Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 51, 2021 - Issue 1
232
Views
0
CrossRef citations to date
0
Altmetric
General Xenobiochemistry

Kinetics of metabolism of deltamethrin and cis- and trans-permethrin in vitro. Studies using rat and human liver microsomes, isolated rat hepatocytes and rat liver cytosol

, , , , , , , , , & show all
Pages 40-50 | Received 12 Jun 2020, Accepted 04 Aug 2020, Published online: 26 Aug 2020

References

  • Anand SS, Bruckner JV, Haines WT, et al. (2006a). Characterization of deltamethrin metabolism by rat plasma and liver microsomes. Toxicol Appl Pharmacol 212:156–66.
  • Anand SS, Kim K-B, Padilla S, et al. (2006b). Ontogeny of hepatic and plasma metabolism of deltamethrin in vitro: role in age-dependent acute neurotoxicity. Drug Metab Dispos 34:389–97.
  • Austin RP, Barton P, Cockroft SL, et al. (2002). The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties. Drug Metab Dispos 30:1497–503.
  • Bhat BK. (1995). Breeding methodologies applicable to pyrethrum. In: Casida JE and Quistad GB, eds. Pyrethrum flowers: production, chemistry, toxicology, and uses. New York: Oxford University Press, 67–94.
  • Crow JA, Borazjani A, Potter PM, Ross MK. (2007). Hydrolysis of pyrethroids by human and rat tissues: examination of intestinal, liver and serum carboxylesterases. Toxicol Appl Pharmacol 221:1–12.
  • Elliott M. (1995). Chemicals in insect control. In: Casida JE and Quistad GB, eds. Pyrethrum flowers: production, chemistry, toxicology, and uses. New York: Oxford University Press, 3–31.
  • Gammon DW, Chandrasekaran A, Elnaggar SF. (2012). Comparative metabolism and toxicology of pyrethroids in mammals. In: Marrs TC, ed. Issues in toxicology no 12, mammalian toxicology of insecticides. Cambridge, UK: RSC Publishing, 137–183.
  • Gertz M, Kilford PJ, Houston JB, Galetin A. (2008). Drug lipophilicity and microsomal protein concentration as determinants in the prediction of the fraction unbound in microsomal incubations. Drug Metab Dispos 36:535–42.
  • Godin SJ, Crow JA, Scollon EJ, et al. (2007). Identification of rat and human cytochrome p450 isoforms and a rat serum esterase that metabolize the pyrethroid insecticides deltamethrin and esfenvalerate. Drug Metab Dispos 35:1664–71.
  • Godin J, DeVito MJ, Hughes MF, et al. (2010). Physiologically based pharmacokinetic modeling of deltamethrin: development of a rat and human diffusion-limited model. Toxicol Sci 115:330–43.
  • Godin SJ, Scollon EJ, Hughes MF, et al. (2006). Species differences in the in vitro metabolism of deltamethrin and esfenvalerate: differential oxidative and hydrolytic metabolism by humans and rats. Drug Metab Dispos 34:1764–71.
  • Hallifax D, Houston JB. (2006). Binding of drugs to hepatic microsomes: comment and assessment of current prediction methodology with recommendation for improvement. Drug Metab Dispos 34:724–6.
  • Hedges L, Brown S, Vardy A, et al. (2019). Metabolism of deltamethrin and cis- and trans-permethrin by rat and human liver microsomes, liver cytosol and plasma preparations. Xenobiotica 49:388–96.
  • Houston JB, Galetin A. (2008). Methods for predicting in vivo pharmacokinetics using data from in vitro assays. Curr Drug Metab 9:940–51.
  • Jones HM, Houston JB. (2004). Substrate depletion approach for determining in vitro metabolic clearance: time dependencies in hepatocyte and microsomal incubations. Drug Metab Dispos 32:973–82.
  • Kalvass JC, Tess DA, Giragossian C, et al. (2001). Influence of microsomal concentration on apparent intrinsic clearance: implications for scaling in vitro data. Drug Metab Dispos 29:1332–6.
  • Kaneko H. (2011). Pyrethroids: mammalian metabolism and toxicity. J Agric Food Chem 59:2786–91.
  • Kilford PJ, Gertz M, Houston JB, Galetin A. (2008). Hepatocellular binding of drugs: correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data. Drug Metab Dispos 36:1194–7.
  • Lake BG. (1987). Preparation and characterisation of microsomal fractions for studies of xenobiotic metabolism. In: Snell K and Mullock, B, eds. Biochemical toxicology: a practical approach. Oxford: IRL Press, 183−215.
  • Laskowski DA. (2002). Physical and chemical properties of pyrethroids. Rev Environ Contam Toxicol 174:49–170.
  • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. (1951). Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–75.
  • Mirfazaelian A, Kim K-B, Anand SS, et al. (2006). Development of a physiologically based pharmacokinetic model for deltamethrin in the adult male Sprague-Dawley rat. Toxicol Sci 93:432–42.
  • Nallani GC, Chandrasekaran A, Kassahun K, et al. (2018). Age dependent in vitro metabolism of bifenthrin in rat and human hepatic microsomes. Toxicol Appl Pharmacol 338:65–72.
  • Obach RS. (1997). Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol. Drug Metab Dispos 25:1359–69.
  • Obach RS. (1999). Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: an examination of in vitro half-life approach and nonspecific binding to microsomes. Drug Metab Dispos 27:1350–9.
  • Parker AJ, Houston JB. (2008). Rate-limiting steps in hepatic drug clearance: comparison of hepatocellular uptake and metabolism with microsomal metabolism of saquinavir, nelfinavir, and ritonavir. Drug Metab Dispos 36:1375–84.
  • Ross MK, Borazjani A, Edwards CC, Potter PM. (2006). Hydrolytic metabolism of pyrethroids by human and other mammalian carboxylesterases. Biochem Pharmacol 71:657–69.
  • Scollon EJ, Starr JM, Godin SJ, et al. (2009). In vitro metabolism of pyrethroid pesticides by rat and human hepatic microsomes and cytochrome P450 isoforms. Drug Metab Dispos 37:221–8.
  • Soderlund DM. (2012). Molecular mechanisms of pyrethroid insecticide neurotoxicity: recent advances. Arch Toxicol 86:165–81.
  • Soderlund DM, Clark JM, Sheets LP, et al. (2002). Mechanisms of pyrethroid neurotoxicity: implications for cumulative risk assessment. Toxicology 171:3–59.
  • Song G, Moreau M, Efremenko A, et al. (2019). Evaluation of age-related pyrethroid pharmacokinetic differences in rats: physiologically-based pharmacokinetic model development using in vitro data and in vitro to in vivo extrapolation. Toxicol Sci 169:365–79.
  • Stringer RA, Strain-Damerell C, Nicklin P, Houston JB. (2009). Evaluation of recombinant cytochrome P450 enzymes as an in vitro system for metabolic clearance predictions. Drug Metab Dispos 37:1025–34.
  • Tornero-Velez R, Mirfazaelian A, Kim K-B, et al. (2010). Evaluation of deltamethrin kinetics and dosimetry in the maturing rat using a PBPK model. Toxicol Appl Pharmacol 244:208–17.
  • Yabe Y, Galetin A, Houston JB. (2011). Kinetic characterization of rat hepatic uptake of 16 actively transported drugs. Drug Metab Dispos 39:1808–14.
  • Yang D, Wang X, Chen Y-T, et al. (2009a). Pyrethroid insecticides: isoform-dependent hydrolysis, induction of cytochrome P450 3A4 and evidence on the involvement of the pregnane X receptor. Toxicol Appl Pharmacol 237:49–58.
  • Yang D, Pearce RE, Wang X, et al. (2009b). Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin. Biochem Pharmacol 77:238–47.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.