Twenty years of metabonomics: so what has metabonomics done for toxicology?

References

• Ament Z, Waterman CL, West JA, et al. (2013). A metabolomics investigation of non-genotoxic carcinogenicity in the rat. J Proteome Res. 12:5775–90.
   PubMed Web of Science ®Google Scholar
• Bando K, Kunimatsu T, Sakai J, et al. (2011). GC-MS-based metabolomics reveals mechanism of action for hydrazine induced hepatotoxicity in rats. J Appl Toxicol 31:524–35.
   PubMed Web of Science ®Google Scholar
• Barupal DK, Fiehn O. (2019). Generating the blood exposome database using a comprehensive text mining and database fusion approach. Environ Health Persp 127:097008.
   PubMed Web of Science ®Google Scholar
• Bollard ME, Stanley EG, Lindon JC, et al. (2005). NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition. NMR Biomed 18:143–62.
   PubMed Web of Science ®Google Scholar
• Buesen R, Chorley BN, DA Silva Lima B, et al. (2017). Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop. Regul Toxicol Pharmacol 91:S3–S13.
   PubMed Web of Science ®Google Scholar
• Chong J, Soufan O, Li C, et al. (2018). MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis. Nucleic Acids Res 46:W486–W494.
   PubMed Web of Science ®Google Scholar
• Clayton TA, Baker D, Lindon JC, et al. (2009). Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proc Natl Acad Sci U S A 106:14728–33.
   PubMed Web of Science ®Google Scholar
• Coen M, Ruepp SU, Lindon JC, et al. (2004). Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse. J Pharm Biomed Anal 35:93–105.
   PubMed Web of Science ®Google Scholar
• Cottret L, Frainay C, Chazalviel M, et al. (2018). MetExplore: collaborative edition and exploration of metabolic networks. Nucleic Acids Res 46:W495–W502.
   PubMed Web of Science ®Google Scholar
• Ebbels TM, Keun HC, Beckonert OP, et al. (2007). Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach. J Proteome Res 6:4407–22.
   PubMed Web of Science ®Google Scholar
• Elbadawi-Sidhu M, Baillie RA, Zhu H, et al. (2017). Pharmacometabolomic signature links simvastatin therapy and insulin resistance. Metabolomics 13:pii:11.
   Google Scholar
• Eliasson M, Rännar S, Trygg J. (2011). From data processing to multivariate validation–essential steps in extracting interpretable information from metabolomics data. Curr Pharm Biotechnol 12:996–1004.
   PubMed Web of Science ®Google Scholar
• Ellis JK, Athersuch TJ, Thomas LD, et al. (2012). Metabolic profiling detects early effects of environmental and lifestyle exposure to cadmium in a human population. BMC Med 10:61.
   PubMed Web of Science ®Google Scholar
• Everett JR. (2015). Pharmacometabonomics in humans: a new tool for personalized medicine. Pharmacogenomics 16:737–54.
   PubMed Web of Science ®Google Scholar
• Garrod S, Humpher E, Connor SC, et al. (2001). High-resolution (1)H NMR and magic angle spinning NMR spectroscopic investigation of the biochemical effects of 2-bromoethanamine in intact renal and hepatic tissue. Magn Reson Med 45:781–90.
   PubMed Web of Science ®Google Scholar
• Gavaghan CL, Holmes E, Lenz E, et al. (2000). An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse. FEBS Lett 484:169–74.
   PubMed Web of Science ®Google Scholar
• Heffernan AL, Gómez-Ramos MM, Gaus C, et al. (2017). Non-targeted, high resolution mass spectrometry strategy for simultaneous monitoring of xenobiotics and endogenous compounds in green sea turtles on the Great Barrier Reef. Sci Total Environ 599-600:1251–62.
   PubMed Web of Science ®Google Scholar
• Holmes E, Loo RL, Stamler J, et al. (2008). Human metabolic phenotype diversity and its association with diet and blood pressure. Nature 453:396–400.
   PubMed Web of Science ®Google Scholar
• Huang Q, Aa J, Jia H, et al. (2015). A pharmacometabonomic approach to predicting metabolic phenotypes and pharmacokinetic parameters of atorvastatin in healthy volunteers. J Proteome Res 14:3970–81.
   PubMed Web of Science ®Google Scholar
• Lee J, Yoon SH, Yi S, et al. (2019). Quantitative prediction of hepatic CYP3A activity using endogenous markers in healthy subjects after administration of CYP3A inhibitors or inducers. Drug Metab Pharmacokinet 34:247–52.
   PubMed Web of Science ®Google Scholar
• Lewis GD, Wei R, Liu E, et al. (2008). Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury. J Clin Invest 118:(10):3503–12.
   PubMed Web of Science ®Google Scholar
• Li S, Cirillo P, Hu X, et al. (2019). Understanding mixed environmental exposures using metabolomics via a hierarchical community network model in a cohort of California women in 1960's. Reprod Toxicol pii:30603–8.
   Google Scholar
• Lindon JC, Keun HC, Ebbels TM, et al. (2005). The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements. Pharmacogenomics 6:691–9.
   PubMed Web of Science ®Google Scholar
• Lindon JC, Nicholson JK, Holmes E, et al. (2003). Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project. Toxicol Appl Pharmacol 187:137–46.
   PubMed Web of Science ®Google Scholar
• Nicholson JK, Lindon JC, Holmes E. (1999). Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29:1181–9.
   PubMed Web of Science ®Google Scholar
• Plumb RS, Stumpf CL, Gorenstein MV, et al. (2002). Metabonomics: the use of electrospray mass spectrometry coupled to reversed-phase liquid chromatography shows potential for the screening of rat urine in drug development. Rapid Commun Mass Spectrom 16:1991–6.
   PubMed Web of Science ®Google Scholar
• Rappaport SM. (2012). Biomarkers intersect with the exposome. Biomarkers 17:483–9.
   PubMed Web of Science ®Google Scholar
• Southam AD, Lange A, Al-Salhi R, et al. (2014). Distinguishing between the metabolome and xenobiotic exposome in environmental field samples analysed by direct-infusion mass spectrometry based metabolomics and lipidomics. Metabolomics 10:1050–8.
   PubMed Web of Science ®Google Scholar
• Warth B, Spangler S, Fang M, et al. (2017). Exposome-scale investigations guided by global metabolomics, pathway analysis, and cognitive computing. Anal Chem 89:11505–13.
   PubMed Web of Science ®Google Scholar
• Watanabe T, Suzuki T, Natsume M, et al. (2012). Discrimination of genotoxic and non-genotoxic hepatocarcinogens by statistical analysis based on gene expression profiling in the mouse liver as determined by quantitative real-time PCR. Mutat Res 747:164–75.
   PubMed Web of Science ®Google Scholar
• Waterman CL, Currie RA, Cottrell LA, et al. (2010). An integrated functional genomic study of acute phenobarbital exposure in the rat. BMC Genomics 11:9.
   PubMed Web of Science ®Google Scholar
• Waters NJ, Holmes E, Williams A, et al. (2001). NMR and pattern recognition studies on the time-related metabolic effects of alpha-naphthylisothiocyanate on liver, urine, and plasma in the rat: an integrative metabonomic approach. Chem Res Toxicol 14:1401–12.
   PubMed Web of Science ®Google Scholar
• Waters NJ, Waterfield CJ, Farrant RD, et al. (2005). Metabonomic deconvolution of embedded toxicity: application to thioacetamide hepato- and nephrotoxicity. Chem Res Toxicol 18:639–54.
   PubMed Web of Science ®Google Scholar
• Yip LY, Aw CC, Lee SH, et al. (2018). The liver-gut microbiota axis modulates hepatotoxicity of tacrine in the rat. Hepatology 67:282–95.
   PubMed Web of Science ®Google Scholar
• Zhang L, Nichols RG, Correll J, et al. (2015). Persistent organic pollutants modify gut microbiota-host metabolic homeostasis in mice through aryl hydrocarbon receptor activation. Environ Health Persp 123:679–88.
   PubMed Web of Science ®Google Scholar
• Zhou J, Tang L, Wang JS. (2019). Assessment of the adverse impacts of aflatoxin B1 on gut-microbiota dependent metabolism in F344 rats. Chemosphere 217:618–28.
   PubMed Web of Science ®Google Scholar