Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 53, 2023 - Issue 3
89
Views
0
CrossRef citations to date
0
Altmetric
Animal Pharmacokinetics and Metabolism

Effect of formulation and route of administration on the distribution of 17-hydroxyprogesterone caproate in rats

, , , , , , & show all
Pages 193-200 | Received 10 Jan 2023, Accepted 06 Apr 2023, Published online: 20 Apr 2023

References

  • Caritis SN, Sharma S, Venkataramanan R, Rouse DJ, Peaceman AM, Sciscione A, Spong CY, Varner MW, Malone FD, Iams JD, et al. 2011. Pharmacokinetics of 17-hydroxyprogesterone caproate in multifetal gestation. 205(1):40.e41–40.e48. Am J Obstet Gynecol.
  • Caritis SN, Venkataramanan R, Thom E, Harper M, Klebanoff MA, Sorokin Y, Thorp JM, Jr., Varner MW, Wapner RJ, Iams JD, et al. 2014. Relationship between 17-alpha hydroxyprogesterone caproate concentration and spontaneous preterm birth. Am J Obstet Gynecol. 210(2):128.e1–128.e6.
  • Frey HA, Klebanoff MA. 2016. The epidemiology, etiology, and costs of preterm birth. Semin Fetal Neonatal Med. 21(2):68–73.
  • Goldenberg RL, Culhane JF, Iams JD, Romero R. 2008. Epidemiology and causes of preterm birth. Lancet. 371(9606):75–84.
  • Johnson JW, Austin KL, Jones GS, Davis GH, King TM. 1975. Efficacy of 17alpha-hydroxyprogesterone caproate in the prevention of premature labor. N Engl J Med. 293(14):675–680.
  • Krop J, Kramer WG. 2017. Comparative bioavailability of hydroxyprogesterone caproate administered via intramuscular injection or subcutaneous autoinjector in healthy postmenopausal women: a randomized, parallel group, open-label study. Clin Ther. 39(12):2345–2354.
  • Manuck TA, Lai Y, Meis PJ, Dombrowski MP, Sibai B, Spong CY, Rouse DJ, Durnwald CP, Caritis SN, Wapner RJ, et al. 2011. Progesterone receptor polymorphisms and clinical response to 17-alpha-hydroxyprogesterone caproate. Am J Obstet Gynecol. 205(2):135.e1–135.e9.
  • Meis PJ, Klebanoff M, Thom E, Dombrowski MP, Sibai B, Moawad AH, Spong CY, Hauth JC, Miodovnik M, Varner MW, et al. 2003. Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. N Engl J Med. 348(24):2379–2385.
  • Monangi NK, Brockway HM, House M, Zhang G, Muglia LJ. 2015. The genetics of preterm birth: progress and promise. Semin Perinatol. 39(8):574–583.
  • National Research Council Committee for the Update of the Guide for the Care and Use of Laboratory Animals. 2011. Guide for the Care and Use of Laboratory Animals. Washington (DC), National Academies Press (US).
  • O’Brien JM, Lewis DF. 2016. Prevention of preterm birth with vaginal progesterone or 17-alpha-hydroxyprogesterone caproate: a critical examination of efficacy and safety. Am J Obstet Gynecol. 214(1):45–56.
  • Shaik IH, Bastian JR, Zhao Y, Caritis SN, Venkataramanan R. 2016. Route of administration and formulation dependent pharmacokinetics of 17-hydroxyprogesterone caproate in rats. Xenobiotica. 46(2):169–174.
  • Sharma S, Ellis EC, Dorko K, Zhang S, Mattison DR, Caritis SN, Venkataramanan R, Strom SC. 2010. Metabolism of 17alpha-hydroxyprogesterone caproate, an agent for preventing preterm birth, by fetal hepatocytes. Drug Metab Dispos. 38(5):723–727.
  • Sharma S, Ellis EC, Gramignoli R, Dorko K, Tahan V, Hansel M, Mattison DR, Caritis SN, Hines RN, Venkataramanan R, et al. 2013. Hepatobiliary disposition of 17-OHPC and taurocholate in fetal human hepatocytes: a comparison with adult human hepatocytes. Drug Metab Dispos. 41(2):296–304.
  • Sharma S, Ou J, Strom S, Mattison D, Caritis S, Venkataramanan R. 2008. Identification of enzymes involved in the metabolism of 17alpha-hydroxyprogesterone caproate: an effective agent for prevention of preterm birth. Drug Metab Dispos. 36(9):1896–1902.
  • Strauss JF, Romero R, Gomez-Lopez N, Haymond-Thornburg H, Modi BP, Teves ME, Pearson LN, York TP, Schenkein HA. 2018. Spontaneous preterm birth: advances toward the discovery of genetic predisposition. Am J Obstet Gynecol. 218(3):294–314 e292.
  • van Zijl MD, Koullali B, Mol BW, Pajkrt E, Oudijk MA. 2016. Prevention of preterm delivery: current challenges and future prospects. Int J Womens Health. 8:633–645.
  • Yan R, Nanovskaya TN, Zharikova OL, Mattison DR, Hankins GD, Ahmed MS. 2008. Metabolism of 17alpha-hydroxyprogesterone caproate by hepatic and placental microsomes of human and baboons. Biochem Pharmacol. 75(9):1848–1857.
  • Zhang S, Mada SR, Sharma S, Torch M, Mattison D, Caritis S, Venkataramanan R. 2008. Simultaneous quantitation of 17alpha-hydroxyprogesterone caproate, 17alpha-hydroxyprogesterone and progesterone in human plasma using high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS). J Pharm Biomed Anal. 48(4):1174–1180.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.