unit 7 22.
   PubMedGoogle Scholar
• Lavandera J, Ruspini S, Batlle A, Buzaleh AM. (2015). Cytochrome P450 expression in mouse brain: specific isoenzymes involved in Phase I metabolizing system of porphyrinogenic agents in both microsomes and mitochondria. Biochem Cell Biol 93:102–7.
   PubMed Web of Science ®Google Scholar
• Mann A, Miksys S, Lee A, et al. (2008). Induction of the drug metabolizing enzyme CYP2D in monkey brain by chronic nicotine treatment. Neuropharmacology 55:1147–55.
   PubMed Web of Science ®Google Scholar
• McMillan DM, Tyndale RF. (2015). Nicotine increases Codeine analgesia through the induction of brain CYP2D and central activation of Codeine to Morphine. Neuropsychopharmacology 40:1804–12.
   PubMed Web of Science ®Google Scholar
• McMillan DM, Tyndale RF. (2017). Inducing rat brain CYP2D with nicotine increases the rate of codeine tolerance; predicting the rate of tolerance from acute analgesic response. Biochem Pharmacol 145:158–68.
   PubMed Web of Science ®Google Scholar
• McMillan DM, Tyndale RF. (2018). CYP-mediated drug metabolism in the brain impacts drug response. Pharmacol Ther 184:189–200.
   PubMed Web of Science ®Google Scholar
• Miksys S, Rao Y, Sellers EM, et al. (2000). Regional and cellular distribution of CYP2D subfamily members in rat brain. Xenobiotica 30:547–64.
   PubMed Web of Science ®Google Scholar
• Miksys S, Wadji FB, Tolledo EC, et al. (2017). Rat brain CYP2D enzymatic metabolism alters acute and chronic haloperidol side-effects by different mechanisms. Prog Neuropsychopharmacol Biol Psychiatry 78:140–8.
   PubMed Web of Science ®Google Scholar
• Miksys SL, Tyndale RF. (2002). Drug-metabolizing cytochrome P450s in the brain. J Psychiatry Neurosci 27:406–15.
   PubMed Web of Science ®Google Scholar
• Mizuno D, Hiroi T, Ng P, et al. (2003). Regulation of CYP2D expression in rat brain by toluene. Osaka City Med J 49:49–56.
   PubMedGoogle Scholar
• Navarro-Mabarak C, Camacho-Carranza R, Espinosa-Aguirre JJ. (2018). Cytochrome P450 in the central nervous system as a therapeutic target in neurodegenerative diseases. Drug Metab Rev 50:95–108.
   PubMed Web of Science ®Google Scholar
• Penas-Lledo EM, Llerena A. (2014). CYP2D6 variation, behaviour and psychopathology: implications for pharmacogenomics-guided clinical trials. Br J Clin Pharmacol 77:673–83.
   PubMed Web of Science ®Google Scholar
• Sangar MC, Anandatheerthavarada HK, Tang W, et al. (2009). Human liver mitochondrial cytochrome P450 2D6-individual variations and implications in drug metabolism. FEBS J 276:3440–53.
   PubMed Web of Science ®Google Scholar
• Toselli F, Dodd PR, Gillam EM. (2016). Emerging roles for brain drug-metabolizing cytochrome P450 enzymes in neuropsychiatric conditions and responses to drugs. Drug Metab Rev 48:379–404.
   PubMed Web of Science ®Google Scholar
• Tyndale RF, Li Y, Li NY, et al. (1999). Characterization of cytochrome P-450 2D1 activity in rat brain: high-affinity kinetics for dextromethorphan. Drug Metab Dispos 27:924–30.
   PubMed Web of Science ®Google Scholar
• Voirol P, Jonzier-Perey M, Porchet F, et al. (2000). Cytochrome P-450 activities in human and rat brain microsomes. Brain Res 855:235–43.
   PubMed Web of Science ®Google Scholar
• Wan J, Imaoka S, Chow T, et al. (1997). Expression of four rat CYP2D isoforms in Saccharomyces cerevisiae and their catalytic specificity. Arch Biochem Biophys 348:383–90.
   PubMed Web of Science ®Google Scholar
• Wang Q, Han X, Li J, et al. (2015). Regulation of cerebral CYP2D alters tramadol metabolism in the brain: interactions of tramadol with propranolol and nicotine. Xenobiotica 45:335–44.
   PubMed Web of Science ®Google Scholar
• Wang X, Li J, Dong G, Yue J. (2014). The endogenous substrates of brain CYP2D. Eur J Pharmacol 724:211–8.
   PubMed Web of Science ®Google Scholar
• Wattiaux-De Coninck S, Dubois F, Wattiaux R. (1974). Effect of imipramine on the behavior of rat-liver mitochondria during centrifugation in a sucrose gradient. Eur J Biochem 48:407–16.
   PubMedGoogle Scholar
• Wu JY, Yue J, Feng YQ. (2011). Determination of brain cytochrome P450 2E1 activity in rat with the probe of chlorzoxazone by liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 879:260–6.
   PubMed Web of Science ®Google Scholar
• Wyss A, Gustafsson JA, Warner M. (1995). Cytochromes P450 of the 2D subfamily in rat brain. Mol Pharmacol 47:1148–55.
   PubMed Web of Science ®Google Scholar
• Yue J, Miksys S, Hoffmann E, Tyndale RF. (2008). Chronic nicotine treatment induces rat CYP2D in the brain but not in the liver: an investigation of induction and time course. J Psychiatry Neurosci 33:54–63.
   PubMed Web of Science ®Google Scholar
• Zhou K, Khokhar JY, Zhao B, Tyndale RF. (2013). First demonstration that brain CYP2D-mediated opiate metabolic activation alters analgesia in vivo. Biochem Pharmacol 85:1848–55.
   PubMed Web of Science ®Google Scholar