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Xenobiotica
the fate of foreign compounds in biological systems
Volume 53, 2023 - Issue 4
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General Xenobiochemistry

Investigation on the in vitro metabolism of bicyclol using liver microsomes, hepatocytes and human recombinant cytochrome P450 enzymes

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Pages 231-240 | Received 07 May 2023, Accepted 04 Jun 2023, Published online: 19 Jun 2023

References

  • Chu NH, Li L, Zhang X, Gu J, Du YD, Cai C, Xiao HP. 2015. Role of bicyclol in preventing drug-induced liver injury in tuberculosis patients with liver disease. Int J Tuberc Lung Dis. 19(4):475–480. doi: 10.5588/ijtld.14.0579.
  • Cui J, Li Z, Qian LB, Gao Q, Wang J, Xue M, Lou XE, Bruce LC, Xia Q, Wang HP. 2013. Reducing the oxidative stress mediates the cardioprotection of bicyclol against ischemia-reperfusion injury in rats. J Zhejiang Univ Sci B. 14(6):487–495. doi: 10.1631/jzus.B1200263.
  • Dong JN, Li S, Liu GX. 2019. In vitro metabolism of ibrutinib in rat, dog and human hepatocytes using liquid chromatography combined with diode-array detection and Q-Exactive orbitrap tandem mass spectrometry. Rapid Commun Mass Spectrom. 33(23):1804–1815. doi: 10.1002/rcm.8542.
  • Erve JC, Gauby S, Maynard JW, Jr, Svensson MA, Tonn G, Quinn KP. 2013. Bioactivation of sitaxentan in liver microsomes, hepatocytes, and expressed human P450s with characterization of the glutathione conjugate by liquid chromatography tandem mass spectrometry. Chem Res Toxicol. 26(6):926–936. doi: 10.1021/tx4001144.
  • Hu MW, Li Y, You F, Bai J, Fan XQ, Zhao SY, Sun YH, Wang BL, Hu JP, Li Y. 2020. Comparison and identification of metabolic profiling of bicyclol in rats, dogs and humans in vitro and in vivo. Eur J Pharm Sci. 154:105518. doi: 10.1016/j.ejps.2020.105518.
  • Hu QW, Liu GT. 2006. Effects of bicyclol on dimethyl nitrosamine-induced liver fibrosis in mice and its mechanism of action. Life Sci. 79(6):606–612. doi: 10.1016/j.lfs.2006.02.025.
  • Huang XC, Jia MQ, Liu YC, Wang SW, Tang YJ, Li XJ, Jiang XH, Wu ZH, Lou YF, Fan GR. 2022. Identification of bicyclol metabolites in rat plasma, urine and feces by UPLC-Q-TOF-MS/MS and evaluation of the efficacy and safety of these metabolites based on network pharmacology and molecular docking combined with toxicity prediction. J Pharm Biomed Anal. 220:114947. doi: 10.1016/j.jpba.2022.114947.
  • Kalgutkar AS, Gardner I, Obach RS, Shaffer CL, Callegari E, Henne KR, Mutlib AE, Dalvie DK, Lee JS, Nakai Y, et al. 2005. A comprehensive listing of bioactivation pathways of organic functional groups. Curr Drug Metab. 6(3):161–225. doi: 10.2174/1389200054021799.
  • Liu GT. 2009. Bicyclol: a novel drug for treating chronic viral hepatitis B and C. Med Chem. 5(1):29–43. doi: 10.2174/157340609787049316.
  • Liu GT, Li Y, Wei HL, Zhang H, Xu JY, Yu LH. 2005. Mechanism of protective action of bicyclol against CCl4-induced liver injury in mice. Liver Int. 25(4):872–879. doi: 10.1111/j.1478-3231.2005.01103.x.
  • Luo Y, Zhang B, Xu DQ, Liu Y, Dong MQ, Zhao PT, Li ZC. 2011. Protective effect of bicyclol on lipopolysaccharide-induced acute lung injury in mice. Pulm Pharmacol Ther. 24(2):240–246. doi: 10.1016/j.pupt.2010.12.005.
  • Mikami A, Ohtani H, Hori S, Sawada Y. 2013. Pharmacokinetic model incorporating mechanism-based inactivation of CYP2D6 can explain both non-linear kinetics and drug interactions of paroxetine. Int J Clin Pharmacol Ther. 51(5):374–382. doi: 10.5414/CP201798.
  • Tang Y, Hu W, Li Y, Zhang CZ. 2007. Synthesis of metabolites of bicyclol. Acta Pharm Sin. 42:1054–1057.
  • Wang HP, Li Y. 2006. Protective effect of bicyclol on acute hepatic failure induced by lipopolysaccharide and D-galactosamine in mice. Eur J Pharmacol. 534(1-3):194–201. doi: 10.1016/j.ejphar.2005.12.080.
  • Wu XW, Sun S, Wu XY, Sun ZX. 2022. Identification of the metabolites of methylophiopogonanone A by ultra-high-performance liquid chromatography combined with high-resolution mass spectrometry. Rapid Commun Mass Spectrom. 36:e9304.
  • Zhang J, Fu BS, Zhang XJ, Chen LY, Zhang L, Zhao XM, Bai X, Zhu CH, Cui LL, Wang LN. 2013. Neuroprotective effect of bicyclol in rat ischemic stroke: down-regulates TLR4, TLR9, TRAF6, NF-kappa B, MMP-9 and up-regulates claudin-5 expression. Brain Res. 1528:80–88. doi: 10.1016/j.brainres.2013.06.032.
  • Zhao TM, Mao LH, Yu ZH, Hui YY, Feng HJ, Wang XY, Lin L, Fan XF, Chen X, Wang BM, et al. 2021. Therapeutic potential of bicyclol in liver diseases: lessons from a synthetic drug based on herbal derivative in traditional Chinese medicine. Int Immunopharmacol. 91:107308. doi: 10.1016/j.intimp.2020.107308.
  • Zhou Y, Chai XJ. 2020. Protective effect of bicyclol against pulmonary fibrosis via regulation of microRNA-455-3p in rats. J Cell Biochem. 121(1):651–660. doi: 10.1002/jcb.29310.

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