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Xenobiotica
the fate of foreign compounds in biological systems
Volume 51, 2021 - Issue 5
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Pharmacogenetics

Effect of CYP2C9 genetic polymorphism and breviscapine on losartan pharmacokinetics in healthy subjects

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Pages 616-623 | Received 28 Nov 2020, Accepted 20 Jan 2021, Published online: 03 Feb 2021

References

  • Chu, Q., et al., 2005. Simultaneous determination of active ingredients in Erigeron breviscapus (Vant.) Hand-Mazz. by capillary electrophoresis with electrochemical detection. Journal of pharmaceutical and biomedical analysis, 37 (3), 535–541.
  • Faucette, S.R., et al., 2000. Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity. Drug metabolism and disposition: the biological fate of chemicals, 28 (10), 1222–1230.
  • Gao, J., et al., 2017. Therapeutic effects of breviscapine in cardiovascular diseases: a review. Frontiers in pharmacology, 8, 289.
  • Gardin, A., et al., 2018. Siponimod pharmacokinetics, safety, and tolerability in combination with rifampin, a CYP2C9/3A4 inducer, in healthy subjects. European journal of clinical pharmacology, 74 (12), 1593–1604.
  • Gonzalez, L., et al., 2002. Fast screening method for the determination of angiotensin II receptor antagonists in human plasma by high-performance liquid chromatography with fluorimetric detection. Journal of chromatography. A, 949 (1–2), 49–60.
  • Gunes, A., et al., 2007. Inhibitory effect of valproic acid on cytochrome P450 2C9 activity in epilepsy patients. Basic & clinical pharmacology & toxicology, 100 (6), 383–386.
  • Han, Y.L., et al., 2012. Evaluation of impact of Herba Erigerontis injection, a Chinese herbal prescription, on rat hepatic cytochrome P450 enzymes by cocktail probe drugs. Journal of ethnopharmacology, 139 (1), 104–109.
  • Han, Y., et al., 2009. Effect of silymarin on the pharmacokinetics of losartan and its active metabolite E-3174 in healthy Chinese volunteers. European journal of clinical pharmacology, 65 (6), 585–591.
  • Jin, Y., et al., 2018. In vitro studies and in silico predictions of fluconazole and CYP2C9 genetic polymorphism impact on siponimod metabolism and pharmacokinetics. European journal of clinical pharmacology, 74 (4), 455–464.
  • Kirchheiner, J., and Brockmoller, J., 2005. Clinical consequences of cytochrome P450 2C9 polymorphisms. Clinical pharmacology and therapeutics, 77 (1), 1–16.
  • Kobayashi, M., et al., 2008. The effect of bucolome, a CYP2C9 inhibitor, on the pharmacokinetics of losartan. Drug metabolism and pharmacokinetics, 23 (2), 115–119.
  • Lee, C.R., Goldstein, J.A., and Pieper, J.A., 2002. Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data. Pharmacogenetics, 12 (3), 251–263.
  • Lee, Y.J., et al., 2015. Effects of CYP2C9*1/*3 genotype on the pharmacokinetics of flurbiprofen in Korean subjects. Archives of pharmacal research, 38 (6), 1232–1237.
  • Liao, S.G., et al., 2010. Rapid screening and identification of caffeic acid and its esters in Erigeron breviscapus by ultra-performance liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM, 24 (17), 2533–2541.
  • Lin, Z., et al., 2014. In vivo effects of scutellarin on the activities of CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 by cocktail probe drugs in rats. Pharmazie, 69, 537–541.
  • Liu, Y., et al., 2013. UPLC-MS-MS method for simultaneous determination of caffeine, tolbutamide, metoprolol, and dapsone in rat plasma and its application to cytochrome P450 activity study in rats. Journal of chromatographic science, 51 (1), 26–32.
  • Lo, M.W., et al., 1995. Pharmacokinetics of losartan, an angiotensin II receptor antagonist, and its active metabolite EXP3174 in humans. Clinical pharmacology and therapeutics, 58 (6), 641–649.
  • Manikandan, P., and Nagini, S., 2018. Cytochrome P450 structure, function and clinical significance: a review. Current cancer drug targets, 19, 38–54.
  • Mccrea, J.B., et al., 1999. Phenotypic and genotypic investigations of a healthy volunteer deficient in the conversion of losartan to its active metabolite E-3174. Clinical pharmacology and therapeutics, 65 (3), 348–352.
  • Pedreros-Rosales, C., et al., 2019. [Association between cytochrome p4502c9 polymorphisms and losartan dosing in hypertensive patients]. Revista medica de Chile, 147 (12), 1527–1534.
  • Pelkonen, O., et al., 2008. Inhibition and induction of human cytochrome P450 enzymes: current status. Archives of toxicology, 82 (10), 667–715.
  • Polinko, M., et al., 2003. Simultaneous determination of losartan and EXP3174 in human plasma and urine utilizing liquid chromatography/tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis, 33 (1), 73–84.
  • Preskorn, S.H., et al., 2007. The potential for clinically significant drug-drug interactions involving the CYP 2D6 system: effects with fluoxetine and paroxetine versus sertraline. Journal of psychiatric practice, 13 (1), 5–12.
  • Quintieri, L., et al., 2010. Flavonoids diosmetin and hesperetin are potent inhibitors of cytochrome P450 2C9-mediated drug metabolism in vitro. Drug metabolism and pharmacokinetics, 25 (5), 466–476.
  • Sekino, K., et al., 2003. Effect of the single CYP2C9*3 allele on pharmacokinetics and pharmacodynamics of losartan in healthy Japanese subjects. European journal of clinical pharmacology, 59 (8–9), 589–592.
  • Si, D., et al., 2004. Identification of a novel variant CYP2C9 allele in Chinese. Pharmacogenetics, 14 (7), 465–469.
  • Sica, D.A., Gehr, T.W., and Ghosh, S., 2005. Clinical pharmacokinetics of losartan. Clinical pharmacokinetics, 44 (8), 797–814.
  • Sipeky, C., et al., 2009. Interethnic differences of CYP2C9 alleles in healthy Hungarian and Roma population samples: relationship to worldwide allelic frequencies. Blood cells, molecules, and diseases, 43 (3), 239–242.
  • Stearns, R.A., et al., 1995. Biotransformation of losartan to its active carboxylic acid metabolite in human liver microsomes. Role of cytochrome P4502C and 3A subfamily members. Drug metabolism and disposition: the biological fate of chemicals, 23 (2), 207–215.
  • Sullivan-Klose, T.H., et al., 1996. The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism. Pharmacogenetics, 6 (4), 341–349.
  • Tannenbaum, C., and Sheehan, N.L., 2014. Understanding and preventing drug-drug and drug-gene interactions. Expert review of clinical pharmacology, 7 (4), 533–544.
  • Triggle, D.J., 1995. Angiotensin II receptor antagonism: losartan - sites and mechanisms of action. Clinical therapeutics, 17 (6), 1005–1030.
  • Vormfelde, S.V., et al., 2009. Relative impact of genotype and enzyme induction on the metabolic capacity of CYP2C9 in healthy volunteers. Clinical pharmacology and therapeutics, 86 (1), 54–61.
  • Wang, H., and Tompkins, L.M., 2008. CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme. Current drug metabolism, 9 (7), 598–610.
  • Wennerholm, A., et al., 2006. Amodiaquine, its desethylated metabolite, or both, inhibit the metabolism of debrisoquine (CYP2D6) and losartan (CYP2C9) in vivo. European journal of clinical pharmacology, 62 (7), 539–546.
  • Williamson, K.M., et al., 1998. Effects of erythromycin or rifampin on losartan pharmacokinetics in healthy volunteers. Clinical pharmacology & therapeutics, 63 (3), 316–323.
  • Yan, L., et al., 2010. Breviscapine protects against cardiac hypertrophy through blocking PKC-alpha-dependent signaling. Journal of cellular biochemistry, 109 (6), 1158–1171.
  • Yin, T., et al., 2008. Genetic variations of CYP2C9 in 724 Japanese individuals and their impact on the antihypertensive effects of losartan. Hypertension research : official journal of the Japanese society of hypertension, 31 (8), 1549–1557.
  • Yun, C.H., et al., 1995. Oxidation of the angiotensin II receptor antagonist losartan (DuP 753) in human liver microsomes. Role of cytochrome P4503A(4) in formation of the active metabolite EXP3174. Drug metabolism and disposition: the biological fate of chemicals, 23 (2), 285–289.
  • Zhang, J.-L., et al., 2003. Study on metabolism of scutellarin in rats by HPLC-MS and HPLC-NMR. Journal of Asian natural products research, 5 (4), 249–256.
  • Zhou, S.F., Liu, J.P., and Chowbay, B., 2009. Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug metabolism reviews, 41 (2), 89–295.
  • Zhou, X., et al., 2018. Effect of breviscapine on CYP3A metabolic activity in healthy volunteers. European journal of clinical pharmacology, 74 (1), 37–44.

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