Inhibitory effect of sixteen pharmaceutical excipients on six major organic cation and anion uptake transporters

References

• Apiwattanakul N, Sekine T, Chairoungdua A, et al. (1999). Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol 55:847–54.
   PubMed Web of Science ®Google Scholar
• Azmin MN, Stuart JF, Florence AT. (1985). The distribution and elimination of methotrexate in mouse blood and brain after concurrent administration of polysorbate 80. Cancer Chemother Pharmacol 14:238–42.
   PubMed Web of Science ®Google Scholar
• Better OS, Rubinstein I, Winaver JM, Knochel JP. (1997). Mannitol therapy revisited (1940–1997). Kidney Int 52:886–94.
   PubMed Web of Science ®Google Scholar
• Burckhardt BC, Brai S, Wallis S, et al. (2003). Transport of cimetidine by flounder and human renal organic anion transporter 1. Am J Physiol Renal Physiol 284:503–9.
   Web of Science ®Google Scholar
• Dintaman JM, Silverman JA. (1999). Inhibition of P-glycoprotein by D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS). Pharm Res 16:1550–6.
   PubMed Web of Science ®Google Scholar
• Eckhardt U, Schroeder A, Stieger B, et al. (1999). Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells. Am J Physiol 276:1037–42.
   PubMed Web of Science ®Google Scholar
• Fromm MF, Kim RB. (2011). Drug transporters. Berlin: Springer.
   Google Scholar
• Goole J, Lindley DJ, Roth W, et al. (2010). The effects of excipients on transporter mediated absorption. Int J Pharm 393:17–31.
   PubMed Web of Science ®Google Scholar
• Gui C, Obaidat A, Chaguturu R, Hagenbuch B. (2010). Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3. Curr Chem Genomics 4:1–8.
   PubMedGoogle Scholar
• Gurjar R, Chan CYS, Curley P, et al. (2018). Inhibitory effects of commonly used excipients on P-glycoprotein in vitro. Mol Pharm 15:4835–42.
   PubMedGoogle Scholar
• Hamman J, Steenekamp J. (2012). Excipients with specialized functions for effective drug delivery. Expert Opin Drug Deliv 9:219–30.
   PubMed Web of Science ®Google Scholar
• Hanke U, May K, Rozehnal V, et al. (2010). Commonly used nonionic surfactants interact differently with the human efflux transporters ABCB1 (p-glycoprotein) and ABCC2 (MRP2). Eur J Pharm Biopharm 76:260–8.
   PubMed Web of Science ®Google Scholar
• Hasannejad H, Takeda M, Taki K, et al. (2004). Interactions of human organic anion transporters with diuretics. J Pharmacol Exp Ther 308:1021–9.
   PubMed Web of Science ®Google Scholar
• Hirano M, Maeda K, Shitara Y, Sugiyama Y. (2004). Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. J Pharmacol Exp Ther 311:139–46.
   PubMed Web of Science ®Google Scholar
• Iwaki M, Shimada H, Irino Y, et al. (2017). Inhibition of methotrexate uptake via organic anion transporters OAT1 and OAT3 by glucuronides of nonsteroidal anti-inflammatory drugs. Biol Pharm Bull 40:926–31.
   PubMed Web of Science ®Google Scholar
• Jones MN. (1999). Surfactants in membrane solubilisation. Int J Pharm 177:137–59.
   PubMed Web of Science ®Google Scholar
• Kalász H, Antal I. (2006). Drug excipients. Curr Med Chem 13:2535–63.
   PubMed Web of Science ®Google Scholar
• Katz DA, Carr R, Grimm DR, et al. (2006). Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics. Clin Pharmacol Ther 79:186–96.
   PubMed Web of Science ®Google Scholar
• Koley D, Bard AG. (2010). Triton X-100 concentration effects on membrane permeability of a single HeLa cell by scanning electrochemical microscopy (SECM). Proc Natl Acad Sci USA 107:16783–7.
   PubMed Web of Science ®Google Scholar
• Kopplow K, Letschert K, König J, et al. (2005). Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells. Mol Pharmacol 68:1031–8.
   PubMed Web of Science ®Google Scholar
• Kullak-Ublick GA, Ismair MG, Stieger B, et al. (2001). Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology 120:525–33.
   PubMed Web of Science ®Google Scholar
• Li-Blatter X, Nervi P, Seelig A. (2009). Detergents as intrinsic P-glycoprotein substrates and inhibitors. Biochim Biophys Acta 1788:2335–44.
   PubMed Web of Science ®Google Scholar
• Liu L, Cui Y, Chung AY, et al. (2006). Vectorial transport of enalapril by Oatp1a1/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers. J Pharmacol Exp Ther 318:395–402.
   PubMed Web of Science ®Google Scholar
• Lu H, Lu Z, Li X, et al. (2017). Interactions of 172 plant extracts with human organic anion transporter 1 (SLC22A6) and 3 (SLC22A8): A study on herb–drug interactions. PeerJ 5: e3333.
   PubMed Web of Science ®Google Scholar
• Nigam SK. (2015). What do drug transporters really do?. Nat Rev Drug Discov 14:29–44.
   PubMed Web of Science ®Google Scholar
• Otter M, Oswald S, Siegmund W, Keiser M. (2017). Effects of frequently used pharmaceutical excipients on the organic cation transporters 1-3 and peptide transporters 1/2 stably expressed in MDCKII cells. Eur J Pharm Biopharm 112:187–95.
   PubMed Web of Science ®Google Scholar
• Prasert W, Gohtani S. (2016). Effect of sucrose on phase behavior of aqueous phase/polyoxyethylene sorbitan fatty acid ester (Tween xx)/vegetable oil systems and food nano-emulsification using low-energy methods. J Food Eng 168:119–28.
   Web of Science ®Google Scholar
• Singer MM, Tjeerdema RS. (1993). Fate and effects of the surfactant sodium dodecyl sulfate. Rev Environ Contam Toxicol 133:95–149.
   PubMedGoogle Scholar
• Soodvilai S, Soodvilai S, Chatsudthipong V, et al. (2017). Interaction of pharmaceutical excipients with organic cation transporters. Int J Pharm 520:14–20.
   PubMed Web of Science ®Google Scholar
• Strickley RG. (2004). Solubilizing excipients in oral and injectable formulations. Pharm Res 21:201–30.
   PubMed Web of Science ®Google Scholar
• ten Tije AJ, Verweij J, Loos WJ, Sparreboom A. (2003). Pharmacological effects of formulation vehicles : implications for cancer chemotherapy. Clin Pharmacokinet 42:665–85.
   PubMed Web of Science ®Google Scholar
• Thakkar HP, Desai JL. (2015). Influence of excipients on drug absorption via modulation of intestinal transporters activity. Asian J Pharm 9:69–82.
   Web of Science ®Google Scholar
• Treiber A, Schneiter R, Häusler S, Stieger B. (2007). Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil. Drug Metab Dispos 35:1400–7.
   PubMed Web of Science ®Google Scholar
• Tweedie D, Polli JW, Berglund EG, et al. (2013). Transporter studies in drug development: experience to date and follow-up on decision trees from the International Transporter Consortium. Clin Pharmacol Ther 94:113–25.
   PubMed Web of Science ®Google Scholar
• Umehara KI, Iwatsubo T, Noguchi K, et al. (2008). Effect of cationic drugs on the transporting activity of human and rat OCT/Oct 1-3 in vitro and implications for drug–drug interactions. Xenobiotica 38:1203–18.
   PubMed Web of Science ®Google Scholar
• Uwai Y, Taniguchi R, Motohashi H, et al. (2004). Methotrexate-loxoprofen interaction: involvement of human organic anion transporters hOAT1 and hOAT3. Drug Metab Pharmacokinet 19:369–74.
   PubMedGoogle Scholar
• Wang Z, Yin O, Tomlinson B, Chow MS. (2008). OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine. Pharmacogenet Genom 18:637–45.
   PubMed Web of Science ®Google Scholar
• Windass AS, Lowes S, Wang Y, Brown CD. (2007). The contribution of organic anion transporters OAT1 and OAT3 to the renal uptake of rosuvastatin. J Pharmacol Exp Ther 322:1221–7.
   PubMed Web of Science ®Google Scholar
• Yamada A, Maeda K, Kamiyama E, et al. (2007). Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor. Drug Metab Dispos 35:2166–76.
   PubMed Web of Science ®Google Scholar
• Yamagata T, Kusuhara H, Morishita M, et al. (2007). Effect of excipients on breast cancer resistance protein substrate uptake activity. J Control Release 124:1–5.
   PubMed Web of Science ®Google Scholar
• Yamashiro W, Maeda K, Hirouchi M, et al. (2006). Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans. Drug Metab Dispos 34:1247–54.
   PubMed Web of Science ®Google Scholar