Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 52, 2022 - Issue 6
295
Views
1
CrossRef citations to date
0
Altmetric
Clinical Pharmacokinetics and Metabolism

Pharmacokinetics, metabolism and excretion of radiolabeled fostemsavir administered with or without ritonavir in healthy male subjects

ORCID Icon, , , ORCID Icon &
Pages 541-554 | Received 05 Apr 2022, Accepted 26 Aug 2022, Published online: 21 Sep 2022

References

  • Ahn K, Johnson DS, Fitzgerald LR, Liimatta M, Arendse A, Stevenson T, Lund ET, Nugent RA, Nomanbhoy TK, Alexander JP, et al. 2007. Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry. 46(45):13019–13030.
  • Anuurad E, Semrad A, Berglund L. 2009. Human immunodeficiency virus and highly active antiretroviral therapy-associated metabolic disorders and risk factors for cardiovascular disease. Metab Syndr Relat Disord. 7(5):401–410.
  • Avcikurt AS, Sinan S, Kockar F. 2015. Antidepressant and antipsychotic drugs differentially affect PON1 enzyme activity. J Enzyme Inhib Med Chem. 30(2):245–249.
  • Basit A, Neradugomma NK, Wolford C, Fan PW, Murray B, Takahashi RH, Khojasteh SC, Smith BJ, Heyward S, Totah RA, et al. 2020. Characterization of differential tissue abundance of major non-CYP enzymes in human. Mol Pharm. 17(11):4114–4124.
  • Cooke CE, Lee HY, Xing S. 2014. Adherence to antiretroviral therapy in managed care members in the United States: a retrospective claims analysis. J Manag Care Pharm. 20(1):86–92.
  • Descamps D, Assoumou L, Chaix ML, Chaillon A, Pakianather S, de Rougemont A, Storto AD, Santos G, Krivine A, Delaugerre C, et al. 2013. National sentinel surveillance of transmitted drug resistance in antiretroviral-naive chronically HIV-infected patients in France over a decade. J Antimicrob Chemother. 68(11):2626–2631. eng.
  • Fu J, Sadgrove M, Marson L, Jay M. 2016. Biotransformation capacity of carboxylesterase in skin and keratinocytes for the penta-ethyl ester prodrug of DTPA. Drug Metab Dispos. 44(8):1313–1318. eng.
  • Hatfield MJ, Potter PM. 2011. Carboxylesterase inhibitors. Expert Opin Ther Pat. 21(8):1159–1171. eng.
  • Hossain MA, Tran T, Chen T, Mikus G, Greenblatt DJ. 2017. Inhibition of human cytochromes P450 in vitro by ritonavir and cobicistat. J Pharm Pharmacol. 69(12):1786–1793.
  • Huang HY, Daar ES, Sax PE, Young B, Cook P, Benson P, Cohen C, Scribner A, Hu H. 2008. The prevalence of transmitted antiretroviral drug resistance in treatment-naïve patients and factors influencing first-line treatment regimen selection. HIV Med. 9(5):285–293.
  • Inoue NR, Hall A, Lai WG, Williams ET. 2013. Reversible inhibition of human carboxylesterases by acyl glucuronides. Drug Metab Dispos. 41(4):698–703.
  • Jewell C, Ackermann C, Payne NA, Fate G, Voorman R, Williams FM. 2007. Specificity of procaine and ester hydrolysis by human, minipig, and rat skin and liver. Drug Metab Dispos. 35(11):2015–2022.
  • Jiang J, Chen X, Zhong D. 2018. Predominant contributions of carboxylesterase 1 and 2 in hydrolysis of anordrin in humans. Xenobiotica. 48(5):533–540.
  • Kurokawa T, Fukami T, Yoshida T, Nakajima M. 2016. Arylacetamide deacetylase is responsible for activation of Prasugrel in human and dog. Drug Metab Dispos. 44(3):409–416.
  • Li B, Sedlacek M, Manoharan I, Boopathy R, Duysen EG, Masson P, Lockridge O. 2005. Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma. Biochem Pharmacol. 70(11):1673–1684.
  • Margolis AM, Heverling H, Pham PA, Stolbach A. 2014. A review of the toxicity of HIV medications. J Med Toxicol. 10(1):26–39.
  • Marzolini C, Gibbons S, Khoo S, Back D. 2016. Cobicistat versus ritonavir boosting and differences in the drug-drug interaction profiles with co-medications. J Antimicrob Chemother. 71(7):1755–1758.
  • Meanwell NA, Krystal MR, Nowicka-Sans B, Langley DR, Conlon DA, Eastgate MD, Grasela DM, Timmins P, Wang T, Kadow JF. 2018. Inhibitors of HIV-1 attachment: the discovery and development of Temsavir and its Prodrug Fostemsavir. J Med Chem. 61(1):62–80.
  • Mizoi K, Takahashi M, Sakai S, Ogihara T, Haba M, Hosokawa M. 2020. Structure-activity relationship of atorvastatin derivatives for metabolic activation by hydrolases. Xenobiotica. 50(3):261–269.
  • Nettles R, Chien C, Elefant E, Wang X, Chung E, Zhu L, Zhang D, Wu Y, Persson A, Grasela D. 2011. Single and multiple dose pharmacokinetics and safety in non-HIV-infected healthy subjects dosed with BMS-663068, an oral HIV attachment inhibitor. 12th International Workshop on Clinical Pharmacology of HIV Therapy.
  • Palella FJ, Jr., Delaney KM, Moorman AC, Loveless MO, Fuhrer J, Satten GA, Aschman DJ, Holmberg SD. 1998. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med. 338(13):853–860. eng.
  • Pancera M, Lai YT, Bylund T, Druz A, Narpala S, O'Dell S, Schön A, Bailer RT, Chuang GY, Geng H, et al. 2017. Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529. Nat Chem Biol. 13(10):1115–1122.
  • Patricelli MP, Szardenings AK, Liyanage M, Nomanbhoy TK, Wu M, Weissig H, Aban A, Chun D, Tanner S, Kozarich JW. 2007. Functional interrogation of the kinome using nucleotide acyl phosphates. Biochemistry. 46(2):350–358.
  • Reese M, Sakatis M, Ambroso J, Harrell A, Yang E, Chen L, Taylor M, Baines I, Zhu L, Ayrton A, et al. 2011. An integrated reactive metabolite evaluation approach to assess and reduce safety risk during drug discovery and development. Chem Biol Interact. 192(1–2):60–64.
  • Reust CE. 2011. Common adverse effects of antiretroviral therapy for HIV disease. Am Fam Physician. 83(12):1443–1451.
  • RUKOBIA (fostemsavir) [package insert]. 2020. ViiV HealthCare; [accessed 2022 August 11]. www.accessdata.fda.gov/drugsatfda_docs/label/2020/212950s000lbl.pdf.
  • Tseng A, Hughes CA, Wu J, Seet J, Phillips EJ. 2017. Cobicistat versus Ritonavir: similar pharmacokinetic enhancers but some important differences. Ann Pharmacother. 51(11):1008–1022. eng.
  • Umehara K, Zollinger M, Kigondu E, Witschi M, Juif C, Huth F, Schiller H, Chibale K, Camenisch G. 2016. Esterase phenotyping in human liver in vitro: specificity of carboxylesterase inhibitors. Xenobiotica. 46(10):862–867.
  • UNAIDS. 2016. Global Aids Update 2016.
  • Watkins ME, Wring S, Randolph R, Park S, Powell K, Lutz L, Nowakowski M, Ramabhadran R, Domanico PL. 2017. Development of a Novel formulation that improves preclinical bioavailability of tenofovir disoproxil fumarate. J Pharm Sci. 106(3):906–919.
  • Ziessman HA. 2019. Sincalide: a review of clinical utility, proper infusion methodology, and alternative cholecystogogues. J Nucl Med Technol. 47(3):210–212.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.