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Xenobiotica
the fate of foreign compounds in biological systems
Volume 50, 2020 - Issue 5
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General Xenobiochemistry

Predicting successful/unsuccessful extrapolation for in vivo total clearance of model compounds with a variety of hepatic intrinsic metabolism and protein bindings in humans from pharmacokinetic data using chimeric mice with humanised liver

, , , & ORCID Icon
Pages 526-535 | Received 08 Aug 2019, Accepted 03 Sep 2019, Published online: 13 Sep 2019

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