Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 50, 2020 - Issue 10
275
Views
2
CrossRef citations to date
0
Altmetric
Xenobiotic transporters

Is aspirin a substrate of MDR1/P-glycoprotein?

ORCID Icon, , , , , & show all
Pages 1258-1264 | Received 13 Mar 2020, Accepted 15 Apr 2020, Published online: 29 Apr 2020

References

  • Bakar SK, Niazi S. (1983). Stability of aspirin in different media. J Pharm Sci 72:1024–6.
  • Choo EF, Leake B, Wandel C, et al. (2000). Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug Metab Dispos 28:655–60.
  • Crowe A, Wright C. (2012). The impact of P-glycoprotein mediated efflux on absorption of 11 sedating and less-sedating antihistamines using Caco-2 monolayers. Xenobiotica 42:538–49.
  • Desborough MJR, Keeling DM. (2017). The aspirin story – from willow to wonder drug. Br J Haematol 177:674–83.
  • Didziapetris R, Japertas P, Avdeef A, Petrauskas A. (2003). Classification analysis of P-glycoprotein substrate specificity. J Drug Target 11:391–406.
  • Fromm MF, Kim RB, Stein CM, et al. (1999). Inhibition of P-glycoprotein-mediated drug transport: a unifying mechanism to explain the interaction between digoxin and quinidine. Circulation 99:552–7.
  • Gault H, Longerich L, Dawe M, Fine A. (1984). Digoxin–rifampin interaction. Clin Pharmacol Ther 35:750–4.
  • Giacomini KM, Huang SM, Tweedie DJ, et al. (2010). Membrane transporters in drug development. Nat Rev Drug Discov 9:215–36.
  • Glaeser H. (2011). Importance of P-glycoprotein for drug–drug interactions. Handb Exp Pharmacol 201:285–97.
  • Hamman MA, Bruce MA, Haehner-Daniels BD, Hall SD. (2001). The effect of rifampin administration on the disposition of fexofenadine. Clin Pharmacol Ther 69:114–21.
  • Hidalgo IJ, Raub TJ, Borchardt RT. (1989). Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 96:736–49.
  • Ittaman SV, VanWormer JJ, Rezkalla SH. (2014). The role of aspirin in the prevention of cardiovascular disease. Clin Med Res 12:147–54.
  • Kato H, Yoshimoto K, Kobayashi M, et al. (2010). Oral administration of ethanol with aspirin increases the concentration of salicylic acid in plasma and organs, especially the brain, in mice. Eur J Pharmacol 635:184–7.
  • Kugai M, Uchiyama K, Tsuji T, et al. (2013). MDR1 is related to intestinal epithelial injury induced by acetylsalicylic acid. Cell Physiol Biochem 32:942–50.
  • Nalamachu S, Joseph V, Pergolizzi JV, Raffa RB, et al. (2014). Drug–drug interaction between NSAIDS and low-dose aspirin: a focus on cardiovascular and GI toxicity. Expert Opin Drug Saf 13:903–17.
  • Peng L-l, Zhao Y-Q, Zhou Z-Y, et al. (2016). Associations of MDR1, TBXA2R, PLA2G7, and PEAR1 genetic polymorphisms with the platelet activity in Chinese ischemic stroke patients receiving aspirin therapy. Acta Pharmacol Sin 37:1442–8.
  • Pergolizzi JV, Jr, Labhsetwar SA, Puenpatom RA, et al. (2012a). Economic impact of potential CYP450 pharmacokinetic drug–drug interactions among chronic low back pain patients taking opioids. Pain Pract 12:45–56.
  • Pergolizzi JV, Jr, Labhsetwar SA, Puenpatom RA, et al. (2012b). Economic impact of potential drug–drug interactions among osteoarthritis patients taking opioids. Pain Pract 12:33–44.
  • Pergolizzi JV, Jr, Labhsetwar SA, Puenpatom RA, et al. (2011). Exposure to potential CYP450 pharmacokinetic drug–drug interactions among osteoarthritis patients: incremental risk of multiple prescriptions. Pain Pract 11:325–36.
  • Rautio J, Humphreys JE, Webster LO, et al. (2006). In vitro P-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates. Drug Metabol Dispos 34:786–92.
  • Shirasaka Y, Li Y, Shibue Y, et al. (2009). Concentration-dependent effect of naringin on intestinal absorption of beta(1)-adrenoceptor antagonist talinolol mediated by P-glycoprotein and organic anion transporting polypeptide (Oatp). Pharm Res 26:560–7.
  • Skibinski R, Komsta L. (2016). The stability and degradation kinetics of acetylsalicylic acid in different organic solutions revisited – an UHPLC–ESI-QTOF spectrometry study. Curr Issues Pharm Med Sci 29:39–41.
  • Staud F, Ceckova M, Micuda S, Pavek P. (2010). Expression and function of P-glycoprotein in normal tissues: effect on pharmacokinetics. Methods Mol Biol 596:199–222.
  • Sun Z, Wu Y, Yang B, et al. (2018). Inhibitory influence of Panax notoginseng saponins on aspirin hydrolysis in human intestinal caco-2 cells. Molecules 23:455.
  • Wang Z-Y, Chen M, Zhu L-L, et al. (2015). Pharmacokinetic drug interactions with clopidogrel: updated review and risk management in combination therapy. Ther Clin Risk Manage 11:449–67.
  • Wang C, Wang C, Liu Q, et al. (2014). Aspirin and probenecid inhibit organic anion transporter 3-mediated renal uptake of cilostazol and probenecid induces metabolism of cilostazol in the rat. Drug Metab Dispos 42:996–1007.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.