Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice

References

• Adamsen D, Ramaekers V, Ho HT, et al. (2014). Autism spectrum disorder associated with low serotonin in CSF and mutations in the SLC29A4 plasma membrane monoamine transporter (PMAT) gene. Mol Autism 5:43.
   PubMed Web of Science ®Google Scholar
• Amphoux A, Vialou V, Drescher E, et al. (2006). Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Neuropharmacology 50:941–52.
   PubMed Web of Science ®Google Scholar
• Bacq A, Balasse L, Biala G, et al. (2012). Organic cation transporter 2 controls brain norepinephrine and serotonin clearance and antidepressant response. Mol Psychiatr 17:926–39.
   PubMed Web of Science ®Google Scholar
• Baganz N, Horton R, Martin K, et al. (2010). Repeated swim impairs serotonin clearance via a corticosterone-sensitive mechanism: organic cation transporter 3, the smoking gun. J Neurosci 30:15185–95.
   PubMed Web of Science ®Google Scholar
• Berton O, Nestler EJ. (2006). New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci 7:137–51.
   PubMed Web of Science ®Google Scholar
• Chao C, Hong H, Dachao F. (1989). Protective effects of jatrorrhizine on myocardial ischaemia and reperfusion damage in experimental animals. Chin Pharmacol Bull 5:373–6.
   Google Scholar
• Charney DS. (1998). Monoamine dysfunction and the pathophysiology and treatment of depression. J Clin Psychiat 59:11–4.
   PubMed Web of Science ®Google Scholar
• Courousse T, Bacq A, Belzung C, et al. (2015). Brain organic cation transporter 2 controls response and vulnerability to stress and GSK3beta signaling. Mol Psychiatry 20:889–900.
   PubMed Web of Science ®Google Scholar
• Cui M, Aras R, Christian WV, et al. (2009). The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway. Proc Natl Acad Sci USA 106:8043–8.
   PubMed Web of Science ®Google Scholar
• Dahlin A, Xia L, Kong W, et al. (2007). Expression and immunolocalization of the plasma membrane monoamine transporter in the brain. Neuroscience 146:1193–211.
   PubMed Web of Science ®Google Scholar
• Daws LC. (2009). Unfaithful neurotransmitter transporters: focus on serotonin uptake and implications for antidepressant efficacy. Pharmacol Ther 121:89–99.
   PubMed Web of Science ®Google Scholar
• Du W, Jin L, Li L, et al. (2018). Development and validation of a HPLC-ESI-MS/MS method for simultaneous quantification of fourteen alkaloids in mouse plasma after oral administration of the extract of Corydalis yanhusuo Tuber: application to pharmacokinetic study. Molecules 23:714.
   Web of Science ®Google Scholar
• Duan HC, Wang J. (2010). Selective transport of monoamine neurotransmitters by human plasma membrane monoamine transporter and organic cation transporter 3. J Pharmacol Exp Ther 335:743–53.
   PubMed Web of Science ®Google Scholar
• Dubovsky SL. (2018). What is new about new antidepressants? Psychother Psychosom 87:129–39.
   PubMed Web of Science ®Google Scholar
• Gasser PJ, Lowry CA, Orchinik M. (2006). Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus: potential role for organic cation transporter 3 in stress-induced modulation of monoaminergic neurotransmission. J Neurosci 26:8758–66.
   PubMed Web of Science ®Google Scholar
• Gilman TL, George CM, Vitela M, et al. (2018). Constitutive plasma membrane monoamine transporter (PMAT, Slc29a4) deficiency subtly affects anxiety-like and coping behaviours. Eur J Neurosci 48:1706–16.
   PubMed Web of Science ®Google Scholar
• Haenisch B, Drescher E, Thiemer L, et al. (2012). Interaction of antidepressant and antipsychotic drugs with the human organic cation transporters hOCT1, hOCT2 and hOCT3. N-S Arch Pharmacol 385:1017–23.
   PubMed Web of Science ®Google Scholar
• Han H, Fang DC. (1989). The blocking and partial agonistic actions of jatrorrhizine on alpha-adrenoceptors. Acta Pharm Sin 10:385–9.
   Web of Science ®Google Scholar
• Horton RE, Apple DM, Owens WA, et al. (2013). Decynium-22 enhances SSRI-induced antidepressant-like effects in mice: uncovering novel targets to treat depression. J Neurosci 33:10534–43.
   PubMed Web of Science ®Google Scholar
• Li L, Sun S, Weng Y, et al. (2016). Interaction of six protoberberine alkaloids with human organic cation transporters 1, 2 and 3. Xenobiotica 46:175–83.
   PubMed Web of Science ®Google Scholar
• Marcinkiewcz CA, Devine DP. (2015). Modulation of OCT3 expression by stress, and antidepressant-like activity of decynium-22 in an animal model of depression. Pharmacol Biochem Behav 131:33–41.
   PubMed Web of Science ®Google Scholar
• Mooney JJ, Samson JA, Hennen J, et al. (2008). Enhanced norepinephrine output during long-term desipramine treatment: a possible role for the extraneuronal monoamine transporter (SLC22A3). J Psychiatr Res 42:605–11.
   PubMed Web of Science ®Google Scholar
• Owens MJ, Krulewicz S, Simon JS, et al. (2008). Estimates of serotonin and norepinephrine transporter inhibition in depressed patients treated with paroxetine or venlafaxine. Neuropsychopharmacology 33:3201–12.
   PubMed Web of Science ®Google Scholar
• Patel MB, Mishra S. (2011). Hypoglycemic activity of alkaloidal fraction of Tinospora cordifolia. Phytomedicine 18:1045–52.
   PubMed Web of Science ®Google Scholar
• Rahman Z, Ring RH, Young K, et al. (2008). Inhibition of uptake 2 (or extraneuronal monoamine transporter) by normetanephrine potentiates the neurochemical effects of venlafaxine. Brain Res 1203:68–78.
   PubMed Web of Science ®Google Scholar
• Rappold PM, Cui M, Chesser AS, et al. (2011). Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3. Proc Natl Acad Sci USA 108:20766–71.
   PubMed Web of Science ®Google Scholar
• Steru L, Chermat R, Thierry B, Simon P. (1985). The Tail Suspension test: a new method for screening antidepressants in mice. Psychopharmacology 85:367–70.
   PubMed Web of Science ®Google Scholar
• Sun S, Wang K, Lei H, et al. (2014). Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine. Prog Neuropsychopharmacol Biol Psychiatry 49:1–6.
   PubMed Web of Science ®Google Scholar
• Tu M, Sun S, Wang K, et al. (2013). Organic cation transporter 1 mediates the uptake of monocrotaline and plays an important role in its hepatotoxicity. Toxicology 311:225–30.
   PubMed Web of Science ®Google Scholar
• Wang K, Sun S, Li L, et al. (2014). Involvement of organic cation transporter 2 inhibition in potential mechanisms of antidepressant action. Prog Neuropsychopharmacol Biol Psychiatry 53:90–8.
   PubMed Web of Science ®Google Scholar
• Wu D, Zhou J, Hu Z. (2006). The application of jatrorrhizine, the monomer component derived from the plant Coptis chinensis, in the preparation of gastric pro-kinetic drugs. Invention Patent.
   Google Scholar
• Wultsch T, Grimberg G, Schmitt A, et al. (2009). Decreased anxiety in mice lacking the organic cation transporter 3. J Neural Transm 116:689–97.
   PubMed Web of Science ®Google Scholar
• Yu Y, Yi ZB, Liang YZ. (2007). Main antimicrobial components of Tinospora capillipes, and their mode of action against Staphylococcus aureus. FEBS Lett 581:4179–83.
   PubMed Web of Science ®Google Scholar
• Yuan JY, Zhou JY, Hu ZB, et al. (2011). The effects of jatrorrhizine on contractile responses of rat ileum. Eur J Pharmacol 663:74–9.
   PubMed Web of Science ®Google Scholar
• Zhang BB, Cao AL, Zhou JY, et al. (2012). Effect of jatrorrhizine on delayed gastrointestinal transit in rat postoperative ileus. J Pharm Pharmacol 64:413–9.
   PubMed Web of Science ®Google Scholar
• Zhu HJ, Appel DI, Grundemann D, Markowitz JS. (2010). Interaction of organic cation transporter 3 (SLC22A3) and amphetamine. J Neurochem 114:142–9.
   PubMed Web of Science ®Google Scholar
• Zhu HJ, Appel DI, Grundemann D, et al. (2012). Evaluation of organic cation transporter 3 (SLC22A3) inhibition as a potential mechanism of antidepressant action. Pharmacol Res 65:491–6.
   PubMed Web of Science ®Google Scholar