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Xenobiotica
the fate of foreign compounds in biological systems
Volume 52, 2022 - Issue 3
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General Xenobiochemistry

Comparison of mouse and human cytochrome P450 mediated-drug metabolising activities in hepatic and extrahepatic microsomes

ORCID Icon, , , , ORCID Icon & ORCID Icon
Pages 229-239 | Received 12 Mar 2022, Accepted 12 Apr 2022, Published online: 26 Apr 2022

References

  • Bieche I, Narjoz C, Asselah T, Vacher S, Marcellin P, Lidereau R, Beaune P, de Waziers I. 2007. Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)1, CYP2 and CYP3 families in 22 different human tissues. Pharmacogenet Genomics. 17(9):731–742.
  • Bogaards JJ, Bertrand M, Jackson P, Oudshoorn MJ, Weaver RJ, van Bladeren PJ, Walther B. 2000. Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man. Xenobiotica. 30(12):1131–1152.
  • Born SL, Caudill D, Fliter KL, Purdon MP. 2002. Identification of the cytochromes P450 that catalyze coumarin 3,4-epoxidation and 3-hydroxylation. Drug Metab Dispos. 30(5):483–487.
  • Emoto C, Yamazaki H, Yamasaki S, Shimada N, Nakajima M, Yokoi T. 2000. Characterization of cytochrome P450 enzymes involved in drug oxidations in mouse intestinal microsomes. Xenobiotica. 30(10):943–953.
  • Guengerich FP. 2021. A history of the roles of cytochrome P450 enzymes in the toxicity of drugs. Toxicol Res. 37(1):1–23.
  • Lasker JM, Wester MR, Aramsombatdee E, Raucy JL. 1998. Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations. Arch Biochem Biophys. 353(1):16–28.
  • Martignoni M, Groothuis G, de Kanter R. 2006. Comparison of mouse and rat cytochrome P450-mediated metabolism in liver and intestine. Drug Metab Dispos. 34(6):1047–1054.
  • Mimura M, Yamazaki H, Sugahara C, Hiroi T, Funae Y, Shimada T. 1994. Differential roles of cytochromes P450 2D1, 2C11, and 1A1/2 in the hydroxylation of bufuralol by rat liver microsomes. Biochem Pharmacol. 47(11):1957–1963.
  • Murayama N, Kaneko N, Horiuchi K, Ohyama K, Shimizu M, Ito K, Yamazaki H. 2009. Cytochrome P450-dependent drug oxidation activity of liver microsomes from microminipigs, a possible new animal model for humans in non-clinical studies. Drug Metab Pharmacokinet. 24(4):404–408.
  • Murayama N, Yamazaki H. 2021. Metabolic activation and deactivation of dietary-derived coumarin mediated by cytochrome P450 enzymes in rat and human liver preparations. J Toxicol Sci. 46(8):371–378.
  • Nelson DR. 2006. Cytochrome P450 nomenclature, 2004. Methods Mol Biol. 320:1–10.
  • Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW. 2004. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics. 14(1):1–18.
  • Pearce R, Greenway D, Parkinson A. 1992. Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: effects on coumarin, dicumarol, and testosterone oxidation. Arch Biochem Biophys. 298(1):211–225.
  • Renaud HJ, Cui JY, Khan M, Klaassen CD. 2011. Tissue distribution and gender-divergent expression of 78 cytochrome P450 mRNAs in mice. Toxicol Sci. 124(2):261–277.
  • Sakai N, Saito K, Kim HS, Kazusaka A, Ishizuka M, Funae Y, Fujita S. 2005. Importance of CYP2D3 in polymorphism of diazepam p-hydroxylation in rats. Drug Metab Dispos. 33(11):1657–1660.
  • Sharma V, McNeill JH. 2009. To scale or not to scale: the principles of dose extrapolation. Br J Pharmacol. 157(6):907–921.
  • Shimada T, Mimura M, Inoue K, Nakamura S, Oda H, Ohmori S, Yamazaki H. 1997. Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans. Arch Toxicol. 71(6):401–408.
  • Tracy TS, Marra C, Wrighton SA, Gonzalez FJ, Korzekwa KR. 1996. Studies of flurbiprofen 4'-hydroxylation. Additional evidence suggesting the sole involvement of cytochrome P450 2C9. Biochem Pharmacol. 52(8):1305–1309.
  • Turpeinen M, Ghiciuc C, Opritoui M, Tursas L, Pelkonen O, Pasanen M. 2007. Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: a comparative study in vitro. Xenobiotica. 37(12):1367–1377.
  • Uehara S, Murayama N, Yamazaki H, Suemizu H. 2019. Regioselective hydroxylation of an antiarrhythmic drug, propafenone, mediated by rat liver cytochrome P450 2D2 differs from that catalyzed by human P450 2D6. Xenobiotica. 49(11):1323–1331.
  • Uehara S, Yoneda N, Higuchi Y, Yamazaki H, Suemizu H. 2022. Cytochrome P450-dependent drug oxidation activities and their expression levels in liver microsomes of chimeric TK-NOG mice with humanized livers. Drug Metab Pharmacokinet. 44: 100454.
  • von Weymarn LB, Murphy SE. 2003. CYP2A13-catalysed coumarin metabolism: comparison with CYP2A5 and CYP2A6. Xenobiotica. 33(1):73–81.
  • Yamazaki H, Mimura M, Sugahara C, Shimada T. 1994. Catalytic roles of rat and human cytochrome P450 2A enzymes in testosterone 7 alpha- and coumarin 7-hydroxylations. Biochem Pharmacol. 48(7):1524–1527.
  • Yasumori T, Nagata K, Yang SK, Chen LS, Murayama N, Yamazoe Y, Kato R. 1993. Cytochrome P450 mediated metabolism of diazepam in human and rat: involvement of human CYP2C in N-demethylation in the substrate concentration-dependent manner. Pharmacogenetics. 3(6):291–301.
  • Zanger UM, Schwab M. 2013. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther. 138(1):103–141.
  • Zhuo X, Gu J, Zhang QY, Spink DC, Kaminsky LS, Ding X. 1999. Biotransformation of coumarin by rodent and human cytochromes P-450: metabolic basis of tissue-selective toxicity in olfactory mucosa of rats and mice. J Pharmacol Exp Ther. 288(2):463–471.

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