Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 50, 2020 - Issue 11
124
Views
6
CrossRef citations to date
0
Altmetric
Animal Pharmacokinetics and Metabolism

In vivo pharmacokinetics, distribution, and excretion of an anticancer agent isolated from red ginseng, in rat

, , , &
Pages 1323-1331 | Received 14 Mar 2020, Accepted 02 May 2020, Published online: 14 May 2020

References

  • Baek KS, Yi YS, Son YJ, et al. (2017). Comparison of anticancer activities of Korean red ginseng-derived fractions. J Ginseng Res 41:386–91.
  • Chen XJ, Zhang XJ, Shui YM, et al. (2016). Anticancer activities of protopanaxadiol- and protopanaxatriol-type ginsenosides and their metabolites. Evid Based Complementary Alternative Med 2016:5738694.
  • Cook D, Brown D, Alexander R, et al. (2014). Lessons learned from the fate of AstraZeneca’s drug pipeline: a five-dimensional framework. Nat Rev Drug Disc 13:419–31.
  • Di L, Feng B, Goosen TC, et al. (2013). A perspective on the prediction of drug pharmacokinetics and disposition in drug research and development. Drug Metabolism Disposition 41:1975–93.
  • Endo H, Yoshida H, Hasegawa M, et al. (2001). Stereoselectivity and species difference in plasma protein binding of KE-298 and its metabolites. Biol Pharmac Bull 24:800–5.
  • Gao H, Li Z, Li P, et al. (2013). Determination of pseudoginsengenin DQ in rat plasma by UPLC-MS/MS and application of the method in a pharmacokinetic study. J Chromatography B 933:1–7.
  • Gu Y, Wang G, Sun J, et al. (2006). In vitro assessment of plasma protein binding of 20(R)-ginsenoside Rh2 by equilibrium dialysis and LC-MS analysis: a case of species differences. Biol Pharmac Bull 29:951–6.
  • Gu Y, Wang GJ, Sun JG, et al. (2009). Pharmacokinetic characterization of ginsenoside Rh2, an anticancer nutrient from ginseng, in rats and dogs. Food Chem Toxicol 47:2257–68.
  • Han M, Chen J, Wang Y, et al. (2013). Determination of 20(S)-protopanaxadiol in rat plasma by LC-MS/MS and its application to the pharmacokinetic study: a comparative study of its solution and two oral formulations. J Anal Chem 68:730–5.
  • Hasegawa H, Lee KS, Nagaoka T, et al. (2000). Pharmacokinetics of ginsenoside deglycosylated by intestinal bacteria and its transformation to. Biol Active Fatty Acid Esters Biol Pharmac Bull 23:298–304.
  • Howard M, Hill J, Galluppi G, McLean M. (2010). Plasma protein binding in drug discovery and development. Combinatorial Chem High Throughput Screen 13:170–87.
  • Lin M, Gao H, Liu J, et al. (2013). UPLC-MS/MS determination and pharmacokinetic study of 26-OH-panaxadiol in rat plasma. Anal Methods 5:6656–62.
  • Meng X, Jiang J, Pan H, et al. (2019). Preclinical absorption, distribution, metabolism, and excretion of sodium danshensu, one of the main water-soluble ingredients in salvia miltiorrhiza, in rats. Front Pharmacol 10:554.
  • Paek IB, Moon Y, Kim J, et al. (2006). Pharmacokinetics of a ginseng saponin metabolite compound K in rats. Biopharmac Drug Dispos 27:39–45.
  • Riccardi K, Cawley S, Yates PD, et al. (2015). Plasma protein binding of challenging compounds. J Pharmac Sci 104:2627–36.
  • Smith DA, Di L, Kerns EH. (2010). The effect of plasma protein binding on in vivo efficacy: Misconceptions in drug discovery. Nat Rev Drug Disc 9:929–39.
  • So SH, Lee JW, Kim YS, et al. (2018). Red ginseng monograph. J Ginseng Res 42:549–61.
  • Wang CZ, Anderson S, Du W, et al. (2016). Red ginseng and cancer treatment. Chin J Natural Med 14:7–16.
  • Wang W, Rayburn ER, Hang J, et al. (2009). Anti-lung cancer effects of novel ginsenoside 25-OCH3-PPD. Lung Cancer 65:306–11.
  • Yu H, Teng L, Meng Q, et al. (2013). Development of liposomal ginsenoside Rg3: Formulation optimization and evaluation of its anticancer effects. Inter J Pharmac 450:250–8.
  • Zare-Zardini H, Taheri-Kafrani A, Amiri A, Bordbar AK. (2018). New generation of drug delivery systems based on ginsenoside Rh2-, Lysine- and Arginine-treated highly porous graphene for improving anticancer activity. Sci Rep 8:586.
  • Zhang S, Liu J, Ge B, et al. (2017). Enhanced antitumor activity in A431 cells via encapsulation of 20(R)-ginsenoside Rg3 in PLGA nanoparticles. Drug Devel Industrial Pharmacy 43:1734–41.
  • Zheng Q, Li Z, Liu J, et al. (2016). Two new dammarane-type triterpene sapogenins from Chinese red ginseng. Nat Product Res 30:95–9.
  • Zheng Q, Wang ZH, Qi Z, Li PY. (2019). Anticancer effect and molecular docking mechanism of 24-OH-panaxadiol. Chin J Exp Formulas Chinese Med 25:89–96.
  • Zheng X, Huang XT, Li N, et al. (2012). Determination of geniposidic acid in rat plasma by LC-MS/MS and its application to in vivo pharmacokinetic studies. J Chromatogr B 887-888:138–42.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.