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Xenobiotica
the fate of foreign compounds in biological systems
Volume 52, 2022 - Issue 3
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Animal Pharmacokinetics and Metabolism

Identification of in vivo metabolites of a potential anti-rheumatoid arthritis compound, the quinazolinone derivative PD110, using ultra-high performance liquid chromatography coupled with Q-Exactive plus mass spectrometrys

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Pages 284-294 | Received 20 Feb 2022, Accepted 03 Apr 2022, Published online: 13 Apr 2022

References

  • Chang J, Chen H, Chen J, Sun X, Wu X, Liu L, Xu Z, Chen W, Zhang J, Wang X, et al. 2021. Characterization of the metabolite of cabozantinib generated from liver microsomes and hepatocytes by ultra-high performance liquid chromatography coupled to quadrupole/orbitrap high resolution mass spectrometry. J Pharm Biomed Anal. 205:114343.
  • Cushing TD, Hao X, Shin Y, Andrews K, Brown M, Cardozo M, Chen Y, Duquette J, Fisher B, Gonzalez-Lopez de Turiso F, et al. 2015. Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease. J Med Chem. 58(1):480–511.
  • Garces AE, Stocks MJ. 2019. Class 1 PI3K clinical candidates and recent inhibitor design strategies: a medicinal chemistry perspective. J Med Chem. 62(10):4815–4850.
  • Ghigo A, Damilano F, Braccini L, Hirsch E. 2010. PI3K inhibition in inflammation: toward tailored therapies for specific diseases. Bioessays. 32(3):185–196.
  • Hawkins PT, Stephens LR. 2015. PI3K signalling in inflammation. Biochim Biophys Acta. 1851(6):882–897.
  • Jia H, Dai G, Su W, Xiao K, Weng J, Zhang Z, Wang Q, Yuan T, Shi F, Zhang Z, et al. 2019. Discovery, optimization, and evaluation of potent and highly selective PI3Kγ-PI3Kδ dual inhibitors. J Med Chem. 62(10):4936–4948.
  • Li J, Li L, Wang Y, Zhao Y, Hu P, Xu Z, Liu F, Liang Q, Tian X, Huang C. 2021. Systematic investigation on the anti-rheumatoid arthritis material basis and mechanism of Juan Bi Tang. Part 1: integrating metabolic profiles and network pharmacology. J Pharm Biomed Anal. 202:114133.
  • Liu J, Tang M, Lai H, Dong Y, Xie C, Ye H, Ma L, Qiu N, Li Y, Cai L, et al. 2013. Identification of metabolites of honokiol in rat urine using 13C stable isotope labeling and liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry. J Chromatogr A. 1295:48–56.
  • Liu K, Li D, Zheng W, Shi M, Chen Y, Tang M, Yang T, Zhao M, Deng D, Zhang C, et al. 2021. Discovery, optimization, and evaluation of quinazolinone derivatives with novel linkers as orally efficacious phosphoinositide-3-kinase delta inhibitors for treatment of inflammatory diseases. J Med Chem. 64(13):8951–8970.
  • Liu S, Ma H, Zhang H, Deng C, Xin P. 2021. Recent advances on signaling pathways and their inhibitors in rheumatoid arthritis. Clin Immunol. 230:108793.
  • Methot JL, Zhou H, Kattar SD, McGowan MA, Wilson K, Garcia Y, Deng Y, Altman M, Fradera X, Lesburg C, et al. 2019. Structure overhaul affords a potent purine PI3Kδ inhibitor with improved tolerability. J Med Chem. 62(9):4370–4382.
  • Panday NK, Thakkar D, Patel S, Shard A, Sengupta P. 2021. Metabolite profiling of IMID-2, a novel anticancer molecule of piperazine derivative: in silico prediction, in vitro and in vivo metabolite characterization using UPLC-QTOF-MS/MS. Biomed Chromatogr. 35(6):e5082.
  • Patel L, Chandrasekhar J, Evarts J, Forseth K, Haran AC, Ip C, Kashishian A, Kim M, Koditek D, Koppenol S, et al. 2016. Discovery of orally efficacious phosphoinositide 3-Kinase δ inhibitors with improved metabolic stability. J Med Chem. 59(19):9228–9242.
  • Patel L, Chandrasekhar J, Evarts J, Haran AC, Ip C, Kaplan JA, Kim M, Koditek D, Lad L, Lepist EI, et al. 2016. 2,4,6-triaminopyrimidine as a novel hinge binder in a series of PI3Kδ selective inhibitors. J Med Chem. 59(7):3532–3548.
  • Sahu AK, Sengupta P. 2020. Time of flight mass spectrometry based in vitro and in vivo metabolite profiling of ribociclib and their toxicity prediction. J Chromatogr B Analyt Technol Biomed Life Sci. 1147:122142.
  • Saidi M, Kamali S, Beaudry F. 2019. Neuropeptidomics: comparison of parallel reaction monitoring and data-independent acquisition for the analysis of neuropeptides using high-resolution mass spectrometry. Biomed Chromatogr. 33(7):e4523.
  • Shin Y, Suchomel J, Cardozo M, Duquette J, He X, Henne K, Hu YL, Kelly RC, McCarter J, McGee LR, et al. 2016. Discovery, optimization, and in vivo evaluation of benzimidazole derivatives AM-8508 and AM-9635 as potent and selective PI3Kδ inhibitors. J Med Chem. 59(1):431–447.
  • Singh A, Thatikonda T, Kumar A, Wazir P, V V, Nandi U, Singh PP, Singh S, Gupta AP, Tikoo MK, et al. 2018. Determination of ZSTK474, a novel Pan PI3K inhibitor in mouse plasma by LC-MS/MS and its application to pharmacokinetics. J Pharm Biomed Anal. 149:387–393.
  • Somoza JR, Koditek D, Villasenor AG, Novikov N, Wong MH, Liclican A, Xing W, Lagpacan L, Wang R, Schultz BE, et al. 2015. Structural, biochemical, and biophysical characterization of idelalisib binding to phosphoinositide 3-kinase δ. J Biol Chem. 290(13):8439–8446.
  • Wang H, Li X, Ye H, Qiu N, Ma L, Wang C, Yang Q, Tang M, Wan L, Chen L. 2016. Characterization of in vivo metabolites of a potential anti-obesity compound, the 3-Methyl-1H-Purine-2,6-Dione Derivative C-11, employing ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Chromatographia. 79(11–12):693–702.
  • Yao J, Jiang X, Liu Q, Yuan X, Feng T, Li K, Zhao L. 2019. An available strategy based on accurate mass by ultra high performance liquid chromatography coupled to Fourier transform ion cyclotron resonance mass spectrometry technology to characterization of metabolic profile of palbociclib in rat urine, feces and bile. J Chromatogr B Analyt Technol Biomed Life Sci. 1124:37–46.
  • Yuan L, Li J, Feng M, Zou XR. 2021. Identification of the metabolites of XL092 in rat and human by using ultra-high performance liquid chromatography high resolution mass spectrometry. J Pharm Biomed Anal. 206:114390.
  • Zhou J, Chen J, Hu C, Xie Z, Li H, Wei S, Wang D, Wen C, Xu G. 2016. Exploration of the serum metabolite signature in patients with rheumatoid arthritis using gas chromatography-mass spectrometry. J Pharm Biomed Anal. 127:60–67.

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