References
- Agola JO, Jim PA, Ward HH, et al. (2011). Rab GTPases as regulators of endocytosis, targets of disease and therapeutic opportunities. Clin Genet 80:305–18.
- Allen JD, van Loevezijn A, Lakhai JM, et al. (2002). Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C. Mol Cancer Ther 1:417–25.
- Chavrier P, Parton RG, Hauri HP, et al. (1990). Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments. Cell 62:317–29.
- Diestra JE, Scheffer GL, Catala I, et al. (2002). Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin-embedded material. J Pathol 198:213–9.
- Doyle LA, Yang W, Abruzzo LV, et al. (1998). A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci USA 95:15665–70.
- Ferrandiz-Huertas C, Fernandez-Carvajal A, Ferrer-Montiel A. (2011). Rab4 interacts with the human P-glycoprotein and modulates its surface expression in multidrug resistant K562 cells. Int J Cancer 128:192–205.
- Fu D. (2013). Where is it and how does it get there – intracellular localization and traffic of P-glycoprotein. Front Oncol 3:321.
- Fu D, van Dam EM, Brymora A, et al. (2007). The small GTPases Rab5 and RalA regulate intracellular traffic of P-glycoprotein. Biochim Biophys Acta 1773:1062–72.
- Kim H, Barroso M, Samanta R, et al. (1997). Experimentally induced changes in the endocytic traffic of P-glycoprotein alter drug resistance of cancer cells. Am J Physiol 273:C687–702.
- Liang SC, Yang CY, Tseng JY, Wang HL, et al. (2015). ABCG2 localizes to the nucleus and modulates CDH1 expression in lung cancer cells. Neoplasia 17:265–78.
- Litman T, Brangi M, Hudson E, et al. (2000). The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2). J Cell Sci 113:2011–21.
- Mellman I, Warren G. (2000). The road taken: past and future foundations of membrane traffic. Cell 100:99–112.
- Miyake K, Mickley L, Litman T, et al. (1999). Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes. Cancer Res 59:8–13.
- Orban TI, Seres L, Ozvegy-Laczka C, et al. (2008). Combined localization and real-time functional studies using a GFP-tagged ABCG2 multidrug transporter. Biochem Biophys Res Commun 367:667–73.
- Pellinen T, Arjonen A, Vuoriluoto K, et al. (2006). Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins. J Cell Biol 173:767–80.
- Robey RW, Ierano C, Zhan Z, Bates SE. (2011). The challenge of exploiting ABCG2 in the clinic. Curr Pharm Biotechnol 12:595–608.
- Rocchi E, Khodjakov A, Volk EL, et al. (2000). The product of the ABC half-transporter gene ABCG2 (BCRP/MXR/ABCP) is expressed in the plasma membrane. Biochem Biophys Res Commun 271:42–6.
- Roosterman D, Schmidlin F, Bunnett NW. (2003). Rab5a and rab11a mediate agonist-induced trafficking of protease-activated receptor 2. Am J Physiol Cell Physiol 284:C1319–29.
- Ross DD, Karp JE, Chen TT, Doyle LA. (2000). Expression of breast cancer resistance protein in blast cells from patients with acute leukemia. Blood 96:365–8.
- Rothman JE, Wieland FT. (1996). Protein sorting by transport vesicles. Science 272:227–34.
- Shen F, Chu S, Bence AK, et al. (2008). Quantitation of doxorubicin uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells. J Pharmacol Exp Ther 324:95–102.
- Simpson JC, Griffiths G, Wessling-Resnick M, et al. (2004). A role for the small GTPase Rab21 in the early endocytic pathway. J Cell Sci 117:6297–311.
- Srikanth S, Woo JS, Gwack Y. (2017). A large Rab GTPase family in a small GTPase world. Small GTPases 8:43–8.
- Studzian M, Bartosz G, Pulaski L. (2015). Endocytosis of ABCG2 drug transporter caused by binding of 5D3 antibody: trafficking mechanisms and intracellular fate. Biochim Biophys Acta 1853:1759–71.
- Sun Q, Westphal W, Wong KN, et al. (2010). Rubicon controls endosome maturation as a Rab7 effector. Proc Natl Acad Sci USA 107:19338–43.
- Taylor NMI, Manolaridis I, Jackson SM, et al. (2017). Structure of the human multidrug transporter ABCG2. Nature 546:504–9.
- Westover D, Li F. (2015). New trends for overcoming ABCG2/BCRP-mediated resistance to cancer therapies. J Exp Clin Cancer Res 34:159.
- Yang X, Zhang Y, Li S, et al. (2012). Rab21 attenuates EGF-mediated MAPK signaling through enhancing EGFR internalization and degradation. Biochem Biophys Res Commun 421:651–7.
- Yu M, Ocana A, Tannock IF. (2013). Reversal of ATP-binding cassette drug transporter activity to modulate chemoresistance: why has it failed to provide clinical benefit? Cancer Metastasis Rev 32:211–27.
- Zeng H, Park JW, Guo M, et al. (2009). Lack of ABCG2 expression and side population properties in humanpluripotent stem cells. Stem Cells 27:2435–45.