Oral antibiotics used in the treatment of chronic rhinosinusitis have limited penetration into the sinonasal mucosa: a randomized trial

References

• Ambrose PG, Anon JB, Bhavnani SM, et al. (2008). Use of pharmacodynamic endpoints for the evaluation of levofloxacin for the treatment of acute maxillary sinusitis. Diagn Microbiol Infect Dis 61:13–20.
   PubMed Web of Science ®Google Scholar
• Antunes MB, Feldman MD, Cohen NA, Chiu AG. (2007). Dose-dependent effects of topical tobramycin in an animal model of Pseudomonas sinusitis. Am J Rhinol Allergy 21:423–7.
   Web of Science ®Google Scholar
• Bandet T, Whitehead S, Blondel-Hill E, et al. (2014). Susceptibility of clinical Moraxella catarrhalis isolates in British Columbia to six empirically prescribed antibiotic agents. Can J Infect Dis Med Microbiol 25:155–8.
   PubMed Web of Science ®Google Scholar
• Bryskier A. (1998). Roxithromycin: review of its antimicrobial activity. J Antimicrobial Chemother 41:1–21.
   PubMedGoogle Scholar
• Campbell MJ. (1970). Tetracycline levels in bronchial secretions. J Clin Pathol 23:427–34.
   PubMed Web of Science ®Google Scholar
• Chastre J, Brun P, Fourtillan JB, Soler P, et al. (1987). Pulmonary disposition of roxithromycin (RU 28965), a new macrolide antibiotic. Antimicrobial Agents Chemother 31:1312–6.
   PubMed Web of Science ®Google Scholar
• Cherrier P, Tod M, Gros VL, et al. (1993). Cefotiam concentrations in the sinus fluid of patients with chronic sinusitis after administration of cefotiam hexetil. Eur J Clin Microbiol Infect Dis 12:211–5.
   PubMed Web of Science ®Google Scholar
• Crosbie PAJ, Woodhead MA. (2009). Long-term macrolide therapy in chronic inflammatory airway diseases. Eur Respir J 33:171–81.
   PubMed Web of Science ®Google Scholar
• Dinis PB, Monteiro MC, Martins ML, et al. (2000). Sinus tissue pharmacokinetics after oral administration of amoxicillin/clavulanic acid. Laryngoscope 110:1050–5.
   PubMed Web of Science ®Google Scholar
• Dinis PB, Monteiro MC, Martins ML, et al. (2004). Sinus tissue concentration of moxifloxacin after a single oral dose. Ann Otol Rhinol Laryngo 113:142–6.
   PubMed Web of Science ®Google Scholar
• Ehnhage A, Rautiainen M, Fang AF, Sanchez SP. (2008). Pharmacokinetics of azithromycin in serum and sinus fluid after administration of extended-release and immediate-release formulations in patients with acute bacterial sinusitis. Int J Antimicrob Agents 31:561–6.
   PubMed Web of Science ®Google Scholar
• EMA. 2011. Guideline on bioanalytical method validation (EMEA/CHMP/EWP/192217/2009 Rev.1 Corr 2**).
   Google Scholar
• EUCAST. 2020. The European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 10.0, 2020. http://www.eucast.org.
   Google Scholar
• Fang AF, Palmer JN, Chiu AG, et al. (2009). Pharmacokinetics of azithromycin in plasma and sinus mucosal tissue following administration of extended-release or immediate-release formulations in adult patients with chronic rhinosinusitis. Int J Antimicrob Agents 34:67–71.
   PubMed Web of Science ®Google Scholar
• FDA. (2001). USFDA. Guidance for industry: bioanalytical method validation. U.S. Department of Health and Human Services, Food and Drug Administration. p. 66.
   Google Scholar
• Fokkens W, Lund V, Hopkins C, et al. (2020). European position paper on rhinosinusitis and nasal polyps 2020. Rhinol J 58:1–464.
   Web of Science ®Google Scholar
• Gehanno P, Darantière S, Dubreuil C, et al. (2002). A prospective, multicentre study of moxifloxacin concentrations in the sinus mucosa tissue of patients undergoing elective surgery of the sinus. J Antimicrob Chemother 49:821–6.
   PubMed Web of Science ®Google Scholar
• Ha KR, Psaltis AJ, Butcher AR, et al. (2008). In vitro activity of mupirocin on clinical isolates of Staphylococcus aureus and its potential implications in chronic rhinosinusitis. Laryngoscope 118:535–40.
   PubMed Web of Science ®Google Scholar
• Hand WL, Corwin RW, Steinberg TH, Grossman GD. (1984). Uptake of antibiotics by human alveolar macrophages. Am Rev Respir Dis 129:933–7.
   PubMed Web of Science ®Google Scholar
• Hartnett BJ, Marlin GE. (1976). Doxycycline in serum and bronchial secretions. Thorax 31:144–8.
   PubMed Web of Science ®Google Scholar
• Hoggard M, Biswas K, Zoing M, Wagner Mackenzie B, et al. (2017). Evidence of microbiota dysbiosis in chronic rhinosinusitis. Int Forum Allergy Rhinol 7:230–9.
   PubMed Web of Science ®Google Scholar
• Holmes NE, Charles PGP. (2009). Safety and efficacy review of doxycycline. Clin Med Therapeut. 1:CMT.S2035.
   Google Scholar
• Honeybourne D. (1994). Antibiotic penetration into lung tissues. Thorax 49:104–6.
   PubMed Web of Science ®Google Scholar
• Hopkins C, Browne JP, Slack R, et al. (2007). The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict? Otolaryngol Head Neck Surg 137:555–61.
   PubMed Web of Science ®Google Scholar
• Huck W, Reed BD, Nielsen RW, et al. (1993). Cefaclor vs amoxicillin in the treatment of acute, recurrent, and chronic sinusitis. Archives of Family Medicine 2:497–503.
   PubMedGoogle Scholar
• Jakobsson HE, Jernberg C, Andersson AF, et al. (2010). Short-term antibiotic treatment has differing long-term impacts on the human throat and gut microbiome. PLoS ONE 5:e9836.
   PubMed Web of Science ®Google Scholar
• Kennedy J, Borish L. (2013). Chronic rhinosinusitis and antibiotics: The good, the bad, and the ugly. Am J Rhinol Allergy 27:467–72.
   PubMed Web of Science ®Google Scholar
• Kuehnel TS, Schurr C, Lotter K, Kees F. (2005). Penetration of telithromycin into the nasal mucosa and ethmoid bone of patients undergoing rhinosurgery for chronic sinusitis. J Antimicrob Chemother 55:591–4.
   PubMed Web of Science ®Google Scholar
• Langdon A, Crook N, Dantas G. (2016). The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation. Genome Med 8:39.
   PubMed Web of Science ®Google Scholar
• Lee JT, Frank DN, Ramakrishnan V. (2016). Microbiome of the paranasal sinuses: Update and literature review. Am J Rhinol Allergy 30:3–16.
   PubMed Web of Science ®Google Scholar
• Legent F, Bordure P, Beauvillain C, Berche P. (1994). A Double-Blind Comparison of Ciprofloxacin and Amoxycillin/Clavulanic Acid in the Treatment of Chronic Sinusitis. Chemotherapy 40:8–15.
   PubMed Web of Science ®Google Scholar
• Margaritis VK, Ismailos GS, Naxakis SS, et al. (2007). Sinus fluid penetration of oral clarithromycin and azithromycin in patients with acute rhinosinusitis. Am J Rhinol 21:574–8.
   PubMedGoogle Scholar
• Mouton JW, Theuretzbacher U, Craig WA, et al. (2008). Tissue concentrations: do we ever learn?. J Antimicrob Chemother 61:235–7.
   PubMed Web of Science ®Google Scholar
• Namyslowski G, Misiolek M, Czecior E, et al. (2002). Comparison of the efficacy and tolerability of amoxycillin/clavulanic acid 875 mg b.i.d. with cefuroxime 500 mg b.i.d. in the treatment of chronic and acute exacerbation of chronic sinusitis in adults. J Chemother 14:508–17.
   PubMed Web of Science ®Google Scholar
• Onufrak NJ, Forrest A, Gonzalez D. (2016). Pharmacokinetic and Pharmacodynamic Principles of Anti-infective Dosing. Clin Ther 38:1930–47.
   PubMed Web of Science ®Google Scholar
• Orlandi RR, Kingdom TT, Hwang PH, et al. (2016). International Consensus Statement on Allergy and Rhinology: Rhinosinusitis. Int Forum Allergy Rhinol 6: S22–S209.
   PubMed Web of Science ®Google Scholar
• Pea F, Marioni G, Pavan F, et al. (2007). Penetration of levofloxacin into paranasal sinuses mucosa of patients with chronic rhinosinusitis after a single 500 mg oral dose. Pharmacol Res 55:38–41.
   PubMed Web of Science ®Google Scholar
• Psaltis AJ, Li G, Vaezeafshar R, et al. (2014). Modification of the Lund-Kennedy endoscopic scoring system improves its reliability and correlation with patient-reported outcome measures. Laryngoscope 124:2216–23.
   PubMed Web of Science ®Google Scholar
• Raymond F, Deraspe M, Boissinot M, et al. (2016). Partial recovery of microbiomes after antibiotic treatment. Gut Microbes 7:428–34.
   PubMed Web of Science ®Google Scholar
• Rodvold KA, Hope WW, Boyd SE. (2017). Considerations for effect site pharmacokinetics to estimate drug exposure: concentrations of antibiotics in the lung. Curr Opin Pharmacol 36:114–23.
   PubMed Web of Science ®Google Scholar
• Stewart PS, Costerton JW. (2001). Antibiotic resistance of bacteria in biofilms. Lancet 358:135–8.
   PubMed Web of Science ®Google Scholar
• TGA. 2004. Australian regulatory guidelines for prescription medicines – Appendix 15: Biopharmaceutic studies. Canberra, Australia: Australian Government Department of Health and Ageing Therapeutic Goods Administration.
   Google Scholar
• Tolsdorff P. (1993). Penetration of ofloxacin into nasal tissues. Infection 21:66–70.
   PubMed Web of Science ®Google Scholar
• Toma S, Hopkins C. (2016). Stratification of SNOT-22 scores into mild, moderate or severe and relationship with other subjective instruments. Rhinology 54:129–33.
   PubMed Web of Science ®Google Scholar
• Tristram S, Jacobs MR, Appelbaum PC. (2007). Antimicrobial Resistance in Haemophilus influenzae. Clin Microbiol Rev 20:368–89.
   PubMed Web of Science ®Google Scholar
• Valcke Y, Pauwels R, Van der Straeten M. (1990). Pharmacokinetics of antibiotics in the lungs. Eur Respir J 3:715–22.
   PubMed Web of Science ®Google Scholar
• Van Zele T, Gevaert P, Holtappels G, et al. (2010). Oral steroids and doxycycline: two different approaches to treat nasal polyps. J Allergy Clin Immunol 125:1069–76.e4.
   PubMed Web of Science ®Google Scholar
• Wagner Mackenzie B, Waite DW, Hoggard M, et al. (2017). Bacterial community collapse: a meta-analysis of the sinonasal microbiota in chronic rhinosinusitis. Environ Microbiol 19:381–92.
   PubMed Web of Science ®Google Scholar