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Xenobiotica
the fate of foreign compounds in biological systems
Volume 50, 2020 - Issue 6
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General Xenobiochemistry

Liver metabolomic characterization of Sophora flavescens alcohol extract-induced hepatotoxicity in rats through UPLC/LTQ-Orbitrap mass spectrometry

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Pages 670-676 | Received 18 Sep 2019, Accepted 29 Oct 2019, Published online: 20 Nov 2019

References

  • Coen M, Lenz EM, Nicholson JK, et al. (2003). An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy. Chem Res Toxicol 16:295–303.
  • Gao X, Guo S, Zhang S, et al. (2018). Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway. J Transl Med 16:319.
  • Geng L, Ma C, Zhang L, et al. (2013). Metabonomic study of genkwa flos-induced hepatotoxicity and effect of herb-processing procedure on toxicity. Phytother Res 27:521–9.
  • Harrigan GG, Yates LA. (2006). High-throughput screening, metabolomics and drug discovery. IDrugs 9:188–92.
  • Huang Y, Tian Y, Li G, et al. (2013). Discovery of safety biomarkers for realgar in rat urine using UFLC-IT-TOF/MS and 1H NMR based metabolomics. Anal Bioanal Chem 405:4811–22.
  • Jiang P, Sun YC, Cai Y, et al. (2018). A urinary metabolomics analysis of rat hepatotoxicity induced by Sophora flavescens alcohol extract based on ultra-performance liquid chromatography–high resolution mass spectrometry. J Anhui Univ Chin Med 37:55–9.
  • Jiang P, Zhang XW, Huang YT, et al. (2017). Hepatotoxicity induced by Sophora flavescens and hepatic accumulation of kurarinone, a major hepatotoxic constituent of Sophora flavescens in rats. Molecules 22.
  • Kakisaka K, Cazanave SC, Fingas CD, et al. (2012). Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis. Am J Physiol Gastrointest Liver Physiol 302:G77–G84.
  • Liu D, Chan BC, Cheng L, et al. (2018). Sophora flavescens protects against mycobacterial trehalose dimycolate-induced lung granuloma by inhibiting inflammation and infiltration of macrophages. Sci Rep 8:3903.
  • Ma H, Huang Q, Qu W, et al. (2018). In vivo and in vitro anti-inflammatory effects of Sophora flavescens residues. J Ethnopharmacol 224:497–503.
  • Pekkinen J, Olli K, Huotari A, et al. (2013). Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high-fat diet as studied by nontargeted LC–MS metabolomics approach. Mol Nutr Food Res 57:1959–68.
  • Schooneman MG, Vaz FM, Houten SM, et al. (2013). Acylcarnitines: reflecting or inflicting insulin resistance? Diabetes 62:1–8.
  • Shi LJ, Shi L, Song GY, et al. (2013). Oxymatrine attenuates hepatic steatosis in non-alcoholic fatty liver disease rats fed with high fructose diet through inhibition of sterol regulatory element binding transcription factor 1 (Srebf1) and activation of peroxisome proliferator activated receptor alpha (Pparalpha). Eur J Pharmacol 714:89–95.
  • Snyder NW, Khezam M, Mesaros CA, et al. (2013). Untargeted metabolomics from biological sources using ultraperformance liquid chromatography–high resolution mass spectrometry (UPLC–HRMS). J Vis Exp 75:e50433.
  • Tai WP, Yue H, Zhai HZ. (2010). Zhixue capsule caused seven cases of drug induced hepatitis. Hepatogastroenterology 57:571–2.
  • Wagner S, Scholz K, Sieber M, et al. (2007). Tools in metabonomics: an integrated validation approach for LC–MS metabolic profiling of mercapturic acids in human urine. Anal Chem 79:2918–26.
  • Wang Y, Aoki H, Yang J, et al. (2017). The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice. Hepatology 65:2005–18.
  • Wang X, Zheng R, Huang X, et al. (2018). Effects of alkaloids from Sophora flavescens on osteoblasts infected with Staphylococcus aureus and osteoclasts. Phytother Res 32:1354–63.
  • Yamazaki M, Miyake M, Sato H, et al. (2013). Perturbation of bile acid homeostasis is an early pathogenesis event of drug induced liver injury in rats. Toxicol Appl Pharmacol 268:79–89.
  • Yang JM, Ip SP, Xian Y, et al. (2012). Impact of the herbal medicine Sophora flavescens on the oral pharmacokinetics of indinavir in rats: the involvement of CYP3A and P-glycoprotein. PLoS One 7:e31312.
  • Yu QQ, Cheng NN, Ni XJ. (2013). Identifying 2 prenylflavanones as potential hepatotoxic compounds in the ethanol extract of Sophora flavescens. J Food Sci 78:T1830–T1834.
  • Zhang YB, Luo D, Yang L, et al. (2018). Matrine-type alkaloids from the roots of Sophora flavescens and their antiviral activities against the hepatitis B virus. J Nat Prod 81:2259–26.
  • Zhang CE, Niu M, Li Q, et al. (2016). Urine metabolomics study on the liver injury in rats induced by raw and processed Polygonum multiflorum integrated with pattern recognition and pathways analysis. J Ethnopharmacol 194:299–306.
  • Zhang A, Sun H, Wang Z, et al. (2010). Metabolomics: towards understanding traditional Chinese medicine. Planta Med 76:2026–35.

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