Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 50, 2020 - Issue 4
293
Views
7
CrossRef citations to date
0
Altmetric
General Xenobiochemistry

In vitro characterization of glycyrol metabolites in human liver microsomes using HR-resolution MS spectrometer coupled with tandem mass spectrometry

, , , , , , ORCID Icon & ORCID Icon show all
Pages 380-388 | Received 18 Mar 2019, Accepted 23 Jun 2019, Published online: 05 Jul 2019

References

  • Adianti M, Aoki C, Komoto M, et al. (2014). Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species. Microbiol Immunol 58:180–7.
  • Clarke TC, Black LI, Stussman BJ, et al. (2015). Trends in the use of complementary health approaches among adults: United States, 2002–2012. Natl Health Stat Report 1–16.
  • Fu Y, Zhou H, Wang S, Wei Q. (2014). Glycyrol suppresses collagen-induced arthritis by regulating autoimmune and inflammatory responses. PLoS One 9:e98137.
  • Groothuis GMM, de Kanter R. (2006). Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction AU - Martignoni, Marcella. Expert Opin Drug Metabol Toxicol 2:875–94.
  • Kim SJ, Kim SJ, Hong M, et al. (2016). Investigation of selective inhibitory effects of glycyrol on human CYP 1A1 and 2C9. Xenobiotica 46:857–61.
  • Li J, Tu Y, Tong L, et al. (2010). Immunosuppressive activity on the murine immune responses of glycyrol from Glycyrrhiza uralensis via inhibition of calcineurin activity. Pharm Biol 48:1177–84.
  • Oda S, Fukami T, Yokoi T, Nakajima M. (2015). A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development. Drug Metab Pharmacokinet 30:30–51.
  • Qiao X, Ji S, Yu SW, et al. (2014). Identification of key licorice constituents which interact with cytochrome P450: evaluation by LC/MS/MS cocktail assay and metabolic profiling. AAPS J 16:101–13.
  • Rowland A, Miners JO, Mackenzie PI. (2013). The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification. Int J Biochem Cell Biol 45:1121–32.
  • Shin EM, Kim S, Merfort I, Kim YS. (2011). Glycyrol induces apoptosis in human Jurkat T cell lymphocytes via the Fas-FasL/caspase-8 pathway. Planta Med 77:242–7.
  • Shin EM, Zhou HY, Guo LY, et al. (2008). Anti-inflammatory effects of glycyrol isolated from Glycyrrhiza uralensis in LPS-stimulated RAW264.7 macrophages. Int Immunopharmacol 8:1524–32.
  • Sim J, Jang HW, Song M, et al. (2014). Potent inhibitory effect of alpha-viniferin on human cytochrome P450. Food Chem Toxicol 69:276–80.
  • Tanaka Y, Kikuzaki H, Fukuda S, Nakatani N. (2001). Antibacterial compounds of licorice against upper airway respiratory tract pathogens. J Nutr Sci Vitaminol 47:270–3.
  • Wang Q, Qiao X, Qian Y, et al. (2015). Metabolites identification of glycyrin and glycyrol, bioactive coumarins from licorice. J Chromatogr B Analyt Technol Biomed Life Sci 983-984:39–46.
  • Wienkers LC, Heath TG. (2005). Predicting in vivo drug interactions from in vitro drug discovery data. Nat Rev Drug Discov 4:825.
  • Xu MY, Kim YS. (2014). Antitumor activity of glycyrol via induction of cell cycle arrest, apoptosis and defective autophagy. Food Chem Toxicol 74:311–9.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.