The effect of ARVs on the MEKKK1 gene promoter, inflammatory cytokine expression and signalling in acute treated Jurkat T cells

References

• Abdel-Hameed EA, Ji H, Shata MT. 2016. HIV-Induced Epigenetic Alterations in Host Cells. In: Minarovits J, Niller HH, editors. Patho-Epigenetics of Infectious Disease. Cham: Springer International Publishing. p. 27–38.
   Google Scholar
• Acchioni C, Remoli AL, Marsili G, et al. 2019. Alternate NF-κB-independent signaling reactivation of latent HIV-1 provirus. J Virol. 93(18):e00495-19.
   PubMed Web of Science ®Google Scholar
• Alegre F, Martí-Rodrigo A, Polo M, Ortiz-Masiá D, Bañuls C, Pinti M, Álvarez Á, Apostolova N, Esplugues JV, Blas-García A, et al. 2022. Macrophages modulate hepatic injury involving NLRP3 inflammasome: the example of efavirenz. Biomedicines. 10(1):109.
   PubMed Web of Science ®Google Scholar
• Altorok N, Sawalha AH. 2013. Epigenetics in the pathogenesis of systemic lupus erythematosus. Curr Opin Rheumatol. 25(5):569–576.
   PubMed Web of Science ®Google Scholar
• Argaw T, Colon-Moran W, Wilson C. 2016. Susceptibility of porcine endogenous retrovirus to anti-retroviral inhibitors. Xenotransplantation. 23(2):151–158.
   PubMed Web of Science ®Google Scholar
• Arnold R, Patzak IM, Neuhaus B, Vancauwenbergh S, Veillette A, Van Lint J, Kiefer F. 2005. Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase D1. Mol Cell Biol. 25(6):2364–2383.
   PubMed Web of Science ®Google Scholar
• Ballantyne AD, Perry CM. 2013. Dolutegravir: first global approval. Drugs. 73(14):1627–1637.
   PubMed Web of Science ®Google Scholar
• Brenner D, Golks A, Kiefer F, Krammer PH, Arnold R. 2005. Activation or suppression of NFkappaB by HPK1 determines sensitivity to activation-induced cell death. Embo J. 24(24):4279–4290.
   PubMed Web of Science ®Google Scholar
• Brenner DR, Scherer D, Muir K, Schildkraut J, Boffetta P, Spitz MR, Le Marchand L, Chan AT, Goode EL, Ulrich CM, et al. 2014. A review of the application of inflammatory biomarkers in epidemiologic cancer research. Cancer Epidemiol Biomarkers Prevent. 23(9):1729–1751.
   PubMed Web of Science ®Google Scholar
• Calza L, Legnani G, Fulgaro C, Verucchi G, Bon I, Lazzarotto T, Viale P. 2022. Changes in serum inflammatory markers in antiretroviral therapy–naive HIV-infected patients starting dolutegravir/lamivudine or dolutegravir/lamivudine/abacavir. J AIDS. 89(3):e30–e30.
   PubMed Web of Science ®Google Scholar
• Dhingra S, Sharma AK, Arora RC, Slezak J, Singal PK. 2009. IL-10 attenuates TNF-α-induced NFκB pathway activation and cardiomyocyte apoptosis. Cardiovascular Res. 82(1):59–66.
   PubMed Web of Science ®Google Scholar
• Ehrlich M. 2019. DNA hypermethylation in disease: mechanisms and clinical relevance. Epigenetics. 14(12):1141–1163.
   PubMed Web of Science ®Google Scholar
• Farivar S, Aghamaleki FS. 2018. Effects of major epigenetic factors on systemic lupus erythematosus. Iran Biomed J. 22(5):294–302.
   PubMedGoogle Scholar
• Funderburg NT, McComsey GA, Kulkarni M, Bannerman T, Mantini J, Thornton B, Liu HC, Zhang Y, Song Q, Fang L, et al. 2016. Equivalent decline in inflammation markers with tenofovir disoproxil fumarate vs. Tenofovir Alafenamide. EBioMedicine. 13:321–327.
   PubMed Web of Science ®Google Scholar
• García-Trejo JJ, Ortega R, Zarco-Zavala M. 2021. Putative repurposing of lamivudine, a nucleoside/nucleotide analogue and antiretroviral to improve the outcome of cancer and COVID-19 patients. Front Oncol. 11:664794.
   PubMed Web of Science ®Google Scholar
• George JW, Mattingly JE, Roland NJ, Small CM, Lamberty BG, Fox HS, Stauch KL. 2021. Physiologically relevant concentrations of dolutegravir, emtricitabine, and efavirenz induce distinct metabolic alterations in HeLa epithelial and BV2 microglial cells. Front Immunol. 12:639378–639378.
   PubMed Web of Science ®Google Scholar
• Ghazi T, Nagiah S, Naidoo P, Chuturgoon AA. 2019. Fusaric acid-induced promoter methylation of DNA methyltransferases triggers DNA hypomethylation in human hepatocellular carcinoma (HepG2) cells. Epigenetics. 14(8):804–817.
   PubMed Web of Science ®Google Scholar
• Hattab S, Guihot A, Guiguet M, Fourati S, Carcelain G, Caby F, Marcelin A-G, Autran B, Costagliola D, Katlama C, et al. 2014. Comparative impact of antiretroviral drugs on markers of inflammation and immune activation during the first two years of effective therapy for HIV-1 infection: an observational study. BMC Infect Dis. 14(1):122.
   PubMedGoogle Scholar
• Hayden MS, Ghosh S. 2014. Regulation of NF-κB by TNF family cytokines. Semin Immunol. 26(3):253–266.
   PubMed Web of Science ®Google Scholar
• Hileman CO, Funderburg NT. 2017. Inflammation, immune activation, and Antiretroviral therapy in HIV. Curr HIV/AIDS Rep. 14(3):93–100.
   PubMed Web of Science ®Google Scholar
• Huang THM, Perry MR, Laux DE. 1999. Methylation profiling of CpG islands in human breast cancer cells. Hum Mol Genet. 8(3):459–470.
   PubMed Web of Science ®Google Scholar
• Islam H, Chamberlain TC, Mui AL, Little JP. 2021. Elevated interleukin-10 levels in COVID-19: potentiation of pro-inflammatory responses or impaired anti-inflammatory action? Front Immunol. 12:677008.
   PubMed Web of Science ®Google Scholar
• Iyer SS, Cheng G. 2012. Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease. Crit Rev Immunol. 32(1):23–63.
   PubMed Web of Science ®Google Scholar
• Jamaluddin MS, Lin PH, Yao Q, Chen C. 2010. Non-nucleoside reverse transcriptase inhibitor efavirenz increases monolayer permeability of human coronary artery endothelial cells. Atherosclerosis. 208(1):104–111.
   PubMed Web of Science ®Google Scholar
• Khalaf H, Jass J, Olsson PE. 2010. Differential cytokine regulation by NF-kappaB and AP-1 in Jurkat T-cells. BMC Immunol. 11:26–26.
   PubMed Web of Science ®Google Scholar
• Kiraly O, Gong G, Olipitz W, Muthupalani S, Engelward BP. 2015. Inflammation-induced cell proliferation potentiates DNA damage-induced mutations in vivo. PLoS Genet. 11(2):e1004901–e1004901.
   PubMed Web of Science ®Google Scholar
• Lederman MM, Funderburg NT, Sekaly RP, Klatt NR, Hunt PW. 2013. Residual immune dysregulation syndrome in treated HIV infection. Adv Immunol. 119:51–83.
   PubMed Web of Science ®Google Scholar
• Liu T, Zhang L, Joo D, Sun S-C. 2017. NF-κB signaling in inflammation. Signal Transduct Target Ther. 2(1):17023–17023.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T.)). Method. Methods. 25(4):402–408.
   PubMed Web of Science ®Google Scholar
• Long H, Yin H, Wang L, Gershwin ME, Lu Q. 2016. The critical role of epigenetics in systemic lupus erythematosus and autoimmunity. J Autoimmun. 74:118–138.
   PubMed Web of Science ®Google Scholar
• Lu N, Malemud CJ. 2019. Extracellular Signal-Regulated Kinase: A Regulator of Cell Growth, Inflammation, Chondrocyte and Bone Cell Receptor-Mediated Gene Expression. IJMS. 20(15):3792.
   Google Scholar
• Luo Y, Zheng SG. 2016. Hall of fame among pro-inflammatory cytokines: interleukin-6 gene and its transcriptional regulation mechanisms. Front Immunol. 7:604.
   PubMed Web of Science ®Google Scholar
• Mendelsohn AS, Ritchwood T. 2020. COVID-19 and antiretroviral therapies: south africa’s charge towards 90–90–90 in the midst of a second pandemic. AIDS Behav. 24(10):2754–2756.
   PubMed Web of Science ®Google Scholar
• Miller MA, Zachary JF. 2017. Mechanisms and morphology of cellular injury, adaptation, and death. Pathol Basis Vet Dis. 2017:2–43. e19.
   Google Scholar
• Mitoma H, Horiuchi T, Tsukamoto H, Ueda N. 2018. Molecular mechanisms of action of anti-TNF-α agents - Comparison among therapeutic TNF-α antagonists. Cytokine. 101:56–63.
   PubMed Web of Science ®Google Scholar
• Molnár B, Galamb O, Péterfia B, Wichmann B, Csabai I, Bodor A, Kalmár A, Szigeti KA, Barták BK, Nagy ZB, et al. 2018. Gene promoter and exon DNA methylation changes in colon cancer development – mRNA expression and tumor mutation alterations. BMC Cancer. 18(1):695.
   PubMedGoogle Scholar
• Moraes Filho A. V d, Carvalho C. d J S, Carneiro CC, Vale C. R d, Lima D. C d S, Carvalho WF, Vieira TB, Silva D. d M E, Cunha KS, Chen-Chen L, et al. 2016. Genotoxic and cytotoxic effects of antiretroviral combinations in mice bone marrow. PLoS One. 11(11):e0165706.
   PubMed Web of Science ®Google Scholar
• Moses AK, Ghazi T, Naidoo DB, Chuturgoon A. 2021. DNA methylation of MEKKK1: a strategy to reactivate the NF-κB pathway and reverse HIV latency. AIDS. 35(13):2221–2224.
   PubMed Web of Science ®Google Scholar
• Murray P. 2006. Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response. Curr Opin Pharmacol. 6(4):379–386.
   PubMed Web of Science ®Google Scholar
• Nakano R, Kitanaka T, Namba S, Kitanaka N, Suwabe Y, Konno T, Yamazaki J, Nakayama T, Sugiya H. 2020. Non-Transcriptional and Translational Function of Canonical NF-κB Signaling in Activating ERK1/2 in IL-1β-Induced COX-2 Expression in Synovial Fibroblasts. Front Immunol. 11:579266.
   PubMed Web of Science ®Google Scholar
• Niwa T, Ushijima T. 2010. 2 - Induction of epigenetic alterations by chronic inflammation and its significance on carcinogenesis. In: Herceg Z, Ushijima T, editors. Advances in genetics. Tokyo (Japan): Academic Press. p. 41–56.
   Google Scholar
• Reddy KB, Mohanambal E. 2011. Formulation and evaluation of lamivudine enclosed alginate microbeads. Der Pharmacia Lettre. 3 (6):294–304.
   Google Scholar
• Sandler NG, Sereti I. 2014. Can early therapy reduce inflammation? Curr Opin HIV AIDS. 9(1):72–79.
   PubMed Web of Science ®Google Scholar
• Schreiner E, Richter F, Nerdinger S. 2016. Development of synthetic routes to dolutegravir, in synthesis of heterocycles in contemporary medicinal chemistry. (Časar Z, Editor). Cham: Springer International Publishing. p. 187–208.
   Google Scholar
• Spainhour JC, Lim HS, Yi SV, Qiu P. 2019. Correlation Patterns Between DNA Methylation and Gene Expression in The Cancer Genome Atlas. Cancer Inform. 18:1176935119828776. 1176935119828776.
   Web of Science ®Google Scholar
• Stenvinkel P, Ketteler M, Johnson RJ, Lindholm B, Pecoits-Filho R, Riella M, Heimbürger O, Cederholm T, Girndt M. 2005. IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia–the good, the bad, and the ugly. Kidney Int. 67(4):1216–1233.
   PubMed Web of Science ®Google Scholar
• Stylianou E, Aukrust P, Kvale D, Müller F, Frøland SS. 1999. IL-10 in HIV infection: increasing serum IL-10 levels with disease progression–down-regulatory effect of potent anti-retroviral therapy. Clin Exp Immunol. 116(1):115–120.
   PubMed Web of Science ®Google Scholar
• Su D-L, Lu Z-M, Shen M-N, Li X, Sun L-Y. 2012. Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE. J Biomed Biotechnol. 2012(347141):347141.
   PubMedGoogle Scholar
• Thabethe KR, Adefolaju GA, Hosie MJ. 2015. The effects of HAART on the expression of MUC1 and P65 in a cervical cancer cell line, HCS-2. Biomed Pharmacother. 71:227–232.
   PubMed Web of Science ®Google Scholar
• Wandeler G, Johnson LF, Egger M. 2016. Trends in life expectancy of HIV-positive adults on antiretroviral therapy across the globe: comparisons with general population. Curr Opin HIV Aids. 11(5):492–500.
   PubMed Web of Science ®Google Scholar
• Yin L-M, Wei Y, Wang Y, Xu Y-D, Yang Y-Q. 2013. Long term and standard incubations of WST-1 reagent reflect the same inhibitory trend of cell viability in rat airway smooth muscle cells. Int J Med Sci. 10(1):68–72.
   PubMed Web of Science ®Google Scholar
• Zhang JM, An J. 2007. Cytokines, inflammation and pain. Int Anesthesiol Clin. 45(2):27–37.
   PubMedGoogle Scholar
• Zhang X, Wang R, Piotrowski M, Zhang H, Leach KL. 2015. Intracellular concentrations determine the cytotoxicity of adefovir, cidofovir and tenofovir. Toxicol in Vitro. 29(1):251–258.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Long H, Liao J, Zhao M, Liang G, Wu X, Zhang P, Ding S, Luo S, Lu Q, et al. 2011. Inhibited expression of hematopoietic progenitor kinase 1 associated with loss of jumonji domain containing 3 promoter binding contributes to autoimmunity in systemic lupus erythematosus. J Autoimmun. 37(3):180–189.
   PubMed Web of Science ®Google Scholar