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Xenobiotica
the fate of foreign compounds in biological systems
Volume 52, 2022 - Issue 3
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Animal Pharmacokinetics and Metabolism

Role of hesperidin and fresh orange juice in altering the bioavailability of beta-blocker, metoprolol tartrate. An in vivo model

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Pages 295-300 | Received 18 Feb 2022, Accepted 14 Apr 2022, Published online: 26 Apr 2022

References

  • Bailey DG, Dresser GK, Leake BF, Kim RB. 2007. Naringin is a major and selective clinical inhibitor of organic anion‐transporting polypeptide 1A2 (OATP1A2) in grapefruit juice. Clin Pharmacol Ther. 81(4):495–502.
  • Bailey DG, Spence JD, Munoz C, Arnold JMO. 1991. Interaction of citrus juices with felodipine and nifedipine. The Lancet. 337(8736):268–269.
  • Dresser GK, Bailey DG, Leake BF, Schwarz UI, Dawson PA, Freeman DJ, Kim RB. 2002. Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine. Clin Pharmacol Ther. 71(1):11–20.
  • Ekelund LG, Olsson AG, Orö L, Rössner S. 1976. Effects of the cardioselective beta-adrenergic receptor blocking agent metoprolol in angina pectoris. Subacute study with exercise tests. Br Heart J. 38(2):155–161.
  • Freestone S, Silas JH, Lennard MS, Ramsay LE. 1982. Comparison of two long-acting preparations of metoprolol with conventional metoprolol and atenolol in healthy men during chronic dosing. Br J Clin Pharmacol. 14(5):713–718.
  • Gil-Izquierdo A, Gil MI, Ferreres F, Tomás-Barberán FA. 2001. In vitro availability of flavonoids and other phenolics in orange juice. J Agric Food Chem. 49(2):1035–1041.
  • Glaeser H, Bailey DG, Dresser GK, Gregor JC, Schwarz UI, Mcgrath JS, Jolicoeur E, Lee W, Leake BF, Tirona RG, et al. 2007. Intestinal drug transporter expression and the impact of grapefruit juice in humans. Clin Pharmacol Ther. 81(3):362–370.
  • Ha HR, Follath F. 2004. Metabolism of antiarrhythmics. Curr Drug Metab. 5(6):543–571.
  • Hukkinen SK, Varhe A, Olkkola KT, Neuvonen PJ. 1995. Plasma concentrations of triazolam are increased by concomitant ingestion of grapefruit juice. Clin Pharmacol Ther. 58(2):127–131.
  • Husain T, Shoaib MH, Yousuf RI, Maboos M, Khan M, Bashir L, Naz S. 2016. Formulation development and comparative in vitro study of metoprolol tartrate (IR) tablets. Pak J Pharma Sci. 29(3):853–860.
  • Ikemura M, Sasaki Y, Giddings JC, Yamamoto J. 2012. Preventive effects of hesperidin, glucosyl hesperidin and naringin on hypertension and cerebral thrombosis in stroke-prone spontaneously hypertensive rats. Phytother Res. 26(9):1272–1277.
  • Jetter A, Kinzig‐Schippers M, Walchner‐Bonjean M, Hering U, Bulitta J, Schreiner P, Sörgel F, Fuhr U. 2002. Effects of grapefruit juice on the pharmacokinetics of sildenafil. Clin Pharmacol Ther. 71(1):21–29.
  • Kantola T, Kivistö KT, Neuvonen PJ. 1998. Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid. Clin Pharmacol Ther. 63(4):397–402.
  • Lilja JJ, Juntti‐Patinen L, Neuvonen PJ. 2004. Orange juice substantially reduces the bioavailability of the β‐adrenergic–blocking agent celiprolol. Clin Pharmacol Ther. 75(3):184–190.
  • Lilja JJ, Kivistö KT, Backman JT, Lamberg TS, Neuvonen PJ. 1998. Grapefruit juice substantially increases plasma concentrations of buspirone. Clin Pharmacol Ther. 64(6):655–660.
  • Lilja JJ, Kivistö KT, Neuvonen PJ. 1998. Grapefruit juice—simvastatin interaction: effect on serum concentrations of simvastatin, simvastatin acid, and HMG‐CoA reductase inhibitors. Clin Pharmacol Ther. 64(5):477–483.
  • Lilja JJ, Raaska K, Neuvonen PJ. 2005a. Effects of grapefruit juice on the pharmacokinetics of acebutolol. Br J Clin Pharmacol. 60(6):659–663.
  • Lilja JJ, Raaska K, Neuvonen PJ. 2005b. Effects of orange juice on the pharmacokinetics of atenolol. Eur J Clin Pharmacol. 61(5–6):337–340.
  • Luch JR. 1983. Metoprolol tartrate. In: Analytical profiles of drug substances. Vol. 12. Cambridge (MA): Academic Press; p. 325–356.
  • Manach C1, Morand C, Gil-Izquierdo A, Bouteloup-Demange C, Remesy C. 2003. Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice. Eur J Clin Nutr. 57(2):235–242.
  • Morris J, Dunham A. 2018. Metoprolol. Treasure Island (FL): StatPearls Publishing.
  • Neuhofel AL, Wilton JH, Victory JM, Hejmanowski LG, Amsden GW. 2002. Lack of bioequivalence of ciprofloxacin when administered with calcium‐fortified orange juice: a new twist on an old interaction. J Clin Pharmacol. 42(4):461–466.
  • Nisa Z, Ali SI, Rizvi M, Khan MA, Sultan RA, Fatima R, Shaheen N, Zafar F, Kashif SS, Khatian N. 2019. Development and validation of reverse phase HPLC method for determination of angiotensin receptor blocking agent irbesartan in plasma. Pak J Pharm Sci. 32(2):853–858.
  • Piao YJ, Choi JS. 2008. Enhanced bioavailability of verapamil after oral administration with hesperidin in rats. Arch Pharm Res. 31(4):518–522.
  • Robertson JIS. 1983. State-of-the-art review: β-blockade and the treatment of hypertension. Drugs. 25(2):5–11.
  • Schwarz UI, Seemann D, Oertel R, Miehlke S, Kuhlisch E, Fromm MF, Kim RB, Bailey DG, Kirch W. 2005. Grapefruit juice ingestion significantly reduces talinolol bioavailability. Clin Pharmacol Ther. 77(4):291–301.
  • Takanaga H, Ohnishi A, Yamada S, Matsuo H, Morimoto S, Shoyama Y, Ohtani H, Sawada Y. 2000. Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4. J Pharmacol Exp Ther. 293(1):230–236.
  • Uesawa Y, Mohri K. 2008. Hesperidin in orange juice reduces the absorption of celiprolol in rats. Biopharm Drug Dispos. 29(3):185–188.
  • Yee GC, Stanley DL, Pessa LJ, Costa TD, Beltz SE, Ruiz J, Lowenthal DT. 1995. Effect of grapefruit juice on blood cyclosporin concentration. The Lancet. 345(8955):955–956.

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