The metabolite profiling of YR-1702 injection in human plasma, urine and feces by HPLC-Q-TOF-MS/MS

References

• Bian Y, Sun M, Chen H, Ren G, Fu K, Yang N, Zhang M, Zhou N, Lu Y, Li N, et al. 2022. Metabolites identification and species comparison of Oroxylin A, an anti-cancer flavonoid, in vitro and in vivo by HPLC-Q-TOF-MS/MS. Xenobiotica. 52(2):165–176. doi: 10.1080/00498254.2021.2014080.
   PubMed Web of Science ®Google Scholar
• Childers WE, Abou-Gharbia MA. 2021. I’ll Be Back”: the Resurrection of Dezocine. ACS Med Chem Lett. 12(6):961–968. doi: 10.1021/acsmedchemlett.1c00233.
   PubMed Web of Science ®Google Scholar
• Choi SM, Kim Y, Lee J, Kim J-H, Lee T, Min BS, Kim JA, Lee S. 2020. Characterization of hydrocoptisonine metabolites in human liver microsomes using a high-resolution quadrupole-orbitrap mass spectrometer. Xenobiotica. 50(12):1423–1433. doi: 10.1080/00498254.2020.1795304.
   PubMed Web of Science ®Google Scholar
• Crabtree D, Ganty P. 2016. Common functional pain syndromes. BJA Education. 16(10):334–340. doi: 10.1093/bjaed/mkw010.
   Google Scholar
• Dowell D, Ragan KR, Jones CM, Baldwin GT, Chou R. 2022. CDC clinical practice guideline for prescribing opioids for pain — United States, 2022. MMWR Recomm Rep. 71(3):1–95. doi: 10.15585/mmwr.rr7103a1.
   PubMed Web of Science ®Google Scholar
• Dubin AE, Patapoutian A. 2010. Nociceptors: the sensors of the pain pathway. J Clin Invest. 120(11):3760–3772. doi: 10.1172/JCI42843.
   PubMed Web of Science ®Google Scholar
• Feng R, Zhang X, Yin J, Zhang Y, Ma Y, Zhang X, Zhang L, Li D. 2021. A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS. J Pharm Biomed Anal. 197:113905. doi: 10.1016/j.jpba.2021.113905.
   PubMed Web of Science ®Google Scholar
• Gao H, Li J, Chen X, Sun Z, Cui G, Cheng M, Ding L. 2022. Pharmacokinetics, metabolite profiling, safety, and tolerability of inhalation aerosol of 101BHG-D01, a novel, long-acting and selective muscarinic receptor antagonist, in healthy Chinese subjects. Front Pharmacol. 13:1064364. doi: 10.3389/fphar.2022.1064364.
   PubMed Web of Science ®Google Scholar
• Gharagozlou P, Hashemi E, DeLorey TM, Clark JD, Lameh J. 2006. Pharmacological profiles of opioid ligands at Kappa opioid receptors. BMC Pharmacol. 6(1):3. doi: 10.1186/1471-2210-6-3.
   PubMedGoogle Scholar
• Hamilton RA, Garnett WR, Kline BJ. 1981. Determination of mean valproic acid serum level by assay of a single pooled sample. Clin Pharmacol Ther. 29(3):408–413. doi: 10.1038/clpt.1981.56.
   PubMed Web of Science ®Google Scholar
• Jasinski DR, Preston KL. 1985. Assessment of dezocine for morphine-like subjective effects and miosis. Clin Pharmacol Ther. 38(5):544–548. doi: 10.1038/clpt.1985.221.
   PubMed Web of Science ®Google Scholar
• Kong L, Berg FJ. 2018. Identification of cholecystokinin tetrapeptide amide metabolites in liver microsomes of human, Rhesus Monkey, Sprague-Dawley rat and CD1 mouse using ultra-high performance liquid chromatography coupled to high resolution mass spectrometer. J Chromatogr B Analyt Technol Biomed Life Sci. 1096:80–87. doi: 10.1016/j.jchromb.2018.08.012.
   PubMed Web of Science ®Google Scholar
• Remesic M, Hruby VJ, Porreca F, Lee YS. 2017. Recent advances in the realm of allosteric modulators for opioid receptors for future therapeutics. ACS Chem Neurosci. 8(6):1147–1158. doi: 10.1021/acschemneuro.7b00090.
   PubMed Web of Science ®Google Scholar
• Strain EC, Preston KL, Liebson IA, Bigelow GE. 1996. Opioid antagonist effects of dezocine in opioid-dependent humans. Clin Pharmacol Ther. 60(2):206–217. doi: 10.1016/S0009-9236(96)90137-X.
   PubMed Web of Science ®Google Scholar
• Volkow ND, McLellan AT. 2016. Opioid abuse in chronic pain—misconceptions and mitigation strategies. N Engl J Med. 374(13):1253–1263. doi: 10.1056/NEJMra1507771.
   PubMed Web of Science ®Google Scholar
• Wang K, Chai L, Feng X, Liu Z, Liu H, Ding L, Qiu F. 2017. Metabolites identification of berberine in rats using ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry. J Pharm Biomed Anal. 139:73–86. doi: 10.1016/j.jpba.2017.02.038.
   PubMed Web of Science ®Google Scholar
• Wang L, Liu X, Wang J, Sun Y, Zhang G, Liang L. 2017. Comparison of the efficacy and safety between dezocine injection and morphine injection for persistence of pain in Chinese cancer patients: a meta-analysis. Biosci Rep. 37(3):BSR20170243. doi: 10.1042/BSR20170243.
   PubMedGoogle Scholar
• Wang Y-H, Chai J-R, Xu X-J, Ye R-F, Zan G-Y, Liu GY-K, Long J-D, Ma Y, Huang X, Xiao Z-C, et al. 2018. Pharmacological characterization of dezocine, a potent analgesic acting as a κ partial agonist and μ partial agonist. Sci Rep. 8(1):14087. doi: 10.1038/s41598-018-32568-y.
   PubMedGoogle Scholar
• Yin J, Zhang X, Zhang Y, Ma Y, Li L, Li D, Zhang L, Zhang Z. 2019. Comprehensive study of the in vivo and in vitro metabolism of dietary isoflavone biochanin A based on UHPLC-Q-TOF-MS/MS. J Agric Food Chem. 67(45):12481–12495. doi: 10.1021/acs.jafc.9b05776.
   PubMed Web of Science ®Google Scholar
• Yuan S, Gao P, Shi Y, Tu P, Jiang Y. 2022. Rapid screening and identification of metabolites of murpanicin in rats by UHPLC/Q-TOF-MS/MS combined with diagnostic fragment ions (DFIs) and multiple mass defect filter. J Pharm Biomed Anal. 213:114679. doi: 10.1016/j.jpba.2022.114679.
   PubMed Web of Science ®Google Scholar
• Zhu Z-J, Schultz AW, Wang J, Johnson CH, Yannone SM, Patti GJ, Siuzdak G. 2013. Liquid chromatography quadrupole time-of-flight mass spectrometry characterization of metabolites guided by the METLIN database. Nat Protoc. 8(3):451–460. doi: 10.1038/nprot.2013.004.
   PubMed Web of Science ®Google Scholar