Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 53, 2023 - Issue 5
898
Views
1
CrossRef citations to date
0
Altmetric
Clinical Pharmacokinetics and Metabolism

Absorption, distribution, metabolism and excretion of 14C-vatiquinone in rats, dogs, and human subjects

, , , , , , , & ORCID Icon show all
Pages 396-411 | Received 27 Jun 2023, Accepted 03 Aug 2023, Published online: 18 Aug 2023

References

  • Atkuri KR, Cowan TM, Kwan T, Ng A, Herzenberg LA, Herzenberg LA, Enns GM. 2009. Inherited disorders affecting mitochondrial function are associated with glutathione deficiency and hypocitrullinemia. Proc Natl Acad Sci U S A. 106(10):3941–3945. doi: 10.1073/pnas.0813409106.
  • Blankenberg FG, Kinsman SL, Cohen BH, Goris ML, Spicer KM, Perlman SL, Krane EJ, Kheifets V, Thoolen M, Miller G, et al. 2012. Brain uptake of Tc99m-HMPAO correlates with clinical response to the novel redox modulating agent EPI-743 in patients with mitochondrial disease. Mol Genet Metab. 107(4):690–699. doi: 10.1016/j.ymgme.2012.09.023.
  • Chuang JC, Matel HD, Nambiar KP, Kim S-H, Fadel JG, Holstege DM, Clifford AJ. 2011. Quantitation of [5-CH3]-(2R, 4'R, 8'R)-α-tocopherol in humans. J Nutr. 141(8):1482–1488. doi: 10.3945/jn.111.138925.
  • Enns GM, Kinsman SL, Perlman SL, Spicer KM, Abdenur JE, Cohen BH, Amagata A, Barnes A, Kheifets V, Shrader WD, et al. 2012. Initial experience in the treatment of inherited mitochondrial disease with EPI-743. Mol Genet Metab. 105(1):91–102. doi: 10.1016/j.ymgme.2011.10.009.
  • Hinman A, Holst CR, Latham JC, Bruegger JJ, Ulas G, McCusker KP, Amagata A, Davis D, Hoff KG, Kahn-Kirby AH, et al. 2018. Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase. PLoS One. 13(8):e0201369. doi: 10.1371/journal.pone.0201369.
  • Kaneko K, Kiyose C, Ueda T, Ichikawa H, Igarashi O. 2000. Studies of the metabolism of α-tocopherol stereoisomers in rats using [5-methyl-14C]SRR- and RRR-α-tocopherol. J Lipid Res. 41(3):357–367. doi: 10.1016/S0022-2275(20)34474-6.
  • Kiyose C, Ueda T. 2004. Distribution and metabolism of tocopherols and tocotrienols in vivo. J Clin Biochem Nutr. 35(1):47–52. doi: 10.3164/jcbn.35.47.
  • Lee L, Ma M, Murase K, Thoolen M, Kong R. 2022. The clinical pharmacology of vatiquinone, a 15-lipoxygenase inhibitor targeting inflammation and oxidative stress. Poster at Behind the Exhibit Hall. American Epilepsy Society; Dec 2022; Nashville, TN.
  • Lee L, Murase K, Ma J, Thoolen M. 2023. Clinical drug-drug interaction between vatiquinone, a 15-lipoxygenase inhibitor, and rosuvastatin, a breast cancer resistance protein substrate. Clin Pharmacol Drug Dev. 12(3):279–286. doi: 10.1002/cpdd.1199.
  • Martinelli D, Catteruccia M, Piemonte F, Pastore A, Tozzi G, Dionisi-Vici C, Pontrelli G, Corsetti T, Livadiotti S, Kheifets V, et al. 2012. EPI-743 reverses the progression of the pediatric mitochondrial disease-genetically defined Leigh Syndrome. Mol Genet Metab. 107(3):383–388. doi: 10.1016/j.ymgme.2012.09.007.
  • Murase K, Lee L, Ma J, Barrett R, Thoolen M. 2022. Evaluation of vatiquinone drug-drug interaction potential in vitro and in a phase 1 clinical study with tolbutamide, a CYP2C9 substrate, and omeprazole, a CYP2C19 substrate, in healthy subjects. Eur J Clin Pharmacol. 78(11):1823–1831. doi: 10.1007/s00228-022-03393-0.
  • Pastore A, Petrillo S, Tozzi G, Carrozzo R, Martinelli D, Dionisi-Vici C, Giovamberardino GD, Ceravolo F, Klein MB, Miller G, et al. 2013. Glutathione: a redox signature in monitoring EPI-743 therapy in children with mitochondrial encephalomyopathies. Mol Genet Metab. 109(2):208–214. doi: 10.1016/j.ymgme.2013.03.011.
  • Sadun AA, Chicani CF, Ross-Cisneros FN, Barboni P, Thoolen M, Shrader WD, Kubis K, Carelli V, Miller G. 2012. Effect of EPI-743 on the clinical course of the mitochondrial disease Leber hereditary optic neuropathy. Arch Neurol. 69(3):331–338. doi: 10.1001/archneurol.2011.2972.
  • Schmölz L, Birringer M, Lorkowski S, Wallert M. 2016. Complexity of vitamin E metabolism. World J Biol Chem. 7(1):14–43. doi: 10.4331/wjbc.v7.i1.14.
  • Shrader WD, Amagata A, Barnes A, Enns GM, Hinman A, Jankowski O, Kheifets V, Komatsuzaki R, Lee E, Mollard P, et al. 2011. α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. Bioorg Med Chem Lett. 21(12):3693–3698. doi: 10.1016/j.bmcl.2011.04.085.
  • Simon EJ, Eisengart A, Sundheim L, Milhorat AT. 1956. The metabolism of vitamin E. II. purification and characterization of urinary metabolites of α-tocopherol. J Biol Chem. 221(2):807–817. doi: 10.1016/S0021-9258(18)65194-4.
  • Simon EJ, Gross CS, Milhorat AT. 1956. The metabolism of vitamin E. 1. The absorption and excretion of d-α-tocopheroI-5-methyl-C14-succinate. J Biol Chem. 221(2):797–805. doi: 10.1016/S0021-9258(18)65193-2.
  • Wechter WJ, Kantoci D, Murray ED, D'Amico DC, Jung ME, Wang WH. 1996. A new endogenous natriuretic factor: LLU-α. Proc Natl Acad Sci U S A. 93(12):6002–6007. doi: 10.1073/pnas.93.12.6002.
  • Zesiewicz T, Salemi JL, Perlman S, Sullivan KL, Shaw JD, Huang Y, Isaacs C, Gooch C, Lynch DR, Klein MB. 2018. Double-blind, randomized and controlled trial of EPI-743 in Friedreich’s ataxia. Eurodegener Dis Manag. 8(4):233–242. doi: 10.2217/nmt-2018-0013.