Proteomic characterisation of drug metabolising enzymes and drug transporters in pig liver

References

• Achour B, Barber J. (2013). The activities of Achromobacter lysyl endopeptidase and Lysobacter lysyl endoproteinase as digestive enzymes for quantitative proteomics. Rapid Commun Mass Spectrom 27:1669–72.
   PubMed Web of Science ®Google Scholar
• Achour B, Barber J, Rostami-Hodjegan A. (2011). Cytochrome P450 pig liver pie: determination of individual cytochrome P450 isoform contents in microsomes from two pig livers using liquid chromatography in conjunction with mass spectrometry. Drug Metab Dispos 39:2130–4.
   PubMed Web of Science ®Google Scholar
• Achour B, Barber J, Rostami-Hodjegan A. (2014a). Expression of hepatic drug-metabolizing cytochrome p450 enzymes and their intercorrelations: a meta-analysis. Drug Metab Dispos 42:1349–56.
   PubMed Web of Science ®Google Scholar
• Achour B, Rostami-Hodjegan A, Barber J. (2014b). Protein expression of various hepatic uridine 5′‐diphosphate glucuronosyltransferase (UGT) enzymes and their inter‐correlations: a meta‐analysis. Biopharm Drug Dispos 35:353–61.
   PubMed Web of Science ®Google Scholar
• Achour B, Russell MR, Barber J, Rostami-Hodjegan A. (2014c). Simultaneous quantification of the abundance of several cytochrome P450 and uridine 5′-diphospho-glucuronosyltransferase enzymes in human liver microsomes using multiplexed targeted proteomics. Drug Metab Dispos 42:500–10.
   PubMed Web of Science ®Google Scholar
• Al Feteisi H, Achour B, Rostami-Hodjegan A, Barber J. (2015). Translational value of liquid chromatography coupled with tandem mass spectrometry-based quantitative proteomics for in vitro – in vivo extrapolation of drug metabolism and transport and considerations in selecting appropriate techniques. Expert Opin Drug Metab Toxicol 11:1357–69.
   PubMed Web of Science ®Google Scholar
• Anzenbacher P, Anzenbacherová E, Gut I, et al. (1998). Presence and activity of cytochrome P450 isoforms in minipig liver microsomes. Comparison with human liver samples. Drug Metab Dispos 26:56–9.
   PubMed Web of Science ®Google Scholar
• Barter Z, Bayliss MK, Beaune PH, et al. (2007). Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: Reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver. Curr Drug Metab 8: 33–45.
   PubMed Web of Science ®Google Scholar
• Burt HJ, Riedmaier AE, Harwood MD, et al. (2016). Abundance of hepatic transporters in Caucasians: a meta-analysis. Drug Metab Dispos 44:1550–61.
   PubMed Web of Science ®Google Scholar
• Chang Q, Wang W, Regev-Yochay G, et al. (2015). Antibiotics in agriculture and the risk to human health: How worried should we be?. Evol Appl 8:240–7.
   PubMed Web of Science ®Google Scholar
• Colleton C, Brewster D, Chester A, et al. (2016). The use of minipigs for preclinical safety assessment by the pharmaceutical industry. Toxicol Pathol 44:458–66.
   PubMed Web of Science ®Google Scholar
• Couto N, Al-Majdoub ZM, Achour B, et al. (2019). Quantification of proteins involved in drug metabolism and disposition in the human liver using label-free global proteomics. Mol Pharm 16:632–47.
   PubMed Web of Science ®Google Scholar
• Erde J, Loo RRO, Loo JA. (2014). Enhanced FASP (eFASP) to increase proteome coverage and sample recovery for quantitative proteomic experiments. J Proteome Res 13:1885–95.
   PubMed Web of Science ®Google Scholar
• Forster R, Bode G, Ellegaard L, van der Laan J-W. (2010). The RETHINK project on minipigs in the toxicity testing of new medicines and chemicals: Conclusions and recommendations. J Pharmacol Toxicol Methods 62:236–42.
   PubMed Web of Science ®Google Scholar
• Gonzalez FJ. (2002). Transgenic models in xenobiotic metabolism and toxicology. Toxicology 181-182:237–9.
   PubMed Web of Science ®Google Scholar
• Groenen MAM, Archibald AL, Uenishi H, et al. (2012). Analyses of pig genomes provide insight into porcine demography and evolution. Nature 491:393–8.
   PubMed Web of Science ®Google Scholar
• Guillemette C, Levesque E, Rouleau M. (2014). Pharmacogenomics of human uridine diphospho-glucuronosyltransferases and clinical implications. Clin Pharmacol Ther 96:324–39.
   PubMed Web of Science ®Google Scholar
• Harwood MD, Achour B, Russell MR, et al. (2015). Application of an LC-MS/MS method for the simultaneous quantification of human intestinal transporter proteins absolute abundance using a QconCAT technique. J Pharm Biomed Anal 110:27–33.
   PubMed Web of Science ®Google Scholar
• Harwood MD, Russell MR, Neuhoff S, et al. (2014). Lost in centrifugation! Accounting for transporter protein losses in quantitative targeted absolute proteomics. Drug Metab Dispos 42:1766–72.
   PubMed Web of Science ®Google Scholar
• Heikkinen AT, Lignet F, Cutler P, Parrott N. (2015). The role of quantitative ADME proteomics to support construction of physiologically based pharmacokinetic models for use in small molecule drug development. Proteomics Clin Appl 9:732–44.
   PubMed Web of Science ®Google Scholar
• Helke KL, Swindle MM. (2013). Animal models of toxicology testing: the role of pigs. Expert Opin Drug Metab Toxicol 9:127–39.
   PubMed Web of Science ®Google Scholar
• Ishihama Y, Oda Y, Tabata T, et al. (2005). Exponentially modified protein abundance index (emPAI) for estimation of absolute protein amount in proteomics by the number of sequenced peptides per protein. Mol Cell Proteomics 4:1265–72.
   PubMed Web of Science ®Google Scholar
• Langenfeld E, Zanger UM, Jung K, et al. (2009). Mass spectrometry-based absolute quantification of microsomal cytochrome P450 2D6 in human liver. Proteomics 9:2313–23.
   PubMed Web of Science ®Google Scholar
• Lunney JK. (2007). Advances in swine biomedical model genomics. Int J Biol Sci 3:179–84.
   PubMed Web of Science ®Google Scholar
• Michaels S, Wang MZ. (2014). The revised human liver cytochrome P450 “pie”: absolute protein quantification of CYP4F and CYP3A enzymes using targeted quantitative proteomics. Drug Metab Dispos 42:1241–51.
   PubMed Web of Science ®Google Scholar
• Millecam J, De Clerck L, Govaert E, et al. (2018). The ontogeny of cytochrome P450 enzyme activity and protein abundance in conventional pigs in support of preclinical pediatric drug research. Front Pharmacol 9:470.
   PubMed Web of Science ®Google Scholar
• Needleman SB, Wunsch CD. (1970). A general method applicable to search for similarities in amino acid sequence of two proteins. J Mol Biol 48:443–53.
   PubMed Web of Science ®Google Scholar
• Prasad B, Achour B, Artursson P, et al. (2019). Toward a consensus on applying quantitative liquid chromatography‐tandem mass spectrometry proteomics in translational pharmacology research: a white paper. Clin Pharmacol Ther 106:525–43.
   PubMed Web of Science ®Google Scholar
• Rasmussen MK, Scavenius C, Gerbal-Chaloin S, Enghild J. (2019). Sex dictates the constitutive expression of hepatic cytochrome P450 isoforms in Gottingen minipigs. Toxicol Lett 314:181–6.
   PubMed Web of Science ®Google Scholar
• Suenderhauf C, Parrott N. (2013). A physiologically based pharmacokinetic model of the minipig: data compilation and model implementation. Pharm Res 30:1–15.
   PubMed Web of Science ®Google Scholar
• Wiśniewski JR. (2016). Quantitative evaluation of filter aided sample preparation (FASP) and multienzyme digestion FASP protocols. Anal Chem 88:5438–43.
   PubMed Web of Science ®Google Scholar
• Wiśniewski JR, Zougman A, Nagaraj N, Mann M. (2009). Universal sample preparation method for proteome analysis. Nat Methods 6:359–62.
   PubMed Web of Science ®Google Scholar