Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 49, 2019 - Issue 12
305
Views
10
CrossRef citations to date
0
Altmetric
General Xenobiochemistry

Concentration dependence of human and mouse aryl hydrocarbon receptor responsiveness to polychlorinated biphenyl exposures: Implications for aroclor mixtures

, , , , , & show all
Pages 1414-1422 | Received 16 Oct 2018, Accepted 04 Jan 2019, Published online: 16 Apr 2019

References

  • Ampleman MD, Martinez A, Dewall J, et al. (2015). Inhalation and dietary exposure to PCBs in urban and rural cohorts via congener-specific measurements. Environ Sci Technol 49:1156–64.
  • Angrish MM, Mets BD, Jones AD, Zacharewski TR. (2012). Dietary fat is a lipid source in 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD)-elicited hepatic steatosis in C57BL/6 mice. Toxicol Sci 128:377–86.
  • Aparicio-Vergara M, Tencerova M, Morgantini C, et al. (2017). Isolation of Kupffer cells and hepatocytes from a single mouse liver. Methods Mol Biol 1639:161–71.
  • Bannister R, Davis D, Zacharewski T, et al. (1987). Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: effects on enzyme induction and immunotoxicity. Toxicology 46:29–42.
  • Battelle Memorial Institute. (2012). A handbook for determining the sources of PCB contamination in sediments. In: Hueneme CA, ed. Technical Report TR-NAVFAC EXWC-EV-1302. Port: NAVFAC Engineering and Expeditionary Warfare Center.
  • Brennan JC, He G, Tsutsumi T, et al. (2015). Development of species-specific Ah receptor-responsive third generation CALUX cell lines with enhanced responsiveness and improved detection limits. Environ Sci Technol 49:11903–12.
  • Burgin DE, Diliberto JJ, Derr-Yellin EC, et al. (2001). Differential effects of two lots of Aroclor 1254 on enzyme induction, thyroid hormones, and oxidative stress. Environ Health Perspect 109:1163–8.
  • Cave M, Appana S, Patel M, et al. (2010). Polychlorinated biphenyls, lead, and mercury are associated with liver disease in American adults: NHANES 2003–2004. Environ Health Perspect 118:1735–42.
  • Clair HB, Pinkston CM, Rai SN, et al. (2018). Liver disease in a residential cohort with elevated polychlorinated biphenyl exposures. Toxicol Sci 164:39–49.
  • Diliberto JJ, Burgin D, Birnbaum LS. (1997). Role of CYP1A2 in hepatic sequestration of dioxin: studies using CYP1A2 knock-out mice. Biochem Biophys Res Commun 236:431–3.
  • Flaveny C, Reen RK, Kusnadi A, Perdew GH. (2008). The mouse and human Ah receptor differ in recognition of LXXLL motifs. Arch Biochem Biophys 471:215–23.
  • Flaveny CA, Murray IA, Chiaro CR, Perdew GH. (2009). Ligand selectivity and gene regulation by the human aryl hydrocarbon receptor in transgenic mice. Mol Pharmacol 75:1412–20.
  • Gadupudi GS, Klaren WD, Olivier AK, et al. (2016). PCB126-induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats. Toxicol Sci 149:98–110.
  • Hardesty JE, Al-Eryani L, Wahlang B, et al. (2018). Epidermal growth factor receptor signaling disruption by endocrine and metabolic disrupting chemicals. Toxicol Sci 162:622–34.
  • Hardesty JE, Wahlang B, Falkner KC, et al. (2017). Polychlorinated biphenyls disrupt hepatic epidermal growth factor receptor signaling. Xenobiotica 47:807–20.
  • Harris M, Zacharewski T, Safe S. (1993). Comparative potencies of Aroclors 1232, 1242, 1248, 1254, and 1260 in male Wistar rats–assessment of the toxic equivalency factor (TEF) approach for polychlorinated biphenyls (PCBs). Fundam Appl Toxicol 20:456–63.
  • Heindel JJ, Blumberg B, Cave M, et al. (2017). Metabolism disrupting chemicals and metabolic disorders. Reprod Toxicol 68:3–33.
  • Hennig B, Reiterer G, Toborek M, et al. (2005). Dietary fat interacts with PCBs to induce changes in lipid metabolism in mice deficient in low-density lipoprotein receptor. Environ Health Perspect 113:83–7.
  • Jones JM, Anderson JW. (1999). Relative potencies of PAHs and PCBs based on the response of human cells. Environ Toxicol Pharmacol 7:19–26.
  • Kim MJ, Marchand P, Henegar C, et al. (2011). Fate and complex pathogenic effects of dioxins and polychlorinated biphenyls in obese subjects before and after drastic weight loss. Environ Health Perspect 119:377–83.
  • Kumar J, Lind L, Salihovic S, et al. (2014). Persistent organic pollutants and liver dysfunction biomarkers in a population-based human sample of men and women. Environ Res 134:251–6.
  • Larsson M, Van den Berg M, Brenerova P, et al. (2015). Consensus toxicity factors for polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls combining in silico models and extensive in vitro screening of AhR-mediated effects in human and rodent cells. Chem Res Toxicol 28:641–50.
  • Lee JH, Wada T, Febbraio M, et al. (2010). A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis. Gastroenterology 139:653–63.
  • Murray IA, Patterson AD, Perdew GH. (2014). Aryl hydrocarbon receptor ligands in cancer: friend and foe. Nat Rev Cancer 14:801–14.
  • Nault R, Forgacs AL, Dere E, Zacharewski TR. (2013). Comparisons of differential gene expression elicited by TCDD, PCB126, βNF, or ICZ in mouse hepatoma Hepa1c1c7 cells and C57BL/6 mouse liver. Toxicol Lett 223:52–9.
  • Ockenden WA, Breivik K, Meijer SN, et al. (2003). The global re-cycling of persistent organic pollutants is strongly retarded by soils. Environmental Pollution 121:75–80.
  • Peters AK, Leonards PE, Zhao B, et al. (2006). Determination of in vitro relative potency (REP) values for mono-ortho polychlorinated biphenyls after purification with active charcoal. Toxicol Lett 165:230–41.
  • Peters AK, Van Londen K, Bergman A, et al. (2004). Effects of polybrominated diphenyl ethers on basal and TCDD-induced ethoxyresorufin activity and cytochrome P450-1A1 expression in MCF-7, HepG2, and H4IIE cells. Toxicol Sci 82:488–96.
  • Ramadoss P, Perdew GH. (2004). Use of 2-azido-3-[125I]iodo-7,8-dibromodibenzo-p-dioxin as a probe to determine the relative ligand affinity of human versus mouse aryl hydrocarbon receptor in cultured cells. Molecular Pharmacology 66:129–36.
  • Rantakokko P, Mannisto V, Airaksinen R, et al. (2015). Persistent organic pollutants and non-alcoholic fatty liver disease in morbidly obese patients: a cohort study. Environ Health 14:79.
  • Schecter A, Quynh HT, Pavuk M, et al. (2003). Food as a source of dioxin exposure in the residents of Bien Hoa City, Vietnam. J Occup Environ Med 45:781.
  • Schrenk D, Stilven T, Gohl G, et al. (1995). Induction of CYP1A and glutathione S-transferase activities by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human hepatocyte cultures. Carcinogenesis 16:943–6.
  • Serdar B, Leblanc WG, Norris JM, Dickinson LM. (2014). Potential effects of polychlorinated biphenyls (PCBs) and selected organochlorine pesticides (OCPs) on immune cells and blood biochemistry measures: a cross-sectional assessment of the NHANES 2003–2004 data. Environ Health 13:114.
  • Shi H, Jan J, Hardesty JE, et al. (2018). Polychlorinated biphenyl exposures differentially regulate hepatic metabolism and pancreatic function: implications for nonalcoholic steatohepatitis and diabetes. Toxicol Appl Pharmacol 363:22–33.
  • Silkworth JB, Koganti A, Illouz K, et al. (2005). Comparison of TCDD and PCB CYP1A induction sensitivities in fresh hepatocytes from human donors, Sprague-Dawley rats, and Rhesus monkeys and HepG2 cells. Toxicol Sci 87:508–19.
  • Strapacova S, Brenerova P, Krcmar P, et al. (2018). Relative effective potencies of dioxin-like compounds in rodent and human lung cell models. Toxicology 404–405:33–41.
  • Suzuki T, Nohara K. (2007). Regulatory factors involved in species-specific modulation of arylhydrocarbon receptor (AhR)-dependent gene expression in humans and mice. J Biochem 142:443–52.
  • Thomas RS, Penn SG, Holden K, et al. (2002). Sequence variation and phylogenetic history of the mouse AhR gene. Pharmacogenetics 12:151–63.
  • Van den Berg, Birnbaum M, Bosveld L, et al. (1998). Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ Health Perspect 106:775–92.
  • Van den Berg M, Birnbaum LS, Denison M, et al. (2006). The 2005 World Health Organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol Sci 93:223–41.
  • van Ede KI, van Duursen MB, van den Berg M. (2016). Evaluation of relative effect potencies (REPs) for dioxin-like compounds to derive systemic or human-specific TEFs to improve human risk assessment. Arch Toxicol 90:1293–305.
  • Wahlang B, Falkner KC, Clair HB, et al. (2014a). Human receptor activation by Aroclor 1260, a polychlorinated biphenyl mixture. Toxicol Sci 140:283–97.
  • Wahlang B, Falkner KC, Gregory B, et al. (2013). Polychlorinated biphenyl 153 is a diet-dependent obesogen that worsens nonalcoholic fatty liver disease in male C57BL6/J mice. J Nutr Biochem 24:1587–95.
  • Wahlang B, Perkins JT, Petriello MC, et al. (2017). A compromised liver alters polychlorinated biphenyl-mediated toxicity. Toxicology 380:11–22.
  • Wahlang B, Prough RA, Falkner KC, et al. (2016). Polychlorinated biphenyl-xenobiotic nuclear receptor interactions regulate energy metabolism, behavior, and inflammation in non-alcoholic-steatohepatitis. Toxicol Sci 149:396–410.
  • Wahlang B, Song M, Beier JI, et al. (2014b). Evaluation of Aroclor 1260 exposure in a mouse model of diet-induced obesity and non-alcoholic fatty liver disease. Toxicol Appl Pharmacol 279:380–90.
  • Yorita Christensen KL, Carrico CK, Sanyal AJ, Gennings C. (2013). Multiple classes of environmental chemicals are associated with liver disease: NHANES 2003–2004. Int J Hyg Environ Health 216:703–709
  • Zeiger M, Haag R, Hockel J, et al. (2001). Inducing effects of dioxin-like polychlorinated biphenyls on CYP1A in the human hepatoblastoma cell line HepG2, the rat hepatoma cell line H4IIE, and rat primary hepatocytes: comparison of relative potencies. Toxicol Sci 63:65–73.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.