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Xenobiotica
the fate of foreign compounds in biological systems
Volume 52, 2022 - Issue 2
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General Xenobiochemistry

Species and tissue differences in regorafenib glucuronidation

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Pages 129-133 | Received 02 Feb 2022, Accepted 16 Mar 2022, Published online: 29 Mar 2022

References

  • Buckley DB, Klaassen CD. 2007. Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice. Drug Metab Dispos. 35(1):121–127.
  • Fisher MB, Paine MF, Strelevitz TJ, Wrighton SA. 2001. The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism. Drug Metab Rev. 33(3–4):273–297.
  • Fu Q, Chen M, Anderson JT, Sun X, Hu S, Sparreboom A, Baker SD. 2019. Interaction between sex and organic anion-transporting polypeptide 1b2 on the pharmacokinetics of regorafenib and its metabolites regorafenib-N-oxide and regorafenib-glucuronide in mice. Clin Transl Sci. 12(4):400–407.
  • Fu Q, Chen M, Hu S, McElroy CA, Mathijssen RH, Sparreboom A, Baker SD. 2018. Development and validation of an analytical method for regorafenib and its metabolites in mouse plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 1090:43–51.
  • Gerisch M, Hafner FT, Lang D, Radtke M, Diefenbach K, Cleton A, Lettieri J. 2018. Mass balance, metabolic disposition, and pharmacokinetics of a single oral dose of regorafenib in healthy human subjects. Cancer Chemother Pharmacol. 81(1):195–206.
  • Gregory PA, Lewinsky RH, Gardner-Stephen DA, Mackenzie PI. 2004. Regulation of UDP glucuronosyltransferases in the gastrointestinal tract. Toxicol Appl Pharmacol. 199(3):354–363.
  • Harbourt DE, Fallon JK, Ito S, Baba T, Ritter JK, Glish GL, Smith PC. 2012. Quantification of human uridine-diphosphate glucuronosyl transferase 1A isoforms in liver, intestine, and kidney using nanobore liquid chromatography-tandem mass spectrometry. Anal Chem. 84(1):98–105.
  • Knights KM, Rowland A, Miners JO. 2013. Renal drug metabolism in humans: the potential for drug-endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT). Br J Clin Pharmacol. 76(4):587–602.
  • Kojima A, Sogabe A, Nadai M, Katoh M. 2021. Species differences in oxidative metabolism of regorafenib. Xenobiotica. 51(12):1400–1407.
  • Mackenzie PI, Bock KW, Burchell B, Guillemette C, Ikushiro S, Iyanagi T, Miners JO, Owens IS, Nebert DW. 2005. Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. Pharmacogenet Genomics. 15(10):677–685.
  • Miners JO, Knights KM, Houston JB, Mackenzie PI. 2006. In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises. Biochem Pharmacol. 71(11):1531–1539.
  • Mukai M, Tanaka S, Yamamoto K, Murata M, Okada K, Isobe T, Shigeyama M, Hichiya H, Hanioka N. 2014. In vitro glucuronidation of propofol in microsomal fractions from human liver, intestine and kidney: tissue distribution and physiological role of UGT1A9. Pharmazie. 69(11):829–832.
  • Mukai M, Isobe T, Okada K, Murata M, Shigeyama M, Hanioka N. 2015. Species and sex differences in propofol glucuronidation in liver microsomes of humans, monkeys, rats and mice. Pharmazie. 70(7):466–470.
  • Nishiyama T, Kobori T, Arai K, Ogura K, Ohnuma T, Ishii K, Hayashi K, Hiratsuka A. 2006. Identification of human UDP-glucuronosyltransferase isoform(s) responsible for the C-glucuronidation of phenylbutazone. Arch Biochem Biophys. 454(1):72–79.
  • Ohno S, Nakajin S. 2009. Determination of mRNA expression of human UDP-glucuronosyltransferases and application for localization in various human tissues by real-time reverse transcriptase-polymerase chain reaction. Drug Metab Dispos. 37(1):32–40.
  • Sakakibara Y, Katoh M, Kawayanagi T, Nadai M. 2016. Species and tissue differences in serotonin glucuronidation. Xenobiotica. 46(7):605–611.
  • Shi R, Wu J, Meng C, Ma B, Wang T, Li Y, Ma Y. 2016. Cyp3a11-mediated testosterone-6β-hydroxylation decreased, while UGT1a9-mediated propofol O-glucuronidation increased, in mice with diabetes mellitus. Biopharm Drug Dispos. 37(7):433–443.
  • Shimizu M, Matsumoto Y, Yamazaki H. 2007. Effects of propofol analogs on glucuronidation of propofol, an anesthetic drug, by human liver microsomes. Drug Metab Lett. 1(1):77–79.
  • Uno Y, Takahira R, Murayama N, Ishii Y, Ikenaka Y, Ishizuka M, Yamazaki H, Ikushiro S. 2018. Molecular and functional characterization of UDP-glucuronosyltransferase 1A in cynomolgus macaques. Biochem Pharmacol. 155:172–181.
  • Wang YK, Xiao XR, Xu KP, Li F. 2018. Metabolic profiling of the anti-tumor drug regorafenib in mice. J Pharm Biomed Anal. 159:524–535.

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